{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:35:45Z","timestamp":1780400145809,"version":"3.54.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","amjmedsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.amjms.2017.04.007","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T16:30:28Z","timestamp":1491841828000},"page":"190-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Potential Cardiovascular and Renal Protective Effects of Vitamin D and Coenzyme Q 10 in l -NAME-Induced Hypertensive Rats"],"prefix":"10.1016","volume":"354","author":[{"given":"Hanan A.","family":"Shamardl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar M.","family":"El-Ashmony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala F.","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer H.","family":"Fatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"70","key":"10.1016\/j.amjms.2017.04.007_bib1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jacc.2012.04.026","article-title":"Trends in prevalence, awareness, management, and control of hypertension among United States adults, 1999 to 2010","volume":"60","author":"Guo","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"9841","key":"10.1016\/j.amjms.2017.04.007_bib2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0140-6736(12)60861-7","article-title":"Hypertension in developing countries","volume":"380","author":"Ibrahim","year":"2012","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.amjms.2017.04.007_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10654-013-9790-2","article-title":"Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants","volume":"28","author":"Kunutsor","year":"2013","journal-title":"Eur J Epidemiol"},{"issue":"3","key":"10.1016\/j.amjms.2017.04.007_bib4","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1210\/er.2012-1000","article-title":"The non-skeletal effects of vitamin D: an endocrine society scientific statement","volume":"33","author":"Rosen","year":"2012","journal-title":"Endocr Rev"},{"issue":"4","key":"10.1016\/j.amjms.2017.04.007_bib5","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/01.HYP.0000182662.82666.37","article-title":"Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies","volume":"46","author":"Forman","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.amjms.2017.04.007_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00000441-200608000-00004","article-title":"Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements","volume":"332","author":"Goodwin","year":"2006","journal-title":"Am J Med Sci"},{"issue":"10","key":"10.1016\/j.amjms.2017.04.007_bib7","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/sj.ejcn.1600880","article-title":"Coenzyme Q10 in health and disease","volume":"53","author":"Overvad","year":"1999","journal-title":"Eur J Clin Nutr"},{"issue":"7","key":"10.1016\/j.amjms.2017.04.007_bib8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0002-9149(90)90824-K","article-title":"Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy","volume":"65","author":"Langsjoen","year":"1990","journal-title":"Am J Cardiol"},{"issue":"3","key":"10.1016\/j.amjms.2017.04.007_bib9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00125-001-0760-y","article-title":"Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in type II diabetes mellitus","volume":"45","author":"Watts","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.amjms.2017.04.007_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/sj.jhh.1002138","article-title":"Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials","volume":"2","author":"Rosenfeldt","year":"2007","journal-title":"J Hum Hypertens"},{"issue":"1","key":"10.1016\/j.amjms.2017.04.007_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.14423\/SMJ.0000000000000393","article-title":"Coenzyme Q-10 in human health: supporting evidence?","volume":"109","author":"Saha","year":"2016","journal-title":"South Med J"},{"key":"10.1016\/j.amjms.2017.04.007_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1470320309347785","article-title":"The angiotensin II type 2 receptor in cardiovascular disease","volume":"11","author":"Lemarie","year":"2010","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"10","key":"10.1016\/j.amjms.2017.04.007_bib13","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1089\/ars.2012.4641","article-title":"Angiotensin II, NADPH oxidase, and redox signaling in the vasculature","volume":"19","author":"Nguyen Dinh Cat","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.amjms.2017.04.007_bib14","first-page":"503","article-title":"Nitric oxide as a unique signaling molecule in the vascular system: a historical overview","volume":"53","author":"Ignarro","year":"2002","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.amjms.2017.04.007_bib15","doi-asserted-by":"crossref","first-page":"917","DOI":"10.5603\/KP.2013.0226","article-title":"Structure and function of large arteries in hypertension in relation to oxidative stress markers","volume":"71","author":"Klima","year":"2013","journal-title":"Kardiol Pol."