{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:51:44Z","timestamp":1791082304617,"version":"4.1.0"},"reference-count":104,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470277"],"award-info":[{"award-number":["81470277"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670186"],"award-info":[{"award-number":["81670186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870096"],"award-info":[{"award-number":["81870096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjmedsci.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.amjms.2021.02.011","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T08:22:02Z","timestamp":1613463722000},"page":"5-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["MicroRNAs in \u03b2-thalassemia"],"prefix":"10.1016","volume":"362","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1533-7004","authenticated-orcid":false,"given":"Fangfang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duonan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10053","key":"10.1016\/j.amjms.2021.02.011_bib0001","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(16)31460-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Kassebaum","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.amjms.2021.02.011_bib0002","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2471\/BLT.06.036673","article-title":"Global epidemiology of haemoglobin disorders and derived service indicators","volume":"86","author":"Modell","year":"2008","journal-title":"Bull World Health Organ"},{"issue":"7","key":"10.1016\/j.amjms.2021.02.011_bib0003","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3109\/08880018.2014.937884","article-title":"Guidelines for diagnosis and management of Beta-thalassemia intermedia","volume":"31","author":"Karimi","year":"2014","journal-title":"Pediatr Hematol Oncol"},{"issue":"11","key":"10.1016\/j.amjms.2021.02.011_bib0004","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/archdischild-2014-308112","article-title":"Thalassaemia in children: from quality of care to quality of life","volume":"100","author":"Amid","year":"2015","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.amjms.2021.02.011_bib0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1172-5-11","article-title":"Beta-thalassemia","volume":"5","author":"Galanello","year":"2010","journal-title":"Orphanet J Rare Dis"},{"issue":"4","key":"10.1016\/j.amjms.2021.02.011_bib0006","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.blre.2018.02.001","article-title":"A paradigm shift on beta-thalassaemia treatment: How will we manage this old disease with new therapies?","volume":"32","author":"Cappellini","year":"2018","journal-title":"Blood Rev"},{"issue":"16","key":"10.1016\/j.amjms.2021.02.011_bib0007","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1056\/NEJMoa1705342","article-title":"Gene therapy in patients with transfusion-dependent beta-thalassemia","volume":"378","author":"Thompson","year":"2018","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.amjms.2021.02.011_bib0008","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41573-019-0020-9","article-title":"Gene therapy targeting haematopoietic stem cells for inherited diseases: progress and challenges","volume":"18","author":"Cavazzana","year":"2019","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0009","first-page":"5","article-title":"Foetal haemoglobin inducers and thalassaemia: novel achievements","volume":"8","author":"Gambari","year":"2010","journal-title":"Blood Transfus"},{"issue":"8","key":"10.1016\/j.amjms.2021.02.011_bib0010","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrg3471","article-title":"Adult-specific functions of animal microRNAs","volume":"14","author":"Sun","year":"2013","journal-title":"Nat Rev Genet"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0011","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan microRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.amjms.2021.02.011_bib0012","first-page":"161","article-title":"The role of microRNAs in human diseases","volume":"2","author":"Ardekani","year":"2010","journal-title":"Avicenna J Med Biotechnol"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0013","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2217\/epi.11.104","article-title":"Involvement of miRNA in erythroid differentiation","volume":"4","author":"Bianchi","year":"2012","journal-title":"Epigenomics"},{"key":"10.1016\/j.amjms.2021.02.011_bib0014","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/695754","article-title":"MicroRNAs as haematopoiesis regulators","volume":"2013","author":"Undi","year":"2013","journal-title":"Adv Hematol"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0015","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2478\/s11658-012-0038-z","article-title":"microRNAs: fine tuning of erythropoiesis","volume":"18","author":"Listowski","year":"2013","journal-title":"Cell Mol Biol Lett"},{"issue":"16","key":"10.1016\/j.amjms.2021.02.011_bib0016","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1101\/gad.1565607","article-title":"A slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway","volume":"21","author":"O'Carroll","year":"2007","journal-title":"Genes