{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:29:51Z","timestamp":1759364991634,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Otolaryngology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.amjoto.2022.103458","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T11:17:59Z","timestamp":1649330279000},"page":"103458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is adenotonsillectomy safe in covid-19 era? Investigation of sars-cov2 in adenoid and tonsil tissues"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4014-8176","authenticated-orcid":false,"given":"Togay","family":"Muderris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abd\u00fclhalim","family":"Aysel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5774-0315","authenticated-orcid":false,"given":"Reyhan","family":"Yi\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8538-5864","authenticated-orcid":false,"given":"Tuba","family":"Muderris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3185-8355","authenticated-orcid":false,"given":"\u0130brahim Mehmet Ali","family":"\u00d6ktem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"\u00c7orak\u00e7\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.amjoto.2022.103458_bb0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41579-020-00468-6","article-title":"Coronavirus biology and replication: implications for SARS-CoV-2","volume":"19","author":"V\u2019kovski","year":"2021","journal-title":"Nat Rev Microbiol"},{"issue":"8","key":"10.1016\/j.amjoto.2022.103458_bb0010","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.amjoto.2022.103458_bb0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.46234\/ccdcw2020.032","article-title":"The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19)\u2014China, 2020","volume":"2","author":"E. Team","year":"2020","journal-title":"China CDC Wkly"},{"key":"10.1016\/j.amjoto.2022.103458_bb0020","series-title":"Coronavirus disease 2019 (COVID-19): situation report","volume":"73","author":"W. H. Organization","year":"2020"},{"year":"2020","series-title":"Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV)","key":"10.1016\/j.amjoto.2022.103458_bb0025"},{"year":"2020","series-title":"WHO coronavirus disease (COVID-19) dashboard. 2020","author":"W. H. Organization","key":"10.1016\/j.amjoto.2022.103458_bb0030"},{"issue":"12","key":"10.1016\/j.amjoto.2022.103458_bb0035","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1056\/NEJMc2001737","article-title":"SARS-CoV-2 viral load in upper respiratory specimens of infected patients","volume":"382","author":"Zou","year":"2020","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.amjoto.2022.103458_bb0040","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.amjoto.2022.103458_bb0045","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2020.04.035","article-title":"SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues","volume":"181","author":"Ziegler","year":"2020","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.amjoto.2022.103458_bb0050","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00133-20","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection","volume":"34","author":"Synowiec","year":"2021","journal-title":"Clin Microbiol Rev"},{"issue":"10","key":"10.1016\/j.amjoto.2022.103458_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009037","article-title":"On the whereabouts of SARS-CoV-2 in the human body: a systematic review","volume":"16","author":"Trypsteen","year":"2020","journal-title":"PLoS Pathog"},{"year":"2020","series-title":"Generation of tonsil organoids as an ex vivo model for SARS-CoV-2 infection","author":"Kim","key":"10.1016\/j.amjoto.2022.103458_bb0060"},{"issue":"4","key":"10.1016\/j.amjoto.2022.103458_bb0065","first-page":"293","article-title":"Children's quality of life after adenotonsillectomy","volume":"9","author":"Kanmaz","year":"2013","journal-title":"B-ENT"},{"issue":"3","key":"10.1016\/j.amjoto.2022.103458_bb0070","first-page":"532","article-title":"A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples","volume":"15","author":"Chomczynski","year":"1993","journal-title":"Biotechniques"},{"key":"10.1016\/j.amjoto.2022.103458_bb0075","unstructured":"https:\/\/www.bioeksen.com.tr\/Media\/Documents\/biospeedy--sars-cov2-double-gene-rtqpcr-kit-brochure15642.pdf (accessed."