{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:59:21Z","timestamp":1758045561735,"version":"3.44.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["HL-098744"],"award-info":[{"award-number":["HL-098744"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK-101390","#52006923"],"award-info":[{"award-number":["DK-101390","#52006923"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH NIDDK","award":["R25DK101390"],"award-info":[{"award-number":["R25DK101390"]}]}],"content-domain":{"domain":["amjmedsci.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.amjms.2019.04.003","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T10:54:52Z","timestamp":1554893692000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Altered Autonomic Reactivity During Lower Body Negative Pressure in End-Stage Renal Disease"],"prefix":"10.1016","volume":"358","author":[{"given":"Kara","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida T.","family":"Fonkoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana R.","family":"DaCosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanie","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjms.2019.04.003_bib0001","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ki.1981.127","article-title":"Mechanisms of autonomic nervous system dysfunction in uremia","volume":"20","author":"Campese","year":"1981","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjms.2019.04.003_bib0002","first-page":"174","article-title":"Autonomic nervous system in haemodialysis","volume":"3","author":"Bondia","year":"1988","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjms.2019.04.003_bib0003","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1161\/01.CIR.47.5.1015","article-title":"Baroreceptor activity in normotensive and hypertensive uremic patients","volume":"47","author":"Lazarus","year":"1973","journal-title":"Circulation"},{"key":"10.1016\/j.amjms.2019.04.003_bib0004","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1161\/HYPERTENSIONAHA.110.164780","article-title":"Early sympathetic activation in the initial clinical stages of chronic renal failure","volume":"57","author":"Grassi","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.amjms.2019.04.003_bib0005","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1152\/japplphysiol.90849.2008","article-title":"Differential distribution of muscle and skin sympathetic nerve activity in patients with end-stage renal disease","volume":"105","author":"Park","year":"2008","journal-title":"J Appl Physiol (Bethesda, Md: 1985)"},{"key":"10.1016\/j.amjms.2019.04.003_bib0006","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/ki.1991.236","article-title":"Effect of dialysis and renal transplantation on autonomic dysfunction in chronic renal failure","volume":"40","author":"Agarwal","year":"1991","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjms.2019.04.003_bib0007","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1159\/000188906","article-title":"Autonomic dysfunction in hemodialysis patients with persistent hypotension","volume":"72","author":"Takahashi","year":"1996","journal-title":"Nephron"},{"key":"10.1016\/j.amjms.2019.04.003_bib0008","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/s-2004-817720","article-title":"Diabetic autonomic neuropathy","volume":"23","author":"Vinik","year":"2003","journal-title":"Semin Neurol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0009","article-title":"Neurological complications in chronic kidney disease","volume":"5","author":"Arnold","year":"2016","journal-title":"JRSM Cardiovasc Dis"},{"key":"10.1016\/j.amjms.2019.04.003_bib0010","first-page":"79","article-title":"Baroreceptor, not left ventricular, dysfunction is the cause of hemodialysis hypotension","volume":"32","author":"Heber","year":"1989","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0011","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000417384","article-title":"Autonomic neuropathy in diabetic nephropathy. Effect of regular dialysis treatment and simultaneous transplantation of kidney and pancreas","volume":"73","author":"Heidbreder","year":"1989","journal-title":"Contrib Nephrol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0012","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s11906-015-0537-1","article-title":"Blood pressure variability: assessment, predictive value, and potential as a therapeutic target","volume":"17","author":"Parati","year":"2015","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.amjms.2019.04.003_bib0013","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1159\/000180525","article-title":"Autonomic function in patients with chronic renal failure on intermittent haemodialysis","volume":"15","author":"Ewing","year":"1975","journal-title":"Nephron"},{"key":"10.1016\/j.amjms.2019.04.003_bib0014","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology Circulation","volume":"93","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.amjms.2019.04.003_bib0015","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1007\/s10157-015-1189-9","article-title":"Heart rate variability is an indicator for intradialytic hypotension among chronic hemodialysis patients","volume":"20","author":"Chang","year":"2016","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0016","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1046\/j.1523-1755.2002.00659.x","article-title":"Cardiovascular