{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:46:21Z","timestamp":1788993981684,"version":"build-2803163510"},"reference-count":56,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.anai.2011.07.018","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T18:39:39Z","timestamp":1316111979000},"page":"407-416.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Evidence of effect of subcutaneous immunotherapy in children: complete and updated review from 2006 onward"],"prefix":"10.1016","volume":"107","author":[{"given":"D\u00e9sir\u00e9e E.S.","family":"Larenas-Linnemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dino R.","family":"Pietropaolo-Cienfuegos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s A.","family":"Calder\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2011.07.018_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1399-3038.2007.00648.x","article-title":"Immunotherapy in children and adolescents with allergic rhinoconjunctivitis: a systematic review","volume":"19","author":"Roder","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1378\/chest.06-1425","article-title":"Meta-analysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age","volume":"133","author":"Penagos","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.anai.2011.07.018_bib3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1081-1206(10)60004-X","article-title":"Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials","volume":"97","author":"Penagos","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib4","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jaci.2009.11.021","article-title":"Evaluation of meta-analyses about sublingual immunotherapy in allergic respiratory diseases","volume":"125","author":"Calamita","year":"2010","journal-title":"J Allergy Clin Immunol"},{"issue":"4 suppl","key":"10.1016\/j.anai.2011.07.018_bib5","first-page":"23","article-title":"An evidence based overview of sublingual immunotherapy in children","volume":"22","author":"Scala","year":"2009","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.anai.2011.07.018_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11882-008-0087-6","article-title":"Subcutaneous and sublingual immunotherapy in children: complete update on controversies, dosing and efficacy","volume":"8","author":"Larenas-Linnemann","year":"2008","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.anai.2011.07.018_bib7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/ACI.0b013e328329a2a9","article-title":"Sublingual immunotherapy in children: complete and updated review supporting evidence of effect","volume":"9","author":"Larenas-Linnemann","year":"2009","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1399-3038.2008.00809.x","article-title":"Sublingual immunotherapy in children: more optimism today","volume":"20","author":"Larenas-Linnemann","year":"2009","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib9","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1398-9995.2007.01335.x","article-title":"Sublingual immunotherapy for asthma: need for high quality meta-analyses to prove the concept","volume":"62","author":"Larenas-Linnemann","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib10","first-page":"CD001936","article-title":"Allergen injection immunotherapy for seasonal allergic rhinitis","volume":"1","author":"Calderon","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anai.2011.07.018_bib11","first-page":"CD002893","article-title":"Sublingual immunotherapy for allergic rhinitis","volume":"12","author":"Radulovic","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anai.2011.07.018_bib12","first-page":"CD001186","article-title":"Injection allergen immunotherapy for asthma","volume":"8","author":"Abramson","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anai.2011.07.018_bib13","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.anai.2011.07.018_bib14","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/j.1398-9995.2010.02439.x","article-title":"Development and implementation of guidelines in allergic rhinitis: an ARIA-GA2LEN paper","volume":"65","author":"Bousquet","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib15","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1398-9995.2009.01973.x","article-title":"Grading quality of evidence and strength of recommendations in clinical practice guidelines, part 1 of 3: an overview of the GRADE approach and grading quality of evidence about interventions","volume":"64","author":"Brozek","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Control Clin Trials"},{"issue":"14 suppl","key":"10.1016\/j.anai.2011.07.018_bib17","first-page":"7","article-title":"Position paper: immunotherapy","volume":"48","year":"1993","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1398-9995.2005.00913.x","article-title":"A double-blind, placebo-controlled study of house dust mite immunotherapy in Chinese asthmatic patients","volume":"61","author":"Wang","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000301575","article-title":"Induction of CD4+CD25+Foxp3+IL-10+ T cells in HDM-allergic asthmatic children with or without SIT","volume":"153","author":"Wei","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib20","first-page":"2099","article-title":"Effect of house dust mite immunotherapy on interleukin-10-secreting regulatory T cells in asthmatic children","volume":"123","author":"Wang","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.anai.2011.07.018_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.anai.2009.11.010","article-title":"Allergen immunotherapy and health care cost benefits for children with allergic rhinitis: a large-scale, retrospective, matched cohort study","volume":"104","author":"Hankin","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1875-9572(10)60004-6","article-title":"Clinical efficacy of house dust mite-specific immunotherapy in asthmatic children","volume":"51","author":"Tsai","year":"2010","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.anai.2011.07.018_bib23","first-page":"85","article-title":"Prevention of new sensitizations by specific immunotherapy in children with rhinitis and\/or asthma monosensitized to house dust mite","volume":"17","author":"Inal","year":"2007","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1398-9995.2006.01011.x","article-title":"Twelve-year follow-up after discontinuation of preseasonal grass pollen immunotherapy in childhood","volume":"61","author":"Eng","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1399-3038.2006.00442.x","article-title":"The effects of grass pollen allergoid immunotherapy on clinical and immunological parameters in children with allergic rhinitis","volume":"17","author":"Keskin","year":"2006","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib26","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jaci.2010.06.002","article-title":"Steroid-sparing effects with allergen-specific immunotherapy in children with asthma: a randomized controlled trial","volume":"126","author":"Zielen","year":"2010","journal-title":"J Allergy Clin Immunol"},{"issue":"1 pt 2","key":"10.1016\/j.anai.2011.07.018_bib27","first-page":"e185","article-title":"Ultra-short course immunotherapy in children and adolescents during a 3-yrs post-marketing surveillance study","volume":"21","author":"Rosewich","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2249.2010.04106.x","article-title":"Tolerance induction after specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A in children","volume":"160","author":"Rosewich","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib29","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1398-9995.2007.01451.x","article-title":"Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study","volume":"62","author":"Jacobsen","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1399-3038.2007.00589.x","article-title":"Double-blind, placebo-controlled study of Alternaria alternata immunotherapy: clinical efficacy and