{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:33:45Z","timestamp":1785267225161,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaerobe"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.anaerobe.2014.03.006","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T03:16:18Z","timestamp":1396322178000},"page":"56-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Antimicrobial and anti-inflammatory properties of nostocionone isolated from Nostoc commune Vauch and its derivatives against Propionibacterium acnes"],"prefix":"10.1016","volume":"27","author":[{"given":"Tomohiro","family":"Itoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Tsuchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Tsukamasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Koketsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anaerobe.2014.03.006_bib1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1056\/NEJMcp033487","article-title":"Clinical practice: acne","volume":"352","author":"James","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib2","first-page":"3","article-title":"Overview of acne and its treatment","volume":"81","author":"Thiboutot","year":"2008","journal-title":"Cutis"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib3","first-page":"734","article-title":"Diagnosis and treatment of acne","volume":"86","author":"Titus","year":"2012","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/1523-1747.ep12610239","article-title":"Quantification of bacteria isolated in pilosebaceous follicles in normal skin","volume":"65","author":"Puhvel","year":"1975","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2672.1981.tb01234.x","article-title":"A\u00a0review, the microbiology of acne","volume":"51","author":"Holland","year":"1981","journal-title":"J\u00a0Appl Bacteriol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/09546634.2012.699179","article-title":"A\u00a0sysmatic review of benzoyl peroxide for acne vulgaris","volume":"24","author":"Mohd Nor","year":"2013","journal-title":"J\u00a0Dermatolog Treat"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jadohealth.2008.06.005","article-title":"A\u00a0review of adapalene in the treatment of acne vulgaris","volume":"43","author":"Irby","year":"2008","journal-title":"J\u00a0Adolesc Health"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib8","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.3390\/molecules15053200","article-title":"Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells","volume":"15","author":"Zu","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib9","first-page":"1","article-title":"Acne and its treatment lines","volume":"3","author":"Ray","year":"2013","journal-title":"Int J Res Pharm Biosci"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib10","first-page":"465","article-title":"Nostoc, ecology of cyanobacteria: their diversity in time and space","author":"Potts","year":"2000"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.0022-3646.1995.00002.x","article-title":"The ecology of Nostoc","volume":"31","author":"Dodds","year":"1995","journal-title":"J\u00a0Phycol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib12","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1021\/tx00028a003","article-title":"Three new microcystins, cyclic heptapeptide hepatotoxins, from Nostoc sp. strain 152","volume":"5","author":"Sivone","year":"1992","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib13","doi-asserted-by":"crossref","first-page":"12228","DOI":"10.1073\/pnas.0404926101","article-title":"A\u00a0mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam","volume":"101","author":"Murch","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/tox.20561","article-title":"Cytotoxicity and secondary metabolites production in terrestrial Nostoc strains, originating from different climatic\/geographic regions and habitats: is their cytotoxicity environmentally dependent?","volume":"26","author":"Hrouzek","year":"2009","journal-title":"Environ Toxicol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02179772","article-title":"Inhibition of Candida albicans and Staphylococcus aureus by phenolic compounds from the terrestrial cyanobacterium Nostoc muscorum","volume":"2","author":"de Cano","year":"1990","journal-title":"J\u00a0Appl Phycol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib16","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.7164\/antibiotics.43.1236","article-title":"Cytotoxic, antiviral indolocarbazoles from a blue-green alga belonging to the Nostocaceae","volume":"12","author":"Knube","year":"1990","journal-title":"J\u00a0Antibiot"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib17","doi-asserted-by":"crossref","first-page":"7891","DOI":"10.1021\/jo00129a032","article-title":"Nostocyclamide: a new macrocyclic, thiazole-containing allelochemical from Nostoc sp. 31 (Cyanobacteria)","volume":"60","author":"Todorova","year":"1995","journal-title":"J\u00a0Org Chem"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib18","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1021\/ja00090a020","article-title":"Total structures of cryptophycins, potent anti-tumor depsipeptides from the blue-green alga Nostoc sp. Strain","volume":"116","author":"Trimurtulu","year":"1994","journal-title":"J\u00a0Am Chem Soc"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2307\/3223790","article-title":"Species of nostoc Vaucher occurring in the Sonoran Desert in Arizona","volume":"81","author":"Cameron","year":"1962","journal-title":"Trans Am Microsc Soc"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF01091230","article-title":"Hypocholesterolemic effect of blue-green alga, ishikurage (Nostoc commune) in rats fed atherogenic diet","volume":"45","author":"Hori","year":"1994","journal-title":"Plant Foods Hum Nutr"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib21","first-page":"61","article-title":"The anti-infectious activity of edible blue-green algae, Nostoc flagelliforme, Nostoc commune, and Aphanothece sacrum on Listeria monocytogenes in mice, (in Japanese with English abstract), Algal","volume":"1","author":"Yamaguchi","year":"2009","journal-title":"Resour"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1021\/np9903090","article-title":"Novel extracellular diterpenoids with biological activity from the cyanobacterium Nostoc commune","volume":"63","author":"Jaki","year":"2000","journal-title":"J\u00a0Nat Prod"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib23","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1021\/np000033s","article-title":"New antibacterial metabolites from the cyanobacterium Nostoc commune (EAWAG 122b)","volume":"63","author":"Jaki","year":"2000","journal-title":"J\u00a0Nat Prod"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib24","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1271\/bbb.110466","article-title":"Antioxidative activity and chemical constituents of edible terrestrial alga Nostoc commune Vauch","volume":"75","author":"Ninomiya","year":"2011","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jphotobiol.2011.07.003","article-title":"Novel glycosylated mycosporine-like amino