{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:59:04Z","timestamp":1779112744969,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["americanjournalofsurgery.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Surgery"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.amjsurg.2005.03.034","type":"journal-article","created":{"date-parts":[[2005,8,15]],"date-time":"2005-08-15T07:05:49Z","timestamp":1124089549000},"page":"479-484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":146,"title":["Are we giving enough coagulation factors during major trauma resuscitation?"],"prefix":"10.1016","volume":"190","author":[{"given":"Anthony M.-H.","family":"Ho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj K.","family":"Karmakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W.","family":"Dion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjsurg.2005.03.034_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00005373-199502000-00006","article-title":"Epidemiology of trauma deaths","volume":"38","author":"Sauaia","year":"1995","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib2","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1164\/ajrccm.163.3.2004106","article-title":"Trauma critical care","volume":"163","author":"Gentilello","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib3","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/archsurg.134.9.964","article-title":"Improved survival following massive transfusion in patients who have undergone trauma","volume":"134","author":"Cinat","year":"1999","journal-title":"Arch Surg"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0039-6109(05)70099-2","article-title":"Hypothermia, coagulopathy, and acidosis","volume":"80","author":"Eddy","year":"2000","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib5","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/00005373-199205000-00012","article-title":"Coagulopathy and catecholamines in severe head injury","volume":"32","author":"Kearney","year":"1992","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1053\/spsu.2001.19381","article-title":"Glasgow Coma Scale predicts coagulopathy in pediatric trauma patients","volume":"10","author":"Keller","year":"2001","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib7","first-page":"233","article-title":"Coagulopathy in severe closed head injury","volume":"63","author":"May","year":"1997","journal-title":"Am Surg"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib8","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/01.TA.0000069184.82147.06","article-title":"Acute traumatic coagulopathy","volume":"54","author":"Brohi","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib9","first-page":"1084","article-title":"Implications of excessive fibrinolysis and \u03b12-plasmin inhibitor deficiency in patients with severe head injury","volume":"49","author":"Kushimoto","year":"2001","journal-title":"Neurosurgery"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00005373-199304000-00002","article-title":"Blood component supplementation during massive transfusion of AS-1 red cells in trauma patients","volume":"34","author":"Faringer","year":"1993","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib11","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/00005373-199406000-00015","article-title":"The impact of hypothermia on diltutional coagulopathy","volume":"36","author":"Gubler","year":"1994","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00005373-199409000-00014","article-title":"Functional equivalence of hypothermia to specific clotting factor deficiencies","volume":"37","author":"Johnston","year":"1994","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/00005373-199209000-00022","article-title":"The disparity between hypothermic coagulopathy and clotting studies","volume":"33","author":"Reed","year":"1992","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib14","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/01.TA.0000064328.97941.FC","article-title":"A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function","volume":"56","author":"Wolberg","year":"2004","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib15","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/00005373-199212000-00007","article-title":"The effects of hypothermia and injury severity on blood loss during trauma laparotomy","volume":"33","author":"Bernabei","year":"1992","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/00005373-198709000-00011","article-title":"Hypothermia in trauma victims","volume":"27","author":"Jurkovich","year":"1987","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib17","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/01.TA.0000066184.20808.A5","article-title":"The effect of temperature and pH on the activity of factor VIIa","volume":"55","author":"Meng","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib18","unstructured":"Viuff D, Johansson PI, Holcomb JB, et al. In vitro evaluation of the impact of colloid hemodilution, acidosis, and hypothermia on the effect of recombinant factor VIIa (NovoSeven). Presented at the Advanced Technology Applications for Combat Casualty Care 2004 Conference, St. Pete Beach, FL, August 16\u201318, 2004."},{"key":"10.1016\/j.amjsurg.2005.03.034_bib19","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1001\/archsurg.1979.01370300061009","article-title":"pH induced platelet ultrastructural alterations","volume":"114","author":"Djaldetti","year":"1979","journal-title":"Arch Surg"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib20","first-page":"471","article-title":"Acidosis induced coagulopathy","volume":"30","author":"Dunn","year":"1979","journal-title":"Surg Forum"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib21","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/00005373-199705000-00016","article-title":"Predicting life-threatening coagulopathy in the massively transfused trauma patient","volume":"42","author":"Cosgriff","year":"1997","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00005373-200107000-00033","article-title":"Excessive use of normal saline in managing traumatized patients in shock","volume":"51","author":"Ho","year":"2001","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib23","first-page":"498","article-title":"Practice guidelines for blood component therapy. A report by the American Society of Anesthesiologists Task Force on blood component therapy","volume":"84","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib24","series-title":"Trauma Management","first-page":"75","article-title":"Resuscitation","author":"Stern","year":"2001"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib25","series-title":"Complications in Anesthesia","first-page":"668","article-title":"Complications of massive transfusion","author":"Montenegro","year":"1999"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00044067-199902000-00007","article-title":"Massive transfusion in trauma","volume":"10","author":"Waldspurger Robb","year":"1999","journal-title":"AACN Clin Issues"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib27","series-title":"Textbook of Anaesthesia","first-page":"619","article-title":"Emergency anaesthesia","author":"Turner","year":"2001"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib28","unstructured":"http:\/\/www.usc.edu\/hsc\/medicine\/surgery\/trauma\/Trauma_Protocols\/5MASSBLD.html, accessed Aug 18, 2004."