safety","volume":"19","author":"Tabar","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib31","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jaci.2010.11.036","article-title":"Efficacy and safety of immunotherapy for allergies to Alternaria alternata in children","volume":"127","author":"Kuna","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib32","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.aller.2010.03.011","article-title":"Clinical evolution of patients with respiratory allergic disease due to sensitisation to Alternaria alternata being treated with subcutaneous immunotherapy","volume":"39","author":"Zapatero","year":"2011","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.anai.2011.07.018_bib33","first-page":"36","article-title":"Clinical efficacy and immunological changes in children with allergic rhinitis receiving specific immunotherapy with Dermatophagoides pteronyssinus [in Japanese]","volume":"46","author":"Wang","year":"2011","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"10.1016\/j.anai.2011.07.018_bib34","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1111\/j.1365-2222.2009.03357.x","article-title":"The effect of oral steroids with and without vitamin D3 on early efficacy of immunotherapy in asthmatic children","volume":"39","author":"Majak","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib35","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jaci.2010.12.016","article-title":"Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection","volume":"127","author":"Majak","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib36","first-page":"194","article-title":"Significant improvement of specific bronchial hyperreactivity in asthmatic children after 4 months of treatment with a modified extract of dermatophagoides pteronyssinus","volume":"16","author":"Ibero","year":"2006","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib37","first-page":"286","article-title":"Specific allergen immunotherapy: effect on immunologic markers and clinical parameters in asthmatic children","volume":"17","author":"Cevit","year":"2007","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib38","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3346\/jkms.2009.24.3.392","article-title":"The effect of rush immunotherapy with house dust mite in the production of IL-5 and IFN-gamma from the peripheral blood T cells of asthmatic children","volume":"24","author":"Kim","year":"2009","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.anai.2011.07.018_bib39","first-page":"1157","article-title":"Effects of dermatophagoides pteronyssinus allergen-specific immunotherapy on the serum interleukin-13 and pulmonary functions in asthmatic children","volume":"122","author":"Chen","year":"2009","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.anai.2011.07.018_bib40","first-page":"1179","article-title":"Effects of Dermatophagoides pteronyssinus allergen-specific immunotherapy on the prognosis of asthmatic children [in Japanese]","volume":"29","author":"Chen","year":"2009","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.anai.2011.07.018_bib41","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S1081-1206(10)60592-3","article-title":"Effect of house dust mite immunotherapy on transforming growth factor beta1-producing T cells in asthmatic children","volume":"100","author":"Ajduk","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib42","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1157\/13101337","article-title":"Specific immunotherapy is effective in the prevention of new sensitivities","volume":"35","author":"Reha","year":"2007","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.anai.2011.07.018_bib43","first-page":"7","article-title":"Evaluation of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy","volume":"28","author":"Harmanci","year":"2010","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib44","first-page":"7","article-title":"Development of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy","volume":"25","author":"Gulen","year":"2007","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jaci.2005.09.054","article-title":"Grass pollen immunotherapy as an effective therapy for childhood seasonal allergic asthma","volume":"117","author":"Roberts","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jaci.2005.11.014","article-title":"Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis","volume":"117","author":"Frew","year":"2006","journal-title":"J Allergy Clin Immunol"},{"issue":"14 suppl","key":"10.1016\/j.anai.2011.07.018_bib47","first-page":"36","article-title":"Position paper: immunotherapy with Hymenoptera venoms","volume":"48","year":"1993","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000161585","article-title":"Safety and immunogenicity of a cluster specific immunotherapy in children with bronchial asthma and mite allergy","volume":"148","author":"Schubert","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaci.2010.09.017","article-title":"The Consolidated Standards of Reporting Trials (CONSORT) Statement applied to allergen-specific immunotherapy with inhalant allergens: A Global Allergy and Asthma European Network (GA(2)LEN) article","volume":"127","author":"Bousquet","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib50","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1398-9995.2011.02590.x","article-title":"How to design and evaluate randomized controlled trials in immunotherapy for allergic rhinitis: an ARIA-GA(2) LEN statement","volume":"66","author":"Bousquet","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib51","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jaci.2009.07.054","article-title":"Recommendations for appropriate sublingual immunotherapy clinical trials","volume":"124","author":"Casale","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib52","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1398-9995.2009.02083.x","article-title":"Grading quality of evidence and strength of recommendations in clinical practice guidelines, part 2 of 3: the GRADE approach to grading quality of evidence about diagnostic tests and strategies","volume":"64","author":"Brozek","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2011.07.018_bib53","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jaci.2009.10.060","article-title":"Speaking the same language: The World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System","volume":"125","author":"Cox","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2011.07.018_bib54","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0140-6736(96)90538-3","article-title":"Completeness of reporting of trials published in languages other than English: implications for conduct and reporting of systematic reviews","volume":"347","author":"Moher","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.anai.2011.07.018_bib55","first-page":"CD001186","article-title":"Allergen immunotherapy for asthma","volume":"4","author":"Abramson","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anai.2011.07.018_bib56","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1056\/NEJM199701303360502","article-title":"A controlled trial of immunotherapy for asthma in allergic children","volume":"336","author":"Adkinson","year":"1997","journal-title":"N Engl J Med"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120611005898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120611005898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:06:14Z","timestamp":1761051974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120611005898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S1081120611005898"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2011.07.018","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence of effect of subcutaneous immunotherapy in children: complete and updated review from 2006 onward","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2011.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American College of Allergy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}