{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:28:15Z","timestamp":1794479295461,"version":"4.9.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["americanjournalofsurgery.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Surgery"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.amjsurg.2026.117200","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T14:39:01Z","timestamp":1787409541000},"page":"117200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Deletion of Annexin A2 protects from liver injury after massive small bowel resection in mice"],"prefix":"10.1016","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0032-2525","authenticated-orcid":false,"given":"Daniel","family":"Alligood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Swanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Mayse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Pyarali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah C.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas O.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Alvarado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.amjsurg.2026.117200_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s12072-020-10048-8","article-title":"Intestinal failure-associated liver disease (IFALD): insights into pathogenesis and advances in management","volume":"14","author":"Lee","year":"2020","journal-title":"Hepatol Int"},{"key":"10.1016\/j.amjsurg.2026.117200_bib2","first-page":"70","volume":"38","author":"Lauriti","year":"2014"},{"key":"10.1016\/j.amjsurg.2026.117200_bib3","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1097\/MPG.0000000000002384","article-title":"Outcomes of children with chronic intestinal failure: experience over 2 decades at a tertiary paediatric Hospital","volume":"69","author":"Jo","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.amjsurg.2026.117200_bib4","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.jpedsurg.2017.08.049","article-title":"The extent of intestinal failure-associated liver disease in patients referred for intestinal rehabilitation is associated with increased mortality: an analysis of the Pediatric intestinal failure consortium database","volume":"53","author":"Javid","year":"2018","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.amjsurg.2026.117200_bib5","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/ajt.14715","article-title":"Visceral transplantation in patients with intestinal-failure associated liver disease: evolving indications, graft selection, and outcomes","volume":"18","author":"Hawksworth","year":"2018","journal-title":"Am J Transplant"},{"key":"10.1016\/j.amjsurg.2026.117200_bib6","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1016\/j.bbagen.2017.08.024","article-title":"Protein phosphorylation and its role in the regulation of Annexin A2 function","volume":"1861","author":"Grindheim","year":"2017","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"10.1016\/j.amjsurg.2026.117200_bib7","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3390\/pathogens13070564","article-title":"Annexin A2: a double-edged sword in pathogen infection","volume":"13","author":"Wang","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.amjsurg.2026.117200_bib8","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41420-025-02469-x","article-title":"ANXA2 in cancer: aberrant regulation of tumour cell apoptosis and its immune interactions","volume":"11","author":"Huang","year":"2025","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.amjsurg.2026.117200_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.amjsurg.2026.117200_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1725965","article-title":"Annexin A1 and A2 in inflammatory bowel disease pathogenesis: exploring new avenues for diagnosis and treatment","volume":"16","author":"Murshed","year":"2026","journal-title":"Front Immunol"},{"key":"10.1016\/j.amjsurg.2026.117200_bib11","volume":"1868","author":"Wang","year":"2022","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.amjsurg.2026.117200_bib12","article-title":"Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential","volume":"3","author":"Carlessi","year":"2023","journal-title":"Cell Genom"},{"key":"10.1016\/j.amjsurg.2026.117200_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1108167","article-title":"ANXA2 is a potential biomarker for cancer prognosis and immune infiltration: a systematic pan-cancer analysis","volume":"14","author":"Ning","year":"2023","journal-title":"Front Genet"},{"key":"10.1016\/j.amjsurg.2026.117200_bib14","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.3390\/cancers16223764","article-title":"Annexin A2 in tumors of the gastrointestinal tract, liver, and pancreas","volume":"16","author":"Christofidis","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.amjsurg.2026.117200_bib15","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1007\/s12072-023-10622-w","article-title":"The upregulation of Annexin A2 by TLR4 pathway facilitates lipid accumulation and liver injury via blocking AMPK\/mTOR-mediated autophagy flux during the development of non-alcoholic fatty liver disease","volume":"18","author":"Wu","year":"2024","journal-title":"Hepatol Int"},{"key":"10.1016\/j.amjsurg.2026.117200_bib16","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.3390\/ijms14023568","article-title":"Annexin A2: the importance of being redox sensitive","volume":"14","author":"Madureira","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.amjsurg.2026.117200_bib17","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jpedsurg.2020.02.037","article-title":"Effects