{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:37:29Z","timestamp":1777581449163,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Geriatric Pharmacotherapy"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.amjopharm.2008.03.003","type":"journal-article","created":{"date-parts":[[2008,4,6]],"date-time":"2008-04-06T11:52:16Z","timestamp":1207482736000},"page":"33-36","source":"Crossref","is-referenced-by-count":22,"title":["Intracerebral hemorrhage secondary to a warfarin-metronidazole interaction"],"prefix":"10.1016","volume":"6","author":[{"given":"Amanda","family":"Howard-Thompson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"April C.","family":"Hurdle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori B.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K.","family":"Finch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Sands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy H.","family":"Self","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 3","key":"10.1016\/j.amjopharm.2008.03.003_bib1","doi-asserted-by":"crossref","first-page":"204S","DOI":"10.1378\/chest.126.3_suppl.204S","article-title":"The pharmacology and management of the vitamin K antagonists: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Ansell","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.amjmed.2003.12.036","article-title":"Role of dietary vitamin K intake in chronic oral anticoagulation: Prospective evidence from observational and randomized protocols","volume":"116","author":"Franco","year":"2004","journal-title":"Am J Med"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib3","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/jnnp.69.5.601","article-title":"Incidence of intracerebral and subarachnoid hemorrhage in southern Sweden","volume":"69","author":"Nilsson","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/01.STR.28.3.491","article-title":"Comparable studies of the incidence of stroke and its pathological types: Results from an international collaboration","volume":"28","author":"Sudlow","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib5","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1161\/01.STR.29.12.2501","article-title":"A prospective community-based study of stroke in Germany\u2014the Erlangen Stroke Project (ESPro): Incidence and case fatality at 1, 3, and 12 months","volume":"29","author":"Kolominsky-Rabas","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/01.STR.0000196989.09900.f8","article-title":"Intracerebral hemorrhage associated with oral anticoagulant therapy: Current practices and unresolved questions","volume":"37","author":"Steiner","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1046\/j.1365-2141.1998.00988.x","article-title":"Analysis of risk factors for over-anticoagulation in patients receiving long-term warfarin","volume":"103","author":"Panneerselvam","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/pds.1291","article-title":"Cerebral hemorrhage induced by warfarin-the influence of drug-drug interactions","volume":"16","author":"J\u00f6nsson","year":"2007","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib9","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1056\/NEJM197608122950702","article-title":"The stereoselective interaction of warfarin and metronidazole in man","volume":"295","author":"O'Reilly","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib10","first-page":"782","article-title":"A significant interaction between metronidazole and warfarin","volume":"51","author":"Kazmier","year":"1976","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib11","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1177\/106002808001401212","article-title":"Bleeding associated with concurrent warfarin and metronidazole therapy","volume":"14","author":"Dean","year":"1980","journal-title":"Drug Intell Clin Pharm"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib12","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/archinte.166.9.1009","article-title":"Reducing warfarin medication interactions: An interrupted time series evaluation","volume":"166","author":"Feldstein","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/clpt.1987.104","article-title":"Enoxacin-warfarin interaction: Pharmacokinetic and stereochemical aspects","volume":"42","author":"Toon","year":"1987","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib14","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/archinte.1991.00400050139027","article-title":"Adverse reaction reporting of interaction between warfarin and fluoroquinolones","volume":"151","author":"Jolson","year":"1991","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib15","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1592\/phco.26.10.1446","article-title":"Anticoagulation-related outcomes in patients receiving warfarin after starting levofloxacin or gatifloxacin","volume":"26","author":"Mathews","year":"2006","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib16","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1177\/009127009603601111","article-title":"Absence of an effect of levofloxacin on warfarin pharmacokinetics and anticoagulation in male volunteers","volume":"36","author":"Liao","year":"1996","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1592\/phco.23.3.333.32101","article-title":"Effect of levofloxacin coadministration on the international normalized ratios during warfarin therapy","volume":"23","author":"Yamreudeewong","year":"2003","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib18","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.amjmed.2005.06.066","article-title":"The safety of levofloxacin in elderly patients on warfarin","volume":"118","author":"Stroud","year":"2005","journal-title":"Am J Med"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.amjopharm.2008.03.003_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0749-0690(05)70102-6","article-title":"Oral anticoagulants. Pharmacologic issues for use in the elderly","volume":"17","author":"Hylek","year":"2001","journal-title":"Clin Geriatr Med"}],"container-title":["The American Journal of Geriatric Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1543594608000056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1543594608000056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T22:29:49Z","timestamp":1557440989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1543594608000056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S1543594608000056"],"URL":"https:\/\/doi.org\/10.1016\/j.amjopharm.2008.03.003","relation":{},"ISSN":["1543-5946"],"issn-type":[{"value":"1543-5946","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}