{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:13:50Z","timestamp":1772774030008,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009697","name":"The Hashemite University","doi-asserted-by":"publisher","award":["54\/2020"],"award-info":[{"award-number":["54\/2020"]}],"id":[{"id":"10.13039\/501100009697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjmedsci.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.amjms.2025.06.010","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T02:37:57Z","timestamp":1749782277000},"page":"496-504","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic efficacy of scopoletin on oxidative stress and cardiac dysfunction in streptozotocin-induced diabetic rats"],"prefix":"10.1016","volume":"370","author":[{"given":"Abdelrahim","family":"Alqudah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esam","family":"Qnais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Gammoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousra","family":"Bseiso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Wedyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sireen Abdul Rahim","family":"Shilbayeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawan","family":"Abudalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muna","family":"Oqal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa A.A.","family":"Aljabali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjms.2025.06.010_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinthera.2015.02.016","article-title":"Cardiometabolic effects of a new class of antidiabetic agents","author":"Desouza","year":"2015","journal-title":"Clin Ther."},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0003","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1038\/s41598-018-20703-8","article-title":"Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia","volume":"8","author":"Chandramouli","year":"2018","journal-title":"Sci Rep"},{"issue":"OCT","key":"10.1016\/j.amjms.2025.06.010_bib0004","article-title":"Diabetic cardiomyopathy: current and future therapies. Beyond glycemic control","volume":"9","author":"Borghetti","year":"2018","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/15701611113119990003","article-title":"Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction","volume":"13","author":"Neri","year":"2015","journal-title":"Curr Vasc Pharmacol"},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0006","doi-asserted-by":"crossref","first-page":"39","DOI":"10.5001\/omj.2014.09","article-title":"Effect of EPA and vitamin C on superoxide dismutase, glutathione peroxidase, total antioxidant capacity and malondialdehyde in type 2 diabetic patients","volume":"29","author":"Shakouri Mahmoudabadi","year":"2014","journal-title":"Oman Med J"},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JOE-17-0672","article-title":"SRT2104 attenuates diabetes-induced aortic endothelial dysfunction via inhibition of P53","volume":"237","author":"Wu","year":"2018","journal-title":"J Endocrinol"},{"issue":"5","key":"10.1016\/j.amjms.2025.06.010_bib0008","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2217\/fca-2018-0042","article-title":"VCAM-1, ICAM-1 and Selectins in gestational diabetes mellitus and the risk for vascular disorders","volume":"15","author":"Siddiqui","year":"2019","journal-title":"Future Cardiol"},{"issue":"5","key":"10.1016\/j.amjms.2025.06.010_bib0009","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.bbadis.2017.10.035","article-title":"Molecular mechanisms of cardiac pathology in diabetes \u2013 Experimental insights","volume":"1864","author":"Varma","year":"2018","journal-title":"Biochim Biophys Acta - Mol Basis Dis"},{"key":"10.1016\/j.amjms.2025.06.010_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2023.110900","article-title":"The potential of cardiac biomarkers, NT-ProBNP and troponin T, in predicting the progression of nephropathy in diabetic patients: a meta-analysis of prospective cohort studies","volume":"204","author":"Roointan","year":"2023","journal-title":"Diabetes Res Clin Pract"},{"issue":"7\u20138","key":"10.1016\/j.amjms.2025.06.010_bib0011","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1515\/znc-2021-0193","article-title":"Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities","volume":"77","author":"Antika","year":"2022","journal-title":"Zeitschrift fur Naturforsch - Sect C J Biosci"},{"key":"10.1016\/j.amjms.2025.06.010_bib0012","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.indcrop.2015.03.039","article-title":"Confertin and scopoletin from leaf and root extracts of Hypochaeris radicata have anti-inflammatory and antioxidant activities","volume":"70","author":"Jamuna","year":"2015","journal-title":"Ind Crops