{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:24:23Z","timestamp":1792023863125,"version":"4.4.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaerobe"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.anaerobe.2011.07.005","type":"journal-article","created":{"date-parts":[[2011,7,24]],"date-time":"2011-07-24T15:34:00Z","timestamp":1311521640000},"page":"463-467","source":"Crossref","is-referenced-by-count":11,"title":["Human microbial ecology: Lactobacilli, probiotics, selective decontamination"],"prefix":"10.1016","volume":"17","author":[{"given":"Marika","family":"Mikelsaar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anaerobe.2011.07.005_bib1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/icb\/42.2.319","article-title":"Mutualistic fermentative digestion in the gastrointestinal tract: diversity and evolution","volume":"42","author":"Mackie","year":"2002","journal-title":"Integ Comp Biol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib2","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1128\/AEM.71.7.4153-4155.2005","article-title":"Colonic microbiota signatures across five northern European countries","volume":"71","author":"Lay","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.tree.2006.06.013","article-title":"Assembly of the human intestinal microbiota","volume":"21","author":"Dethlefsen","year":"2006","journal-title":"Trends Ecol Evol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/MOG.0b013e32831da7c4","article-title":"Renewed interest in a difficult disease: Clostridium difficile infections - epidemiology and current treatment strategies","volume":"25","author":"McFarland","year":"2008","journal-title":"Curr Op Gastroenterol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib5","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1128\/IAI.00187-08","article-title":"Bacteria in the intestine, helpful residents or enemies from within?","volume":"76","author":"Canny","year":"2008","journal-title":"Infect Immun"},{"issue":"Suppl. 1","key":"10.1016\/j.anaerobe.2011.07.005_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000089775","article-title":"Enteric flora in health and disease","volume":"73","author":"Guarner","year":"2006","journal-title":"Digestion"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0750-7658(00)90209-0","article-title":"Consequences of antibiotic therapy to the intestinal ecosystem","volume":"19","author":"Andremont","year":"2000","journal-title":"Ann Fr Anesth Reanim"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib8","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1128\/AEM.70.10.6113-6122.2004","article-title":"Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects","volume":"70","author":"Woodmansey","year":"2004","journal-title":"Appl Environ Microbiol"},{"issue":"Suppl. 1","key":"10.1016\/j.anaerobe.2011.07.005_bib9","first-page":"1A","article-title":"Probiotics in clinical practice: an overview","volume":"36","author":"Zuccotti","year":"2008","journal-title":"J\u00a0Int Med Res"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib10","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1128\/AEM.70.6.3575-3581.2004","article-title":"Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota","volume":"70","author":"Bartosch","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib11","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/j.archger.2010.01.012","article-title":"Mortality and bloodstream infections in geriatrics units","volume":"51","author":"Burlaud","year":"2010","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/ageing\/22.6.431","article-title":"Bloodstream infections in patients older than eighty years","volume":"22","author":"Leibovici","year":"1993","journal-title":"Age Ageing"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.medmal.2009.12.008","article-title":"Immunosenescence and infections, myth or reality?","volume":"40","author":"Cretel","year":"2010","journal-title":"Med Mal Infect"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib14","first-page":"501031","article-title":"Selective decontamination of the digestive tract reduces pneumonia and mortality","volume":"2010","author":"Haas","year":"2010","journal-title":"Crit Care Res Pract"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jhin.2009.01.008","article-title":"Epidemiology of nosocomial bloodstream infections in Estonia","volume":"71","author":"Mitt","year":"2009","journal-title":"J\u00a0Hosp Infect"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study","volume":"39","author":"Wisplinghoff","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib17","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/jac\/19.4.513","article-title":"The effect of oral non-absorbable antibiotics on the emergence of resistant bacteria in patients in an intensive care unit","volume":"19","author":"Stoutenbeek","year":"1987","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib18","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1007\/s00134-010-1826-4","article-title":"Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patients","volume":"36","author":"Benus","year":"2010","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00134-007-0934-2","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008","volume":"34","author":"Dellinger","year":"2008","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1086\/649554","article-title":"Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America","volume":"50","author":"Solomkin","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.fmrre.2005.04.009","article-title":"Diversity, vitality