{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:52:36Z","timestamp":1762253556081,"version":"3.44.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmedsci.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.amjms.2020.09.013","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T12:26:40Z","timestamp":1600345600000},"page":"624-634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["miR-129 Blocks Secondary Hyperparathyroidism-Inducing Fgf23\/\u03b1Klotho Signaling in Mice with Chronic Kidney Disease"],"prefix":"10.1016","volume":"361","author":[{"given":"Mingzhi","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiqing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruman","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yishan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.amjms.2020.09.013_bib0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158765","article-title":"Global prevalence of chronic kidney disease-a systematic review and meta-analysis","volume":"11","author":"Hill","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.amjms.2020.09.013_bib0002","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/1744-9987.12772","article-title":"Secondary hyperparathyroidism: pathogenesis and latest treatment","volume":"23","author":"Mizobuchi","year":"2019","journal-title":"Ther Apher Dial"},{"key":"10.1016\/j.amjms.2020.09.013_bib0003","article-title":"Regulation and effects of FGF23 in chronic kidney disease","volume":"82","author":"Musgrove","year":"2019","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"10.1016\/j.amjms.2020.09.013_bib0004","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/physrev.00002.2011","article-title":"Regulation and function of the FGF23\/klotho endocrine pathways","volume":"92","author":"Martin","year":"2012","journal-title":"Physiol Rev"},{"issue":"2","key":"10.1016\/j.amjms.2020.09.013_bib0005","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/2229-3485.179431","article-title":"MicroRNA therapeutics: discovering novel targets and developing specific therapy","volume":"7","author":"Christopher","year":"2016","journal-title":"Perspect Clin Res"},{"issue":"8","key":"10.1016\/j.amjms.2020.09.013_bib0006","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1681\/ASN.2016050585","article-title":"Let-7 and MicroRNA-148 regulate parathyroid hormone levels in secondary hyperparathyroidism","volume":"28","author":"Shilo","year":"2017","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"10.1016\/j.amjms.2020.09.013_bib0007","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1530\/ERC-17-0204","article-title":"The aberrantly expressed miR-372 partly impairs sensitivity to apoptosis in parathyroid tumor cells","volume":"25","author":"Verdelli","year":"2018","journal-title":"Endocr Relat Cancer"},{"issue":"22","key":"10.1016\/j.amjms.2020.09.013_bib0008","first-page":"8022","article-title":"Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism","volume":"63","author":"Libutti","year":"2003","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.amjms.2020.09.013_bib0009","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2337\/diabetes.55.01.06.db05-0681","article-title":"A vHNF1\/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells","volume":"55","author":"Poll","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.amjms.2020.09.013_bib0010","doi-asserted-by":"crossref","first-page":"40534","DOI":"10.1038\/srep40534","article-title":"Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease","volume":"7","author":"Kawakami","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.amjms.2020.09.013_bib0011","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1681\/ASN.2009121311","article-title":"Klotho deficiency causes vascular calcification in chronic kidney disease","volume":"22","author":"Hu","year":"2011","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"10.1016\/j.amjms.2020.09.013_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003975","article-title":"Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion","volume":"9","author":"Olauson","year":"2013","journal-title":"PLos Genet"},{"issue":"3","key":"10.1016\/j.amjms.2020.09.013_bib0013","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ki.2009.464","article-title":"Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease","volume":"77","author":"Galitzer","year":"2010","journal-title":"Kidney Int"},{"issue":"3","key":"10.1016\/j.amjms.2020.09.013_bib0014","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000274483","article-title":"Involvement of alpha-klotho and fibroblast growth factor receptor in the development of secondary hyperparathyroidism","volume":"31","author":"Kumata","year":"2010","journal-title":"Am J Nephrol"},{"issue":"7","key":"10.1016\/j.amjms.2020.09.013_bib0015","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1681\/ASN.2008070692","article-title":"Vascular calcification: the killer of patients with chronic kidney disease","volume":"20","author":"Mizobuchi","year":"2009","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.amjms.2020.09.013_bib0016","doi-asserted-by":"crossref","first-page":"F514","DOI":"10.1152\/ajprenal.00449.2014","article-title":"Urinary vimentin mRNA as a potential novel biomarker of renal fibrosis","volume":"309","author":"Cao","year":"2015","journal-title":"Am J Physiol-Renal Physiol"},{"issue":"2","key":"10.1016\/j.amjms.2020.09.013_bib0017","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/j.ajkd.2012.02.336","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"60","author":"Bhavsar","year":"2012","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1016\/j.amjms.2020.09.013_bib0018","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1053\/j.ajkd.2010.12.027","article-title":"Role of Klotho in aging, phosphate metabolism, and CKD","volume":"58","author":"John","year":"2011","journal-title":"Am J Kidney