},{"issue":"1","key":"10.1016\/j.amjms.2017.04.007_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1753944711434039","article-title":"Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats","volume":"6","author":"Moniwa","year":"2012","journal-title":"Ther Adv Cardiovasc Dis"},{"issue":"2","key":"10.1016\/j.amjms.2017.04.007_bib17","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ijcard.2014.02.041","article-title":"Calcitriol modulates receptor for advanced glycation end products (RAGE) in diabetic hearts","volume":"173","author":"Lee","year":"2014","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.amjms.2017.04.007_bib18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3164\/jcbn.EL50_145","article-title":"Effect of coenzyme Q10 and \u03b1-lipoic acid supplementation in fructose fed rats","volume":"51","author":"Serhatozdogan","year":"2012","journal-title":"J Clin Biochem Nutr"},{"key":"10.1016\/j.amjms.2017.04.007_bib19","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3109\/10641963.2012.665542","article-title":"Role of propolis on tyrosine hydroxylase activity and blood pressure in nitric oxide synthase-inhibited hypertensive rats","volume":"34","author":"Gogebakan","year":"2012","journal-title":"Clin Exp Hypertens"},{"issue":"7","key":"10.1016\/j.amjms.2017.04.007_bib20","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1161\/STROKEAHA.107.510677","article-title":"Pulse pressure and mean arterial pressure in relation to ischemic stroke among patients with uncontrolled hypertension in rural areas of China","volume":"39","author":"Zheng","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.amjms.2017.04.007_bib21","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1021\/bi00733a026","article-title":"Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of triglycerides by lipoprotein lipase from different sources","volume":"12","author":"Havel","year":"1973","journal-title":"Biochemistry"},{"key":"10.1016\/j.amjms.2017.04.007_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of low-density lipoprotein cholesterol in plasma, without use of the preparative centrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.amjms.2017.04.007_bib23","first-page":"1","article-title":"Total antioxidant capacity: a biomarker in biomedical and nutritional studies","volume":"7","author":"Kusano","year":"2008","journal-title":"J Cell Mol Biol"},{"key":"10.1016\/j.amjms.2017.04.007_bib24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0076-6879(84)05042-4","article-title":"Assay of lipid peroxidation in blood plasma or serum","volume":"105","author":"Yagi","year":"1984","journal-title":"Methods Enzymol"},{"issue":"2","key":"10.1016\/j.amjms.2017.04.007_bib25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF02172085","article-title":"Immunomodulatory effect of tumor necrosis factor","volume":"3","author":"Bonavida","year":"1991","journal-title":"Biotherapy"},{"key":"10.1016\/j.amjms.2017.04.007_bib26","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/01.ATV.18.9.1456","article-title":"Inhibition of NO synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vessels","volume":"9","author":"Tomita","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.amjms.2017.04.007_bib27","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.freeradbiomed.2012.08.585","article-title":"Blood pressure-lowering effect of dietary (-)-epicatechin administration in L-NAME-treated rats is associated with restored nitric oxide levels","volume":"53","author":"Litterio","year":"2012","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"10.1016\/j.amjms.2017.04.007_bib28","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1210\/jc.2012-1584","article-title":"Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging","volume":"97","author":"Giallauria","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.amjms.2017.04.007_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/me.2013-1252","article-title":"Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice","volume":"28","author":"Andrukhova","year":"2014","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.amjms.2017.04.007_bib30","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/biof.5520320115","article-title":"Oxidative stress, endothelial function and coenzyme Q10","volume":"32","author":"Belardinelli","year":"2008","journal-title":"Biofactors"},{"key":"10.1016\/j.amjms.2017.04.007_bib31","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.2337\/db13-0566","article-title":"Combination pravastatin and valsartan treatment has additive beneficial effects to simultaneously improve both metabolic and cardiovascular phenotypes beyond that of monotherapy with either drug in patients with primary hypercholesterolemia","volume":"62","author":"Kon Koh","year":"2013","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.amjms.2017.04.007_bib32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5717\/jenb.2015.15070703","article-title":"The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats","volume":"19","author":"Babaei","year":"2015","journal-title":"J Exerc Nutr Biochem"},{"key":"10.1016\/j.amjms.2017.04.007_bib33","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.plipres.2011.05.001","article-title":"Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids","volume":"50","author":"Jorde","year":"2011","journal-title":"Prog Lipid