{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:25:51Z","timestamp":1781655951013,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["americanjournalofsurgery.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Surgery"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.amjsurg.2025.116550","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T20:14:22Z","timestamp":1754424862000},"page":"116550","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Drunk Platelets: Ethanol intoxication is associated with platelet inhibition in male Trauma patients"],"prefix":"10.1016","volume":"249","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7624-3756","authenticated-orcid":false,"given":"Brittany M.","family":"Stansbury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3853-0383","authenticated-orcid":false,"given":"Rigel P.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3051-3761","authenticated-orcid":false,"given":"Andrea Carolina","family":"Vazquez-Loreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2027-4577","authenticated-orcid":false,"given":"Robert A.","family":"Easter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor M.","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody L.","family":"Handschug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina M.","family":"Kupanoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dih-Dih","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Czarkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1790-9283","authenticated-orcid":false,"given":"Hahn","family":"Soe-Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan A.","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6777-687X","authenticated-orcid":false,"given":"James N.","family":"Bogert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10036","key":"10.1016\/j.amjsurg.2025.116550_bib1","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0140-6736(16)00648-6","article-title":"Global burden of diseases, injuries, and risk factors for young people's health during 1990-2013: a systematic analysis for the global burden of disease study 2013","volume":"387","author":"Mokdad","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.amjsurg.2025.116550_bib2","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.surg.2019.03.003","article-title":"Higher mortality in pediatric and adult trauma patients with traumatic coagulopathy, using age-adjusted diagnostic criteria","volume":"165","author":"Reed","year":"2019","journal-title":"Surgery"},{"issue":"9","key":"10.1016\/j.amjsurg.2025.116550_bib3","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1007\/s00268-011-1191-7","article-title":"Acute ethanol intoxication and the trauma patient: hemodynamic pitfalls","volume":"35","author":"Bilello","year":"2011","journal-title":"World J Surg"},{"issue":"11","key":"10.1016\/j.amjsurg.2025.116550_bib4","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1111\/add.13031","article-title":"Alcohol attributable fraction for injury morbidity from the dose-response relationship of acute alcohol consumption: emergency department data from 18 countries","volume":"110","author":"Cherpitel","year":"2015","journal-title":"Addiction"},{"issue":"3","key":"10.1016\/j.amjsurg.2025.116550_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/SLA.0b013e3182658180","article-title":"Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients","volume":"256","author":"Holcomb","year":"2012","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.amjsurg.2025.116550_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00068-016-0643-z","article-title":"Adenosine diphosphate platelet dysfunction on thromboelastogram is independently associated with increased morality in traumatic brain injury","volume":"43","author":"Daley","year":"2017","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"11","key":"10.1016\/j.amjsurg.2025.116550_bib7","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/bjs.9592","article-title":"Risk of bleeding and adverse outcomes predicted by thromboelastography platelet mapping in patients taking clopidogrel within 7 days of non-cardiac surgery","volume":"101","author":"Kasivisvanathan","year":"2014","journal-title":"Br J Surg"},{"issue":"2","key":"10.1016\/j.amjsurg.2025.116550_bib8","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ahj.2010.05.034","article-title":"Adenosine diphosphate-induced platelet-fibrin clot strength: a new thrombelastographic indicator of long-term poststenting ischemic events","volume":"160","author":"Gurbel","year":"2010","journal-title":"Am Heart J"},{"issue":"2","key":"10.1016\/j.amjsurg.2025.116550_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12028-012-9745-6","article-title":"Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy","volume":"18","author":"Davis","year":"2013","journal-title":"Neurocritical Care"},{"issue":"3","key":"10.1016\/j.amjsurg.2025.116550_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0248810","article-title":"Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients","volume":"16","author":"Wang","year":"2021","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.amjsurg.2025.116550_bib11","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/TA.0000000000000357","article-title":"The