{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:52:40Z","timestamp":1793253160740,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjmedsci.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.amjms.2023.11.013","type":"journal-article","created":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T17:13:16Z","timestamp":1700413996000},"page":"119-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of serum uric acid and gout on the incidence of colorectal cancer: A meta-analysis"],"prefix":"10.1016","volume":"367","author":[{"given":"Yani","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjms.2023.11.013_bib0001","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0140-6736(21)00569-9","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Gout. Lancet"},{"key":"10.1016\/j.amjms.2023.11.013_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101070","article-title":"Metabolic syndrome and cancer risk: the role of xanthine oxidoreductase","volume":"21","author":"Battelli","year":"2019","journal-title":"Redox Biol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14194959","article-title":"The good, the bad and the new about uric acid in cancer","volume":"14","author":"Allegrini","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.amjms.2023.11.013_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13194803","article-title":"Precision medicine for colorectal cancer with liquid biopsy and immunotherapy","volume":"13","author":"Nagayama","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.amjms.2023.11.013_bib0005","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.6004\/jnccn.2022.7056","article-title":"Diagnosis and management of rectal cancer in patients younger than 50 years: rising global incidence and unique challenges","volume":"20","author":"Lang","year":"2022","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.amjms.2023.11.013_bib0006","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s13193-022-01496-9","article-title":"Worrisome trends in young-onset colorectal cancer: now is the time for action","volume":"13","author":"Patel","year":"2022","journal-title":"Indian J Surg Oncol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0007","doi-asserted-by":"crossref","first-page":"139","DOI":"10.15430\/JCP.2022.27.3.139","article-title":"Dietary intervention for preventing colorectal cancer: a practical guide for physicians","volume":"27","author":"Kim","year":"2022","journal-title":"J Cancer Prev"},{"key":"10.1016\/j.amjms.2023.11.013_bib0008","doi-asserted-by":"crossref","first-page":"16677","DOI":"10.1038\/s41598-022-20357-7","article-title":"The relationship between serum uric acid and colorectal cancer: a prospective cohort study","volume":"12","author":"Li","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.amjms.2023.11.013_bib0009","doi-asserted-by":"crossref","first-page":"42332","DOI":"10.18632\/oncotarget.16198","article-title":"Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study","volume":"8","author":"Yiu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.amjms.2023.11.013_bib0010","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1038\/bjc.2017.313","article-title":"Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study","volume":"117","author":"Kuhn","year":"2017","journal-title":"Br J Cancer"},{"key":"10.1016\/j.amjms.2023.11.013_bib0011","first-page":"225","article-title":"Relationship of serum uric acid to cancer occurrence in a prospective male cohort","volume":"3","author":"Kolonel","year":"1994","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.amjms.2023.11.013_bib0012","first-page":"2916","article-title":"Serum uric acid unrelated to cancer incidence in humans","volume":"48","author":"Hiatt","year":"1988","journal-title":"Cancer Res"},{"key":"10.1016\/j.amjms.2023.11.013_bib0013","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ijc.33807","article-title":"High serum uric acid may associate with the increased risk of colorectal cancer in females: a prospective cohort study","volume":"150","author":"Mi","year":"2022","journal-title":"Int J Cancer"},{"key":"10.1016\/j.amjms.2023.11.013_bib0014","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0015","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/sim.3013","article-title":"Facilitating meta-analyses by deriving relative effect and precision estimates for alternative comparisons from a set of estimates presented by exposure level or disease category","volume":"27","author":"Hamling","year":"2008","journal-title":"Stat Med"},{"key":"10.1016\/j.amjms.2023.11.013_bib0016","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/oxfordjournals.aje.a116237","article-title":"Methods for trend estimation from summarized dose-response data, with applications to meta-analysis","volume":"135","author":"Greenland","year":"1992","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0017","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/aje\/kwr265","article-title":"Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software","volume":"175","author":"Orsini","year":"2012","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0018","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3899\/jrheum.200497","article-title":"Risk of cancer in middle-aged patients with gout: a nationwide population-based study in Korea","volume":"48","author":"Lee","year":"2021","journal-title":"J Rheumatol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0019","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-028892","article-title":"Association of gout and colorectal cancer in Taiwan: a nationwide population-based cohort study","volume":"9","author":"Chuang","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.amjms.2023.11.013_bib0020","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/annrheumdis-2018-eular.2302","article-title":"Gout is associated with an increased risk of cancer-a nationwide cohort study including over 70,000 gout patients","volume":"77","author":"Zobbe","year":"2018","journal-title":"Annals the Rheumatic Diseases"},{"key":"10.1016\/j.amjms.2023.11.013_bib0021","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/03009742.2013.878387","article-title":"Gout patients have an increased risk of developing most cancers, especially urological cancers","volume":"43","author":"Chen","year":"2014","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0022","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jbspin.2011.09.011","article-title":"Increased risk of cancer among gout patients: a nationwide population study","volume":"79","author":"Kuo","year":"2012","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.amjms.2023.11.013_bib0023","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/CEJ.0b013e328313631a","article-title":"A prospective study of gout and cancer","volume":"18","author":"Boffetta","year":"2009","journal-title":"Eur