Dis"},{"issue":"12","key":"10.1016\/j.amjms.2020.09.013_bib0019","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/ki.2011.47","article-title":"Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int"},{"issue":"6","key":"10.1016\/j.amjms.2020.09.013_bib0020","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1046\/j.1523-1755.2003.00328.x","article-title":"Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers","volume":"64","author":"Larsson","year":"2003","journal-title":"Kidney Int"},{"issue":"7","key":"10.1016\/j.amjms.2020.09.013_bib0021","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1681\/ASN.2009040427","article-title":"FGF23 fails to inhibit uremic parathyroid glands","volume":"21","author":"Canalejo","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"10.1016\/j.amjms.2020.09.013_bib0022","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1210\/en.2005-0777","article-title":"Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1, 25-dihydroxyvitamin D metabolism in mice","volume":"146","author":"Perwad","year":"2005","journal-title":"Endocrinology"},{"year":"2009","series-title":"ASBMR primer on the metabolic bone diseases and disorders of mineral metabolism:","author":"Rosen","key":"10.1016\/j.amjms.2020.09.013_bib0023"},{"issue":"4","key":"10.1016\/j.amjms.2020.09.013_bib0024","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1172\/JCI114840","article-title":"Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat","volume":"86","author":"Naveh-Many","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.amjms.2020.09.013_bib0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fphys.2013.00247","article-title":"Pathophysiological roles of FGF signaling in the heart","volume":"4","author":"Itoh","year":"2013","journal-title":"Front Physiol"},{"issue":"3","key":"10.1016\/j.amjms.2020.09.013_bib0026","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/wdev.176","article-title":"The fibroblast growth factor signaling pathway","volume":"4","author":"Ornitz","year":"2015","journal-title":"Wiley Interdiscip Rev: Dev Biol"},{"issue":"10","key":"10.1016\/j.amjms.2020.09.013_bib0027","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/me.2010-0142","article-title":"Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse","volume":"24","author":"Fon Tacer","year":"2010","journal-title":"Mol Endocrinol"},{"issue":"1","key":"10.1016\/j.amjms.2020.09.013_bib0028","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1677\/JOE-07-0267","article-title":"Fibroblast growth factor-23 regulates parathyroid hormone and 1-hydroxylase expression in cultured bovine parathyroid cells","volume":"195","author":"Krajisnik","year":"2007","journal-title":"J Endocrinol"},{"issue":"12","key":"10.1016\/j.amjms.2020.09.013_bib0029","first-page":"4003","article-title":"The parathyroid is a target organ for FGF23 in rats","volume":"117","author":"Ben-Dov","year":"2007","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.amjms.2020.09.013_bib0030","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/path.2409","article-title":"Amelioration of the premature ageing\u2010like features of Fgf\u201023 knockout mice by genetically restoring the systemic actions of FGF\u201023","volume":"216","author":"DeLuca","year":"2008","journal-title":"J Pathol"},{"issue":"11","key":"10.1016\/j.amjms.2020.09.013_bib0031","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1210\/en.2004-0233","article-title":"Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders","volume":"145","author":"Bai","year":"2004","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.amjms.2020.09.013_bib0032","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1210\/en.2003-1768","article-title":"Transgenic mice expressing fibroblast growth factor 23 under the control of the \u03b11 (I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis","volume":"145","author":"Larsson","year":"2004","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.amjms.2020.09.013_bib0033","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.amjms.2020.09.013_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003975","article-title":"Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion","volume":"9","author":"Olauson","year":"2013","journal-title":"PLos Genet"},{"issue":"3","key":"10.1016\/j.amjms.2020.09.013_bib0035","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.beem.2013.02.006","article-title":"Role of the calcium-sensing receptor in extracellular calcium homeostasis","volume":"27","author":"Brown","year":"2013","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.amjms.2020.09.013_bib0036","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1046\/j.1523-1755.2003.00114.x","article-title":"Gene expression of vitamin D hydroxylase and megalin in the remnant kidney of nephrectomized rats","volume":"64","author":"Takemoto","year":"2003","journal-title":"Kidney Int"},{"issue":"11","key":"10.1016\/j.amjms.2020.09.013_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142510","article-title":"Deregulated renal calcium and phosphate transport during experimental kidney failure","volume":"10","author":"Pulskens","year":"2015","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.amjms.2020.09.013_bib0038","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/ki.2012.322","article-title":"Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet","volume":"82","author":"Lau","year":"2012","journal-title":"Kidney Int"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962920304183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962920304183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:39:03Z","timestamp":1757702343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962920304183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0002962920304183"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2020.09.013","relation":{},"ISSN":["0002-9629"],"issn-type":[{"type":"print","value":"0002-9629"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-129 Blocks Secondary Hyperparathyroidism-Inducing Fgf23\/\u03b1Klotho Signaling in Mice with Chronic Kidney Disease","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2020.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}