Dev"},{"issue":"2","key":"10.1016\/j.amjms.2021.02.011_bib0017","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrm2632","article-title":"Biogenesis of small RNAs in animals","volume":"10","author":"Kim","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"17","key":"10.1016\/j.amjms.2021.02.011_bib0018","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1093\/emboj\/cdf476","article-title":"MicroRNA maturation: stepwise processing and subcellular localization","volume":"21","author":"Lee","year":"2002","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0019","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","article-title":"Regulation of microRNA function in animals","volume":"20","author":"Gebert","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.amjms.2021.02.011_bib0020","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0021","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s41544-019-0035-8","article-title":"miR-144\/451 in hematopoiesis and beyond","volume":"1","author":"Wang","year":"2019","journal-title":"ExRNA"},{"issue":"9","key":"10.1016\/j.amjms.2021.02.011_bib0022","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1073\/pnas.0712312105","article-title":"A GATA-1-regulated microRNA locus essential for erythropoiesis","volume":"105","author":"Dore","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.amjms.2021.02.011_bib0023","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/s41388-017-0055-5","article-title":"Activating and sustaining c-Myc by depletion of miR-144\/451 gene locus contributes to B-lymphomagenesis","volume":"37","author":"Ding","year":"2018","journal-title":"Oncogene"},{"issue":"15","key":"10.1016\/j.amjms.2021.02.011_bib0024","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1101\/gad.1942110","article-title":"miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta","volume":"24","author":"Yu","year":"2010","journal-title":"Genes Dev"},{"issue":"3","key":"10.1016\/j.amjms.2021.02.011_bib0025","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3324\/haematol.2017.177394","article-title":"miR-144\/451 represses the LKB1\/AMPK\/mTOR pathway to promote red cell precursor survival during recovery from acute anemia","volume":"103","author":"Fang","year":"2018","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.amjms.2021.02.011_bib0026","doi-asserted-by":"crossref","first-page":"13194","DOI":"10.1096\/fj.202000941R","article-title":"miR-144\/451 inhibits c-Myc to promote erythroid differentiation","volume":"34","author":"Xu","year":"2020","journal-title":"The FASEB Journal"},{"issue":"12","key":"10.1016\/j.amjms.2021.02.011_bib0027","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.tig.2018.09.004","article-title":"Wake-up sleepy gene: reactivating fetal globin for beta-hemoglobinopathies","volume":"34","author":"Wienert","year":"2018","journal-title":"Trends Genet"},{"key":"10.1016\/j.amjms.2021.02.011_bib0028","first-page":"383","article-title":"Erythropoietic development and hemoglobin switching in human embryos: cellular and molecular aspects","volume":"191","author":"Peschle","year":"1985","journal-title":"Prog Clin Biol Res"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10059-012-0048-8","article-title":"Chromatin loop formation in the beta-globin locus and its role in globin gene transcription","volume":"34","author":"Kim","year":"2012","journal-title":"Mol Cells"},{"key":"10.1016\/j.amjms.2021.02.011_bib0030","series-title":"Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT)[M]","author":"MD","year":"2014"},{"issue":"14","key":"10.1016\/j.amjms.2021.02.011_bib0031","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1073\/pnas.79.14.4428","article-title":"5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons","volume":"79","author":"DeSimone","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"10.1016\/j.amjms.2021.02.011_bib0032","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1056\/NEJM198212093072401","article-title":"5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia","volume":"307","author":"Ley","year":"1982","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.amjms.2021.02.011_bib0033","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s00277-018-3357-y","article-title":"Efficacy of decitabine as hemoglobin F inducer in HbE\/beta-thalassemia","volume":"97","author":"Kalantri","year":"2018","journal-title":"Ann Hematol"},{"issue":"10","key":"10.1016\/j.amjms.2021.02.011_bib0034","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1182\/blood-2011-03-341909","article-title":"A pilot study of subcutaneous decitabine in beta-thalassemia intermedia","volume":"118","author":"Olivieri","year":"2011","journal-title":"Blood"},{"issue":"1-2","key":"10.1016\/j.amjms.2021.02.011_bib0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cca.2009.06.019","article-title":"Response to hydroxyurea in beta thalassemia major and intermedia: experience in western India","volume":"407","author":"Italia","year":"2009","journal-title":"Clin Chim Acta"},{"issue":"3","key":"10.1016\/j.amjms.2021.02.011_bib0036","first-page":"285","article-title":"Detection of miR-144 gene in peripheral blood of children with \u03b2-thalassemia major and its significance","volume":"10","author":"Wu","year":"2010","journal-title":"China Trop