{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:05:43Z","timestamp":1790611543465,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Geriatric Pharmacotherapy"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.amjopharm.2004.09.006","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T01:41:18Z","timestamp":1103161278000},"page":"181-189","source":"Crossref","is-referenced-by-count":34,"title":["Clinical efficacy, tolerability, and cost savings associated with the use of open-label metronidazole plus ceftriaxone once daily compared with ticarcillin\/clavulanate every 6 hours as empiric treatment for diabetic lower-extremity infections in older males"],"prefix":"10.1016","volume":"2","author":[{"given":"Patrick G.","family":"Clay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maqual R.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron C.","family":"Lindsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth C.","family":"Lamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Glaros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjopharm.2004.09.006_bib1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1053\/jhsu.1999.0682","article-title":"Upper extremity infections in patients with diabetes mellitus","volume":"24","author":"Gonzalez","year":"1999","journal-title":"J Hand Surg [Am]"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1056-8727(99)00065-3","article-title":"Deep foot infections in patients with diabetes and foot ulcer: An entity with different characteristics, treatments, and prognosis","volume":"13","author":"Eneroth","year":"1999","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0891-5520(20)30645-0","article-title":"Diabetic foot infections. Antimicrobial therapy","volume":"9","author":"Grayson","year":"1995","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0891-5520(20)30609-7","article-title":"Dermatologie manifestations of infections in diabetics","volume":"8","author":"Kemmerly","year":"1994","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib5","series-title":"2004 Infectious Diseases Society of America Policy and Advocacy Statement","article-title":"Bad bugs, no drugs: As antibiotic development stagnates a publie health crisis brews","author":"Olson","year":"2004"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib6","series-title":"Value of Medicines: Past Successes and Positive Prognoses Pharmaceutical Research and Development","first-page":"16","article-title":"Investing in health: Research and development","author":"Sullivan","year":"2004"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib7","first-page":"90s","article-title":"Diagnosis and treatment of skin and soft tissue infections: Clinical experience with ticarcillin disodium-clavulanate potassium","volume":"11","author":"Pankcy","year":"1999","journal-title":"Pharmacotherapy"},{"issue":"Suppl 9","key":"10.1016\/j.amjopharm.2004.09.006_bib8","doi-asserted-by":"crossref","first-page":"S733","DOI":"10.1093\/clinids\/13.Supplement_9.S733","article-title":"Ticarcillin-clavulanate therapy for bacterial skin and soft tissue infections","volume":"13","author":"File","year":"1991","journal-title":"Rev Infect Dis."},{"key":"10.1016\/j.amjopharm.2004.09.006_bib9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1179\/joc.1996.8.4.284","article-title":"Efficacy of sulbactam-ampicillin for the treatment of severe diabetic foot infections","volume":"8","author":"Akova","year":"1996","journal-title":"J Chemother"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/clinids\/18.5.683","article-title":"Use of ampicillin\/sulbactam versus imipenem\/cilastatin in the treatment of limb-threatening foot infections in diabetic patients","volume":"18","author":"Grayson","year":"1994","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib11","first-page":"671","article-title":"Comparison of serum and tissue antibiotic levels in diabetes-related foot infections","volume":"110","author":"Seabrook","year":"1991","journal-title":"Surgery"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1086\/314874","article-title":"Effect of parenteral antibiotic administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract","volume":"180","author":"Donskey","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib13","first-page":"8","article-title":"Bacterial infections in diabetic foot","volume":"37","author":"Pathare","year":"1997","journal-title":"J Diab Assoc India"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib14","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1128\/AAC.35.7.1508","article-title":"In vitro comparison of GR69153, a novel catechol-substituted cephalosporin, with ceftazidime and ceftriaxone against 5,203 recent clinical isolates","volume":"35","author":"Washington","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib15","first-page":"63","article-title":"Ceftriaxone treatment of skin and soft tissue infections in a once daily regimen","volume":"77","author":"Bradsher","year":"1984","journal-title":"Am J Med"},{"issue":"Suppl 5","key":"10.1016\/j.amjopharm.2004.09.006_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/21548331.1991.11707737","article-title":"Pharmacokinetics of ceftriaxone","volume":"26","author":"Blumer","year":"1991","journal-title":"Hosp Pract (Off Ed)"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0732-8893(94)90026-4","article-title":"A five-year multicenter study of the susceptibility of the Bacteroides fragilis group isolates to cephalosporins, cephamins, penicillins, clindamycin, and metronidazole in the United States","volume":"18","author":"Aldridge","year":"1994","journal-title":"Diagn Microbial Infect Dis"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib18","first-page":"185","article-title":"Bactericidal activity of low-dose ceftizoxime plus metronidazole compared wth cefoxitin and ampicillin-sulbactam","volume":"14","author":"Freeman","year":"1994","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib19","first-page":"1782","article-title":"Serum bactericidal activity of ceftriaxone plus metronidazole against common intra-abdominal pathogens","volume":"51","author":"Freeman","year":"1994","journal-title":"Am J Hosp