autonomic dysfunction in uremia","volume":"62","author":"Robinson","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjms.2019.04.003_bib0017","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/bja\/aer394","article-title":"Investigation of the agreement of a continuous non-invasive arterial pressure device in comparison with invasive radial artery measurement","volume":"108","author":"Ilies","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.amjms.2019.04.003_bib0018","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1681\/ASN.V91105","article-title":"Hemodynamic response during lower body negative pressure: role of volume status","volume":"9","author":"Ligtenberg","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0019","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.clnu.2011.04.001","article-title":"Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population","volume":"30","author":"Ling","year":"2011","journal-title":"Clin Nutr"},{"key":"10.1016\/j.amjms.2019.04.003_bib0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.ajkd.2010.05.022","article-title":"Comparison of multifrequency bioelectrical impedance analysis and dual-energy X-ray absorptiometry assessments in outpatient hemodialysis patients","volume":"57","author":"Furstenberg","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.amjms.2019.04.003_bib0021","first-page":"667","article-title":"Nutritional status and overhydration: can bioimpedance spectroscopy be useful in haemodialysis patients?","volume":"33","author":"Garagarza","year":"2013","journal-title":"Nefrologia"},{"year":"2016","series-title":"R: A Language and Environment for Statistical Computing","key":"10.1016\/j.amjms.2019.04.003_bib0022"},{"key":"10.1016\/j.amjms.2019.04.003_bib0023","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0002-9149(93)91070-X","article-title":"Components of heart rate variability\u2013what they really mean and what we really measure","volume":"72","author":"Malik","year":"1993","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0024","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/hrt.37.8.882","article-title":"RR interval variations in young male diabetics","volume":"37","author":"Murray","year":"1975","journal-title":"Br Heart J"},{"key":"10.1016\/j.amjms.2019.04.003_bib0025","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0002-9149(87)90795-8","article-title":"Decreased heart rate variability and its association with increased mortality after acute myocardial infarction","volume":"59","author":"Kleiger","year":"1987","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0026","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.CIR.84.2.482","article-title":"Cardiovascular neural regulation explored in the frequency domain","volume":"84","author":"Malliani","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.amjms.2019.04.003_bib0027","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1161\/01.CIR.90.4.1826","article-title":"Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt","volume":"90","author":"Montano","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.amjms.2019.04.003_bib0028","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/0735-1097(89)90408-7","article-title":"Beat to beat variability in cardiovascular variables: noise or music?","volume":"14","author":"Appel","year":"1989","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/hrt.71.1.1","article-title":"Power spectrum analysis of heart rate variability: a tool to explore neural regulatory mechanisms","volume":"71","author":"Malliani","year":"1994","journal-title":"Br Heart J"},{"key":"10.1016\/j.amjms.2019.04.003_bib0030","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10286-007-0427-y","article-title":"Balance between sympathetic response to head-up tilt and cardiac vagal factors in healthy humans","volume":"17","author":"Ramirez-Marrero","year":"2007","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.amjms.2019.04.003_bib0031","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1681\/ASN.2005010005","article-title":"Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study","volume":"16","author":"Kurella","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0032","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.ekir.2017.03.002","article-title":"Cardiac autonomic neuropathy predicts all-cause and cardiovascular mortality in patients with end-stage renal failure: a 5-year prospective study","volume":"2","author":"Doulgerakis","year":"2017","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.amjms.2019.04.003_bib0033","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1681\/ASN.2009111112","article-title":"Heart rate variability predicts ESRD and CKD-related hospitalization","volume":"21","author":"Brotman","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0034","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4239\/wjd.v5.i1.17","article-title":"Cardiac autonomic neuropathy in patients with diabetes mellitus","volume":"5","author":"Dimitropoulos","year":"2014","journal-title":"World J Diabetes"},{"key":"10.1016\/j.amjms.2019.04.003_bib0035","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.amjmed.2007.05.009","article-title":"Orthostatic hypotension-related hospitalizations in the United States","volume":"120","author":"Shibao","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.amjms.2019.04.003_bib0036","first-page":"6","article-title":"Orthostatic