{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:28:19Z","timestamp":1792070899879,"version":"4.4.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.anai.2010.06.008","type":"journal-article","created":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T09:11:26Z","timestamp":1280999486000},"page":"168-173","source":"Crossref","is-referenced-by-count":133,"title":["Double-blind, placebo-controlled study of azelastine and fluticasone in a single nasal spray delivery device"],"prefix":"10.1016","volume":"105","author":[{"given":"Frank C.","family":"Hampel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"Ratner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Van Bavel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.J.","family":"Amar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramila","family":"Daftary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Sacks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2010.06.008_bib1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S1081-1206(10)60408-5","article-title":"Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis","volume":"100","author":"Ratner","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S1081-1206(10)63155-9","article-title":"Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology","volume":"81","author":"Dykewicz","year":"1998","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2008.06.003","article-title":"The diagnosis and management of rhinitis: an updated practice parameter","volume":"122","author":"Wallace","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib4","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1067\/mai.2001.118891","article-title":"Allergic rhinitis and its impact on asthma","volume":"108","author":"Bousquet","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1081-1206(10)60560-1","article-title":"A novel and effective approach to treating rhinitis with nasal antihistamines","volume":"99","author":"Kaliner","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1185\/030079903125003053","article-title":"Economic impact and quality-of-life burden of allergic rhinitis","volume":"20","author":"Schoenwetter","year":"2004","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.anai.2010.06.008_bib7","first-page":"185","article-title":"Demographics and epidemiology of allergic and nonallergic rhinitis","volume":"22","author":"Settipane","year":"2001","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.anai.2010.06.008_bib8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0091-6749(99)70380-5","article-title":"Validation of the standardized version of the Rhinoconjunctivitis Quality of Life Questionnaire","volume":"104","author":"Juniper","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib9","doi-asserted-by":"crossref","first-page":"244","DOI":"10.2500\/aap.2009.30.3230","article-title":"Sleep, quality of life, and productivity impact of nasal symptoms in the United States: findings from the Burden of Rhinitis in America survey","volume":"30","author":"Meltzer","year":"2009","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.anai.2010.06.008_bib11","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/0091-6749(93)90192-I","article-title":"Determinants of patient compliance with allergen immunotherapy","volume":"91","author":"Cohn","year":"1993","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib12","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/ACI.0b013e328332b8df","article-title":"Evidence of adherence to allergen-specific immunotherapy","volume":"9","author":"Senna","year":"2009","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib13","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.jaci.2007.06.019","article-title":"Allergen immunotherapy: a practice parameter second update","volume":"120","author":"Cox","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF03256639","article-title":"Comparison of intranasal corticosteroids and antihistamines in allergic rhinitis: a review of randomized, controlled trials","volume":"2","author":"Nielsen","year":"2003","journal-title":"Am J Respir Med"},{"key":"10.1016\/j.anai.2010.06.008_bib15","doi-asserted-by":"crossref","first-page":"S460","DOI":"10.1016\/j.jaci.2004.12.016","article-title":"Clinical trial design, nasal allergen challenge models, and considerations of relevance to pediatrics, nasal polyposis, and different classes of medication","volume":"115","author":"Akerlund","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib16","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0091-6749(99)70070-9","article-title":"Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis","volume":"104","author":"Howarth","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1081-1206(10)62352-6","article-title":"Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis","volume":"86","author":"Banov","year":"2001","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1081-1206(10)62179-5","article-title":"Efficacy of azelastine nasal spray in patients with an unsatisfactory response to loratadine","volume":"91","author":"Berger","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib19","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S1081-1206(10)61468-8","article-title":"Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine","volume":"93","author":"LaForce","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib20","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1081-1206(10)60804-6","article-title":"Impact of azelastine nasal spray on symptoms and quality of life compared with cetirizine oral tablets in patients with seasonal allergic rhinitis","volume":"97","author":"Berger","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2010.06.008_bib21","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.clinthera.2005.04.012","article-title":"Effectiveness of azelastine nasal spray compared with oral cetirizine in patients with seasonal allergic rhinitis","volume":"27","author":"Corren","year":"2005","journal-title":"Clin Ther"}],"updated-by":[{"DOI":"10.1016\/j.anai.2010.10.007","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000}}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120610006058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120610006058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T01:25:55Z","timestamp":1544318755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120610006058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S1081120610006058"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2010.06.008","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}