Prod"},{"key":"10.1016\/j.amjms.2025.06.010_bib0013","article-title":"Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity","volume":"15","author":"Gao","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.amjms.2025.06.010_bib0014","first-page":"1","article-title":"Exploring scopoletin\u2019s therapeutic efficacy in DSS-induced ulcerative colitis: insights into inflammatory pathways, immune modulation, and microbial dynamics","author":"Alqudah","year":"2024","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.amjms.2025.06.010_bib0015","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1021\/np300824h","article-title":"Scopoletin and scopolin isolated from Artemisia iwayomogi suppress differentiation of osteoclastic macrophage RAW 264.7 cells by scavenging reactive oxygen species","volume":"76","author":"Lee","year":"2013","journal-title":"J Nat Prod"},{"issue":"2\u20133","key":"10.1016\/j.amjms.2025.06.010_bib0016","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ejphar.2006.10.021","article-title":"Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the i\u03bab\/NF-\u03bab signal cascade in the human mast cell line HMC-1","volume":"555","author":"Moon","year":"2007","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10.1016\/j.amjms.2025.06.010_bib0017","first-page":"111","article-title":"Role of NF-kappa B (NF-\u03baB) in diabetes","volume":"4","author":"Indira","year":"2013","journal-title":"Onco Ther"},{"issue":"4","key":"10.1016\/j.amjms.2025.06.010_bib0018","doi-asserted-by":"crossref","first-page":"611","DOI":"10.4314\/tjpr.v14i4.8","article-title":"Effect of scopoletin on apoptosis and cell cycle arrest in Human prostate cancer cells In vitro","volume":"14","author":"Li","year":"2015","journal-title":"Trop J Pharm Res"},{"issue":"4","key":"10.1016\/j.amjms.2025.06.010_bib0019","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1080\/13813455.2021.1890129","article-title":"Kaempferol attenuates diabetic nephropathy in streptozotocin-induced diabetic rats by a hypoglycaemic effect and concomitant activation of the nrf-2\/Ho-1\/antioxidants axis","volume":"129","author":"Alshehri","year":"2023","journal-title":"Arch Physiol Biochem"},{"issue":"2","key":"10.1016\/j.amjms.2025.06.010_bib0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3390\/cells12020267","article-title":"New treatment for type 2 diabetes mellitus using a novel bipyrazole compound","volume":"12","author":"Alqudah","year":"2023","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.amjms.2025.06.010_bib0021","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1016\/S0021-9258(19)45155-7","article-title":"The purification and properties of superoxide dismutase from neurospora crassa","volume":"247","author":"Misra","year":"1972","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.amjms.2025.06.010_bib0022","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.71.10.3879","article-title":"The identity of glutathione S-transferase B with ligandin, a major binding protein of liver","volume":"71","author":"Habig","year":"1974","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0023","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","article-title":"A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase","volume":"195","author":"BEERS","year":"1952","journal-title":"J Biol Chem"},{"key":"10.1016\/j.amjms.2025.06.010_bib0024","doi-asserted-by":"crossref","unstructured":"Haque R., Bin-Hafeez B., Parvez S., et al. Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamideinduced biochemical toxicity. 2003;22(9):473\u2013480. doi:10.1191\/0960327103HT388OA.","DOI":"10.1191\/0960327103ht388oa"},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0025","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0026","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0305-0491(85)90138-5","article-title":"Comparison of the membrane-bound (Ca2+ + Mg2+)-ATPase in erythrocyte ghosts from some mammalian species","volume":"82","author":"Bewaji","year":"1985","journal-title":"Comp Biochem Physiol Part B Comp Biochem"},{"issue":"6","key":"10.1016\/j.amjms.2025.06.010_bib0027","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/clinchem\/39.6.972","article-title":"Cardiac-specific immunoenzymometric assay of troponin I in the early phase of acute myocardial infarction","volume":"39","author":"Larue","year":"1993","journal-title":"Clin Chem"},{"issue":"4","key":"10.1016\/j.amjms.2025.06.010_bib0028","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/vec.12074","article-title":"Assessment of circulating N-terminal pro B-type natriuretic peptide concentration to differentiate between cardiac from noncardiac causes of pleural effusion in cats","volume":"23","author":"Hassdenteufel","year":"2013","journal-title":"J Vet Emerg Crit Care"},{"issue":"2","key":"10.1016\/j.amjms.2025.06.010_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2024.100548","article-title":"Ocimum