and activities of intestinal lactic acid bacteria and bifidobacteria assessed by molecular approaches","volume":"29","author":"Vaughan","year":"2005","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib22","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1128\/AEM.70.6.3189-3194.2004","article-title":"A\u00a0special fondness for lactobacilli","volume":"70","author":"Tannock","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib23","unstructured":"Kandler O, Weiss N. Regular Non-sporing Gram-positive Rods. 1986:1209\u20131234."},{"key":"10.1016\/j.anaerobe.2011.07.005_bib24","doi-asserted-by":"crossref","unstructured":"Hammes W, Vogel RF. The Genus Lactobacillus. 1995:19\u201354.","DOI":"10.1007\/978-1-4615-5817-0_3"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib25","doi-asserted-by":"crossref","unstructured":"Axelsson L. Lactic acid bacteria: classification physiology. 1998:1\u201372.","DOI":"10.1201\/b11503-2"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0168-1605(98)00128-7","article-title":"Demonstration of safety of probiotics \u2013 a review","volume":"44","author":"Salminen","year":"1998","journal-title":"Int J Food Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib27","first-page":"44","article-title":"Taxonomy of lactobacilli and bifidobacteria","volume":"8","author":"Felis","year":"2007","journal-title":"Curr Issues Intest Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib28","series-title":"Lactobacillus acidophilus. Its Therapeutic Application","author":"Rettger","year":"1935"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib29","first-page":"354","article-title":"A\u00a0contribution to the method of isolation and differentiation of aerobic \"lactobacilli\" (Genus \"Lactobacillus Beijerinck\")","volume":"179","author":"Lerche","year":"1960","journal-title":"Zentralbl Bakteriol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib30","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1093\/ajcn\/30.11.1781","article-title":"Fecal microbial flora in seventh day adventist populations and control subjects","volume":"30","author":"Finegold","year":"1977","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib31","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1093\/ajcn\/31.10.S33","article-title":"Some current concepts in intestinal bacteriology","volume":"31","author":"Moore","year":"1978","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1365-2672.1993.tb03031.x","article-title":"Numerical taxonomy of Lactobacillus spp. associated with healthy and diseased mucosa of the human intestines","volume":"74","author":"Molin","year":"1993","journal-title":"J\u00a0Appl Bacteriol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib33","doi-asserted-by":"crossref","unstructured":"Tannock GW. The microecology of lactobacilli inhabiting the gastrointestinal tract. 1990:147\u2013171.","DOI":"10.1007\/978-1-4684-7612-5_4"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1046\/j.1365-2672.1998.00480.x","article-title":"The normal Lactobacillus flora of healthy human rectal and oral mucosa","volume":"85","author":"Ahrne","year":"1998","journal-title":"J\u00a0Appl Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1128\/AEM.68.1.114-123.2002","article-title":"Molecular diversity of Lactobacillus spp. and other lactic acid bacteria in the human intestine as determined by specific amplification of 16S ribosomal DNA","volume":"68","author":"Heilig","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib36","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00248-003-2001-z","article-title":"Increased complexity of the species composition of lactic acid bacteria in human feces revealed by alternative incubation condition","volume":"45","author":"Dal Bello","year":"2003","journal-title":"Microb Ecol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib37","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1128\/AEM.00753-08","article-title":"Ecological role of lactobacilli in the gastrointestinal tract: implications for fundamental and biomedical research","volume":"74","author":"Walter","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/08910600260081711","article-title":"Intestinal lactobacilli of Estonian and Swedish children","volume":"14","author":"Mikelsaar","year":"2002","journal-title":"Microb Ecol Health Dis"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib39","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.anaerobe.2010.03.001","article-title":"Intestinal Lactobacillus spp. is associated with some cellular and metabolic characteristics of blood in elderly people","volume":"16","author":"Mikelsaar","year":"2010","journal-title":"Anaerobe"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib40","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1017\/S0007114510004770","article-title":"Diversity and metabolic impact of intestinal Lactobacillus spp. in healthy adults and the