Med"},{"issue":"4","key":"10.1016\/j.amjms.2021.02.011_bib0037","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.phoj.2017.11.153","article-title":"Novel and innovative approaches for treatment of \u03b2-thalassemia","volume":"2","author":"Soni","year":"2017","journal-title":"Pediatr Hematol Oncol J"},{"issue":"7","key":"10.1016\/j.amjms.2021.02.011_bib0038","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1182\/blood.V96.7.2379","article-title":"2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia","volume":"96","author":"Koshy","year":"2000","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.amjms.2021.02.011_bib0039","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1182\/blood-2003-05-1738","article-title":"Effects of 5-aza-2\u2032-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease","volume":"102","author":"Saunthararajah","year":"2003","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.amjms.2021.02.011_bib0040","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/ajh.2830170416","article-title":"5-Azacytidine and fetal hemoglobin","volume":"17","author":"Heller","year":"1984","journal-title":"Am J Hematol"},{"issue":"3","key":"10.1016\/j.amjms.2021.02.011_bib0041","first-page":"534","article-title":"Reversal of DNA methylation with 5-azacytidine alters chromosome replication patterns in human lymphocyte and fibroblast cultures","volume":"36","author":"Shafer","year":"1984","journal-title":"Am J Hum Genet"},{"issue":"2","key":"10.1016\/j.amjms.2021.02.011_bib0042","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/03630269.2017.1290651","article-title":"Comparison of microRNAs mediated in reactivation of the gamma-globin in beta-thalassemia patients, responders and non-Responders to hydroxyurea","volume":"41","author":"Hojjati","year":"2017","journal-title":"Hemoglobin"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0043","first-page":"53","article-title":"Evaluation of the effect of miR-26b up-regulation on HbF expression in erythroleukemic K-562 cell line","volume":"6","author":"Alijani","year":"2014","journal-title":"Avicenna J Med Biotechnol"},{"issue":"7","key":"10.1016\/j.amjms.2021.02.011_bib0044","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/1535370216636725","article-title":"Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells","volume":"241","author":"Ward","year":"2016","journal-title":"Exp Biol Med (Maywood)"},{"issue":"3","key":"10.1016\/j.amjms.2021.02.011_bib0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.14348\/molcells.2014.2288","article-title":"The up-regulation of miR-199b-5p in erythroid differentiation is associated with GATA-1 and NF-E2","volume":"37","author":"Li","year":"2014","journal-title":"Mol Cells"},{"issue":"9","key":"10.1016\/j.amjms.2021.02.011_bib0046","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106924","article-title":"LIN28A expression reduces sickling of cultured human erythrocytes","volume":"9","author":"de Vasconcellos","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.amjms.2021.02.011_bib0047","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144977","article-title":"Erythroid-specific expression of LIN28A is sufficient for robust gamma-globin gene and protein expression in adult erythroblasts","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.amjms.2021.02.011_bib0048","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1182\/blood-2012-12-472308","article-title":"LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo","volume":"122","author":"Lee","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.amjms.2021.02.011_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2018.03.004","article-title":"miR-326 regulates HbF synthesis by targeting EKLF in human erythroid cells","volume":"63","author":"Li","year":"2018","journal-title":"Exp Hematol"},{"issue":"7","key":"10.1016\/j.amjms.2021.02.011_bib0050","doi-asserted-by":"crossref","first-page":"e22838","DOI":"10.1371\/journal.pone.0022838","article-title":"MicroRNA-96 directly inhibits gamma-globin expression in human erythropoiesis","volume":"6","author":"Azzouzi","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0051","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41598-017-00150-7","article-title":"Reciprocal regulation of gamma-globin expression by exo-miRNAs: Relevance to gamma-globin silencing in beta-thalassemia major","volume":"7","author":"Sun","year":"2017","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.amjms.2021.02.011_bib0052","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1007\/s00277-019-03737-4","article-title":"miR-144 regulates oxidative stress tolerance of thalassemic erythroid cell via targeting NRF2","volume":"98","author":"Srinoun","year":"2019","journal-title":"Ann Hematol"},{"issue":"70","key":"10.1016\/j.amjms.2021.02.011_bib0053","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.exphem.2018.11.002","article-title":"MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease","author":"Li","year":"2019","journal-title":"Exp Hematol"},{"issue":"8","key":"10.1016\/j.amjms.2021.02.011_bib0054","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.3324\/haematol.2016.160788","article-title":"NRF2 mediates gamma-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors","volume":"102","author":"Zhu","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.amjms.2021.02.011_bib0055","article-title":"MicroRNA