J Cancer Prev"},{"key":"10.1016\/j.amjms.2023.11.013_bib0024","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/CEJ.0000000000000440","article-title":"Serum uric acid and cancer mortality and incidence: a systematic review and meta-analysis","volume":"27","author":"Dovell","year":"2018","journal-title":"Eur J Cancer Prev"},{"key":"10.1016\/j.amjms.2023.11.013_bib0025","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4166\/kjg.2015.66.4.202","article-title":"Uric acid is a risk indicator for metabolic syndrome-related colorectal adenoma: results in a korean population receiving screening colonoscopy","volume":"66","author":"Kim","year":"2015","journal-title":"Korean J Gastroenterol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0026","doi-asserted-by":"crossref","first-page":"647","DOI":"10.21037\/apm-21-3943","article-title":"Risk factors and correlation of colorectal polyps with type 2 diabetes mellitus","volume":"11","author":"Xu","year":"2022","journal-title":"Ann Palliat Med"},{"key":"10.1016\/j.amjms.2023.11.013_bib0027","doi-asserted-by":"crossref","first-page":"e5463","DOI":"10.1097\/MD.0000000000005463","article-title":"Relationship between serum uric acid and metastatic and nonmetastatic rectal cancer patients with undergoing no chemotherapy","volume":"95","author":"Yuan","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.amjms.2023.11.013_bib0028","first-page":"485","article-title":"Hyperuricemia at the time of diagnosis is a factor for poor prognosis in patients with stage ii and iii colorectal cancer (uric acid and colorectal cancer)","volume":"18","author":"Cetin","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.amjms.2023.11.013_bib0029","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.2147\/OTT.S175112","article-title":"Elevated urinary 8-oxo-7,8-dihydro-2\u2032-deoxyguanosine and serum uric acid are associated with progression and are prognostic factors of colorectal cancer","volume":"11","author":"Mao","year":"2018","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.amjms.2023.11.013_bib0030","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.2147\/IJGM.S314834","article-title":"Hyperuricemia is a Adverse Prognostic Factor for Colon Cancer Patients","volume":"14","author":"Yan","year":"2021","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.amjms.2023.11.013_bib0031","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.12659\/MSM.909692","article-title":"Decreased serum bilirubin levels and increased uric acid levels are associated with ulcerative colitis","volume":"24","author":"Tian","year":"2018","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.amjms.2023.11.013_bib0032","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/jgh.14356","article-title":"Altered uric acid metabolism in isolated colonic Crohn's disease but not ulcerative colitis","volume":"34","author":"Zhu","year":"2019","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0033","doi-asserted-by":"crossref","first-page":"10665","DOI":"10.7150\/thno.43528","article-title":"Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis","volume":"10","author":"Wu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.amjms.2023.11.013_bib0034","article-title":"Nonenzymatic serum antioxidant capacity in IBD and its association with the severity of bowel inflammation and corticosteroids treatment","volume":"55","author":"Neubauer","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.amjms.2023.11.013_bib0035","doi-asserted-by":"crossref","first-page":"e15664","DOI":"10.1097\/MD.0000000000015664","article-title":"Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease","volume":"98","author":"Su","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.amjms.2023.11.013_bib0036","doi-asserted-by":"crossref","first-page":"14364","DOI":"10.1002\/jcp.28138","article-title":"Hyperuricemia and gout are associated with cancer incidence and mortality: a meta-analysis based on cohort studies","volume":"234","author":"Xie","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102271","article-title":"U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia","volume":"51","author":"Crawley","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0038","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/03009742.2017.1293728","article-title":"Decreased colorectal atypia among a cohort of gout patients","volume":"47","author":"Slobodnick","year":"2018","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0039","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21238968","article-title":"Expression of main toll-like receptors in patients with different types of colorectal polyps and their relationship with Gut microbiota","volume":"21","author":"Rezasoltani","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.amjms.2023.11.013_bib0040","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.3389\/fimmu.2018.02918","article-title":"NLRP3 inflammasome: a possible link between obesity-associated low-grade chronic inflammation and colorectal cancer development","volume":"9","author":"Ahechu","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.amjms.2023.11.013_bib0041","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.7150\/thno.56747","article-title":"The double-edged roles of ROS in cancer prevention and therapy","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.amjms.2023.11.013_bib0042","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0167-5699(97)81662-3","article-title":"Cytokine regulation of endothelial cell function: from molecular level to the bedside","volume":"18","author":"Mantovani","year":"1997","journal-title":"Immunol Today"},{"key":"10.1016\/j.amjms.2023.11.013_bib0043","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3835(00)00635-2","article-title":"Susceptibility of lean and obese Zucker rats to tumorigenesis induced by N-methyl-N-nitrosourea","volume":"162","author":"Lee","year":"2001","journal-title":"Cancer Lett"},{"key":"10.1016\/j.amjms.2023.11.013_bib0044","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf9044","article-title":"A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice","volume":"9","author":"Chiaro","year":"2017","journal-title":"Sci Transl Med"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962923014155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962923014155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:43:19Z","timestamp":1757702599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962923014155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0002962923014155"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2023.11.013","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of serum uric acid and gout on the incidence of colorectal cancer: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2023.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}