{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:25:05Z","timestamp":1791307505019,"version":"4.3.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Matching Fund Subsidy"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaerobe"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.anaerobe.2016.10.012","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T03:45:57Z","timestamp":1477453557000},"page":"166-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Emergence of fluoroquinolone-resistant Propionibacterium acnes caused by amino acid substitutions of DNA gyrase but not DNA topoisomerase IV"],"prefix":"10.1016","volume":"42","author":[{"given":"Keisuke","family":"Nakase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemasa","family":"Nakaminami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihisa","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anaerobe.2016.10.012_bib1","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1099\/mic.0.049676-0","article-title":"A\u00a0novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens","volume":"157","author":"McDowell","year":"2011","journal-title":"Microbiology"},{"key":"10.1016\/j.anaerobe.2016.10.012_bib2","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.anaerobe.2010.06.003","article-title":"Detection of a new erm(X)-mediated antibiotic resistance in Egyptian cutaneous propionibacteria","volume":"16","author":"El-Mahdy","year":"2010","journal-title":"Anaerobe"},{"key":"10.1016\/j.anaerobe.2016.10.012_bib3","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1365-2133.2003.05067.x","article-title":"Antibiotic-resistant acne: lessons from Europe","volume":"148","author":"Ross","year":"2003","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib4","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1346-8138.2011.01423.x","article-title":"First report of high levels of clindamycin-resistant Propionibacterium acnes carrying erm(X) in Japanese patients with acne vulgaris","volume":"39","author":"Nakase","year":"2012","journal-title":"J.\u00a0Dermatol."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/jac\/49.1.165","article-title":"Detection of transposon Tn5432-mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneous propionibacteria from six European cities","volume":"49","author":"Ross","year":"2002","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib6","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1586\/14787210.2015.1040765","article-title":"Antibiotic resistance to Propionobacterium acnes: worldwide scenario, diagnosis and management","volume":"13","author":"Sardana","year":"2015","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib7","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1365-4632.2010.04506.x","article-title":"In\u00a0vitro antimicrobial susceptibility of Propionibacterium acnes isolated from acne patients in northern Mexico","volume":"49","author":"Gonzalez","year":"2010","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1099\/jmm.0.067611-0","article-title":"Relationship between the severity of acne vulgaris and antimicrobial resistance of bacteria isolated from acne lesions in a hospital in Japan","volume":"63","author":"Nakase","year":"2014","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib9","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1021\/bi00435a039","article-title":"Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug\u2013DNA binding model","volume":"28","author":"Shen","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/j.anaerobe.2016.10.012_bib10","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S1473-3099(02)00369-9","article-title":"Fluoroquinolone resistance among Gram-positive cocci","volume":"2","author":"Hooper","year":"2002","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib11","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1128\/AAC.35.8.1647","article-title":"Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli","volume":"35","author":"Yoshida","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/jac\/dkg168","article-title":"Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals","volume":"51","author":"Saenz","year":"2003","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib13","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ijantimicag.2014.02.002","article-title":"A\u00a0novel GyrB mutation in meticillin-resistant Staphylococcus aureus (MRSA) confers a high level of resistance to third-generation quinolones","volume":"43","author":"Nakaminami","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.anaerobe.2016.10.012_bib14","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1128\/AAC.01065-09","article-title":"Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus","volume":"54","author":"Nakaminami","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1128\/AAC.00886-08","article-title":"High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals","volume":"53","author":"Ma","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib16","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.tim.2014.04.007","article-title":"Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success","volume":"22","author":"Redgrave","year":"2014","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib17","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1128\/JCM.02690-05","article-title":"Antimicrobial agent of susceptibilities and antiseptic resistance gene distribution among methicillin-resistant Staphylococcus aureus isolates from patients with impetigo and staphylococcal scalded skin syndrome","volume":"44","author":"Noguchi","year":"2006","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1348-0421.2008.00081.x","article-title":"Antimicrobial susceptibilities of Propionibacterium acnes isolated from patients with acne vulgaris","volume":"52","author":"Ishida","year":"2008","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib19","series-title":"Methods of Antimicrobial Susceptibility Testing of Anaerobic Bacteria-eighth Edition; Approved Standard","author":"CLSI","year":"2012"},{"key":"10.1016\/j.anaerobe.2016.10.012_bib20","series-title":"Performance Standard for Antimicrobial Susceptibility Testing; Approved Standard","author":"CLSI","year":"2011"},{"key":"10.1016\/j.anaerobe.2016.10.012_bib21","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1093\/jac\/dkr292","article-title":"Multidrug resistance in European Clostridium difficile clinical isolates","volume":"66","author":"Spigaglia","year":"2011","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib22","doi-asserted-by":"crossref","first-page":"e104199","DOI":"10.1371\/journal.pone.0104199","article-title":"A\u00a0novel high-resolution single locus sequence typing scheme for mixed populations of Propionibacterium acnes in\u00a0vivo","volume":"9","author":"Scholz","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.anaerobe.2016.10.012_bib23","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1248\/yakushi.131.1653","article-title":"Antimicrobial activity and frequency of spontaneous gentamicin-resistant mutants in bacteria related skin infections","volume":"131","author":"Iwaki","year":"2011","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.anaerobe.2016.10.012_bib24","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1128\/jb.179.22.7174-7180.1997","article-title":"Glucose-1-phosphate utilization by Listeria monocytogenes is PrfA dependent and coordinately expressed with virulence factors","volume":"179","author":"Ripio","year":"1997","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib25","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/jac\/45.5.583","article-title":"Intracellular targets of moxifloxacin: a comparison with other fluoroquinolones","volume":"45","author":"Pestova","year":"2000","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib26","first-page":"223","article-title":"A\u00a0clinical study on levofloxacin concentration in the skin on antibiotic prophylaxis for outpatient surgery","volume":"50","author":"Nakatani","year":"2002","journal-title":"Jpn. J. Chemother."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ajo.2013.01.027","article-title":"Endophthalmitis isolates and antibiotic susceptibilities: a 10-year review of culture-proven cases","volume":"156","author":"Schimel","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.anaerobe.2016.10.012_bib28","first-page":"1045","article-title":"A\u00a0acne vulgaris treatment guideline","volume":"126","author":"Hayashi","year":"2016","journal-title":"Jpn. J. Dermatol."}],"container-title":["Anaerobe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1075996416301317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1075996416301317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T07:52:34Z","timestamp":1536306754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1075996416301317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":28,"alternative-id":["S1075996416301317"],"URL":"https:\/\/doi.org\/10.1016\/j.anaerobe.2016.10.012","relation":{},"ISSN":["1075-9964"],"issn-type":[{"value":"1075-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emergence of fluoroquinolone-resistant Propionibacterium acnes caused by amino acid substitutions of DNA gyrase but not DNA topoisomerase IV","name":"articletitle","label":"Article Title"},{"value":"Anaerobe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anaerobe.2016.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}