expression patterns in HbE\/beta-thalassemia patients: The passwords to unlock fetal hemoglobin expression in beta-hemoglobinopathies","volume":"87","author":"Das","year":"2020","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.amjms.2021.02.011_bib0056","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gene.2019.04.077","article-title":"Integrative microRNA and gene expression analysis identifies new drug repurposing candidates for fetal hemoglobin induction in beta-hemoglobinopathies","volume":"706","author":"Das","year":"2019","journal-title":"Gene"},{"issue":"30","key":"10.1016\/j.amjms.2021.02.011_bib0057","doi-asserted-by":"crossref","first-page":"49931","DOI":"10.18632\/oncotarget.18263","article-title":"Genome-wide analysis of aberrantly expressed lncRNAs and miRNAs with associated co-expression and ceRNA networks in beta-thalassemia and hereditary persistence of fetal hemoglobin","volume":"8","author":"Lai","year":"2017","journal-title":"Oncotarget"},{"issue":"5909","key":"10.1016\/j.amjms.2021.02.011_bib0058","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1126\/science.1165409","article-title":"Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A","volume":"322","author":"Sankaran","year":"2008","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.amjms.2021.02.011_bib0059","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.0711566105","article-title":"Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia","volume":"105","author":"Uda","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.amjms.2021.02.011_bib0060","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1182\/blood-2009-03-210146","article-title":"The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells","volume":"114","author":"Wahlberg","year":"2009","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.amjms.2021.02.011_bib0061","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/ng.630","article-title":"Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin","volume":"42","author":"Borg","year":"2010","journal-title":"Nat Genet"},{"issue":"13","key":"10.1016\/j.amjms.2021.02.011_bib0062","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1084\/jem.20121846","article-title":"Bcl11a is essential for lymphoid development and negatively regulates p53","volume":"209","author":"Yu","year":"2012","journal-title":"J Exp Med"},{"issue":"6058","key":"10.1016\/j.amjms.2021.02.011_bib0063","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1126\/science.1211053","article-title":"Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing","volume":"334","author":"Xu","year":"2011","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.amjms.2021.02.011_bib0064","doi-asserted-by":"crossref","first-page":"e60436","DOI":"10.1371\/journal.pone.0060436","article-title":"MicroRNA-486-3p regulates gamma-globin expression in human erythroid cells by directly modulating BCL11A","volume":"8","author":"Lulli","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.amjms.2021.02.011_bib0065","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.3390\/ijms18122530","article-title":"BCL11A mRNA targeting by miR-210: a possible network regulating gamma-globin gene expression","volume":"18","author":"Gasparello","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.amjms.2021.02.011_bib0066","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121567","article-title":"Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells","volume":"10","author":"Bianchi","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.amjms.2021.02.011_bib0067","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41588-019-0568-7","article-title":"Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation","volume":"52","author":"Basak","year":"2020","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0068","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ygeno.2019.03.002","article-title":"Identification of deleterious SNPs and their effects on BCL11A, the master regulator of fetal hemoglobin expression","volume":"112","author":"Das","year":"2020","journal-title":"Genomics"},{"issue":"10","key":"10.1016\/j.amjms.2021.02.011_bib0069","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1172\/JCI87885","article-title":"Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype","volume":"126","author":"Brendel","year":"2016","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.amjms.2021.02.011_bib0070","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1182\/blood-2008-08-174854","article-title":"Mir-144 selectively regulates embryonic alpha-hemoglobin synthesis during primitive erythropoiesis","volume":"113","author":"Fu","year":"2009","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0071","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jcp.22729","article-title":"MicroRNAs: Allies or foes in erythropoiesis?","volume":"227","author":"Byon","year":"2012","journal-title":"J Cell Physiol"},{"issue":"10","key":"10.1016\/j.amjms.2021.02.011_bib0072","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3390\/ijms18102167","article-title":"Ferritin heavy subunit silencing blocks the erythroid commitment of K562 cells via miR-150 up-regulation and GATA-1 