{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:58:05Z","timestamp":1781326685057,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ80176"],"award-info":[{"award-number":["2025JJ80176"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Otolaryngology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.amjoto.2026.104792","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:07:44Z","timestamp":1768320464000},"page":"104792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A single-center, randomized, double-blinded, placebo-controlled clinical study on the efficacy and safety of voriconazole ear drops in the treatment of otomycosis"],"prefix":"10.1016","volume":"47","author":[{"given":"Shen'er","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjoto.2026.104792_bb0005","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.otohns.2006.07.008","article-title":"Otomycosis: clinical features and treatment implications","volume":"135","author":"Ho","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.amjoto.2026.104792_bb0010","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/coa.12966","article-title":"Otomycosis in immunocompetent patients: clinical and mycological features. Our experience with 40 cases","volume":"43","author":"Alarid-Coronel","year":"2018","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.amjoto.2026.104792_bb0015","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.clindermatol.2009.12.003","article-title":"Otomycosis: diagnosis and treatment","volume":"28","author":"Vennewald","year":"2010","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.amjoto.2026.104792_bb0020","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1439-0507.2007.01409.x","article-title":"In vitro susceptibilities of aspergillus spp. causing otomycosis to amphotericin B, voriconazole and itraconazole","volume":"50","author":"Kaya","year":"2007","journal-title":"Mycoses"},{"key":"10.1016\/j.amjoto.2026.104792_bb0025","first-page":"705","volume":"51","author":"Peyton","year":"2015","journal-title":"Triazole antifungals: a review Drugs Today (Barc)"},{"key":"10.1016\/j.amjoto.2026.104792_bb0030","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1017\/S0022215114001273","article-title":"Treatment of refractory aspergillus otomycosis with voriconazole: case series and review","volume":"128","author":"Ho","year":"2014","journal-title":"J Laryngol Otol"},{"issue":"2","key":"10.1016\/j.amjoto.2026.104792_bb0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1442-9071.2008.01911.x","article-title":"Penetration of 1% voriconazole eye drops into human vitreous humour: a prospective, open-label study","volume":"37","author":"Lau","year":"2009","journal-title":"Clin Exp Ophthalmol"},{"issue":"11","key":"10.1016\/j.amjoto.2026.104792_bb0040","doi-asserted-by":"crossref","first-page":"6896","DOI":"10.1128\/AAC.00683-16","article-title":"Open-label study of absorption and clearance of 1% voriconazole eye drops","volume":"60","author":"Neoh","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.amjoto.2026.104792_bb0045","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/0003489420946783","article-title":"Administration of 1% topical voriconazole drops was effective and safe in the treatment of refractory otomycosis without tympanic membrane perforation","volume":"130","author":"Zhang","year":"2021","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.amjoto.2026.104792_bb0050","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11046-011-9427-5","article-title":"Otomycosis due to filamentous fungi","volume":"172","author":"Garc\u00eda-Agudo","year":"2011","journal-title":"Mycopathologia"},{"key":"10.1016\/j.amjoto.2026.104792_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009503","article-title":"Climate change and the emergence of fungal pathogens","volume":"17","author":"Nnadi","year":"2021","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.amjoto.2026.104792_bb0060","article-title":"Species distribution patterns and epidemiological characteristics of otomycosis in southeastern Serbia","volume":"30","author":"Tasi\u0107-Ota\u0161evi\u0107","year":"2020","journal-title":"J Mycol M\u00e9dicale"},{"key":"10.1016\/j.amjoto.2026.104792_bb0065","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11046-015-9864-7","article-title":"Otomycosis in Iran: a review","volume":"179","author":"Gharaghani","year":"2015","journal-title":"Mycopathologia"},{"key":"10.1016\/j.amjoto.2026.104792_bb0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/myc.13532","article-title":"Otomycosis: the foremost aetiological agent causing otitis externa and the antifungal susceptibility pattern in North-Western Iran","volume":"66","author":"Roohi","year":"2023","journal-title":"Mycoses"},{"key":"10.1016\/j.amjoto.2026.104792_bb0075","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3906\/sag-1407-17","article-title":"Epidemiology, causative agents, and risk factors affecting human otomycosis infections","volume":"45","author":"Abdelazeem","year":"2015","journal-title":"Turk J Med Sci"},{"key":"10.1016\/j.amjoto.2026.104792_bb0080","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1099\/jmm.0.000948","article-title":"Clinical and microbial epidemiology of otomycosis in the city of Yasuj, Southwest Iran, revealing aspergillus tubingensis as the dominant causative agent","volume":"68","author":"Sabz","year":"2019","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.amjoto.2026.104792_bb0085","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1099\/jmm.0.000985","article-title":"Molecular epidemiology of otomycosis in Isfahan revealed a large diversity in causative agents","volume":"68","author":"Aboutalebian","year":"2019","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.amjoto.2026.104792_bb0090","first-page":"251","article-title":"Otomycosis: clinical and mycological study of 97 cases","volume":"127","author":"Araiza","year":"2006","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"10.1016\/j.amjoto.2026.104792_bb0095","article-title":"Otomycosis in Africa: epidemiology, diagnosis and treatment","volume":"31","author":"Sangar\u00e9","year":"2021","journal-title":"J Mycol M\u00e9dicale"},{"key":"10.1016\/j.amjoto.2026.104792_bb0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11046-018-0299-9","article-title":"The molecular identification and antifungal susceptibilities of aspergillus species causing Otomycosis in Tochigi","volume":"184","author":"Hagiwara","year":"2019","journal-title":"Japan Mycopathologia"},{"key":"10.1016\/j.amjoto.2026.104792_bb0105","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1439-0507.2011.02132.x","article-title":"Otomycosis in Shanghai: aetiology, clinical features and therapy","volume":"55","author":"Jia","year":"2012","journal-title":"Mycoses"},{"key":"10.1016\/j.amjoto.2026.104792_bb0110","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/myc.12979","article-title":"Diagnosis and treatment of otomycosis in southern China","volume":"62","author":"Li","year":"2019","journal-title":"Mycoses"},{"key":"10.1016\/j.amjoto.2026.104792_bb0115","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1099\/mic.0.2007\/007641-0","article-title":"Aspergillus flavus: human pathogen, allergen and mycotoxin producer","volume":"153","author":"Hedayati","year":"2007","journal-title":"Microbiology (Reading)"},{"key":"10.1016\/j.amjoto.2026.104792_bb0120","first-page":"873","article-title":"Otomycosis in Central Iran: a clinical and mycological study","volume":"13","author":"Barati","year":"2011","journal-title":"Iran Red Crescent Med J"},{"key":"10.1016\/j.amjoto.2026.104792_bb0125","article-title":"Valorization of Quercus suber L. bark as a source of phytochemicals with antimicrobial activity against apple tree diseases","volume":"11","author":"S\u00e1nchez-Hern\u00e1ndez","year":"2022","journal-title":"Plants (Basel)"},{"key":"10.1016\/j.amjoto.2026.104792_bb0130","volume":"372","author":"Barry","year":"2021","journal-title":"Otitis externa Bmj"}],"container-title":["American Journal of Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196070926000074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0196070926000074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:41:54Z","timestamp":1781325714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0196070926000074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0196070926000074"],"URL":"https:\/\/doi.org\/10.1016\/j.amjoto.2026.104792","relation":{},"ISSN":["0196-0709"],"issn-type":[{"value":"0196-0709","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A single-center, randomized, double-blinded, placebo-controlled clinical study on the efficacy and safety of voriconazole ear drops in the treatment of otomycosis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Otolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjoto.2026.104792","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104792"}}