{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:15:43Z","timestamp":1783487743462,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["americanjournalofsurgery.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Surgery"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.amjsurg.2020.09.021","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T20:26:18Z","timestamp":1601324778000},"page":"1000-1004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Temporal trends in incidence, evaluation and management of neuroendocrine neoplasms of the appendix: 14\u00a0years\u2019 experience"],"prefix":"10.1016","volume":"221","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8865-3860","authenticated-orcid":false,"given":"Orit","family":"Twito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Paran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shmuel","family":"Avital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Kravtsov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Chava","family":"Rosenblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pnina","family":"Rotman-Pikielny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.amjsurg.2020.09.021_bib1","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1200\/JCO.2007.15.4377","article-title":"One hundred years after \"carcinoid\": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States","volume":"26","author":"Yao","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"issue":"12","key":"10.1016\/j.amjsurg.2020.09.021_bib2","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1038\/ajg.2010.341","article-title":"Carcinoid tumors of the gastrointestinal tract: trends in incidence in England since 1971","volume":"105","author":"Ellis","year":"2010","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.amjsurg.2020.09.021_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000493894","article-title":"Unmet needs in appendiceal neuroendocrine neoplasms","volume":"108","author":"Toumpanakis","year":"2019","journal-title":"Neuroendocrinology"},{"issue":"8","key":"10.1016\/j.amjsurg.2020.09.021_bib4","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.ejca.2012.12.022","article-title":"Incidence and survival of neuroendocrine tumours in The Netherlands according to histological grade: experience of two decades of cancer registry","volume":"49","author":"Korse","year":"2013","journal-title":"Eur J Canc"},{"issue":"12","key":"10.1016\/j.amjsurg.2020.09.021_bib5","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1093\/annonc\/mdt377","article-title":"Gastrointestinal carcinoid: epidemiological and survival evidence from a large population-based study (n\u00a0= 25 531)","volume":"24","author":"Mocellin","year":"2013","journal-title":"Ann Oncol"},{"issue":"10","key":"10.1016\/j.amjsurg.2020.09.021_bib6","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1001\/jamaoncol.2017.0589","article-title":"Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States","volume":"3","author":"Dasari","year":"2017","journal-title":"JAMA Oncol"},{"issue":"3","key":"10.1016\/j.amjsurg.2020.09.021_bib7","doi-asserted-by":"crossref","first-page":"R153","DOI":"10.1530\/ERC-13-0125","article-title":"Incidence of gastroenteropancreatic neuroendocrine tumours: a systematic review of the literature","volume":"21","author":"Fraenkel","year":"2014","journal-title":"Endocr Relat Canc"},{"key":"10.1016\/j.amjsurg.2020.09.021_bib8","first-page":"292","article-title":"Trends of incidence and survival of gastrointestinal neuroendocrine tumors in the United States: a SEER analysis","volume":"3","author":"Tsikitis","year":"2012","journal-title":"J\u00a0Canc"},{"issue":"4","key":"10.1016\/j.amjsurg.2020.09.021_bib9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/cncr.29099","article-title":"Exploring the rising incidence of neuroendocrine tumors: a population-based analysis of epidemiology, metastatic presentation, and outcomes","volume":"121","author":"Hallet","year":"2015","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.amjsurg.2020.09.021_bib10","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1093\/annonc\/mdq022","article-title":"Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE)","volume":"21","author":"Garcia-Carbonero","year":"2010","journal-title":"Ann Oncol"},{"issue":"9","key":"10.1016\/j.amjsurg.2020.09.021_bib11","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1023\/A:1012272314550","article-title":"Epidemiology and survival in patients with carcinoid disease in The Netherlands. An epidemiological study with 2391 patients","volume":"12","author":"Quaedvlieg","year":"2001","journal-title":"Ann Oncol"},{"issue":"7","key":"10.1016\/j.amjsurg.2020.09.021_bib12","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1001\/archsurg.143.7.664","article-title":"Analysis of 900 appendiceal carcinoid tumors for a proposed predictive staging system","volume":"143","author":"Landry","year":"2008","journal-title":"Arch Surg"},{"issue":"6","key":"10.1016\/j.amjsurg.2020.09.021_bib13","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.amjsurg.2010.04.016","article-title":"Appendiceal carcinoid at a large tertiary center: pathologic findings and long-term follow-up evaluation","volume":"201","author":"Shapiro","year":"2011","journal-title":"Am J Surg"},{"issue":"2","key":"10.1016\/j.amjsurg.2020.09.021_bib14","first-page":"150","article-title":"Carcinoid tumors of appendix: treatment and outcome","volume":"12","author":"Co\u015fkun","year":"2006","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"issue":"27","key":"10.1016\/j.amjsurg.2020.09.021_bib15","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1056\/NEJM198712313172704","article-title":"Carcinoid tumor of the appendix: treatment and