repression","volume":"18","author":"Zolea","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.amjms.2021.02.011_bib0073","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1101\/gad.1998711","article-title":"miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1","volume":"25","author":"Zhang","year":"2011","journal-title":"Genes Dev"},{"issue":"7","key":"10.1016\/j.amjms.2021.02.011_bib0074","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.exphem.2007.03.014","article-title":"MicroRNA expression dynamics during murine and human erythroid differentiation","volume":"35","author":"Zhan","year":"2007","journal-title":"Exp Hematol"},{"issue":"2","key":"10.1016\/j.amjms.2021.02.011_bib0075","first-page":"165","article-title":"The Effect of mir-451 upregulation on erythroid lineage differentiation of murine embryonicstem cells","volume":"18","author":"Obeidi","year":"2016","journal-title":"Cell J"},{"issue":"6","key":"10.1016\/j.amjms.2021.02.011_bib0076","first-page":"756","article-title":"miR-451 up-regulation, induce erythroid differentiation of CD133+cells independent of cytokine cocktails","volume":"16","author":"Kouhkan","year":"2013","journal-title":"Iran J Basic Med Sci"},{"issue":"4","key":"10.1016\/j.amjms.2021.02.011_bib0077","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1073\/pnas.1018384108","article-title":"MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13","volume":"108","author":"Sankaran","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.amjms.2021.02.011_bib0078","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/bjh.13164","article-title":"MIR144 and MIR451 regulate human erythropoiesis via RAB14","volume":"168","author":"Kim","year":"2015","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1016\/j.amjms.2021.02.011_bib0079","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000339492","article-title":"hsa-miR-503 is downregulated in beta thalassemia major","volume":"128","author":"Roy","year":"2012","journal-title":"Acta Haematol"},{"issue":"5","key":"10.1016\/j.amjms.2021.02.011_bib0080","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/ijc.30788","article-title":"A polymorphism in miR-1262 regulatory region confers the risk of lung cancer in Chinese population","volume":"141","author":"Xie","year":"2017","journal-title":"Int J Cancer"},{"issue":"1-2","key":"10.1016\/j.amjms.2021.02.011_bib0081","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1159\/000452554","article-title":"Rs56288038 (C\/G) in 3\u2032UTR of IRF-1 regulated by miR-502-5p promotes gastric cancer development","volume":"40","author":"Wang","year":"2016","journal-title":"Cell Physiol Biochem"},{"issue":"6","key":"10.1016\/j.amjms.2021.02.011_bib0082","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5732\/cjc.30.0381","article-title":"Single-nucleotide polymorphisms among microRNA: big effects on cancer","volume":"30","author":"Song","year":"2011","journal-title":"Chin J Cancer"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0083","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ygeno.2018.01.002","article-title":"Diseases and their clinical heterogeneity - Are we ignoring the SNiPers and micRomaNAgers? An illustration using Beta-thalassemia clinical spectrum and fetal hemoglobin levels","volume":"111","author":"Das","year":"2019","journal-title":"Genomics"},{"issue":"6","key":"10.1016\/j.amjms.2021.02.011_bib0084","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1159\/000495963","article-title":"miR-486-3p influences the neurotoxicity of a-synuclein by targeting the SIRT2 gene and the polymorphisms at target sites contributing to parkinson's disease","volume":"51","author":"Wang","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"12","key":"10.1016\/j.amjms.2021.02.011_bib0085","doi-asserted-by":"crossref","first-page":"e28656","DOI":"10.1371\/journal.pone.0028656","article-title":"Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding","volume":"6","author":"Caputo","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.amjms.2021.02.011_bib0086","doi-asserted-by":"crossref","first-page":"13765","DOI":"10.1002\/jcb.28649","article-title":"Identification of association between rs1057317 polymorphism in TLR4 3\u2032-untranslated region and the susceptibility to osteoporosis","volume":"120","author":"Hong","year":"2019","journal-title":"J Cell Biochem"},{"issue":"19","key":"10.1016\/j.amjms.2021.02.011_bib0087","doi-asserted-by":"crossref","first-page":"13434","DOI":"10.1074\/jbc.M113.535203","article-title":"MicroRNA-9 and microRNA-326 regulate human dopamine D2 receptor expression, and the microRNA-mediated expression regulation is altered by a genetic variant","volume":"289","author":"Shi","year":"2014","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.amjms.2021.02.011_bib0088","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1089\/gtmb.2019.0053","article-title":"The CAV1 gene 3\u2032 untranslated region single nucleotide polymorphisms are associated with the risk of pulmonary hypertension in chinese Han chronic obstructive pulmonary patients","volume":"23","author":"Li","year":"2019","journal-title":"Genet Test Mol Biomarkers"},{"issue":"1","key":"10.1016\/j.amjms.2021.02.011_bib0089","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res"},{"issue":"2","key":"10.1016\/j.amjms.2021.02.011_bib0090","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s40291-016-0187-2","article-title":"Structural