elderly","volume":"105","author":"Stsepetova","year":"2011","journal-title":"Brit J Nutr"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib41","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.4315\/0362-028X-61.12.1636","article-title":"Antibiotic susceptibility of potentially probiotic Lactobacillus species","volume":"61","author":"Charteris","year":"1998","journal-title":"J\u00a0Food Prot"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib42","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/003655401750173940","article-title":"Antibacterial susceptibility of intestinal lactobacilli of healthy children","volume":"33","author":"M\u00e4ndar","year":"2001","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1605(02)00254-4","article-title":"Susceptibility of Lactobacillus spp. to antimicrobial agents","volume":"82","author":"Danielsen","year":"2003","journal-title":"Int J Food Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib44","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s00284-010-9653-y","article-title":"Screening and Evaluation of human intestinal lactobacilli for the development of Novel gastrointestinal probiotics","volume":"61","author":"Koll","year":"2010","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib45","series-title":"Susceptibility test methods; general conditions","author":"Jorgensen","year":"2003"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib46","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1469-0691.2009.03099.x","article-title":"European Society of clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI)","volume":"15","author":"Bauer","year":"2009","journal-title":"Clin Microbiol Infect"},{"issue":"Suppl. 2","key":"10.1016\/j.anaerobe.2011.07.005_bib47","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1086\/516183","article-title":"Colonization of infants and hospitalized patients with Clostridium difficile and lactobacilli","volume":"25","author":"Naaber","year":"1997","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib48","first-page":"141","article-title":"Dominant cultivable Lactobacillus species from the feces of healthy adults in northern Spain","volume":"10","author":"Delgado","year":"2007","journal-title":"Int Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib49","doi-asserted-by":"crossref","first-page":"8982","DOI":"10.1128\/AEM.71.12.8982-8986.2005","article-title":"Evaluation of new broth media for microdilution antibiotic susceptibility testing of Lactobacilli, Pediococci, Lactococci, and Bifidobacteria","volume":"71","author":"Klare","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib50","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1093\/jac\/dkm035","article-title":"Antimicrobial susceptibilities of Lactobacillus, Pediococcus and Lactococcus human isolates and cultures intended for probiotic or nutritional use","volume":"59","author":"Klare","year":"2007","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib51","first-page":"412","article-title":"Antibiotic susceptibility profiles of Lactobacillus reuteri and Lactobacillus fermentum","volume":"70","author":"Egerv\u00e4rn","year":"2007","journal-title":"J\u00a0Food Prot"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib52","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0899-9007(98)00003-3","article-title":"Ecoimmunonutrition: a challenge for the third millennium","volume":"14","author":"Bengmark","year":"1998","journal-title":"Nutrition"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib53","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1086\/500214","article-title":"Lactobacillus bacteremia, species identification, and antimicrobial susceptibility of 85 blood isolates","volume":"42","author":"Salminen","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib54","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1471-2180-8-132","article-title":"Eradication of Salmonella Typhimurium infection in a murine model of typhoid fever with the combination of probiotic Lactobacillus fermentum ME-3 and ofloxacin","volume":"8","author":"Truusalu","year":"2008","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib55","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(08)60207-X","article-title":"Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial","volume":"371","author":"Besselink","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.anaerobe.2011.07.005_bib56","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1001\/archinte.165.5.500","article-title":"Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women\u2019s Health Initiative Observational Study","volume":"165","author":"Margolis","year":"2005","journal-title":"Arch Intern Med"}],"container-title":["Anaerobe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1075996411001375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1075996411001375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T04:06:03Z","timestamp":1560398763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1075996411001375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1075996411001375"],"URL":"https:\/\/doi.org\/10.1016\/j.anaerobe.2011.07.005","relation":{},"ISSN":["1075-9964"],"issn-type":[{"value":"1075-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}