{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:47Z","timestamp":1791330947525,"version":"4.3.1"},"reference-count":66,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Otolaryngology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.amjoto.2019.102375","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T11:34:57Z","timestamp":1576236897000},"page":"102375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hyaluronic acid in otology: Its uses, advantages and drawbacks - A review"],"prefix":"10.1016","volume":"41","author":[{"given":"Christophe","family":"Abi Zeid Daou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bassim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.amjoto.2019.102375_bb0005","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.biomaterials.2009.09.030","article-title":"Self-assembled hyaluronic acid nanoparticles for active tumor targeting","volume":"31","author":"Choi","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.amjoto.2019.102375_bb0015","doi-asserted-by":"crossref","DOI":"10.1177\/2058738418766739","article-title":"Topically administered hyaluronic acid in the upper airway: a narrative review","volume":"32","author":"Pignataro","year":"2018","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.amjoto.2019.102375_bb0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pmatsci.2018.04.003","article-title":"The potential of hyaluronic acid in immunoprotection and immunomodulation: chemistry, processing and function","volume":"97","author":"Zamboni","year":"2018","journal-title":"Prog Mater Sci"},{"issue":"4","key":"10.1016\/j.amjoto.2019.102375_bb0025","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.actbio.2013.12.019","article-title":"Hyaluronan: a simple polysaccharide with diverse biological functions","volume":"10","author":"Dicker","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.amjoto.2019.102375_bb0030","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.carbpol.2017.09.017","article-title":"Conjugation of paclitaxel to C-6 hexanediamine-modified hyaluronic acid for targeted drug delivery to enhance antitumor efficacy","volume":"181","author":"Chen","year":"2018","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.amjoto.2019.102375_bb0035","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ijbiomac.2018.10.049","article-title":"Modified hyaluronic acid based materials for biomedical applications","volume":"121","author":"Tiwari","year":"2019","journal-title":"Int J Biol Macromol"},{"issue":"19","key":"10.1016\/j.amjoto.2019.102375_bb0040","first-page":"4411","article-title":"Pathological and cytological changes of the nasal mucosa in acute rhinosinusitis: the role of hyaluronic acid as supportive therapy","volume":"21","author":"Ciofalo","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"9","key":"10.1016\/j.amjoto.2019.102375_bb0045","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/apm.12728","article-title":"Hyaluronate effect on bacterial biofilm in ENT district infections: a review","volume":"125","author":"Marcuzzo","year":"2017","journal-title":"Apmis"},{"issue":"3","key":"10.1016\/j.amjoto.2019.102375_bb0050","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bbrc.2015.08.061","article-title":"Effect of molecular weight and concentration of hyaluronan on cell proliferation and osteogenic differentiation in vitro","volume":"465","author":"Zhao","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.amjoto.2019.102375_bb0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1517\/14712598.2012.634792","article-title":"A review on the use of hyaluronic acid in tympanic membrane wound healing","volume":"12","author":"Teh","year":"2012","journal-title":"Expert Opin Biol Ther"},{"issue":"7","key":"10.1016\/j.amjoto.2019.102375_bb0060","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1016\/j.actbio.2009.05.004","article-title":"Photopatterned collagen\u2013hyaluronic acid interpenetrating polymer network hydrogels","volume":"5","author":"Suri","year":"2009","journal-title":"Acta Biomater"},{"key":"10.1016\/j.amjoto.2019.102375_bb0065","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ejpb.2015.09.005","article-title":"Efficacy study of two novel hyaluronic acid-based formulations for viscosupplementation therapy in an early osteoarthrosic rabbit model","volume":"96","author":"Kaderli","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"issue":"12","key":"10.1016\/j.amjoto.2019.102375_bb0070","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1001\/archotol.1988.01860240085029","article-title":"Hyaluronan improves the healing of experimental tympanic membrane perforations. A comparison of preparations with different rheologic properties","volume":"114","author":"Laurent","year":"1988","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.amjoto.2019.102375_bb0075","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3109\/00016488709102840","article-title":"Hyaluronan and healing of tympanic membrane perforations. An experimental study","volume":"442","author":"Hellstrom","year":"1987","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1016\/j.amjoto.2019.102375_bb0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijporl.2018.09.012","article-title":"A novel gel patch for minimally invasive repair of tympanic membrane perforations","volume":"115","author":"Rubinstein","year":"2018","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"2","key":"10.1016\/j.amjoto.2019.102375_bb0085","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/00016489.1992.11665418","article-title":"Comparative