{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:38:03Z","timestamp":1780493883914,"version":"3.54.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.anai.2012.11.016","type":"journal-article","created":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T01:30:50Z","timestamp":1355707850000},"page":"101-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Glycogen synthase kinase 3 in chronic rhinosinusitis: two faces of a single enzyme in one disease"],"prefix":"10.1016","volume":"110","author":[{"given":"Robert","family":"Linke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Pries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"K\u00f6nnecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Ludwig","family":"Bruchhage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"B\u00f6scke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Gebhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Wollenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2012.11.016_bib1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jaci.2011.08.004","article-title":"Chronic rhinosinusitis: epidemiology and medical management","volume":"128","author":"Hamilos","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2012.11.016_bib2","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1398-9995.2011.02646.x","article-title":"Chronic rhinosinusitis in Europe: an\u00a0underestimated disease: a GA\u00b2LEN study","volume":"66","author":"Hastan","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2012.11.016_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1398-9995.2011.02709.x","article-title":"Asthma in adults and its association with chronic rhinosinusitis: the GA(2) LEN survey in Europe","volume":"67","author":"Jarvis","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2012.11.016_bib4","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"23","author":"Fokkens","year":"2012","journal-title":"Rhinol Suppl"},{"key":"10.1016\/j.anai.2012.11.016_bib5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnmol.2011.00040","article-title":"GSK-3: functional insights from cell biology and animal models","volume":"4","author":"Kaidanovich-Beilin","year":"2011","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.anai.2012.11.016_bib6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pneurobio.2006.07.006","article-title":"The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways","volume":"79","author":"Beurel","year":"2006","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.anai.2012.11.016_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/rns.2011.061","article-title":"GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease","volume":"23","author":"Gao","year":"2011","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.anai.2012.11.016_bib8","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1091\/mbc.e05-07-0688","article-title":"GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction","volume":"17","author":"Sayas","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.anai.2012.11.016_bib9","first-page":"183","article-title":"Staging in rhinosinusitis","volume":"31","author":"Lund","year":"1993","journal-title":"Rhinology"},{"key":"10.1016\/j.anai.2012.11.016_bib10","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s00106-007-1606-9","article-title":"Development of a grading scale for the Sino-Nasal Outcome Test-20 German Adapted Version (SNOT-20 GAV)","volume":"56","author":"Baumann","year":"2008","journal-title":"HNO"},{"key":"10.1016\/j.anai.2012.11.016_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1067\/mhn.2002.121022","article-title":"Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20)","volume":"126","author":"Piccirillo","year":"2002","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anai.2012.11.016_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2796.2012.02559.x","article-title":"Chronic rhinosinusitis and asthma: novel understanding of the role of IgE 'above atopy'","volume":"272","author":"Bachert","year":"2012","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.anai.2012.11.016_bib13","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1365-2222.2011.03898.x","article-title":"Inflammation and remodelling patterns in early stage chronic rhinosinusitis","volume":"42","author":"Van Bruaene","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2012.11.016_bib14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2009.09.007","article-title":"Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)","volume":"31","author":"Beurel","year":"2010","journal-title":"Trends Immunol"},{"key":"10.1016\/j.anai.2012.11.016_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1742-2094-6-9","article-title":"Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain","volume":"6","author":"Beurel","year":"2009","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.anai.2012.11.016_bib16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.immuni.2006.02.014","article-title":"IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB\/AP-1 proteins","volume":"24","author":"Hu","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.anai.2012.11.016_bib17","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/00005537-200404000-00022","article-title":"Origin of nasal polyps: an endoscopic autopsy study","volume":"114","author":"Larsen","year":"2004","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anai.2012.11.016_bib18","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1111\/j.1398-9995.2010.02381.x","article-title":"Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL-6 in nasal epithelial cells in\u00a0vitro","volume":"65","author":"Sachse","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2012.11.016_bib19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cytogfr.2012.04.001","article-title":"Plasticity and cross-talk of interleukin 6-type cytokines","volume":"23","author":"Garbers","year":"2012","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.anai.2012.11.016_bib20","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0006-291X(02)02278-7","article-title":"Regulation of myeloma cell growth through Akt\/Gsk3\/forkhead signaling pathway","volume":"297","author":"G-Amlak","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.anai.2012.11.016_bib21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev.pharmtox.011008.145634","article-title":"Akt\/GSK3 signaling in the action of psychotropic drugs","volume":"49","author":"Beaulieu","year":"2009","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.anai.2012.11.016_bib22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00424-011-1006-6","article-title":"Enhanced catecholamine release in mice expressing PKB\/SGK-resistant GSK3","volume":"462","author":"Siraskar","year":"2011","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.anai.2012.11.016_bib23","doi-asserted-by":"crossref","first-page":"16985","DOI":"10.1074\/jbc.M602446200","article-title":"Novel anti-inflammatory role for glycogen synthase kinase-3beta in the inhibition of tumor necrosis factor-alpha- and interleukin-1beta-induced inflammatory gene expression","volume":"281","author":"Vines","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.anai.2012.11.016_bib24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/0022034510381264","article-title":"TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk","volume":"90","author":"Brown","year":"2011","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.anai.2012.11.016_bib25","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.mcn.2007.10.017","article-title":"Lithium inhibits Smad3\/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling","volume":"37","author":"Liang","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.anai.2012.11.016_bib26","doi-asserted-by":"crossref","first-page":"35337","DOI":"10.1074\/jbc.M803342200","article-title":"Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: requirement for Smads, (beta)-CATENIN, and GSK3(beta)","volume":"283","author":"Clifford","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.anai.2012.11.016_bib27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1126\/science.1156037","article-title":"Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation","volume":"320","author":"Thornton","year":"2008","journal-title":"Science"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120612009416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120612009416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:07:23Z","timestamp":1761052043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120612009416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S1081120612009416"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2012.11.016","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycogen synthase kinase 3 in chronic rhinosinusitis: two faces of a single enzyme in one disease","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2012.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}