{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:04:39Z","timestamp":1761293079105,"version":"3.28.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Otolaryngology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.amjoto.2013.08.006","type":"journal-article","created":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T13:31:04Z","timestamp":1381325464000},"page":"19-24","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["HPV: A factor in organ preservation for locally advanced larynx and hypopharynx cancer?"],"prefix":"10.1016","volume":"35","author":[{"given":"Joseph N.","family":"Shaughnessy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan","family":"Farghaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liz","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Redman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Potts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Bumpous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal E.","family":"Dunlap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjoto.2013.08.006_bb0005","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJM199106133242402","article-title":"Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Veterans Affairs Laryngeal Cancer Study Group","volume":"324","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0010","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa031317","article-title":"Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer","volume":"349","author":"Forastiere","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0015","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/jnci\/88.13.890","article-title":"Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group","volume":"88","author":"Lefebvre","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0020","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1200\/JCO.2006.07.4559","article-title":"American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer","volume":"24","author":"Pfister","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djn011","article-title":"Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial","volume":"100","author":"Fakhry","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0035","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1200\/JCO.2007.12.7597","article-title":"Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number","volume":"26","author":"Worden","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0040","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1200\/JCO.2008.20.2853","article-title":"Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck","volume":"27","author":"Lassen","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0045","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/infdis\/jis698","article-title":"Human papillomavirus infection and laryngeal cancer risk: a systematic review and meta-analysis","volume":"207","author":"Li","year":"2013","journal-title":"J Infect Dis"},{"issue":"Suppl 1","key":"10.1016\/j.amjoto.2013.08.006_bb0050","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1007\/s12105-012-0368-1","article-title":"Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review","volume":"6","author":"Isayeva","year":"2012","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0055","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1001\/archoto.2012.950","article-title":"p16 not a prognostic marker for hypopharyngeal squamous cell carcinoma","volume":"138","author":"Wilson","year":"2012","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0060","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1001\/archotol.1994.01880310047009","article-title":"Human papillomavirus in laryngeal and hypopharyngeal carcinomas. Relationship to survival","volume":"120","author":"Clayman","year":"1994","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0065","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1365-2559.2011.04169.x","article-title":"Transcriptionally-active high-risk human papillomavirus is rare in oral cavity and laryngeal\/hypopharyngeal squamous cell carcinomas\u2014a tissue microarray study utilizing E6\/E7 mRNA in situ hybridization","volume":"60","author":"Lewis","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0070","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0748-7983(95)91591-5","article-title":"The prevalence of different human papillomavirus types and p53 mutations in laryngeal carcinomas: is there a reciprocal relationship?","volume":"21","author":"Salam","year":"1995","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0075","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1200\/JCO.2002.06.161","article-title":"Alteration of p53 pathway in squamous cell carcinoma of the head and neck: impact on treatment outcome in patients treated with larynx preservation intent","volume":"20","author":"Osman","year":"2002","journal-title":"J Clin Oncol"},{"issue":"Suppl 1","key":"10.1016\/j.amjoto.2013.08.006_bb0080","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1007\/s12105-012-0372-5","article-title":"HPV detection methods in head and neck cancer","volume":"6","author":"Venuti","year":"2012","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0085","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1158\/1055-9965.EPI-04-0551","article-title":"Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review","volume":"14","author":"Kreimer","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0090","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/019459989310800616","article-title":"DNA content and tumor response to induction chemotherapy in patients with advanced laryngeal squamous cell carcinoma","volume":"108","author":"Gregg","year":"1993","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.amjoto.2013.08.006_bb0095","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1288\/00005537-199404000-00012","article-title":"Rapid tumor cell proliferation after induction chemotherapy in oropharyngeal cancer","volume":"104","author":"Bourhis","year":"1994","journal-title":"Laryngoscope"}],"container-title":["American Journal of Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019607091300197X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019607091300197X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T18:58:20Z","timestamp":1729796300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019607091300197X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S019607091300197X"],"URL":"https:\/\/doi.org\/10.1016\/j.amjoto.2013.08.006","relation":{},"ISSN":["0196-0709"],"issn-type":[{"type":"print","value":"0196-0709"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HPV: A factor in organ preservation for locally advanced larynx and hypopharynx cancer?","name":"articletitle","label":"Article Title"},{"value":"American Journal of Otolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjoto.2013.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}