{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:57:02Z","timestamp":1788177422793,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Zhejiang Provincial Department of Health","award":["2016KYA080"],"award-info":[{"award-number":["2016KYA080"]}]},{"name":"Zhejiang Province Traditional Chinese Medicine Science And Technology Plan","award":["2017ZA078"],"award-info":[{"award-number":["2017ZA078"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Otolaryngology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.amjoto.2018.09.003","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T04:29:05Z","timestamp":1536812945000},"page":"36-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Vitamin D deficiency are associated with subjective disease severity in Chinese patients with chronic rhinosinusitis with nasal polyps"],"prefix":"10.1016","volume":"40","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjoto.2018.09.003_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhino-sinusitis and nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11882-015-0583-4","article-title":"Cytokine patterns and endotypes in acute and chronic rhinosinusitis","volume":"16","author":"Scheckenbach","year":"2016","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0015","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.jaci.2017.09.009","article-title":"Chronic rhinosinusitis in Asia","volume":"140","author":"Zhang","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0020","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0025","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00109-010-0590-9","article-title":"Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity","volume":"88","author":"Kamen","year":"2010","journal-title":"J Mol Med"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0030","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.ecl.2017.07.010","article-title":"Regulation of immune function by vitamin d and its use in diseases of immunity","volume":"46","author":"Vanherwegen","year":"2017","journal-title":"Endocrinol Metab Clin N Am"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0035","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/alr.21704","article-title":"Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps","volume":"6","author":"Carroll","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0040","doi-asserted-by":"crossref","first-page":"235","DOI":"10.18388\/abp.2009_2454","article-title":"Influence of vitamin D (3) analogues in combination with budesonid R on proliferation of nasal polyp fibroblasts","volume":"56","author":"Rostkowska-Nadolska","year":"2009","journal-title":"Acta Biochim Pol"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0045","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.kjms.2014.11.011","article-title":"Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps","volume":"31","author":"Wang","year":"2015","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0050","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.kjms.2015.02.001","article-title":"Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis","volume":"31","author":"Wang","year":"2015","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0055","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/alr.21474","article-title":"Vitamin D3 as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis","volume":"5","author":"Sansoni","year":"2015","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0060","doi-asserted-by":"crossref","first-page":"7299","DOI":"10.1038\/s41598-017-07561-6","article-title":"Vitamin D attenuates myofibroblast differentiation and extracellular matrix accumulation in nasal polyp-derived fibroblasts through smad2\/3 signaling pathway","volume":"7","author":"Lee","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0065","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2478\/v10039-010-0012-9","article-title":"Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures","volume":"55","author":"Rostkowska-Nadolska","year":"2010","journal-title":"Adv Med Sci"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0070","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/alr.21087","article-title":"Sinonasal epithelial cells synthesize active vitamin D, augmenting host innate immune function","volume":"3","author":"Sultan","year":"2013","journal-title":"Int Forum Allergy Rhinol"},{"issue":"4","key":"10.1016\/j.amjoto.2018.09.003_bb0075","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1177\/0194599812448852","article-title":"Vitamin D3 deficiency increases sinus mucosa dendritic cells in pediatric chronic rhinosinusitis with nasal polyps","volume":"147","author":"Mulligan","year":"2012","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0080","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.ijporl.2004.01.009","article-title":"Nutritional supplements as adjunctive therapy for children with chronic\/recurrent sinusitis: pilot research","volume":"68","author":"Linday","year":"2004","journal-title":"Int J Pediatr Otorhinolarynxgol"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0085","doi-asserted-by":"crossref","first-page":"2","DOI":"10.7243\/2055-091X-1-2","article-title":"Does vitamin D have protective effect on human nasal polyposis: histological and immunohistochemical study","volume":"1","author":"Faruk","year":"2014","journal-title":"J Histol Histopathol"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/bfm.2008.9984","article-title":"Does vitamin D make the world go \u2018round\u2019?","volume":"3","author":"Wagner","year":"2008","journal-title":"Breastfeed Med"},{"issue":"2","key":"10.1016\/j.amjoto.2018.09.003_bb0095","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/alr.21585","article-title":"Evaluation of vitamin D levels in allergic fungal sinusitis, chronic rhinosinusitis, and chronic rhinosinusitis with polyposis","volume":"6","author":"Mostafa","year":"2015","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0100","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jaci.2008.05.038","article-title":"Serum 25-hydroxyvitamin D levels are lower in urban African American subjects with chronic rhino-sinusitis","volume":"22","author":"Pinto","year":"2008","journal-title":"J Allergy Clin Immunol1"},{"issue":"3","key":"10.1016\/j.amjoto.2018.09.003_bb0105","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/alr.21274","article-title":"Impact of vitamin D deficiency upon clinical presentation in nasal polyposis","volume":"4","author":"Schlosser","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0110","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.12659\/MSM.898410","article-title":"Is nasal polyposis related to levels of serum vitamin D and vitamin D receptor gene expression?","volume":"22","author":"Erdag","year":"2016","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0115","first-page":"001","article-title":"Serum levels of vitamin D among patients with nasal polyps in Bolu, Turkey","volume":"5","author":"Apuhan","year":"2011","journal-title":"J Aller Ther S"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0120","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0125","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/B978-0-12-386960-9.00009-5","article-title":"Vitamin D effects on lung immunity and respiratory diseases","volume":"86","author":"Hansdottir","year":"2011","journal-title":"Vitam Horm"},{"issue":"6","key":"10.1016\/j.amjoto.2018.09.003_bb0130","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.2500\/ajra.2013.27.3948","article-title":"Serum 25-hydroxyvitamin D levels are lower in chronic rhinosinusitis with nasal polyposis and are correlated with disease severity in Taiwanese patients","volume":"27","author":"Wang","year":"2013","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0135","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2165\/00129785-200404010-00007","article-title":"Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland","volume":"4","author":"Laufs","year":"2004","journal-title":"Am J Pharmacogenomics"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0140","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jsbmb.2015.01.017","article-title":"Vitamin D for the treatment of respiratory diseases: is it the end or just the beginning?","volume":"148","author":"Yawn","year":"2015","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.amjoto.2018.09.003_bb0145","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/alr.21576","article-title":"Reduced sinonasal levels of 1\u03b1-hydroxylase are associated with worse quality of life in chronic rhinosinusitis with nasal polyps","volume":"6","author":"Schlosser","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"issue":"2","key":"10.1016\/j.amjoto.2018.09.003_bb0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/alr.21852","article-title":"Vitamin D pathway regulatory genes encoding 1\u03b1-hydroxylase and 24-hydroxylase are dysregulated in sinonasal tissue during chronic rhinosinusitis","volume":"7","author":"Christensen","year":"2017","journal-title":"Int Forum Allergy Rhinol"}],"container-title":["American Journal of Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196070918307208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196070918307208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T05:01:57Z","timestamp":1759294917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196070918307208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0196070918307208"],"URL":"https:\/\/doi.org\/10.1016\/j.amjoto.2018.09.003","relation":{},"ISSN":["0196-0709"],"issn-type":[{"value":"0196-0709","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D deficiency are associated with subjective disease severity in Chinese patients with chronic rhinosinusitis with nasal polyps","name":"articletitle","label":"Article Title"},{"value":"American Journal of Otolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjoto.2018.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}