Pharm"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib20","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1128\/AAC.35.12.2602","article-title":"Pharmacokinetics and tissue penetration of a single 1,000-milligram, intravenous dose of metronidazole for antibiotic prophylaxis of colorectal surgery","volume":"35","author":"Martin","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib21","first-page":"397","article-title":"Ceftriaxone\/metronidazole is more effective than ampicillin\/netilmicin\/metronidazole in the treatment of bacterial peritonitis","volume":"157","author":"Luke","year":"1991","journal-title":"Eur J Surg"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib22","series-title":"Presented at the 40th Annual Meeting of the Infectious Diseases Society of America","article-title":"Clinical efficacy of ceftriaxone plus metronidazole in hospitalized patients with documented infections","author":"Lacy","year":"2002"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/107110078100200202","article-title":"The dysvascular foot: A system for diagnosis and treatment","volume":"2","author":"Wagner","year":"1981","journal-title":"Foot Ankle"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatininc clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib25","unstructured":"Timentin [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2001."},{"key":"10.1016\/j.amjopharm.2004.09.006_bib26","unstructured":"Rocephin [package insert]. Nutley, NJ: Roche Laboratories; 2000."},{"key":"10.1016\/j.amjopharm.2004.09.006_bib27","series-title":"Metronidazole intravenous infusion 500mg\/100ml, (Viaflex\u00ae Minibag)","year":"2004"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0149-2918(02)85005-6","article-title":"Clinafloxacin versus piperacillin\/tazobactam in the treatment of severe skin and soft-tissue infections in adults at a Veterans Affairs medical center","volume":"24","author":"Siami","year":"2002","journal-title":"Clin Ther"},{"issue":"Suppl 1","key":"10.1016\/j.amjopharm.2004.09.006_bib29","first-page":"S63","article-title":"Preventive foot care in diabetes","volume":"27","author":"Mayfield","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0002-9343(85)90148-2","article-title":"Ticarcillin plus clavulanic acid versus moxalactam therapy of osteomyclitis, septic arthritis, and skin and soft tissue infections","volume":"79","author":"Siebert","year":"1985","journal-title":"Am J Med"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1086\/341026","article-title":"Once-daily, high-dose levofloxacin versus ticarcillin-clavulanate alone or followed by amoxicillin-clavulanate for complicated skin and skin-structure infections: A randomized, open-label trial","volume":"35","author":"Graham","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib32","first-page":"146","article-title":"Oral ciprofloxacin in the treatment of serious soft tissue and bone infections. Efficacy, safety, and pharmacokinetics","volume":"82","author":"Nix","year":"1987","journal-title":"Am J Med"},{"issue":"Suppl 5","key":"10.1016\/j.amjopharm.2004.09.006_bib33","first-page":"S1","article-title":"Diabetic foot disorders: A clinical practice guideline","volume":"39","author":"Frykberg","year":"2000","journal-title":"J Foot Ankle Surg"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0924-8579(02)00160-7","article-title":"Ertapenem monothcrapy versus combination therapy with ceftriaxone plus metronidazole for treatment of complicated intra-abdominal infections in adults","volume":"20","author":"Yellin","year":"2002","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0924-8579(02)00248-0","volume":"21","author":"Starakis","year":"2003","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0002-9610(02)01125-X","article-title":"A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery","volume":"185","author":"Woodfield","year":"2003","journal-title":"Am J Surg"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0149-2918(98)80044-1","article-title":"Costs and duration of care for lower extremity ulcers in patients with diabetes","volume":"20","author":"Holzer","year":"1998","journal-title":"Clin Ther"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib38","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1592\/phco.19.9.724.31537","article-title":"Efficacy and cost of ampicillin-sulbactam and ticarcillin-clavulanate in the treatment of hospitalized patients with bacterial infections","volume":"19","author":"McKinnon","year":"1999","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib39","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1093\/ajhp\/52.22.2568","article-title":"Stability of ceftizoxime sodium, ceftriaxone sodium, and ceftazidime with metronidazole in ready-to-use metronidazole bags","volume":"52","author":"Rivers","year":"1995","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib40","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/ajhp\/54.4.424","article-title":"Stability of ceftriaxone sodium and metronidazole hydrochloride","volume":"54","author":"Bailey","year":"1997","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.amjopharm.2004.09.006_bib41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0002-9343(85)90153-6","article-title":"Treatment of infections in hospitalized patients with ticarcillin plus clavulanic acid. A comparative study","volume":"79","author":"Holloway","year":"1985","journal-title":"Am J Med"},{"issue":"Suppl 3","key":"10.1016\/j.amjopharm.2004.09.006_bib42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/1120009X.2000.11782304","article-title":"Short-term prophylaxis with ceftriaxone plus metronidazole in esophageal cancer surgery","volume":"12","author":"Ruol","year":"2000","journal-title":"J Chemother"}],"container-title":["The American Journal of Geriatric Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1543594604800060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1543594604800060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T14:39:28Z","timestamp":1625150368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1543594604800060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S1543594604800060"],"URL":"https:\/\/doi.org\/10.1016\/j.amjopharm.2004.09.006","relation":{},"ISSN":["1543-5946"],"issn-type":[{"value":"1543-5946","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}