{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:44:55Z","timestamp":1789991095928,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Otolaryngology"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.amjoto.2003.09.011","type":"journal-article","created":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T06:00:20Z","timestamp":1072764020000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Nasopharyngeal carcinoma with skull base invasion: a necessity of staging subdivision"],"prefix":"10.1016","volume":"25","author":[{"given":"Jong-Lyel","family":"Roh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Whun","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Yoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ha","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae Seo","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Whun","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjoto.2003.09.011_BIB1","first-page":"382","article-title":"Nasopharyngeal cancer","volume":"21","author":"Fandi","year":"1994","journal-title":"Semin Oncol"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1001\/jama.1965.03080150025004","article-title":"Neurologic manifestations of nasopharyngeal malignant tumors","volume":"192","author":"Thomas","year":"1965","journal-title":"JAMA"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3109\/02841869009090061","article-title":"Carcinoma of the nasopharynx","volume":"29","author":"Kajanti","year":"1990","journal-title":"Acta Oncol"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB4","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/1097-0142(19910715)68:2<422::AID-CNCR2820680235>3.0.CO;2-F","article-title":"Cranial nerve involvement and base of the skull erosion in nasopharyngeal carcinoma","volume":"68","author":"Sham","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0360-3016(92)90741-Y","article-title":"Carcinoma of the nasopharynx","volume":"23","author":"Perez","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0360-3016(96)00323-9","article-title":"Significant prognosticators after primary radiotherapy in 903 nondisseminated nasopharyngeal carcinoma evaluated by computer tomography","volume":"36","author":"Teo","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB7","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0360-3016(97)00104-1","article-title":"Carcinoma of the nasopharynx treated by radiotherapy alone","volume":"37","author":"Sanguineti","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB8","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/(SICI)1097-0142(19991115)86:10<1912::AID-CNCR6>3.0.CO;2-S","article-title":"Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma","volume":"86","author":"Heng","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0360-3016(01)01678-9","article-title":"Important prognostic factors in patients with skull base erosion from nasopharyngeal carcinoma after radiotherapy","volume":"51","author":"Lu","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0360-3016(00)00459-4","article-title":"Skull-base invasion of nasopharyngeal carcinoma","volume":"47","author":"Nishioka","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB11","series-title":"Manual for Staging of Cancer","first-page":"33","year":"1997"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB12","series-title":"Manual for Staging of Cancer","first-page":"35","year":"2002"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB13","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s002340050499","article-title":"Nasopharyngeal carcinoma","volume":"39","author":"Ng","year":"1997","journal-title":"Neuroradiology"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1288\/00005537-199206000-00006","article-title":"Complementary use of computed tomography and magnetic resonance imaging in assessing skull base lesions","volume":"102","author":"Kraus","year":"1992","journal-title":"Laryngoscope"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0009-9260(96)80056-0","article-title":"Skull base erosion in nasopharyngeal carcinoma","volume":"51","author":"Chong","year":"1996","journal-title":"Clin Radiol"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB16","series-title":"World Health Organization International Histological Classification of Tumors","article-title":"Histological Typing of Tumors of the Upper Respiratory Tract and Ear","author":"Shanmugaratnam","year":"1991"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0360-3016(89)90318-0","article-title":"Radiation therapy of nasopharyngeal carcinoma","volume":"16","author":"Zhang","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observation","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc (B)"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/(SICI)1097-0215(19990420)84:2<179::AID-IJC15>3.0.CO;2-6","article-title":"Staging of nasopharyngeal carcinoma","volume":"84","author":"Lee","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB22","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/1097-0142(20000715)89:2<242::AID-CNCR6>3.0.CO;2-Z","article-title":"A comparison of the Chinese 1992 and fifth-edition International Union Against Cancer staging systems for staging nasopharyngeal carcinoma","volume":"89","author":"Hong","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB23","series-title":"UICC TNM Classification of Malignant Tumors","author":"Sobin","year":"1997"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB24","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/0360-3016(94)90306-9","article-title":"The effect of loco-regional control on distant metastatic dissemination in carcinoma of the nasopharynx","volume":"30","author":"Kwong","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00000421-199702000-00002","article-title":"Pilot study of concurrent chemotherapy and radiotherapy for stage IV nasopharyngeal cancer","volume":"20","author":"Lin","year":"1997","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB26","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1200\/JCO.1998.16.4.1310","article-title":"Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer","volume":"16","author":"Al-Sarraf","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB27","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0360-3016(98)00092-3","article-title":"Prognostic features and treatment outcome in locoregionally advanced nasopharyngeal carcinoma following concurrent chemotherapy and radiotherapy","volume":"41","author":"Cheng","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB28","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0360-3016(99)00210-2","article-title":"Concurrent chemoradiotherapy followed by adjuvant chemotherapy in Asian patients with nasopharyngeal carcinoma","volume":"45","author":"Tan","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB29","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0360-3016(00)00558-7","article-title":"Improved outcome secondary to concurrent chemoradiotherapy for advanced carcinoma of the nasopharynx","volume":"47","author":"Cooper","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_BIB30","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1200\/JCO.2001.19.23.4305","article-title":"Induction chemotherapy with mitomycin, epirubicin, cisplatin, fluorouracil, and leucovorin followed by radiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma","volume":"19","author":"Hong","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjoto.2003.09.011_FR21","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0360-3016(94)90307-7","article-title":"A new staging system for nasopharyngeal carcinoma in China","volume":"30","author":"Min","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.amjoto.2003.09.011_FR31","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1200\/JCO.1996.14.3.1043","article-title":"Major toxicity of cisplatin, fluorouracil, and leucovorin following chemoradiotherapy in patients with nasopharyngeal carcinoma","volume":"14","author":"Celik","year":"1996","journal-title":"J Clin Oncol"}],"container-title":["American Journal of Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196070903001261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196070903001261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T04:50:11Z","timestamp":1759294211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196070903001261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0196070903001261"],"URL":"https:\/\/doi.org\/10.1016\/j.amjoto.2003.09.011","relation":{},"ISSN":["0196-0709"],"issn-type":[{"value":"0196-0709","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nasopharyngeal carcinoma with skull base invasion: a necessity of staging subdivision","name":"articletitle","label":"Article Title"},{"value":"American Journal of Otolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjoto.2003.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}