and functional insights on an uncharacterized agamma-globin-gene polymorphism present in four beta0-thalassemia families with high fetal hemoglobin levels","volume":"20","author":"Bianchi","year":"2016","journal-title":"Mol Diagn Ther"},{"issue":"11","key":"10.1016\/j.amjms.2021.02.011_bib0091","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165912","article-title":"miR-146a polymorphism (rs2910164) predicts colorectal cancer patients' susceptibility to liver metastasis","volume":"11","author":"Iguchi","year":"2016","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.amjms.2021.02.011_bib0092","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1007\/s10620-013-2640-y","article-title":"Association study of genetic variants in miRNAs in patients with inflammatory bowel disease: preliminary results","volume":"58","author":"Gazouli","year":"2013","journal-title":"Dig Dis Sci"},{"issue":"3","key":"10.1016\/j.amjms.2021.02.011_bib0093","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/03630269.2019.1628043","article-title":"Anemia severity in beta-thalassemia correlates with elevated levels of microRNA-125b in activated phagocytic monocytes","volume":"43","author":"Kuno","year":"2019","journal-title":"Hemoglobin"},{"issue":"3","key":"10.1016\/j.amjms.2021.02.011_bib0094","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s12185-016-2032-0","article-title":"Elevated levels of miR-210 correlate with anemia in beta-thalassemia\/HbE patients","volume":"104","author":"Siwaponanan","year":"2016","journal-title":"Int J Hematol"},{"issue":"5","key":"10.1016\/j.amjms.2021.02.011_bib0095","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.3892\/mmr.2017.6326","article-title":"Plasma microRNA-451 as a novel hemolytic marker for beta0-thalassemia\/HbE disease","volume":"15","author":"Leecharoenkiat","year":"2017","journal-title":"Mol Med Rep"},{"issue":"6","key":"10.1016\/j.amjms.2021.02.011_bib0096","first-page":"1933","article-title":"Serum level of miR-609 and its clinical prognostic value in patients with thalassemia","volume":"27","author":"Wang M","year":"2019","journal-title":"J Exp Hematol"},{"issue":"10","key":"10.1016\/j.amjms.2021.02.011_bib0097","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00277-010-0980-7","article-title":"Expression of microRNA-451 in normal and thalassemic erythropoiesis","volume":"89","author":"Svasti","year":"2010","journal-title":"Ann Hematol"},{"issue":"5","key":"10.1016\/j.amjms.2021.02.011_bib0098","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s12185-017-2291-4","article-title":"MiR-155 enhances phagocytic activity of beta-thalassemia\/HbE monocytes via targeting of BACH1","volume":"106","author":"Srinoun","year":"2017","journal-title":"Int J Hematol"},{"issue":"2","key":"10.1016\/j.amjms.2021.02.011_bib0099","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/21691401.2017.1307210","article-title":"Advances in siRNA delivery in cancer therapy","volume":"46","author":"Singh","year":"2018","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"8","key":"10.1016\/j.amjms.2021.02.011_bib0100","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1007\/s00277-019-03713-y","article-title":"Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo","volume":"98","author":"Jyotsana","year":"2019","journal-title":"Ann Hematol"},{"issue":"33","key":"10.1016\/j.amjms.2021.02.011_bib0101","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1073\/pnas.1512503112","article-title":"Generation of knock-in primary human T cells using Cas9 ribonucleoproteins","volume":"112","author":"Schumann","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.amjms.2021.02.011_bib0102","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41551-018-0252-8","article-title":"Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours","volume":"2","author":"Lee","year":"2018","journal-title":"Nat Biomed Eng"},{"issue":"9","key":"10.1016\/j.amjms.2021.02.011_bib0103","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1080\/17425247.2018.1517746","article-title":"Delivery approaches for CRISPR\/Cas9 therapeutics in vivo: advances and challenges","volume":"15","author":"Luther","year":"2018","journal-title":"Expert Opin Drug Deliv"},{"issue":"3","key":"10.1016\/j.amjms.2021.02.011_bib0104","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s12185-019-02806-8","article-title":"Alpha-hemoglobin-stabilizing protein (AHSP): a modulatory factor in beta-thalassemia","volume":"111","author":"Che Yaacob","year":"2020","journal-title":"Int J Hematol"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962921000628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962921000628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:39:47Z","timestamp":1757702387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962921000628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":104,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0002962921000628"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2021.02.011","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNAs in \u03b2-thalassemia","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2021.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}