{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:42:00Z","timestamp":1789911720775,"version":"4.0.1"},"reference-count":9,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["americanjournalofsurgery.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Surgery"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.amjsurg.2003.03.005","type":"journal-article","created":{"date-parts":[[2003,12,31]],"date-time":"2003-12-31T07:17:39Z","timestamp":1072855059000},"page":"111-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Fondaparinux sodium lacks immunomodulatory effects of heparin"],"prefix":"10.1016","volume":"187","author":[{"given":"Michael","family":"Heinzelmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Bosshart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl","key":"10.1016\/j.amjsurg.2003.03.005_BIB1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1378\/chest.119.1_suppl.132S","article-title":"Prevention of venous thromboembolism","volume":"119","author":"Geerts","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.amjsurg.2003.03.005_BIB2","series-title":"Heparin-binding proteins","author":"Conrad","year":"1998"},{"key":"10.1016\/j.amjsurg.2003.03.005_BIB3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1527-3466.1997.tb00321.x","article-title":"SR90107A\/Org 31540, a novel anti-Factor Xa antithrombotic agent","volume":"15","author":"Herbert","year":"1997","journal-title":"Cardiovasc Drug Rev"},{"key":"10.1016\/j.amjsurg.2003.03.005_BIB4","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1001\/archinte.162.16.1833","article-title":"Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery","volume":"162","author":"Turpie","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.amjsurg.2003.03.005_BIB5","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1056\/NEJM200103013440901","article-title":"A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement","volume":"344","author":"Turpie","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amjsurg.2003.03.005_BIB6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1054-3589(08)60471-8","article-title":"Heparin in inflammation","volume":"46","author":"Tyrrell","year":"1999","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.amjsurg.2003.03.005_BIB7","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/00000658-199904000-00014","article-title":"Heparin and enoxaparin enhance endotoxin-induced tumor necrosis factor-alpha production in human monocytes","volume":"229","author":"Heinzelmann","year":"1999","journal-title":"Ann Surg"},{"key":"10.1016\/j.amjsurg.2003.03.005_BIB8","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.1128\/IAI.70.12.6904-6910.2002","article-title":"Arginine-rich cationic polypeptides amplify lipopolysaccharide-induced monocyte activation","volume":"70","author":"Bosshart","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.amjsurg.2003.03.005_BIB9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0065-2776(08)60597-0","article-title":"Role of cytokines in sepsis","volume":"66","author":"Hack","year":"1997","journal-title":"Adv Immunol"}],"container-title":["The American Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002961003004483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002961003004483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:34:37Z","timestamp":1757698477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002961003004483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0002961003004483"],"URL":"https:\/\/doi.org\/10.1016\/j.amjsurg.2003.03.005","relation":{},"ISSN":["0002-9610"],"issn-type":[{"value":"0002-9610","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fondaparinux sodium lacks immunomodulatory effects of heparin","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjsurg.2003.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}