gratissimum L. leaf flavonoid-rich extracts reduced the expression of p53 and VCAM in streptozotocin-induced cardiomyopathy rats","volume":"4","author":"Ajiboye","year":"2024","journal-title":"Phytomedicine Plus"},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0030","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/brain\/120.1.39","article-title":"Polymyositis with cytochrome oxidase negative muscle fibres. Early quadriceps weakness and poor response to immunosuppressive therapy","volume":"120","author":"Blume","year":"1997","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.amjms.2025.06.010_bib0031","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/heartjnl-2016-310342","article-title":"Diabetic cardiomyopathy","volume":"105","author":"Lee","year":"2019","journal-title":"Heart"},{"issue":"6","key":"10.1016\/j.amjms.2025.06.010_bib0032","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/jdi.12250","article-title":"Diabetic cardiomyopathy and its mechanisms: role of oxidative stress and damage","volume":"5","author":"Liu","year":"2014","journal-title":"J Diabetes Investig"},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s44187-022-00010-y","article-title":"Scopoletin contents and antioxidant properties of some edible plants of Black Sea regions","volume":"2","author":"\u00c7ak\u0131r","year":"2022","journal-title":"Discov Food"},{"issue":"1\u20132","key":"10.1016\/j.amjms.2025.06.010_bib0034","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11010-011-1160-3","article-title":"Polymorphic variations in manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular disease","volume":"363","author":"Chen","year":"2012","journal-title":"Mol Cell Biochem"},{"issue":"6","key":"10.1016\/j.amjms.2025.06.010_bib0035","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s11357-019-00107-w","article-title":"Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases","volume":"41","author":"Ungvari","year":"2019","journal-title":"GeroScience"},{"issue":"6","key":"10.1016\/j.amjms.2025.06.010_bib0036","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1113\/jphysiol.2014.282319","article-title":"Na+\/Ca2+ exchange and Na+\/K+-ATPase in the heart","volume":"593","author":"Shattock","year":"2015","journal-title":"J Physiol"},{"key":"10.1016\/j.amjms.2025.06.010_bib0037","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.toxrep.2019.05.002","article-title":"Effect of untreated pharmaceutical plant effluent on cardiac Na+-K+- ATPase and Ca2+-Mg2+-ATPase activities in mice (Mus musculus)","volume":"6","author":"Abdulkareem","year":"2019","journal-title":"Toxicol Reports"},{"issue":"23\u201326","key":"10.1016\/j.amjms.2025.06.010_bib0038","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.lfs.2009.10.008","article-title":"Increased activities of Na+\/K+-ATPase and Ca2+\/Mg2+-ATPase in the frontal cortex and cerebellum of autistic individuals","volume":"85","author":"Ji","year":"2009","journal-title":"Life Sci"},{"issue":"6","key":"10.1016\/j.amjms.2025.06.010_bib0039","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/10799893.2020.1772297","article-title":"Oxidative stress-induced cardiomyocyte apoptosis is associated with dysregulated Akt\/p53 signaling pathway","volume":"40","author":"Zheng","year":"2020","journal-title":"J Recept Signal Transduct"},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0040","article-title":"Saponin-rich extracts reverse obesity and offer protection against obesity-induced inflammation in high-fat diet mice","volume":"5","author":"Ejelonu","year":"2021","journal-title":"J Med Plants Econ Dev"},{"issue":"1","key":"10.1016\/j.amjms.2025.06.010_bib0041","doi-asserted-by":"crossref","first-page":"36","DOI":"10.21608\/jmh.2019.11528.1053","article-title":"Differential effect of high fat diet (HFD) on the cardiac muscle of adult and aged female mice and the possible protective role of artichoke treatment: histomorphometric and ultrastructural study","volume":"3","author":"Dawood","year":"2019","journal-title":"J Med Histol"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962925010730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962925010730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:16:57Z","timestamp":1762082217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962925010730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0002962925010730"],"URL":"https:\/\/doi.org\/10.1016\/j.amjms.2025.06.010","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic efficacy of scopoletin on oxidative stress and cardiac dysfunction in streptozotocin-induced diabetic rats","name":"articletitle","label":"Article Title"},{"value":"The American Journal of the Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjms.2025.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}