{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:28:28Z","timestamp":1790270908956,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500537"],"award-info":[{"award-number":["81500537"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","amjmedsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.amjms.2017.12.019","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T16:44:14Z","timestamp":1514652254000},"page":"314-321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical Significance of Urinary Biomarkers in Patients With Primary Focal Segmental Glomerulosclerosis"],"prefix":"10.1016","volume":"355","author":[{"given":"Qingyan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengjin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyuan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjms.2017.12.019_bib1","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/0272-6386(95)90437-9","article-title":"Increasing incidence of focal-segmental glomerulosclerosis among adult nephropathies: a 20-year renal biopsy study","volume":"26","author":"Haas","year":"1995","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.amjms.2017.12.019_bib2","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/S0272-6386(97)90179-7","article-title":"Incidence and prevalence of ESRD.","volume":"30","year":"1997","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.amjms.2017.12.019_bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1523-1755.2002.00433.x","article-title":"Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury","volume":"62","author":"Han","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjms.2017.12.019_bib4","doi-asserted-by":"crossref","first-page":"F552","DOI":"10.1152\/ajprenal.00285.2002","article-title":"Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury","volume":"286","author":"Ichimura","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.amjms.2017.12.019_bib5","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0140-6736(05)74811-X","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery","volume":"365","author":"Mishra","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.amjms.2017.12.019_bib6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2215\/CJN.04010907","article-title":"Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study","volume":"3","author":"Bennett","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.amjms.2017.12.019_bib7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/ndt\/gfm541","article-title":"Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients","volume":"23","author":"Bolignano","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjms.2017.12.019_bib8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000151665","article-title":"Pathological and prognostic value of urinary neutrophil gelatinase-associated lipocalin in macroproteinuric patients with worsening renal function","volume":"31","author":"Bolignano","year":"2008","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.amjms.2017.12.019_bib9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2215\/CJN.03530708","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease","volume":"4","author":"Bolignano","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.amjms.2017.12.019_bib10","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1093\/ndt\/gfr135","article-title":"High urinary excretion of kidney injury molecule-1 is an independent predictor of end-stage renal disease in patients with IgA nephropathy","volume":"26","author":"Peters","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjms.2017.12.019_bib11","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1093\/ndt\/gfr023","article-title":"Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity","volume":"26","author":"Xu","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjms.2017.12.019_bib12","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1093\/ndt\/gfr258","article-title":"Urinary NGAL is a useful clinical biomarker of HIV-associated nephropathy","volume":"26","author":"Sola-Del Valle","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjms.2017.12.019_bib13","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1097\/01.ASN.0000135051.62500.97","article-title":"Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants","volume":"15","author":"Chun","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.amjms.2017.12.019_bib14","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2215\/CJN.03531006","article-title":"Adult minimal-change disease: clinical characteristics, treatment, and outcomes","volume":"2","author":"Waldman","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.amjms.2017.12.019_bib15","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.2215\/CJN.02370310","article-title":"Pathological significance of a panel of urinary biomarkers in patients with drug-induced tubulointerstitial nephritis","volume":"5","author":"Wu","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.amjms.2017.12.019_bib16","doi-asserted-by":"crossref","first-page":"905","DOI":"10.7326\/0003-4819-116-11-905","article-title":"Prediction of steroid responsiveness in the idiopathic nephrotic syndrome using urinary retinol-binding protein and beta-2-microglobulin","volume":"116","author":"Sesso","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.amjms.2017.12.019_bib17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1159\/000054730","article-title":"Urinary retinol-binding protein as a prognostic marker in glomerulopathies","volume":"90","author":"Kirsztajn","year":"2002","journal-title":"Nephron"},{"key":"10.1016\/j.amjms.2017.12.019_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000045727","article-title":"Urinary retinol-binding protein as a prognostic marker in the treatment of nephrotic syndrome","volume":"86","author":"Mastroianni Kirsztajn","year":"2000","journal-title":"Nephron"},{"key":"10.1016\/j.amjms.2017.12.019_bib19","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1093\/ndt\/17.11.1890","article-title":"Urinary N-acetyl-beta-glucosaminidase excretion is a marker of tubular cell dysfunction and a predictor of outcome in primary glomerulonephritis","volume":"17","author":"Bazzi","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjms.2017.12.019_bib20","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s004670050519","article-title":"Diagnostic value of urinary retinol-binding protein in childhood nephrotic syndrome","volume":"12","author":"Dillon","year":"1998","journal-title":"Pediatr Nephrol"},{"issue":"Suppl 3","key":"10.1016\/j.amjms.2017.12.019_bib21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/ndt\/14.suppl_3.68","article-title":"Clinical picture and outcome of primary focal segmental glomerulosclerosis","volume":"14","author":"Korbet","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjms.2017.12.019_bib22","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1124\/jpet.112.192807","article-title":"Urinary vanin-1 as a novel biomarker for early detection of drug-induced acute kidney injury","volume":"341","author":"Hosohata","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.amjms.2017.12.019_bib23","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.3390\/ijms18102080","article-title":"Biomarkers for chronic kidney disease associated with high salt intake","volume":"18","author":"Hosohata","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.amjms.2017.12.019_bib24","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.clim.2007.01.010","article-title":"Urinary neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for renal tubulointerstitial injury in IgA nephropathy","volume":"123","author":"Ding","year":"2007","journal-title":"Clin Immunol"},{"key":"10.1016\/j.amjms.2017.12.019_bib25","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1046\/j.1523-1755.1999.055003890.x","article-title":"Proteinuria induces tubular cell turnover: a potential mechanism for tubular atrophy","volume":"55","author":"Thomas","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjms.2017.12.019_bib26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00041552-200401000-00005","article-title":"Cellular responses to protein overload: key event in renal disease progression","volume":"13","author":"Zoja","year":"2004","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.amjms.2017.12.019_bib27","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1442-200X.2010.03067.x","article-title":"Serum and urinary neutrophil gelatinase-associated lipocalin levels in children with chronic renal diseases","volume":"52","author":"Nishida","year":"2010","journal-title":"Pediatr Int"},{"key":"10.1016\/j.amjms.2017.12.019_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000143726","article-title":"Neutrophil gelatinase-associated lipocalin reflects the severity of renal impairment in subjects affected by chronic kidney disease","volume":"31","author":"Bolignano","year":"2008","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.amjms.2017.12.019_bib29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/0961203314550225","article-title":"Predictive role of urinary neutrophil gelatinase-associated lipocalin in lupus nephritis","volume":"24","author":"Elewa","year":"2015","journal-title":"Lupus"},{"key":"10.1016\/j.amjms.2017.12.019_bib30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.lab.2003.08.001","article-title":"Urinary fatty acid-binding protein as a new clinical marker of the progression of chronic renal disease","volume":"143","author":"Kamijo","year":"2004","journal-title":"J Lab Clin Med"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962917307097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962917307097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:24:30Z","timestamp":1617236670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962917307097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0002962917307097"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2017.12.019","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Significance of Urinary Biomarkers in Patients With Primary Focal Segmental Glomerulosclerosis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2017.12.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Southern Society for Clinical Investigation. Published by All rights reserved.","name":"copyright","label":"Copyright"}]}}