{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:12:24Z","timestamp":1771866744547,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.anai.2010.04.015","type":"journal-article","created":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T08:42:25Z","timestamp":1275381745000},"page":"503-510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors"],"prefix":"10.1016","volume":"104","author":[{"given":"Stina","family":"Gregersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trond Mogens","family":"Aal\u00f8kken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Mynarek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00f8rre","family":"Fevang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Are Martin","family":"Holm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johny","family":"Kongerud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig S.","family":"Fr\u00f8land","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2010.04.015_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib2","doi-asserted-by":"crossref","first-page":"488","DOI":"10.4049\/jimmunol.164.1.488","article-title":"Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency","volume":"164","author":"Cambronero","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s10875-007-9075-1","article-title":"Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency","volume":"27","author":"Quinti","year":"2007","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib4","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/qjmed\/95.10.655","article-title":"Common variable immune deficiency: respiratory manifestations, pulmonary function and high-resolution CT scan findings","volume":"95","author":"Thickett","year":"2002","journal-title":"QJM"},{"key":"10.1016\/j.anai.2010.04.015_bib5","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1259\/0007-1285-69-828-1108","article-title":"Chest high resolution CT in adults with primary humoral immunodeficiency","volume":"69","author":"Feydy","year":"1996","journal-title":"Br J Radiol"},{"key":"10.1016\/j.anai.2010.04.015_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1081\/COPD-200050685","article-title":"Outcome in adult bronchiectasis","volume":"2","author":"King","year":"2005","journal-title":"COPD"},{"key":"10.1016\/j.anai.2010.04.015_bib7","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.rmed.2008.12.015","article-title":"High resolution computed tomography and pulmonary function in common variable immunodeficiency","volume":"103","author":"Gregersen","year":"2009","journal-title":"Respir Med"},{"key":"10.1016\/j.anai.2010.04.015_bib8","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1365-2249.2005.02951.x","article-title":"Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis","volume":"142","author":"Fevang","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib9","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1365-2249.2008.03700.x","article-title":"Mannose-binding lectin gene polymorphic variants predispose to the development of bronchopulmonary complications but have no influence on other clinical and laboratory symptoms or signs of common variable immunodeficiency","volume":"153","author":"Litzman","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib10","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1182\/blood.V87.2.674.bloodjournal872674","article-title":"Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency: possible immunologic and clinical consequences","volume":"87","author":"Aukrust","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.anai.2010.04.015_bib11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/clin.1994.1032","article-title":"Elevated serum levels of interleukin-4 and interleukin-6 in patients with common variable immunodeficiency (CVI) are associated with chronic immune activation and low numbers of CD4+ lymphocytes","volume":"70","author":"Aukrust","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.anai.2010.04.015_bib12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1365-2249.1993.tb03380.x","article-title":"The life situations of patients with primary antibody deficiency untreated or treated with subcutaneous gammaglobulin infusions","volume":"92","author":"Gardulf","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib13","first-page":"699","article-title":"Respiratory dysfunction in patients with common variable hypogammaglobulinemia","volume":"134","author":"Watts","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.anai.2010.04.015_bib14","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0091-6749(99)70085-0","article-title":"Pulmonary abnormalities in patients with primary hypogammaglobulinemia","volume":"104","author":"Kainulainen","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib15","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.intimp.2004.02.011","article-title":"Immunoglobulin therapy to control lung damage in patients with common variable immunodeficiency","volume":"4","author":"de Gracia","year":"2004","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.anai.2010.04.015_bib16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1023\/A:1026416017763","article-title":"Primary immunodeficiency diseases in Norway","volume":"20","author":"Stray-Pedersen","year":"2000","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib17","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies: representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies)","volume":"93","author":"Conley","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1183\/09041950.005s1693","article-title":"Yernault Official Statement of the European Respiratory Society: lung volumes and forced ventilatory flows","volume":"16","author":"Quanjer","year":"1993","journal-title":"Eur Respir J Suppl"},{"key":"10.1016\/j.anai.2010.04.015_bib19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1148\/radiology.200.2.8685321","article-title":"Glossary of terms for CT of the lungs: recommendations of the Nomenclature Committee of the Fleischner Society","volume":"200","author":"Austin","year":"1996","journal-title":"Radiology"},{"key":"10.1016\/j.anai.2010.04.015_bib20","series-title":"Practical Statistics for Medical Research","first-page":"403","author":"Altman","year":"1991"},{"key":"10.1016\/j.anai.2010.04.015_bib21","doi-asserted-by":"crossref","first-page":"S273","DOI":"10.1164\/ajrccm\/154.6_Pt_2.S273","article-title":"Age, period, and cohort effects","volume":"154","author":"Lebowitz","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2010.04.015_bib22","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1183\/09031936.05.00035205","article-title":"Interpretative strategies for lung function tests","volume":"26","author":"Pellegrino","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2010.04.015_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jaci.2004.05.057","article-title":"Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency","volume":"114","author":"Bates","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib24","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1378\/chest.100.2.552","article-title":"Bronchiolitis obliterans organizing pneumonia in common variable immunodeficiency syndrome","volume":"100","author":"Kaufman","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.anai.2010.04.015_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00005792-199609000-00002","article-title":"Sarcoidosis and common variable immunodeficiency","volume":"75","author":"Fasano","year":"1996","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.anai.2010.04.015_bib26","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1378\/chest.122.5.1594","article-title":"Pulmonary interstitial disease in Ig deficiency","volume":"122","author":"Popa","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.anai.2010.04.015_bib27","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1067\/mai.2002.124999","article-title":"Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency","volume":"109","author":"Busse","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.04.015_bib28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1053\/rmed.2000.1020","article-title":"Respiratory disorders in common variable immunodeficiency","volume":"95","author":"Martinez Garcia","year":"2001","journal-title":"Respir Med"},{"key":"10.1016\/j.anai.2010.04.015_bib29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1172\/JCI6861","article-title":"Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis","volume":"104","author":"Garred","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.anai.2010.04.015_bib30","first-page":"2986","article-title":"Phase I study of recombinant tumor necrosis factor in cancer patients","volume":"47","author":"Blick","year":"1987","journal-title":"Cancer Res"},{"key":"10.1016\/j.anai.2010.04.015_bib31","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1378\/chest.96.2.334","article-title":"Pulmonary toxicity of recombinant human tumor necrosis factor","volume":"96","author":"Kuei","year":"1989","journal-title":"Chest"},{"key":"10.1016\/j.anai.2010.04.015_bib32","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1136\/thx.2003.019588","article-title":"Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis","volume":"59","author":"Gan","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.anai.2010.04.015_bib33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1465-9921-7-125","article-title":"Role of TNFalpha in pulmonary pathophysiology","volume":"7","author":"Mukhopadhyay","year":"2006","journal-title":"Respir Res"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120610004254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120610004254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:37:28Z","timestamp":1761050248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120610004254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S1081120610004254"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2010.04.015","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2010.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}