acids with radical scavenging activity from the cyanobacterium Nostoc commune","volume":"105","author":"Matsui","year":"2011","journal-title":"J\u00a0Photochem Photobiol B"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.fct.2013.07.016","article-title":"Reduced scytonemin isolated from Nostoc commune induced autophagic cell death in human T-lymphoid cell line Jurkat cells","volume":"60","author":"Itoh","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijantimicag.2005.09.002","article-title":"Antimicrobial activity of flavonoids","volume":"26","author":"Cushnie","year":"2005","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib28","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1016\/j.bmc.2006.01.025","article-title":"A\u00a0novel antimicrobacterial epoxide isolated from larval Galleria mellonella infected by the nematode symbiont, Photorhabdus luminescens (Enterobacteriaceae)","volume":"14","author":"Hu","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib29","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.bmc.2009.01.004","article-title":"Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics","volume":"17","author":"Lee","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1515\/znc-1996-5-602","article-title":"Antibacterial diterpenic acid from Brazilian propolis","volume":"51","author":"Bankova","year":"1996","journal-title":"Z\u00a0Naturforsch C"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib31","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1093\/nar\/4.8.2697","article-title":"The interaction of plant alkaloids with DNA. II. Berberinium chloride","volume":"4","author":"Davidson","year":"1977","journal-title":"Nucleic Acid Res"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib32","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2340\/0001555565428432","article-title":"Enzyme production of propionibacteria from patients with acne vulgaris and healthy persons","volume":"65","author":"Hoeffler","year":"1985","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/sder.2001.28207","article-title":"The evolving role of Propionibacterium acnes in acne","volume":"20","author":"Leyden","year":"2001","journal-title":"Semin Cutan Med Surg"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib34","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1600-0625.2009.00891.x","article-title":"Heat-killed Propionibacterium acnes is capable of inducing inflammatory responses in skin","volume":"18","author":"Lyte","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib35","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.4049\/jimmunol.141.7.2407","article-title":"Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production","volume":"141","author":"Ding","year":"1988","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib36","doi-asserted-by":"crossref","first-page":"8128","DOI":"10.1016\/S0021-9258(17)37169-7","article-title":"Regulation of nitric-oxide synthase mRNA expression by interferon-gamma and picolinic acid","volume":"269","author":"Melillo","year":"1994","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib37","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1084\/jem.182.6.1683","article-title":"A\u00a0hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter","volume":"182","author":"Melillo","year":"1995","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib38","doi-asserted-by":"crossref","first-page":"13725","DOI":"10.1016\/S0021-9258(17)36703-0","article-title":"Regulation of biosynthesis of nitric oxide","volume":"269","author":"Nathan","year":"1994","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbrc.2005.04.088","article-title":"Ethanol alters cellular activation and CD14 partitioning in lipid rafts","volume":"332","author":"Dai","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jlb.64.1.25","article-title":"LPS-binding proteins and receptors","volume":"64","author":"Fenton","year":"1998","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib41","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1128\/IAI.72.4.2312-2320.2004","article-title":"Role for moesin in lipopolysaccharide-stimulated signal transduction","volume":"72","author":"Iontcheva","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib42","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1128\/IAI.69.4.2001-2010.2001","article-title":"Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways","volume":"69","author":"Chan","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib43","doi-asserted-by":"crossref","first-page":"C441","DOI":"10.1152\/ajpcell.2001.280.3.C441","article-title":"IFN-gamma\u00a0+ LPS induction of iNOS is modulated by ERK, JNK\/SAPK, and p38(mapk) in a mouse macrophage cell line","volume":"280","author":"Chan","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib44","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib45","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib46","first-page":"240365","article-title":"Current views of toll-like receptor signaling pathways","author":"Yamamoto","year":"2010","journal-title":"Gastroenterol Res Pract"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib47","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1007\/s00134-010-1983-5","article-title":"Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine?","volume":"36","author":"Lorne","year":"2010","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib48","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1186\/1475-2859-10-S1-S17","article-title":"Immunomodulatory mechanisms of lactobacilli","volume":"10","author":"Wells","year":"2011","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib49","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jdermsci.2012.10.009","article-title":"Propionibacterium acnes-induced iNOS and COX-2 protein expression via ROS-dependent NF-\u03baB and AP-1 activation in macrophages","volume":"69","author":"Tsai","year":"2013","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.anaerobe.2014.03.006_bib50","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/BF01923559","article-title":"The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria","volume":"49","author":"Proteau","year":"1993","journal-title":"Experientia"}],"container-title":["Anaerobe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1075996414000250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1075996414000250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T14:27:03Z","timestamp":1716647223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1075996414000250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":50,"alternative-id":["S1075996414000250"],"URL":"https:\/\/doi.org\/10.1016\/j.anaerobe.2014.03.006","relation":{},"ISSN":["1075-9964"],"issn-type":[{"value":"1075-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimicrobial and anti-inflammatory properties of nostocionone isolated from Nostoc commune Vauch and its derivatives against Propionibacterium acnes","name":"articletitle","label":"Article Title"},{"value":"Anaerobe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anaerobe.2014.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}