{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:37:22Z","timestamp":1791837442080,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmedsci.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.amjms.2019.11.011","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T20:01:47Z","timestamp":1575057707000},"page":"168-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Characteristics of Intestinal-Barrier Damage in Rats With IgA Nephropathy"],"prefix":"10.1016","volume":"359","author":[{"given":"Nan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canxing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.amjms.2019.11.011_bib0001","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/ndt\/gfu343","article-title":"The intestine-renal connection in IgA nephropathy","volume":"30","author":"Coppo","year":"2015","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"10.1016\/j.amjms.2019.11.011_bib0002","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00467-017-3652-1","article-title":"The gut-kidney axis in IgA nephropathy: role of microbiota and diet on genetic predisposition","volume":"33","author":"Coppo","year":"2018","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"10.1016\/j.amjms.2019.11.011_bib0003","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.semnephrol.2018.05.020","article-title":"The gut-renal connection in IgA nephropathy","volume":"38","author":"Coppo","year":"2018","journal-title":"Semin Nephrol"},{"issue":"2","key":"10.1016\/j.amjms.2019.11.011_bib0004","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/cmi.2010.69","article-title":"Dysfunctions of the IgA system: a common link between intestinal and renal diseases","volume":"8","author":"Papista","year":"2011","journal-title":"Cell Mol Immunol"},{"issue":"3","key":"10.1016\/j.amjms.2019.11.011_bib0005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrneph.2015.208","article-title":"The mucosa-kidney axis in IgA nephropathy","volume":"12","author":"Floege","year":"2016","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"10.1016\/j.amjms.2019.11.011_bib0006","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000187211","article-title":"Mucosal immunity in primary glomerulonephritis. III. Study of intestinal permeability","volume":"63","author":"Rostoker","year":"1993","journal-title":"Nephron"},{"issue":"2","key":"10.1016\/j.amjms.2019.11.011_bib0007","first-page":"65","article-title":"Relationship between intestinal permeability and antibodies against food antigens in IgA nephropathy","volume":"137","author":"Kov\u00e1cs","year":"1996","journal-title":"Orv Hetil"},{"issue":"5","key":"10.1016\/j.amjms.2019.11.011_bib0008","doi-asserted-by":"crossref","first-page":"364","DOI":"10.5414\/CNP74364","article-title":"Gastrointestinal sensitivity to soy and milk proteins in patients with IgA nephropathy","volume":"74","author":"Kloster Smerud","year":"2010","journal-title":"Clin Nephrol"},{"issue":"6","key":"10.1016\/j.amjms.2019.11.011_bib0009","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1159\/000169050","article-title":"Do intestinal hyperpermeability and the related food antigens play a role in the progression of IgA nephropathy? I. Study of intestinal permeability","volume":"16","author":"Kov\u00e1cs","year":"1996","journal-title":"Am J Nephrol"},{"issue":"3","key":"10.1016\/j.amjms.2019.11.011_bib0010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.amjms.2018.11.011","article-title":"Correlation of intestinal mucosal healing and tight junction protein expression in ulcerative colitis patients","volume":"357","author":"Tan","year":"2019","journal-title":"Am J Med Sci"},{"issue":"4","key":"10.1016\/j.amjms.2019.11.011_bib0011","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.amjms.2018.01.002","article-title":"Effects of alpinetin on intestinal barrier function, inflammation and oxidative stress in dextran sulfate sodium-induced ulcerative colitis mice","volume":"355","author":"Tan","year":"2018","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.amjms.2019.11.011_bib0012","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ijsu.2017.02.005","article-title":"Prognostic and clinical significance of claudin-1 in colorectal cancer: a systemic review and meta-analysis","volume":"39","author":"Jiang","year":"2017","journal-title":"Int J Surg"},{"issue":"1","key":"10.1016\/j.amjms.2019.11.011_bib0013","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13046-017-0558-5","article-title":"Antibody targeting of claudin-1 as a potential colorectal cancer therapy","volume":"36","author":"Cherradi","year":"2017","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.amjms.2019.11.011_bib0014","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4846876","article-title":"Qingchang Wenzhong decoction attenuates DSS-induced colitis in rats by reducing inflammation and improving intestinal barrier function via upregulating the MSP\/RON signalling pathway","volume":"2017","author":"Mao","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"issue":"26","key":"10.1016\/j.amjms.2019.11.011_bib0015","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.3748\/wjg.v19.i26.4137","article-title":"Effects of rhein on intestinal epithelial tight junction in IgA nephropathy","volume":"19","author":"Peng","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"3","key":"10.1016\/j.amjms.2019.11.011_bib0016","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00441-018-2916-9","article-title":"Mucin 2 (MUC2) promoter characterization: an overview","volume":"374","author":"Yamashita","year":"2018","journal-title":"Cell Tissue Res"},{"issue":"7","key":"10.1016\/j.amjms.2019.11.011_bib0017","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/toxins10070298","article-title":"Intestinal barrier function in chronic kidney disease","volume":"10","author":"Meijers","year":"2018","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.amjms.2019.11.011_bib0018","article-title":"Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis","volume":"26","author":"van der Post","year":"2019","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.amjms.2019.11.011_bib0019","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s10517-018-4187-6","article-title":"Expression of Mucins and Claudins in the colon during acute and chronic experimental colitis","volume":"165","author":"Zolotova","year":"2018","journal-title":"Bull Exp Biol Med"},{"issue":"4","key":"10.1016\/j.amjms.2019.11.011_bib0020","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/ecco-jcc\/jjv223","article-title":"Mucosal barrier depletion and loss of bacterial diversity are primary abnormalities in paediatric ulcerative colitis","volume":"10","author":"Alipour","year":"2016","journal-title":"J Crohns Colitis"},{"issue":"9","key":"10.1016\/j.amjms.2019.11.011_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092809","article-title":"The dynamic changes of gut microbiota in Muc2 deficient mice","volume":"19","author":"Wu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.amjms.2019.11.011_bib0022","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3389\/fmicb.2019.00477","article-title":"A novel postbiotic from Lactobacillus rhamnosus GG with a Beneficial effect on intestinal barrier function","volume":"10","author":"Gao","year":"2019","journal-title":"Front Microbiol"},{"issue":"4","key":"10.1016\/j.amjms.2019.11.011_bib0023","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1177\/1756283X16645055","article-title":"Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease","volume":"9","author":"Briskey","year":"2016","journal-title":"Therap Adv Gastroenterol"},{"issue":"1","key":"10.1016\/j.amjms.2019.11.011_bib0024","doi-asserted-by":"crossref","first-page":"G34","DOI":"10.1152\/ajpgi.00298.2016","article-title":"Probiotic mixture VSL#3 reduces colonic inflammation and improves intestinal barrier function in Muc2 mucin-deficient mice","volume":"312","author":"Kumar","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"5","key":"10.1016\/j.amjms.2019.11.011_bib0025","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/ndt\/gfy238","article-title":"Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression","volume":"34","author":"Gonzalez","year":"2019","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"10.1016\/j.amjms.2019.11.011_bib0026","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/ndt\/gfy323","article-title":"Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice","volume":"34","author":"Chemouny","year":"2019","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"10.1016\/j.amjms.2019.11.011_bib0027","doi-asserted-by":"crossref","first-page":"e99006","DOI":"10.1371\/journal.pone.0099006","article-title":"Microbiota andmetabolome associated with immunoglobulin A nephropathy (IgAN)","volume":"9","author":"De Angelis","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.amjms.2019.11.011_bib0028","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13073-017-0490-5","article-title":"A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients","volume":"9","author":"Hall","year":"2017","journal-title":"Genome Med"},{"issue":"1","key":"10.1016\/j.amjms.2019.11.011_bib0029","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/j.gastro.2017.09.006","article-title":"Intestinal Dysbiosis featuring abundance of Ruminococcus gnavus associates with allergic diseases in Infants","volume":"154","author":"Chua","year":"2018","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.amjms.2019.11.011_bib0030","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/19490976.2017.1353849","article-title":"Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig","volume":"8","author":"Mudd","year":"2017","journal-title":"Gut Microbes"},{"issue":"2","key":"10.1016\/j.amjms.2019.11.011_bib0031","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/ki.2015.94","article-title":"Gluten exacerbates IgA nephropathy in humanized mice through gliadin-CD89 interaction","volume":"88","author":"Papista","year":"2015","journal-title":"Kidney Int"},{"issue":"10","key":"10.1016\/j.amjms.2019.11.011_bib0032","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.4049\/jimmunol.1402598","article-title":"Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88","volume":"195","author":"Guo","year":"2015","journal-title":"J Immunol"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962919304215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962919304215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:36:50Z","timestamp":1757702210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962919304215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0002962919304215"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2019.11.011","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Characteristics of Intestinal-Barrier Damage in Rats With IgA Nephropathy","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2019.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.","name":"copyright","label":"Copyright"}]}}