Res"},{"issue":"31","key":"10.1016\/j.amjms.2017.04.007_bib34","article-title":"Lipid metabolism and inflammation modulated by vitamin D in liver of diabetic rats","volume":"14","author":"Ning","year":"2015","journal-title":"Lipids Health Dis"},{"issue":"3","key":"10.1016\/j.amjms.2017.04.007_bib35","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jep.2009.09.003","article-title":"The effect of total extract of Securigera securidaca L. seeds on serum lipid profiles, antioxidant status, and vascular function in hypercholesterolemic rats","volume":"126","author":"Garjani","year":"2009","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"10.1016\/j.amjms.2017.04.007_bib36","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/mnfr.200900155","article-title":"Supplementation with the reduced form of coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice","volume":"54","author":"Schmelzer","year":"2010","journal-title":"Mol Nutr Food Res"},{"issue":"3","key":"10.1016\/j.amjms.2017.04.007_bib37","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00380-014-0523-6","article-title":"Humid heat exposure induced oxidative stress and apoptosis in cardiomyocytes through the angiotensin II signaling pathway","volume":"30","author":"Wang","year":"2015","journal-title":"Heart Vessels"},{"key":"10.1016\/j.amjms.2017.04.007_bib38","first-page":"133","article-title":"Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury","volume":"152","author":"Xu","year":"2015","journal-title":"Biochem Mol Boil"},{"key":"10.1016\/j.amjms.2017.04.007_bib39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.jhh.1000778","article-title":"Effect of hydrosoluble COQ10 on blood pressure and insulin resistance in hypertensive patients with coronary artery disease","volume":"13","author":"Singh","year":"1999","journal-title":"J Hum Hypertens"},{"issue":"2","key":"10.1016\/j.amjms.2017.04.007_bib40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/sj.jhh.1001785","article-title":"Independent association between inflammatory markers (C reactive protein, interleukin-6, and TNF-\u03b1) and essential hypertension","volume":"19","author":"Bautista","year":"2005","journal-title":"J Hum Hypertens"},{"issue":"10","key":"10.1016\/j.amjms.2017.04.007_bib41","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20070657","article-title":"Role of the T cell in the genesis of angiotensin II-induced hypertension and vascular dysfunction","volume":"204","author":"Guzik","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.amjms.2017.04.007_bib42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000340033","article-title":"Neutralization of tumor necrosis factor-alpha reduces renal fibrosis and hypertension in rats with renal failure","volume":"36","author":"Therrien","year":"2012","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.amjms.2017.04.007_bib43","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s00395-007-0673-0","article-title":"Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy","volume":"102","author":"Westermann","year":"2007","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"10.1016\/j.amjms.2017.04.007_bib44","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1440-1797.2008.00918.x","article-title":"Angiotensin II receptor blocker inhibits tumour necrosis factor-alpha-induced cell damage in human renal proximal tubular epithelial cells","volume":"13","author":"Kagawa","year":"2008","journal-title":"Nephrology(Carlton)"},{"issue":"3","key":"10.1016\/j.amjms.2017.04.007_bib45","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1440-1681.2009.05292.x","article-title":"Prorenin receptor contributes to diabetic nephropathy through enhancing renal inflammation","volume":"37","author":"Matavelli","year":"2010","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"2","key":"10.1016\/j.amjms.2017.04.007_bib46","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s13105-015-0412-1","article-title":"Vitamin D attenuates pro-inflammatory TNF-\u03b1 cytokine expression by inhibiting NF-\u043aB\/p65 signaling in hypertrophied rat hearts","volume":"71","author":"Al-Rasheed","year":"2015","journal-title":"J Physiol Biochem"},{"issue":"6","key":"10.1016\/j.amjms.2017.04.007_bib47","doi-asserted-by":"crossref","first-page":"627","DOI":"10.4103\/0253-7613.144924","article-title":"Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats","volume":"46","author":"Rajesh","year":"2014","journal-title":"Ind J Pharmacol"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962917302136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962917302136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T07:38:16Z","timestamp":1601883496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962917302136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0002962917302136"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2017.04.007","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential Cardiovascular and Renal Protective Effects of Vitamin D and Coenzyme Q10 in l-NAME-Induced Hypertensive Rats","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2017.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Southern Society for Clinical Investigation. Published by All rights reserved.","name":"copyright","label":"Copyright"}]}}