},{"key":"10.1016\/j.amjoto.2022.103458_bb0080","article-title":"Tonsillitis","volume":"2014","author":"Georgalas","year":"2014","journal-title":"BMJ Clin Evid"},{"issue":"2","key":"10.1016\/j.amjoto.2022.103458_bb0085","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/coa.13680","article-title":"Admission avoidance in tonsillitis and peritonsillar abscess: a prospective national audit during the initial peak of the COVID-19 pandemic","volume":"46","author":"T. U. E. T. R. C. Integrate","year":"2021","journal-title":"Clin Otolaryngol"},{"issue":"6","key":"10.1016\/j.amjoto.2022.103458_bb0090","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.anl.2021.05.010","article-title":"COVID-19 findings revealed via otolaryngological examination: findings of a Japan otorhinolaryngologist association questionnaire","volume":"48","author":"Kimura","year":"2021","journal-title":"Auris Nasus Larynx"},{"issue":"1","key":"10.1016\/j.amjoto.2022.103458_bb0095","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.10.010347","article-title":"Combination of CT and RT-PCR in the screening or diagnosis of COVID-19","volume":"10","author":"Wang","year":"2020","journal-title":"J Glob Health"},{"key":"10.1016\/j.amjoto.2022.103458_bb0100","first-page":"1","article-title":"COVID-19 diagnosis\u2014a review of current methods","volume":"172","author":"Y\u00fcce","year":"2020","journal-title":"Biosens Bioelectron"},{"issue":"2","key":"10.1016\/j.amjoto.2022.103458_bb0105","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11684-020-0767-8","article-title":"Coronavirus disease 2019 (COVID-19): a clinical update","volume":"14","author":"Zhou","year":"2020","journal-title":"Front Med"},{"key":"10.1016\/j.amjoto.2022.103458_bb0110","doi-asserted-by":"crossref","first-page":"e769","DOI":"10.1016\/j.wneu.2020.04.155","article-title":"Patients with coronavirus 2019 (COVID-19) and surgery: guidelines and checklist proposal","volume":"139","author":"Grelat","year":"2020","journal-title":"World Neurosurg"},{"issue":"4\u20135","key":"10.1016\/j.amjoto.2022.103458_bb0115","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.micinf.2020.05.008","article-title":"A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients","volume":"22","author":"Liu","year":"2020","journal-title":"Microbes Infect"},{"key":"10.1016\/j.amjoto.2022.103458_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2020.109092","article-title":"Diagnostic impact of bedside chest X-ray features of 2019 novel coronavirus in the routine admission at the emergency department: case series from Lombardy region","volume":"129","author":"Ippolito","year":"2020","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.amjoto.2022.103458_bb0125","article-title":"Analysis of factors causing false-negative real-time polymerase chain reaction results in oropharyngeal and nasopharyngeal swabs of patients with COVID-19","author":"\u0130\u015flek","year":"2021","journal-title":"Ear Nose Throat J"},{"issue":"5","key":"10.1016\/j.amjoto.2022.103458_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0251661","article-title":"Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients","volume":"16","author":"Kortela","year":"2021","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.amjoto.2022.103458_bb0135","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-239108","article-title":"COVID-19 infection in the palatine tonsil tissue and detritus: the detection of the virus compartment with RT-PCR","volume":"14","author":"Kadriyan","year":"2021","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.amjoto.2022.103458_bb0140","article-title":"Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study","volume":"369","author":"Zheng","year":"2020","journal-title":"BMJ"},{"issue":"7","key":"10.1016\/j.amjoto.2022.103458_bb0145","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1007\/s00405-020-06383-z","article-title":"Model for hands-on tonsillectomy surgical training of postgraduate residents during COVID-19 pandemic","volume":"278","author":"Bhat","year":"2021","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["American Journal of Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196070922000850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196070922000850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T05:07:48Z","timestamp":1759295268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196070922000850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0196070922000850"],"URL":"https:\/\/doi.org\/10.1016\/j.amjoto.2022.103458","relation":{},"ISSN":["0196-0709"],"issn-type":[{"type":"print","value":"0196-0709"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is adenotonsillectomy safe in covid-19 era? Investigation of sars-cov2 in adenoid and tonsil tissues","name":"articletitle","label":"Article Title"},{"value":"American Journal of Otolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjoto.2022.103458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103458"}}