effects of alcohol on coagulation in trauma patients: interpreting thrombelastography with caution","volume":"77","author":"Howard","year":"2014","journal-title":"J Trauma Acute Care Surg"},{"issue":"1","key":"10.1016\/j.amjsurg.2025.116550_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/TA.0000000000001716","article-title":"Exposing the bidirectional effects of alcohol on coagulation in trauma: impaired clot formation and decreased fibrinolysis in rotational thromboelastometry","volume":"84","author":"Howard","year":"2018","journal-title":"J Trauma Acute Care Surg"},{"issue":"5","key":"10.1016\/j.amjsurg.2025.116550_bib13","first-page":"1106","article-title":"Effects of ethanol intoxication and gender on blood coagulation","volume":"68","author":"Spoerke","year":"2010","journal-title":"J Trauma"},{"issue":"5","key":"10.1016\/j.amjsurg.2025.116550_bib14","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.amjsurg.2019.02.020","article-title":"Consumption of alcohol leads to platelet inhibition in men","volume":"217","author":"Smith","year":"2019","journal-title":"Am J Surg"},{"issue":"6","key":"10.1016\/j.amjsurg.2025.116550_bib15","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/jth.14450","article-title":"Trauma-induced coagulopathy: the past, present, and future","volume":"17","author":"Kornblith","year":"2019","journal-title":"J Thromb Haemostasis"},{"issue":"18","key":"10.1016\/j.amjsurg.2025.116550_bib16","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1182\/blood-2017-11-784108","article-title":"Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury","volume":"131","author":"Zhang","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.amjsurg.2025.116550_bib17","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1016\/j.wneu.2018.01.025","article-title":"Blood ethanol levels are not related to coagulation changes, as measured by thromboelastography, in traumatic brain injury patients","volume":"112","author":"Rao","year":"2018","journal-title":"World Neurosurg"},{"issue":"9","key":"10.1016\/j.amjsurg.2025.116550_bib18","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1089\/neu.2011.1866","article-title":"Ethanol intoxication is associated with a lower incidence of admission coagulopathy in severe traumatic brain injury patients","volume":"28","author":"Lustenberger","year":"2011","journal-title":"J Neurotrauma"},{"issue":"4","key":"10.1016\/j.amjsurg.2025.116550_bib19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/TA.0000000000003516","article-title":"Traumatic brain injury patients with platelet inhibition receiving platelet transfusion demonstrate decreased need for neurosurgical intervention and decreased mortality","volume":"92","author":"Miles","year":"2022","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.amjsurg.2025.116550_bib20","series-title":"Glasgow Coma Scale. StatPearls","author":"Jain","year":"2025"},{"issue":"4","key":"10.1016\/j.amjsurg.2025.116550_bib21","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.amjsurg.2015.12.018","article-title":"Post-trauma mortality increase at age 60: a cutoff for defining elderly?","volume":"212","author":"Campbell-Furtick","year":"2016","journal-title":"Am J Surg"},{"key":"10.1016\/j.amjsurg.2025.116550_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjsurg.2024.115822","article-title":"Marijuana May lead to increased platelet activity in trauma patients","volume":"238","author":"Tanner","year":"2024","journal-title":"Am J Surg"},{"issue":"3","key":"10.1016\/j.amjsurg.2025.116550_bib23","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1378\/chest.10-1971","article-title":"Beyond thrombosis: the versatile platelet in critical illness","volume":"139","author":"Katz","year":"2011","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.amjsurg.2025.116550_bib24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/TA.0000000000001057","article-title":"Inhibition of platelet function is common following Even minor injury","volume":"81","author":"Sirajuddin","year":"2016","journal-title":"J Trauma Acute Care Surg"},{"issue":"1","key":"10.1016\/j.amjsurg.2025.116550_bib25","first-page":"5","article-title":"The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants","volume":"30","author":"Edenberg","year":"2007","journal-title":"Alcohol Res Health"}],"container-title":["The American Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002961025003733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002961025003733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T22:11:31Z","timestamp":1760047891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002961025003733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":25,"alternative-id":["S0002961025003733"],"URL":"https:\/\/doi.org\/10.1016\/j.amjsurg.2025.116550","relation":{},"ISSN":["0002-9610"],"issn-type":[{"value":"0002-9610","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drunk Platelets: Ethanol intoxication is associated with platelet inhibition in male Trauma patients","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjsurg.2025.116550","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116550"}}