stress induced changes in heart rate variability, pulse transit time and QRS duration","volume":"6","author":"Zaidi","year":"2016","journal-title":"J Bioeng Biomed Sci"},{"key":"10.1016\/j.amjms.2019.04.003_bib0037","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/ckj\/sfv034","article-title":"Uraemic toxins and new methods to control their accumulation: game changers for the concept of dialysis adequacy","volume":"8","author":"Glorieux","year":"2015","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.amjms.2019.04.003_bib0038","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/ndt\/gfh808","article-title":"Reduced baroreflex sensitivity is associated with increased vascular calcification and arterial stiffness","volume":"20","author":"Chesterton","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.amjms.2019.04.003_bib0039","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1042\/cs0430645","article-title":"Baroreflex sensitivity in patients on long-term haemodialysis","volume":"43","author":"Pickering","year":"1972","journal-title":"Clin Sci"},{"key":"10.1016\/j.amjms.2019.04.003_bib0040","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJM199904293401704","article-title":"Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure","volume":"340","author":"Ligtenberg","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjms.2019.04.003_bib0041","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ki.2013.336","article-title":"Volume overload correlates with cardiovascular risk factors in patients with chronic kidney disease","volume":"85","author":"Hung","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.amjms.2019.04.003_bib0042","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2369-15-26","article-title":"Effects of fluid overload on heart rate variability in chronic kidney disease patients on hemodialysis","volume":"15","author":"Ferrario","year":"2014","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0043","first-page":"121","article-title":"Prognostic indicators of cardiovascular risk in renal disease","volume":"2","author":"Hildreth","year":"2011","journal-title":"Front Physiol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0044","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0140-6736(10)60235-8","article-title":"Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis","volume":"375","author":"Webb","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.amjms.2019.04.003_bib0045","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0002-9149(94)90400-6","article-title":"Effects of beta blockers (atenolol or metoprolol) on heart rate variability after acute myocardial infarction","volume":"74","author":"Sandrone","year":"1994","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.amjms.2019.04.003_bib0046","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1161\/HYPERTENSIONAHA.111.174383","article-title":"Effect of antihypertensive agents on blood pressure variability: the Natrilix SR versus candesartan and amlodipine in the reduction of systolic blood pressure in hypertensive patients (X-CELLENT) study","volume":"58","author":"Zhang","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.amjms.2019.04.003_bib0047","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/sj.jhh.1002067","article-title":"Effects of amlodipine and valsartan on vascular damage and ambulatory blood pressure in untreated hypertensive patients","volume":"20","author":"Ichihara","year":"2006","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.amjms.2019.04.003_bib0048","doi-asserted-by":"crossref","first-page":"c31","DOI":"10.1159\/000210572","article-title":"Effects of angiotensin II type 1 receptor blocker on blood pressure variability and cardiovascular remodeling in hypertensive patients on chronic peritoneal dialysis","volume":"112","author":"Shigenaga","year":"2009","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.amjms.2019.04.003_bib0049","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.atherosclerosis.2009.04.005","article-title":"Effect of losartan on ambulatory short-term blood pressure variability and cardiovascular remodeling in hypertensive patients on hemodialysis","volume":"207","author":"Mitsuhashi","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.amjms.2019.04.003_bib0050","first-page":"517","article-title":"Effect of angiotensin-converting enzyme inhibitors on the power spectrum of heart rate variability in post-myocardial infarction patients","volume":"8","author":"Kontopoulos","year":"1997","journal-title":"Coron Artery Dis"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962919301387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962919301387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:36:02Z","timestamp":1757702162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962919301387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0002962919301387"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2019.04.003","relation":{},"ISSN":["0002-9629"],"issn-type":[{"type":"print","value":"0002-9629"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered Autonomic Reactivity During Lower Body Negative Pressure in End-Stage Renal Disease","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2019.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.","name":"copyright","label":"Copyright"}]}}