ototoxic potential of hyaluronic acid and methylcellulose","volume":"112","author":"Martini","year":"1992","journal-title":"Acta Otolaryngol"},{"issue":"1\u20132","key":"10.1016\/j.amjoto.2019.102375_bb0090","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3109\/00016489009122523","article-title":"An alternative treatment for the reduction of tympanic membrane perforations: sodium hyaluronate: a double blind study","volume":"110","author":"Rivas Lacarte","year":"1990","journal-title":"Acta Otolaryngol"},{"issue":"1","key":"10.1016\/j.amjoto.2019.102375_bb0095","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000276182","article-title":"Repair of chronic tympanic membrane perforations using applications of hyaluronan or rice paper prostheses","volume":"53","author":"Laurent","year":"1991","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"11","key":"10.1016\/j.amjoto.2019.102375_bb0100","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1007\/s00405-012-2331-x","article-title":"A prospective controlled trial comparing spontaneous closure and Epifilm\u00ae patching in traumatic tympanic membrane perforations","volume":"270","author":"Sayin","year":"2013","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"3","key":"10.1016\/j.amjoto.2019.102375_bb0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF03050829","article-title":"Repair of tympanic membrane perforation by topical application of 1% sodium hyaluronate","volume":"58","author":"Kaur","year":"2006","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.amjoto.2019.102375_bb0110","first-page":"6","article-title":"Study of effect of 1% sodium hyaluronate application on tympanic membrane perforation","volume":"4","author":"Sahni","year":"2018"},{"issue":"5","key":"10.1016\/j.amjoto.2019.102375_bb0115","first-page":"546","article-title":"The efficacy of hyaluronic acid foam as a middle ear packing agent in experimental tympanoplasty","volume":"19","author":"Krupala","year":"1998","journal-title":"Am J Otol"},{"issue":"11","key":"10.1016\/j.amjoto.2019.102375_bb0120","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.ijporl.2008.07.012","article-title":"The effect of anti-adhesive packing agents in the middle ear of guinea pig","volume":"72","author":"Jang","year":"2008","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"11","key":"10.1016\/j.amjoto.2019.102375_bb0125","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1080\/00016480600678797","article-title":"Effectiveness of MeroGel hyaluronic acid on tympanic membrane perforations","volume":"126","author":"Ozturk","year":"2006","journal-title":"Acta Otolaryngol"},{"issue":"4","key":"10.1016\/j.amjoto.2019.102375_bb0130","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/lary.23213","article-title":"The clinical application and efficacy of sodium hyaluronate-carboxymethylcellulose during tympanomastoid surgery","volume":"122","author":"Ahn","year":"2012","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.amjoto.2019.102375_bb0135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/00016489.2017.1384057","article-title":"Effect of esterified hyaluronic acid as middle ear packing in tympanoplasty for adhesive otitis media","volume":"138","author":"Deng","year":"2018","journal-title":"Acta Otolaryngol"},{"issue":"6","key":"10.1016\/j.amjoto.2019.102375_bb0140","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1749-4486.2008.01823.x","article-title":"Hyaluronic acid fat graft myringoplasty: how we do it","volume":"33","author":"Saliba","year":"2008","journal-title":"Clin Otolaryngol"},{"issue":"2","key":"10.1016\/j.amjoto.2019.102375_bb0145","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/lary.21365","article-title":"Hyaluronic acid fat graft myringoplasty: a minimally invasive technique","volume":"121","author":"Saliba","year":"2011","journal-title":"Laryngoscope"},{"issue":"12","key":"10.1016\/j.amjoto.2019.102375_bb0150","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1001\/archoto.2011.188","article-title":"Hyaluronic acid fat graft myringoplasty: an office-based technique adapted to children","volume":"137","author":"Saliba","year":"2011","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"8","key":"10.1016\/j.amjoto.2019.102375_bb0155","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1007\/s00405-014-2982-x","article-title":"Hyaluronic acid fat graft myringoplasty vs fat patch fat graft myringoplasty","volume":"272","author":"Alzahrani","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"10","key":"10.1016\/j.amjoto.2019.102375_bb0160","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1001\/archotol.2013.210","article-title":"Advantages of hyaluronic acid fat graft myringoplasty over fat graft myringoplasty","volume":"138","author":"Saliba","year":"2012","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"6","key":"10.1016\/j.amjoto.2019.102375_bb0165","doi-asserted-by":"crossref","first-page":"E224","DOI":"10.1002\/lary.24468","article-title":"Growth factors expression in hyaluronic acid fat graft myringoplasty","volume":"124","author":"Saliba","year":"2014","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.amjoto.2019.102375_bb0170","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5152\/iao.2016.1938","article-title":"Comparison of hyaluronic acid fat graft myringoplasty, fat graft myringoplasty and temporal fascia techniques for the closure of different sizes and sites of tympanic membrane perforations","volume":"12","author":"Gun","year":"2016","journal-title":"J Int Adv