{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:55:26Z","timestamp":1760122526364},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"University of Ministry of Education of China","award":["IRT13063"],"award-info":[{"award-number":["IRT13063"]}]},{"name":"Science and Technology Program of Guangzhou","award":["2012A020800004"],"award-info":[{"award-number":["2012A020800004"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaerobe"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.anaerobe.2016.04.005","type":"journal-article","created":{"date-parts":[[2016,4,9]],"date-time":"2016-04-09T12:48:58Z","timestamp":1460206138000},"page":"150-157","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Ex\u00a0vivo pharmacokinetic\/pharmacodynamic relationship of valnemulin against Clostridium perfringens in plasma, the small intestinal and caecal contents of rabbits"],"prefix":"10.1016","volume":"39","author":[{"given":"Yu-Feng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Ting","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ping","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anaerobe.2016.04.005_bib1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1051\/vetres:2005021","article-title":"Epizootic rabbit enteropathy: experimental transmission and clinical characterization","volume":"36","author":"Licois","year":"2005","journal-title":"Vet. Res."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.tvjl.2005.12.013","article-title":"Fractionation of the reference inoculum of epizootic rabbit enteropathy in discontinuous sucrose gradient identifies aetiological agents in high density fractions","volume":"173","author":"Szalo","year":"2007","journal-title":"Vet. J."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib3","doi-asserted-by":"crossref","first-page":"e105707","DOI":"10.1371\/journal.pone.0105707","article-title":"Changes in cecal microbiota and mucosal gene expression revealed new aspects of epizootic rabbit enteropathy","volume":"9","author":"Bauerl","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.anaerobe.2016.04.005_bib4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.tvjl.2014.12.036","article-title":"Efficacy and tolerability of early administration of valnemulin hydrochloride premix on epizootic rabbit enteropathy","volume":"204","author":"Dip","year":"2015","journal-title":"Vet. J."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.tvjl.2005.07.011","article-title":"Infectious agents associated with epizootic rabbit enteropathy: isolation and attempts to reproduce the syndrome","volume":"172","author":"Marlier","year":"2006","journal-title":"Vet. J."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib6","series-title":"Proceedings of the 10th Rabbit Days, Paris, France","first-page":"243","article-title":"Contribution a l\u2019etude toxinotypique des souches de Clostridium perfringens isolees dans l\u2019enteropathie epizootique du lapin (EEL). Relation avec la clinique observe","author":"Le Normand","year":"2003"},{"key":"10.1016\/j.anaerobe.2016.04.005_bib7","series-title":"Proceedings of the 21st International Pig Veterinary Society Congress, Vancouver, Canada","first-page":"83","article-title":"Pleuromutilin susceptibility of Clostridium perfringens and Clostridium difficile isolates from pigs in Italy and Denmark","author":"Agnoletti","year":"2010"},{"key":"10.1016\/j.anaerobe.2016.04.005_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1079\/AHRR200118","article-title":"Susceptibility to pleuromutilins in Brachyspira (Serpulina) hyodysenteriae","volume":"2","author":"Karlsson","year":"2001","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib9","series-title":"Proceedings of the 15th International Pig Veterinary Society Congress, Birmingham, England, UK","first-page":"114","article-title":"In-vitro and in-life studies of efficacy of valnemulin for proliferative enteropathy (ileitis)","author":"McOrist","year":"1998"},{"key":"10.1016\/j.anaerobe.2016.04.005_bib10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/vr.144.5.128","article-title":"Comparative in\u00a0vitro activity of valnemulin against porcine bacterial pathogens","volume":"144","author":"Aitken","year":"1999","journal-title":"Vet. Rec."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib11","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1128\/AAC.00200-15","article-title":"In\u00a0vivo pharmacokinetic\/pharmacodynamic profiles of valnemulin in an experimental intratracheal Mycoplasma gallisepticum infection model","volume":"59","author":"Xiao","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tvjl.2014.05.010","article-title":"Integration of pharmacokinetic and pharmacodynamic indices of valnemulin in broiler chickens after a single intravenous and intramuscular administration","volume":"201","author":"Zhao","year":"2014","journal-title":"Vet. J."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib13","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/00071668.2012.703776","article-title":"Pharmacokinetics and bioavailability of valnemulin in Muscovy ducks (Cairina moschata)","volume":"53","author":"Sun","year":"2012","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2885.2010.01215.x","article-title":"Pharmacokinetics and bioavailability of valnemulin in broiler chickens","volume":"34","author":"Wang","year":"2011","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2885.2010.01230.x","article-title":"A\u00a0physiologically based pharmacokinetic model for valnemulin in rats and extrapolation to pigs","volume":"34","author":"Yuan","year":"2011","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib16","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3923\/javaa.2011.1824.1828","article-title":"Pharmacokinetics and lung tissue concentration of valnemulin in swine","volume":"10","author":"Zhang","year":"2011","journal-title":"J.