of high-fat diet on liver injury after small bowel resection","volume":"55","author":"Onufer","year":"2020","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.amjsurg.2026.117200_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe6729","article-title":"Enterically derived high-density lipoprotein restrains liver injury through the portal vein","volume":"373","author":"Han","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.amjsurg.2026.117200_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2025.101609","article-title":"Single nuclear RNA sequencing reveals unique hepatocyte population in small bowel resection-induced liver injury","volume":"19","author":"Park","year":"2025","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.amjsurg.2026.117200_bib20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.amjsurg.2026.117200_bib21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2002.35276","article-title":"Delayed liver regeneration in peroxisome proliferator-activated receptor-alpha-null mice","volume":"36","author":"Anderson","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.amjsurg.2026.117200_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1061","article-title":"PARK7 deficiency inhibits fatty acid \u03b2-oxidation via PTEN to delay liver regeneration after hepatectomy","volume":"12","author":"Qu","year":"2022","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.amjsurg.2026.117200_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1389329","article-title":"The role of PI3k\/AKT signaling pathway in attenuating liver fibrosis: a comprehensive review","volume":"11","author":"Shamsan","year":"2024","journal-title":"Front Med"},{"key":"10.1016\/j.amjsurg.2026.117200_bib24","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.18632\/oncotarget.375","article-title":"Annexin A2 is a novel cellular redox regulatory protein involved in tumorigenesis","volume":"2","author":"Madureira","year":"2011","journal-title":"Oncotarget"},{"key":"10.1016\/j.amjsurg.2026.117200_bib25","article-title":"The Nrf2 pathway in liver diseases","volume":"10","author":"Zhou","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.amjsurg.2026.117200_bib26","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jcmgh.2021.05.013","article-title":"Activation of AhR-NQO1 signaling pathway protects against alcohol-induced liver injury by improving redox balance","volume":"12","author":"Dong","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.amjsurg.2026.117200_bib27","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1681\/ASN.2011111123","article-title":"Tissue plasminogen activator activates NF-\u03baB through a pathway involving Annexin A2\/CD11b and integrin-linked kinase","volume":"23","author":"Lin","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.amjsurg.2026.117200_bib28","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/glia.70018","article-title":"Multi-omic analysis reveals astrocytic Annexin-A2 as critical for network-level circadian timekeeping in the suprachiasmatic nucleus","volume":"73","author":"Patton","year":"2025","journal-title":"Glia"},{"key":"10.1016\/j.amjsurg.2026.117200_bib29","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.jpedsurg.2023.02.016","article-title":"Intestinal knockout of peroxisome proliferator-activated receptor-alpha affects structural adaptation but not liver injury following massive enterectomy","volume":"58","author":"Phelps","year":"2023","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.amjsurg.2026.117200_bib30","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jpedsurg.2023.02.031","article-title":"Disruption of enterohepatic circulation of bile acids ameliorates small bowel resection associated hepatic injury","volume":"58","author":"Tecos","year":"2023","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.amjsurg.2026.117200_bib31","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.amjsurg.2026.117200_bib32","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.amjsurg.2026.117200_bib33","series-title":"kevinblighe\/PCAtools","author":"Blighe","year":"2025"},{"key":"10.1016\/j.amjsurg.2026.117200_bib34","series-title":"Publication-Ready Volcano Plots with Enhanced Colouring and Labeling","author":"Blighe","year":"2024"},{"key":"10.1016\/j.amjsurg.2026.117200_bib35","first-page":"1","article-title":"Using clusterProfiler to characterize multiomics data","author":"Xu","year":"2024","journal-title":"Nat Protoc"},{"key":"10.1016\/j.amjsurg.2026.117200_bib36","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbac016","article-title":"decoupleR: ensemble of computational methods to infer biological activities from omics data","volume":"2","author":"Badia-i-Mompel","year":"2022","journal-title":"Bioinform Adv"}],"container-title":["The American Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002961026003855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002961026003855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T09:41:56Z","timestamp":1794476516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002961026003855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":36,"alternative-id":["S0002961026003855"],"URL":"https:\/\/doi.org\/10.1016\/j.amjsurg.2026.117200","relation":{},"ISSN":["0002-9610"],"issn-type":[{"value":"0002-9610","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deletion of Annexin A2 protects from liver injury after massive small bowel resection in mice","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amjsurg.2026.117200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117200"}}