Otol"},{"issue":"1","key":"10.1016\/j.amjoto.2019.102375_bb0175","doi-asserted-by":"crossref","first-page":"30","DOI":"10.14740\/jocmr2800w","article-title":"Hyaluronic acid fat graft myringoplasty versus autologous platelet rich plasma","volume":"9","author":"Alhabib","year":"2017","journal-title":"J Clin Med Res"},{"issue":"6","key":"10.1016\/j.amjoto.2019.102375_bb0180","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.amjoto.2018.08.004","article-title":"Topical platelet rich plasma versus hyaluronic acid during fat graft myringoplasty","volume":"39","author":"Fouad","year":"2018","journal-title":"Am J Otolaryngol"},{"issue":"6","key":"10.1016\/j.amjoto.2019.102375_bb0185","first-page":"744","article-title":"Sodium hyaluronate in the repair of perforations of the tympanic membrane","volume":"11","author":"Camarda","year":"1989","journal-title":"Clin Ther"},{"key":"10.1016\/j.amjoto.2019.102375_bb0190","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3109\/00016488709102842","article-title":"An ultrastructural and functional study of the inner ear after administration of hyaluronan into the middle ear of the guinea pig","volume":"442","author":"Engstrom","year":"1987","journal-title":"Acta Otolaryngol Suppl"},{"issue":"3","key":"10.1016\/j.amjoto.2019.102375_bb0195","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.otohns.2009.11.009","article-title":"Safety and efficacy of carbomethylcellulose foam in guinea pig middle ear surgery","volume":"142","author":"Antonelli","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"10.1016\/j.amjoto.2019.102375_bb0200","first-page":"35","article-title":"Sodium hyaluronate application to the open inner ear: an ultrastructural investigation","volume":"12","author":"Bagger-Sjoback","year":"1991","journal-title":"Am J Otol"},{"issue":"5","key":"10.1016\/j.amjoto.2019.102375_bb0205","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1177\/0194599810395115","article-title":"Middle ear packing: comparison of materials in an animal model of mucosal trauma","volume":"144","author":"Lipan","year":"2011","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.amjoto.2019.102375_bb0210","first-page":"501","article-title":"Hyaluronic acid in middle ear surgery","volume":"14","author":"Bagger-Sjoback","year":"1993","journal-title":"Am J Otol"},{"issue":"8","key":"10.1016\/j.amjoto.2019.102375_bb0215","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/01.mao.0000227893.50162.9e","article-title":"Cross-linked hydrogels for middle ear packing","volume":"27","author":"Park","year":"2006","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.amjoto.2019.102375_bb0220","first-page":"1040","article-title":"To pack or not to pack? A contemporary review of middle ear packing agents","volume":"121","author":"Shen","year":"2011"},{"issue":"4","key":"10.1016\/j.amjoto.2019.102375_bb0225","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000092123","article-title":"Efficacy of gene transfer through the round window membrane: an in vitro model","volume":"68","author":"Aarnisalo","year":"2006","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"3","key":"10.1016\/j.amjoto.2019.102375_bb0230","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1089\/hum.2011.086","article-title":"Hyaluronic acid enhances gene delivery into the cochlea","volume":"23","author":"Shibata","year":"2012","journal-title":"Hum Gene Ther"},{"issue":"4","key":"10.1016\/j.amjoto.2019.102375_bb0235","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-2003-38937","article-title":"The effects of Streptolysin-O and sodium hyaluronate on the permeability of the round window membrane in guinea pigs\u2014an electrophysiologic study","volume":"82","author":"Selivanova","year":"2003","journal-title":"Laryngorhinootologie"},{"issue":"1\u20132","key":"10.1016\/j.amjoto.2019.102375_bb0240","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0378-5955(91)90151-X","article-title":"Radial communication between the perilymphatic scalae of the cochlea. II: estimation by bolus injection of tracer into the sealed cochlea","volume":"56","author":"Salt","year":"1991","journal-title":"Hear Res"},{"issue":"1\u20132","key":"10.1016\/j.amjoto.2019.102375_bb0245","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0378-5955(91)90150-8","article-title":"Radial communication between the perilymphatic scalae of the cochlea. I: estimation by tracer perfusion","volume":"56","author":"Salt","year":"1991","journal-title":"Hear Res"},{"issue":"2","key":"10.1016\/j.amjoto.2019.102375_bb0250","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00405-004-0772-6","article-title":"Intratympanic dexamethasone with hyaluronic acid in the treatment of idiopathic sudden sensorineural hearing loss after failure of intravenous steroid and vasoactive therapy","volume":"262","author":"Gouveris","year":"2005","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"1\u20132","key":"10.1016\/j.amjoto.2019.102375_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(01)00224-6","article-title":"Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals","volume":"155","author":"Sha","year":"2001","journal-title":"Hear Res"},{"issue":"5","key":"10.1016\/j.amjoto.2019.102375_bb0260","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/01.mao.0000185050.69394.48","article-title":"Intratympanic dexamethasone and hyaluronic acid in patients with low-frequency and Meniere\u2019s-associated sudden sensorineural hearing loss","volume":"26","author":"Selivanova","year":"2005","journal-title":"Otol