prognosis","volume":"317","author":"Moertel","year":"1987","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.amjsurg.2020.09.021_bib16","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1572-0241.1998.00422.x","article-title":"A\u00a0retrospective analysis of 1570 appendiceal carcinoids","volume":"93","author":"Sandor","year":"1998","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.amjsurg.2020.09.021_bib17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/jso.21888","article-title":"Carcinoid tumors of the appendix: a population-based study","volume":"104","author":"Mullen","year":"2011","journal-title":"J\u00a0Surg Oncol"},{"issue":"3","key":"10.1016\/j.amjsurg.2020.09.021_bib18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000478742","article-title":"Surgical management of patients with neuroendocrine neoplasms of the appendix: appendectomy or more","volume":"106","author":"Pawa","year":"2018","journal-title":"Neuroendocrinology"},{"issue":"1","key":"10.1016\/j.amjsurg.2020.09.021_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000109876","article-title":"Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour\/carcinoma of the appendix and goblet cell carcinoma","volume":"87","author":"Pl\u00f6ckinger","year":"2008","journal-title":"Neuroendocrinology"},{"issue":"6","key":"10.1016\/j.amjsurg.2020.09.021_bib20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/MPA.0b013e3181ebb2a5","article-title":"The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum","volume":"39","author":"Boudreaux","year":"2010","journal-title":"Pancreas"},{"issue":"2","key":"10.1016\/j.amjsurg.2020.09.021_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000335629","article-title":"ENETS Consensus Guidelines for the management of patients with neuroendocrine neoplasms from the jejuno-ileum and the appendix including goblet cell carcinomas","volume":"95","author":"Pape","year":"2012","journal-title":"Neuroendocrinology"},{"issue":"4","key":"10.1016\/j.amjsurg.2020.09.021_bib22","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/MPA.0b013e31828e34a4","article-title":"Consensus guidelines for the management and treatment of neuroendocrine tumors","volume":"42","author":"Kunz","year":"2013","journal-title":"Pancreas"},{"issue":"2","key":"10.1016\/j.amjsurg.2020.09.021_bib23","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000443165","article-title":"ENETS consensus guidelines for neuroendocrine neoplasms of the appendix (excluding goblet cell carcinomas)","volume":"103","author":"Pape","year":"2016","journal-title":"Neuroendocrinology"},{"issue":"2","key":"10.1016\/j.amjsurg.2020.09.021_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000499381","article-title":"Challenging the current risk factors of appendiceal neuroendocrine neoplasms: can they accurately predict local lymph nodal invasion? Results from a large case series","volume":"109","author":"Galanopoulos","year":"2019","journal-title":"Neuroendocrinology"},{"issue":"3","key":"10.1016\/j.amjsurg.2020.09.021_bib25","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4103\/IJPM.IJPM_390_18","article-title":"Assessment of appendix carcinoid tumors: a retrospective study","volume":"62","author":"Koca\u00f6z","year":"2019","journal-title":"Indian J Pathol Microbiol"},{"issue":"1","key":"10.1016\/j.amjsurg.2020.09.021_bib26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF02236899","article-title":"Appendiceal tumors: retrospective clinicopathologic analysis of appendiceal tumors from 7,970 appendectomies","volume":"41","author":"Connor","year":"1998","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.amjsurg.2020.09.021_bib27","first-page":"4421","article-title":"Analysis of appendiceal neoplasms on 3544 appendectomy specimens for acute appendicitis: retrospective cohort study of a single institution","volume":"24","author":"Kunduz","year":"2018","journal-title":"Med Sci Mon Int Med J Exp Clin Res"},{"key":"10.1016\/j.amjsurg.2020.09.021_bib28","article-title":"Appendiceal carcinoid tumors: is there a survival advantage to colectomy over appendectomy?","author":"Guzman","year":"2019","journal-title":"J\u00a0Gastrointest Surg"},{"issue":"3","key":"10.1016\/j.amjsurg.2020.09.021_bib29","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s12253-011-9382-y","article-title":"Distribution, incidence, and prognosis in neuroendocrine tumors: a population based study from a cancer registry","volume":"17","author":"Caldarella","year":"2011","journal-title":"Pathol Oncol Res"},{"issue":"3","key":"10.1016\/j.amjsurg.2020.09.021_bib30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.amjsurg.2013.08.038","article-title":"Postoperative surveillance of small appendiceal carcinoid tumors","volume":"207","author":"Murray","year":"2014","journal-title":"Am J Surg"},{"issue":"3","key":"10.1016\/j.amjsurg.2020.09.021_bib31","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s12020-019-01984-z","article-title":"Histopathological diagnosis of appendiceal neuroendocrine neoplasms: when to perform a right hemicolectomy? A systematic review and meta-analysis","volume":"66","author":"Ricci","year":"2019","journal-title":"Endocrine"}],"container-title":["The American Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002961020305900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002961020305900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:23:03Z","timestamp":1757701383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002961020305900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0002961020305900"],"URL":"https:\/\/doi.org\/10.1016\/j.amjsurg.2020.09.021","relation":{},"ISSN":["0002-9610"],"issn-type":[{"value":"0002-9610","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporal trends in incidence, evaluation and management of neuroendocrine neoplasms of the appendix: 14\u00a0years\u2019 experience","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjsurg.2020.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}