{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:31:59Z","timestamp":1777527119738,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmedsci.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.amjms.2021.06.002","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T21:00:56Z","timestamp":1623186056000},"page":"506-511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Kidney Injury in a Hemodilution Model of Hemorrhagic Shock and Fluid Resuscitation"],"prefix":"10.1016","volume":"362","author":[{"given":"Luhao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.amjms.2021.06.002_bib0001","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","author":"Rivers","year":"2001","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.amjms.2021.06.002_bib0002","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/01.anes.0000281926.54940.6a","article-title":"Improved survival after resuscitation with norepinephrine in a murine model of uncontrolled hemorrhagic shock","volume":"107","author":"Poloujadoff","year":"2007","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.amjms.2021.06.002_bib0003","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40635-018-0212-3","article-title":"Fluid sparing and norepinephrine use in a rat model of resuscitated haemorrhagic shock: end-organ impact","volume":"6","author":"Poissant","year":"2018","journal-title":"Intensive Care Med Exp"},{"issue":"9","key":"10.1016\/j.amjms.2021.06.002_bib0004","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1097\/CCM.0b013e31821f04f0","article-title":"Morphologic and functional renal impact of acute kidney injury after prolonged hemorrhagic shock in mice","volume":"39","author":"Mayeur","year":"2011","journal-title":"Crit. Care Med"},{"issue":"18","key":"10.1016\/j.amjms.2021.06.002_bib0005","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1056\/NEJMra1208943","article-title":"Circulatory shock","volume":"369","author":"Vincent","year":"2013","journal-title":"The New Engl J. Med"},{"issue":"24","key":"10.1016\/j.amjms.2021.06.002_bib0006","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1056\/NEJMoa062200","article-title":"Comparison of two fluid-management strategies in acute lung injury","volume":"354","author":"Wiedemann","year":"2006","journal-title":"New Engl J Med"},{"key":"10.1016\/j.amjms.2021.06.002_bib0007","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/2110-5820-2-S1-S1","article-title":"Fluid management in critically ill patients: the role of extravascular lung water, abdominal hypertension, capillary leak, and fluid balance","volume":"2","author":"Cordemans","year":"2012","journal-title":"Ann Intensive Care"},{"issue":"2","key":"10.1016\/j.amjms.2021.06.002_bib0008","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/ALN.0b013e31829bd9bc","article-title":"Acute normovolemic hemodilution in the pig is associated with renal tissue edema, impaired renal microvascular oxygenation, and functional loss","volume":"119","author":"Konrad","year":"2013","journal-title":"Anesthesiology"},{"issue":"2","key":"10.1016\/j.amjms.2021.06.002_bib0009","first-page":"F796","article-title":"Acute decrease in renal microvascular PO2 during acute normovolemic hemodilution","volume":"292","author":"JOHANNES","year":"2007","journal-title":"Am J Phys Renal phys"},{"issue":"2","key":"10.1016\/j.amjms.2021.06.002_bib0010","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jss.2007.01.031","article-title":"Physiologic response to hemorrhagic shock depends on rate and means of hemorrhage","volume":"143","author":"Frankel","year":"2007","journal-title":"J Surg Res"},{"issue":"2","key":"10.1016\/j.amjms.2021.06.002_bib0011","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jss.2009.11.712","article-title":"Survival and inflammatory responses in experimental models of hemorrhage","volume":"169","author":"Cai","year":"2011","journal-title":"J Surg Res"},{"issue":"2","key":"10.1016\/j.amjms.2021.06.002_bib0012","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000348808","article-title":"Experimental models of hemorrhagic shock: a review","volume":"50","author":"F\u00fcl\u00f6p","year":"2013","journal-title":"Eur Surg Res"},{"issue":"1","key":"10.1016\/j.amjms.2021.06.002_bib0013","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/jat.727","article-title":"A good practice guide to the administration of substances and removal of blood, including routes and volumes","volume":"21","author":"Diehl","year":"2001","journal-title":"J Appl Toxicol"},{"issue":"1","key":"10.1016\/j.amjms.2021.06.002_bib0014","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40635-017-0125-6","article-title":"Experimental assessment of oxygen homeostasis during acute hemodilution: the integrated role of hemoglobin concentration and blood pressure","volume":"5","author":"Kei","year":"2017","journal-title":"Intensive Care Med Exp"},{"issue":"1","key":"10.1016\/j.amjms.2021.06.002_bib0015","first-page":"R403","article-title":"Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats","volume":"292","author":"Mclaren","year":"2007","journal-title":"Am J Phys Regul Integr Comp Phys"},{"issue":"1","key":"10.1016\/j.amjms.2021.06.002_bib0016","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/cc12484","article-title":"Fluid balance and urine volume are independent predictors of mortality in acute kidney injury","volume":"17","author":"Teixeira","year":"2013","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.amjms.2021.06.002_bib0017","doi-asserted-by":"crossref","first-page":"R197","DOI":"10.1186\/cc11682","article-title":"Fluid overload is associated with an increased risk for 90-day mortality in critically ill patients with renal replacement therapy: data from the prospective FINNAKI study","volume":"16","author":"Vaara","year":"2012","journal-title":"Crit Care"},{"issue":"4","key":"10.1016\/j.amjms.2021.06.002_bib0018","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/ki.2009.159","article-title":"Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury","volume":"76","author":"Bouchard","year":"2009","journal-title":"Kidney Int"},{"issue":"2","key":"10.1016\/j.amjms.2021.06.002_bib0019","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1053\/j.jvca.2014.06.014","article-title":"Regional tolerance to acute normovolemic hemodilution: evidence that the kidney may be at greatest risk","volume":"29","author":"Crystal","year":"2015","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"7","key":"10.1016\/j.amjms.2021.06.002_bib0020","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0952-8180(96)00119-5","article-title":"Effects of hemodilution during controlled hypotension of hepatic, renal, and pancreatic function in humans","volume":"8","author":"Fukusaki","year":"1996","journal-title":"J Clin Anesth"},{"issue":"5","key":"10.1016\/j.amjms.2021.06.002_bib0021","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1172\/JCI37829","article-title":"Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models","volume":"119","author":"Brooks","year":"2009","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.amjms.2021.06.002_bib0022","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1111\/jcmm.13203","article-title":"Fibroblast growth factor 2 protects against renal ischaemia\/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling","volume":"21","author":"Tan","year":"2017","journal-title":"J Cell Mol Med"},{"issue":"5","key":"10.1016\/j.amjms.2021.06.002_bib0023","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/bja\/aev346","article-title":"Effects of acute plasma volume expansion on renal perfusion, filtration, and oxygenation after cardiac surgery: a randomized study on crystalloid vs colloid","volume":"115","author":"Skytte Larsson","year":"2015","journal-title":"Br J Anaesth"},{"issue":"1","key":"10.1016\/j.amjms.2021.06.002_bib0024","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.athoracsur.2015.02.034","article-title":"Acute Kidney injury and hemodilution during cardiopulmonary bypass: a changing scenario","volume":"100","author":"Ranucci","year":"2015","journal-title":"Ann Thorac Surg"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962921002159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962921002159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:40:07Z","timestamp":1757702407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962921002159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0002962921002159"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2021.06.002","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kidney Injury in a Hemodilution Model of Hemorrhagic Shock and Fluid Resuscitation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2021.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}