{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:32:53Z","timestamp":1786984373789,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.anai.2013.11.018","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T18:00:29Z","timestamp":1387648829000},"page":"146-153.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":132,"title":["Efficacy and safety of grass sublingual immunotherapy tablet, MK-7243: a large randomized controlled trial"],"prefix":"10.1016","volume":"112","author":[{"given":"Jennifer","family":"Maloney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Creticos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"H\u00e9bert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Noonan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Skoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarjot","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl","key":"10.1016\/j.anai.2013.11.018_bib1","doi-asserted-by":"crossref","first-page":"AB188","DOI":"10.1016\/j.jaci.2012.12.1336","article-title":"Diagnosis of nasal and eye allergies\u2014the Allergies, Immunotherapy & Rhinoconjunctivitis (AIRS) patient survey","volume":"131","author":"Blaiss","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1081-1206(10)62813-X","article-title":"Prevalence of sensitization to aeroallergens in California patients with respiratory allergy. Allergy Skin Test Project Team","volume":"81","author":"Galant","year":"1998","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1081-1206(10)62625-7","article-title":"Effect of tree and grass pollens and fungal spores on spring allergic rhinitis: a comparative study","volume":"83","author":"Wu","year":"1999","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib4","first-page":"583765","article-title":"Early pollen sensitization in children is dependent upon regional aeroallergen exposure","volume":"2012","author":"Wong","year":"2012","journal-title":"J\u00a0Allergy (Cairo)"},{"key":"10.1016\/j.anai.2013.11.018_bib5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1081-1206(10)61509-8","article-title":"Key pollen allergens in North America","volume":"91","author":"White","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib6","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1365-2222.2008.03195.x","article-title":"Phleum pratense alone is sufficient for allergen-specific immunotherapy against allergy to Pooideae grass pollens","volume":"39","author":"Hejl","year":"2009","journal-title":"Clin Exp Allergy"},{"issue":"suppl","key":"10.1016\/j.anai.2013.11.018_bib7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2010.09.034","article-title":"Allergen immunotherapy: a practice parameter third update","volume":"127","author":"Cox","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"suppl 91","key":"10.1016\/j.anai.2013.11.018_bib8","first-page":"1","article-title":"Sub-lingual immunotherapy: World Allergy Organization Position Paper 2009","volume":"64","author":"Canonica","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2013.11.018_bib9","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/alr.21027","article-title":"Factors affecting time required to reach maintenance dose during subcutaneous immunotherapy","volume":"2","author":"Jourdy","year":"2012","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.anai.2013.11.018_bib10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jaci.2010.11.034","article-title":"Efficacy and safety of timothy grass allergy immunotherapy tablets in North American children and adolescents","volume":"127","author":"Blaiss","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaci.2010.11.035","article-title":"Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults","volume":"127","author":"Nelson","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib12","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jaci.2005.12.1358","article-title":"Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis","volume":"117","author":"Durham","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jaci.2008.10.044","article-title":"Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy","volume":"123","author":"Bufe","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2500\/aap.2012.33.3605","article-title":"Safety of ragweed sublingual allergy immunotherapy tablets in adults with allergic rhinoconjunctivitis","volume":"33","author":"Nayak","year":"2012","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.anai.2013.11.018_bib15","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.jaci.2013.03.019","article-title":"Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults","volume":"131","author":"Creticos","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib16","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.anai.2013.03.013","article-title":"Randomized controlled trial of ragweed allergy immunotherapy tablet efficacy and safety in North American adults","volume":"110","author":"Nolte","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1477-5751-12-10","article-title":"A\u00a0phase 3 trial assessing the efficacy and safety of grass allergy immunotherapy tablet in subjects with grass pollen-induced allergic rhinoconjunctivitis with or without asthma","volume":"12","author":"Murphy","year":"2013","journal-title":"J\u00a0Negat Results Biomed"},{"key":"10.1016\/j.anai.2013.11.018_bib18","first-page":"235","article-title":"Efficacy of loratadine versus placebo in the prophylactic treatment of seasonal allergic rhinitis","volume":"73","author":"Dolovich","year":"1994","journal-title":"Ann Allergy"},{"key":"10.1016\/j.anai.2013.11.018_bib19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jaci.2011.12.973","article-title":"SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial","volume":"129","author":"Durham","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"suppl 86","key":"10.1016\/j.anai.2013.11.018_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2013.11.018_bib21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/ACI.0b013e328355b7e4","article-title":"World Allergy Organization. 2012 Update: World Allergy Organization guidelines for the assessment and management of anaphylaxis","volume":"12","author":"Simons","year":"2012","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S1081-1206(10)62921-3","article-title":"A\u00a0comparative, volumetric survey of airborne pollen in Philadelphia, Pennsylvania (1991\u20131997) and Cherry Hill, New Jersey (1995\u20131997)","volume":"87","author":"Dvorin","year":"2001","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"suppl","key":"10.1016\/j.anai.2013.11.018_bib23","doi-asserted-by":"crossref","first-page":"AB226","DOI":"10.1016\/j.jaci.2012.12.1471","article-title":"Patients living with allergy symptoms: the Allergies, Immunotherapy, & Rhinoconjunctivitis (AIRS) patient survey","volume":"131","author":"Dykewicz","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib24","first-page":"S805","article-title":"The prevalence and medical and economic impact of allergic rhinitis in the United States","volume":"99","author":"Meltzer","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib25","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1398-9995.2008.01649.x","article-title":"ARIA-suggested drugs for allergic rhinitis: what impact on quality of life? A GA2LEN review","volume":"63","author":"Baiardini","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2013.11.018_bib26","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jaci.2009.07.054","article-title":"Recommendations for appropriate sublingual immunotherapy clinical trials","volume":"124","author":"Casale","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2013.11.018_bib27","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJM199908123410702","article-title":"Long-term clinical efficacy of grass-pollen immunotherapy","volume":"341","author":"Durham","year":"1999","journal-title":"N\u00a0Engl J Med"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120613009034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120613009034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:09:15Z","timestamp":1761052155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120613009034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S1081120613009034"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2013.11.018","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of grass sublingual immunotherapy tablet, MK-7243: a large randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2013.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}