{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:28:22Z","timestamp":1790796502151,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"UNAH"},{"name":"UCR"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaerobe"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.anaerobe.2018.06.001","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T11:02:42Z","timestamp":1528455762000},"page":"75-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Diversity of multidrug-resistant epidemic Clostridium difficile NAP1\/RT027\/ST01 strains in tertiary hospitals from Honduras"],"prefix":"10.1016","volume":"52","author":[{"given":"Fanny","family":"Hidalgo-Villeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Tzoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luque","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efra\u00edn","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Quesada-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anaerobe.2018.06.001_bib1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1177\/0897190013499521","article-title":"Epidemiology of Clostridium difficile infection","volume":"26","author":"Depestel","year":"2013","journal-title":"J.\u00a0Pharm. Pract."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1469-0691.2006.01580.x","article-title":"Emergence of Clostridium difficile -associated disease in North America and Europe","volume":"12","author":"Kuijper","year":"2006","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib3","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1128\/CMR.00082-09","article-title":"The changing epidemiology of Clostridium difficile infections","volume":"23","author":"Freeman","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1099\/jmm.0.066399-0","article-title":"Spread of epidemic Clostridium difficile NAP1\/027 in Latin America: case reports in Panama","volume":"63","author":"Lopez-Ure\u00f1a","year":"2014","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bjid.2014.07.004","article-title":"Epidemiology of Clostridium difficile: a hospital-based descriptive study in Argentina and Mexico","volume":"19","author":"Lopardo","year":"2015","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib6","doi-asserted-by":"crossref","unstructured":"J. Freeman, J. Vernon, K. Morris, S. Nicholson, S. Todhunter, C. Longshaw, M.H. Wilcox, S. Pfeiffer, M. Delmee, L. Muytjens, J. Van Broeck, K. Ivanova, P. Maikanti-Charalampous, O. Nyc, J. Engberg, F. Barbut, H. Marchandin, H. Jean-Pierre, L. von Muller, R. Mutters, S. Schubert, J. Bader, E. Malamou-Lada, M. Orfanidou, S. Smilakou, E. Nagy, E. Urban, Z. Barna, K. Kristoff, F. Fitzpatrick, M. Skally, L. Fenelon, F. Dennehy, P. Mastrantonio, C. Farina, M. Sanguinetti, L. Masucci, T. Zaccaria, A. Barbui, G. Gesu, M.C. Sironi, A. Balode, H. Pituch, M. Oleastro, E. Novakova, M. Rupnik, E. Bouza, H. Reigadas, L. Alcala, J. Linares, J. Njubo, F. Tubau, T. Noren, A. Widmer, R. Frei, M. Altwegg, E. Kuijper, C. Harmanus, D. Fairley, T. Morris, D. Crook, D. Griffiths, T. Planche, I. Monahan, J. Coia, H. Mather, Pan-European longitudinal surveillance of antibiotic resistance among prevalent Clostridium difficile ribotypes, Clin. Microbiol. Infect.. 21 (2015) 248.e9-248.e16.","DOI":"10.1016\/j.cmi.2014.09.017"},{"key":"10.1016\/j.anaerobe.2018.06.001_bib7","series-title":"Antimicrobial Resistance and Reduced Susceptibility in Clostridium difficile: Potential Consequences for Induction, Treatment, and Recurrence of C.\u00a0difficile Infection","first-page":"267","author":"Baines","year":"2015"},{"key":"10.1016\/j.anaerobe.2018.06.001_bib8","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1053\/j.gastro.2009.02.073","article-title":"Clostridium difficile infection caused by the epidemic BI\/NAP1\/027 strain","volume":"136","author":"O'Connor","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.anaerobe.2018.06.001_bib9","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1093\/jac\/dkx292","article-title":"Novel multiresistance cfr plasmids in linezolid-resistant methicillin-resistant Staphylococcus epidermidis and vancomycin-resistant Enterococcus faecium (VRE) from a hospital outbreak: co-location of cfr and optrA in VRE","volume":"72","author":"Lazaris","year":"2017","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib10","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1093\/jac\/dkr155","article-title":"Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in\u00a0vitro human gut model","volume":"66","author":"Baines","year":"2011","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib11","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1128\/JCM.03058-14","article-title":"Emergence of an outbreak-associated Clostridium difficile variant with increased virulence","volume":"53","author":"Quesada-G\u00f3mez","year":"2015","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib12","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1086\/649213","article-title":"Health care-associated Clostridium difficile infection in Canada: patient age and infecting strain type are highly predictive of severe outcome and mortality","volume":"50","author":"Miller","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib13","doi-asserted-by":"crossref","first-page":"5710","DOI":"10.1128\/JCM.42.12.5710-5714.2004","article-title":"Multiplex PCR targeting tpi (triose phosphate isomerase), tcdA (Toxin A), and tcdB (Toxin B) genes for toxigenic culture of Clostridium difficile","volume":"42","author":"Lemee","year":"2004","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1099\/jmm.0.041053-0","article-title":"Multidrug-resistant North American pulsotype 2 Clostridium difficile was the predominant toxigenic hospital-acquired strain in the province of Manitoba, Canada, in 2006-2007","volume":"61","author":"Karlowsky","year":"2012","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1574-6968.1999.tb13629.x","article-title":"Development of a new PCR-ribotyping method for Clostridium difficile based on ribosomal RNA gene sequencing","volume":"175","author":"Bidet","year":"1999","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib16","series-title":"Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved Standard. CLSI Document M11-a7","author":"Clinical and Laboratory Standards Institute","year":"2007"},{"issue":"2","key":"10.1016\/j.anaerobe.2018.06.001_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/1469-0691.12418","article-title":"Committee, European society of clinical Microbiology and infectious diseases: update of the treatment guidance document for Clostridium difficile infection","volume":"20","author":"Debast","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1086\/651706","article-title":"Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA)","volume":"31","author":"Cohen","year":"2010","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib19","first-page":"109","article-title":"Europe PMC Funders Group Emergence and global spread of epidemic healthcare-associated","volume":"45","author":"He","year":"2012","journal-title":"Clostridium difficile"},{"key":"10.1016\/j.anaerobe.2018.06.001_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0139811","article-title":"Tracing the spread of Clostridium difficile ribotype 027 in Germany based on bacterial genome sequences","volume":"10","author":"Steglich","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.anaerobe.2018.06.001_bib21","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1128\/JCM.01484-07","article-title":"Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat an","volume":"46","author":"Killgore","year":"2008","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib22","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1093\/jac\/dkr292","article-title":"Multidrug resistance in European Clostridium difficile clinical isolates","volume":"66","author":"Spigaglia","year":"2011","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib23","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1128\/AAC.00673-12","article-title":"The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene","volume":"56","author":"Hansen","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.anaerobe.2018.06.001_bib24","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.1128\/AAC.01274-15","article-title":"A\u00a0cfr-like gene from Clostridium difficile confers multiple antibiotic resistance by the same mechanism as the cfr gene","volume":"59","author":"Hansen","year":"2015","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Anaerobe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1075996418301045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1075996418301045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:37:23Z","timestamp":1761035843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1075996418301045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":24,"alternative-id":["S1075996418301045"],"URL":"https:\/\/doi.org\/10.1016\/j.anaerobe.2018.06.001","relation":{},"ISSN":["1075-9964"],"issn-type":[{"value":"1075-9964","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diversity of multidrug-resistant epidemic Clostridium difficile NAP1\/RT027\/ST01 strains in tertiary hospitals from Honduras","name":"articletitle","label":"Article Title"},{"value":"Anaerobe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anaerobe.2018.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}