},{"key":"10.1016\/j.amjsurg.2005.03.034_bib29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/bja\/70.2.205","article-title":"The haemostatic response to surgery and trauma","volume":"70","author":"Murphy","year":"1993","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib30","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1182\/blood.V54.3.694.694","article-title":"The hemostatic imbalance of plasma-exchange transfusion","volume":"54","author":"Flaum","year":"1979","journal-title":"Blood"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib31","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1046\/j.1537-2995.1984.24484275577.x","article-title":"Hemostatic imbalances produced by plasma excahnge","volume":"24","author":"Domen","year":"1984","journal-title":"Transfusion"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/00000542-198812000-00007","article-title":"Coagulation changes during packed red cell replacement of major blood loss","volume":"69","author":"Murray","year":"1988","journal-title":"Anesthesiology"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0022-4804(76)90144-X","article-title":"The effects of acute normovolemic hemodilution on coagulation and blood utilization in major surgery","volume":"20","author":"Laks","year":"1976","journal-title":"J Surg Res"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0022-5223(19)40327-9","article-title":"The effect on blood coagulation of the exclusive use of frozen red cell transfusions during and after cardiopulmonary bypass","volume":"70","author":"Umlas","year":"1975","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib35","first-page":"336","article-title":"Packed red cells in acute blood loss","volume":"80","author":"Murray","year":"1995","journal-title":"Anesth Analg"},{"issue":"Suppl","key":"10.1016\/j.amjsurg.2005.03.034_bib36","first-page":"1","article-title":"Anesthesia for trauma","volume":"96","author":"Barker","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00003246-198505000-00003","article-title":"Coagulopathy related to dilution and hypotension during massive transfusion","volume":"13","author":"Hewson","year":"1985","journal-title":"Crit Care Med"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib38","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/00005373-198708000-00010","article-title":"Outcome of massive transfusion exceeding two blood volumes in trauma and emergency surgery","volume":"27","author":"Phillips","year":"1987","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib39","doi-asserted-by":"crossref","first-page":"356","DOI":"10.5694\/j.1326-5377.1995.tb124628.x","article-title":"Massive blood transfusion in a tertiary referral hospital. Clinical outcomes and haemostatic complications","volume":"163","author":"Harvey","year":"1995","journal-title":"Med J Aust"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib40","first-page":"926","article-title":"Evaluation of massive volume replacement in the penetrating trauma patient","volume":"86","author":"Mitchell","year":"1994","journal-title":"J Natl Med Assoc"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib41","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/ajcp\/96.6.770","article-title":"Laboratory hemostatic abnormalities in massively transfused patients given red blood cells and crystalloid","volume":"96","author":"Leslie","year":"1991","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib42","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/00005373-199205000-00018","article-title":"Coagulopathy and intraoperative blood salvage (IBS)","volume":"32","author":"Horst","year":"1992","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib43","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/01.TA.0000053245.08642.1F","article-title":"Minimizing dilutional coagulopathy in exsanguinating hemorrhage","volume":"54","author":"Hirshberg","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib44","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1213\/01.ANE.0000052711.68903.5D","article-title":"Hemostasis and hemodilution","volume":"96","author":"Singbartl","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib45","series-title":"Trauma Anesthesia and Intensive Care","first-page":"167","article-title":"Transfusion therapy in trauma","author":"Bernstein","year":"1991"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib46","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/00000658-199305010-00019","article-title":"The staged celiotomy for trauma","volume":"217","author":"Morris","year":"1993","journal-title":"Ann Surg"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib47","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/s002689900542","article-title":"Staged physiologic restoration and damage control surgery","volume":"22","author":"Moore","year":"1998","journal-title":"World J Surg"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib48","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00000658-199205000-00009","article-title":"Abdominal packing for surgically uncontrollable hemorrhage","volume":"215","author":"Sharp","year":"1992","journal-title":"Ann Surg"},{"key":"10.1016\/j.amjsurg.2005.03.034_bib49","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/00000542-200304000-00041","article-title":"Use of recombinant activated factor VII in patients with severe coagulopathy and bleeding (letter)","volume":"98","author":"Ho","year":"2003","journal-title":"Anesthesiology"}],"container-title":["The American Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002961005005027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002961005005027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:43:19Z","timestamp":1757698999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002961005005027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0002961005005027"],"URL":"https:\/\/doi.org\/10.1016\/j.amjsurg.2005.03.034","relation":{},"ISSN":["0002-9610"],"issn-type":[{"value":"0002-9610","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are we giving enough coagulation factors during major trauma resuscitation?","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjsurg.2005.03.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Excerpta Medica Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}