Neurotol"},{"issue":"1","key":"10.1016\/j.amjoto.2019.102375_bb0265","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/lary.27392","article-title":"Intratympanic therapies in M\u00e9ni\u00e8re disease: evaluation of outcomes and early vertigo control","volume":"129","author":"Naples","year":"2019","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.amjoto.2019.102375_bb0270","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.otohns.2005.09.028","article-title":"Hyaluronate gel stapedotomy","volume":"134","author":"Angeli","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1\u20136","key":"10.1016\/j.amjoto.2019.102375_bb0275","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3109\/00016486509127035","article-title":"Vestibul\u00e4re Symptome vor und Nach Stapedektomie","volume":"60","author":"Fisch","year":"1965","journal-title":"Acta Otolaryngol"},{"issue":"5","key":"10.1016\/j.amjoto.2019.102375_bb0280","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1258\/0022215021910816","article-title":"Intracochlear insertion of electrodes using hyaluronic acid in cochlear implant surgery","volume":"116","author":"Laszig","year":"2002","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.amjoto.2019.102375_bb0285","article-title":"Clinical improvement of subacute and chronic otitis media with effusion treated with hyaluronic acid plus hypertonic solution via nasal lavage: a randomized controlled trial","volume":"4","author":"Cioffi","year":"2017","journal-title":"Glob Pediatr Health"},{"issue":"3","key":"10.1016\/j.amjoto.2019.102375_bb0290","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1177\/0394632016656012","article-title":"Topical administration of hyaluronic acid in children with recurrent or chronic middle ear inflammations","volume":"29","author":"Torretta","year":"2016","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"10","key":"10.1016\/j.amjoto.2019.102375_bb0295","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/alr.21193","article-title":"Intranasal sodium hyaluronate on the nasal cytology of patients with allergic and nonallergic rhinitis","volume":"3","author":"Gelardi","year":"2013","journal-title":"Int Forum Allergy Rhinol"},{"issue":"1","key":"10.1016\/j.amjoto.2019.102375_bb0300","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/039463201302600112","article-title":"Effects of sodium hyaluronate in children with recurrent upper respiratory tract infections: results of a randomised controlled study","volume":"26","author":"Macchi","year":"2013","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"2","key":"10.1016\/j.amjoto.2019.102375_bb0305","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ijporl.2012.10.018","article-title":"Recurrences in chronic tonsillitis substained by tonsillar biofilm-producing bacteria in children. Relationship with the grade of tonsillar hyperplasy","volume":"77","author":"Torretta","year":"2013","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3","key":"10.1016\/j.amjoto.2019.102375_bb0310","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s00405-016-4327-4","article-title":"Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease","volume":"274","author":"Torretta","year":"2017","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"1","key":"10.1016\/j.amjoto.2019.102375_bb0315","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijporl.2012.09.018","article-title":"Effect of anti-adhesion barrier solution containing ciprofloxacin-hydrocortisone on abraded mucosa with otitis media","volume":"77","author":"Jang","year":"2013","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"6","key":"10.1016\/j.amjoto.2019.102375_bb0320","first-page":"489","article-title":"The effect of hyaluronic acid on the growth of cholesteatoma","volume":"34","author":"Hayashi","year":"1991"},{"issue":"5","key":"10.1016\/j.amjoto.2019.102375_bb0325","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0196-0709(95)90059-4","article-title":"Effect of topical hyaluronic acid on experimental cholesteatoma","volume":"16","author":"White","year":"1995","journal-title":"Am J Otolaryngol"},{"issue":"4","key":"10.1016\/j.amjoto.2019.102375_bb0330","first-page":"468","article-title":"Use of a hyaluronan-based biomembrane in the treatment of chronic cholesteatomatous otitis media","volume":"21","author":"Martini","year":"2000","journal-title":"Am J Otol"},{"issue":"10","key":"10.1016\/j.amjoto.2019.102375_bb0335","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s00405-003-0636-5","article-title":"Clinical aspects and strategy for biomaterial engineering of an auricle based on three-dimensional stereolithography","volume":"260","author":"Naumann","year":"2003","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["American Journal of Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196070919310452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196070919310452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T05:04:17Z","timestamp":1759295057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196070919310452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0196070919310452"],"URL":"https:\/\/doi.org\/10.1016\/j.amjoto.2019.102375","relation":{},"ISSN":["0196-0709"],"issn-type":[{"value":"0196-0709","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyaluronic acid in otology: Its uses, advantages and drawbacks - A review","name":"articletitle","label":"Article Title"},{"value":"American Journal of Otolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjoto.2019.102375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102375"}}