\u00a0Anim. Vet. Adv."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/pmj.78.918.198","article-title":"Enteral feeding. Nasogastric, nasojejunal, percutaneous endoscopic gastrostomy, or jejunostomy: its indications and limitations","volume":"78","author":"Pearce","year":"2002","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib18","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0002-9610(02)00916-9","article-title":"A\u00a0novel approach to the problem of intestinal fistulization arising in patients managed with open peritoneal cavities","volume":"184","author":"Girard","year":"2002","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01117450","article-title":"Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations","volume":"6","author":"Yamaoka","year":"1978","journal-title":"J.\u00a0Pharmacokinet. Biopharm."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib20","series-title":"Pharmacokinetics","author":"Gibaldi","year":"1982"},{"key":"10.1016\/j.anaerobe.2016.04.005_bib21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.tvjl.2015.01.020","article-title":"Ex\u00a0vivo pharmacokinetic and pharmacodynamic analysis of valnemulin against Mycoplasma gallisepticum S6 in Mycoplasma gallisepticum and Escherichia coli co-infected chickens","volume":"204","author":"Xiao","year":"2015","journal-title":"Vet. J."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib22","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/lam.12168","article-title":"Postantibiotic effect and postantibiotic sub-minimum inhibitory concentration effect of valnemulin against Staphylococcus aureus isolates from swine and chickens","volume":"58","author":"Zhao","year":"2014","journal-title":"Lett. Appl. Microbiol."},{"issue":"Suppl.\u00a0A","key":"10.1016\/j.anaerobe.2016.04.005_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jac\/15.suppl_A.37","article-title":"Postantibiotic effects","volume":"15","author":"Vogelman","year":"1985","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1751-0147-54-16","article-title":"Post-antibiotic effect of orbifloxacin against Escherichia coli and Pseudomonas aeruginosa isolates from dogs","volume":"54","author":"Harada","year":"2012","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000238960","article-title":"In\u00a0vivo postantibiotic effect of isepamicin and other aminoglycosides in a thigh infection model in neutropenic mice","volume":"38","author":"Minguez Minguez","year":"1992","journal-title":"Chemotherapy"},{"key":"10.1016\/j.anaerobe.2016.04.005_bib26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jac\/47.4.391","article-title":"Application of a spectrophotometric method for the determination of post-antibiotic effect and comparison with viable counts in agar","volume":"47","author":"Dominguez","year":"2001","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib27","first-page":"865","article-title":"The postantibiotic effect","volume":"11","author":"Spivey","year":"1992","journal-title":"Clin. Pharm."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib28","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/jac\/36.6.987","article-title":"Determination of the in\u00a0vivo post-antibiotic effects of ciprofloxacin and rifampicin","volume":"36","author":"Meng","year":"1995","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib29","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0891-5520(03)00065-5","article-title":"Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolid","volume":"17","author":"Craig","year":"2003","journal-title":"Infect. Dis. Clin. North Am."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1749-6632.2011.06219.x","article-title":"Are pleuromutilin antibiotics finally fit for human use?","volume":"1241","author":"Novak","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0034-5288(02)00039-5","article-title":"The pharmacokinetic\u2013pharmacodynamic approach to a rational dosage regimen for antibiotics","volume":"73","author":"Toutain","year":"2002","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.anaerobe.2016.04.005_bib32","series-title":"The 13th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Nantes, France","first-page":"124","article-title":"Pharmacokinetic\/pharmacodynamic and clinical relationships of valnemulin for the metaphylaxis of epizootic rabbit","author":"Burch","year":"2015"},{"key":"10.1016\/j.anaerobe.2016.04.005_bib33","series-title":"CVMP Assessment Report for the Extension of a Community Marketing Authorization for Econor (EMEA\/V\/C\/000042\/X\/0039)","author":"EMEA (European Medicines Agency)","year":"2013"}],"container-title":["Anaerobe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1075996416300324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1075996416300324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T19:58:01Z","timestamp":1657396681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1075996416300324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":33,"alternative-id":["S1075996416300324"],"URL":"https:\/\/doi.org\/10.1016\/j.anaerobe.2016.04.005","relation":{},"ISSN":["1075-9964"],"issn-type":[{"value":"1075-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ex\u00a0vivo pharmacokinetic\/pharmacodynamic relationship of valnemulin against Clostridium perfringens in plasma, the small intestinal and caecal contents of rabbits","name":"articletitle","label":"Article Title"},{"value":"Anaerobe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anaerobe.2016.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}