{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:37:37Z","timestamp":1787585857023,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjmedsci.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.amjms.2019.09.002","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T01:45:31Z","timestamp":1568857531000},"page":"422-428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Gut Microbial Metabolite Trimethylamine N-Oxide Is Related to Thrombus Formation in Atrial Fibrillation Patients"],"prefix":"10.1016","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-5987","authenticated-orcid":false,"given":"Dingxu","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianliang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjms.2019.09.002_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2014.03.021","volume":"64","author":"January","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjms.2019.09.002_bib0002","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/hrt.49.2.133","article-title":"A study of embolism in mitral valve disease and atrial fibrillation","volume":"49","author":"Dewar","year":"1983","journal-title":"Br Heart J"},{"key":"10.1016\/j.amjms.2019.09.002_bib0003","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"Backhed","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.amjms.2019.09.002_bib0004","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","article-title":"Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk","volume":"368","author":"Tang","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjms.2019.09.002_bib0005","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/jn\/133.5.1302","article-title":"Concentrations of choline-containing compounds and betaine in common foods","volume":"133","author":"Zeisel","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.amjms.2019.09.002_bib0006","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0006-2952(98)00218-4","article-title":"Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3","volume":"56","author":"Lang","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.amjms.2019.09.002_bib0007","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","article-title":"Gut microbial metabolite tmao enhances platelet hyperreactivity and thrombosis risk","volume":"165","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.amjms.2019.09.002_bib0008","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1016\/j.jacc.2013.07.101","article-title":"Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding","volume":"62","author":"Tantry","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjms.2019.09.002_bib0009","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/01.CIR.0000141575.92958.9C","article-title":"Platelet function predicts myocardial damage in patients with acute myocardial infarction","volume":"110","author":"Frossard","year":"2004","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.amjms.2019.09.002_bib0010","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood-2016-11-754416","article-title":"Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2","volume":"130","author":"J\u00e4ckel","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.amjms.2019.09.002_bib0011","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1538-7836.2008.02891.x","article-title":"Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessary","volume":"6","author":"Linnemann","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.amjms.2019.09.002_bib0012","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1194\/jlr.D001503","article-title":"An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples","volume":"51","author":"Zhao","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1016\/j.amjms.2019.09.002_bib0013","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jpba.2015.02.040","article-title":"Development and validation of a simple UHPLC-MS\/MS method for the simultaneous determination of trimethylamine N-oxide, choline, and betaine in human plasma and urine","volume":"109","author":"Ocque","year":"2015","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.amjms.2019.09.002_bib0014","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1001\/jama.285.22.2864","article-title":"Validation of clinical classification schemes for predicting stroke: results from the national registry of atrial fibrillation","volume":"285","author":"Gage","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.amjms.2019.09.002_bib0015","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.jacc.2004.05.084","article-title":"Comparative effects of antiplatelet, anticoagulant, or combined therapy in patients with valvular and nonvalvular atrial fibrillation: a randomized multicenter study","volume":"44","author":"Perez-Gomez","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjms.2019.09.002_bib0016","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1179\/102453309X12473408860460","article-title":"Elevated platelet microparticle levels in valvular atrial fibrillation","volume":"14","author":"Azzam","year":"2009","journal-title":"Hematology"},{"key":"10.1016\/j.amjms.2019.09.002_bib0017","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jacc.2010.11.075","article-title":"Influence of 9p21.3 genetic variants on clinical and angiographic outcomes in early-onset myocardial infarction","volume":"58","author":"Ardissino","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.amjms.2019.09.002_bib0018","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0140-6736(10)61267-6","article-title":"A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses","volume":"376","author":"Ripatti","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.amjms.2019.09.002_bib0019","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0278-6915(99)00028-9","article-title":"Dietary precursors of trimethylamine in man: a pilot study","volume":"37","author":"Zhang","year":"1999","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.amjms.2019.09.002_bib0020","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.amjms.2019.09.002_bib0021","article-title":"Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: a randomized controlled trial","volume":"61","author":"Cho","year":"2017","journal-title":"Mol Nutr Food Res"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962919303210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962919303210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:36:35Z","timestamp":1757702195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962919303210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0002962919303210"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2019.09.002","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut Microbial Metabolite Trimethylamine N-Oxide Is Related to Thrombus Formation in Atrial Fibrillation Patients","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2019.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}