{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:04:55Z","timestamp":1782504295701,"version":"3.54.5"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.anai.2014.03.019","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T10:01:28Z","timestamp":1397642488000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Objective approach for fending off the sublingual immunotherapy placebo effect in subjects with pollenosis: double-blinded, placebo-controlled trial"],"prefix":"10.1016","volume":"113","author":[{"given":"Tanya Z.","family":"Kralimarkova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todor A.","family":"Popov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Staevska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mincheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cvetelina","family":"Lazarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumyana","family":"Racheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tihomir B.","family":"Mustakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violina","family":"Filipova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Koleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalina","family":"Bacheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasil D.","family":"Dimitrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2014.03.019_bib1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.rmed.2009.01.008","article-title":"Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacy","volume":"103","author":"Pipet","year":"2009","journal-title":"Respir Med"},{"key":"10.1016\/j.anai.2014.03.019_bib2","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jaci.2012.08.012","article-title":"Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: a meta-analysis\u2013based comparison","volume":"130","author":"Di Bona","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.03.019_bib3","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jaci.2011.04.048","article-title":"Sublingual immunotherapy: allergen specific or placebo effect?","volume":"128","author":"Kette","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.03.019_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaci.2010.09.017","article-title":"The Consolidated Standards of Reporting Trials (CONSORT) Statement applied to allergen-specific immunotherapy with inhalant allergens: a Global Allergy and Asthma European Network (GA(2)LEN) article","volume":"127","author":"Bousquet","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.03.019_bib5","series-title":"Pollenosis 2000 Global Approach","first-page":"3","article-title":"Definition","author":"Bonini","year":"2001"},{"key":"10.1016\/j.anai.2014.03.019_bib6","unstructured":"European Medicines Agency Committee for Medicinal Products for Human Use (CHMP). Guideline on the Clinical Development of Products for Specific Immunotherapy for the Treatment of Allergic Diseases. CHMP\/EWP\/18504\/2006. London: European Medicines Agency; 2008. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2009\/09\/WC500003605.pdf. Accessed March 4, 2014."},{"key":"10.1016\/j.anai.2014.03.019_bib7","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1398-9995.2007.01393.x","article-title":"Allergenic pollen and pollen allergy in Europe","volume":"62","author":"D\u2019Amato","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2014.03.019_bib8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1164\/ajrccm.165.2.2103053","article-title":"Faster rise of EBT in asthma: a novel marker of airway inflammation?","volume":"165","author":"Paredi","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2014.03.019_bib9","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1183\/09031936.02.00237702","article-title":"Relationship between exhaled air temperature and exhaled nitric oxide in childhood asthma","volume":"20","author":"Piacentini","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2014.03.019_bib10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1183\/20734735.021811","article-title":"Measurement of exhaled breath temperature in science and clinical practice","volume":"8","author":"Popov","year":"2012","journal-title":"Breathe"},{"key":"10.1016\/j.anai.2014.03.019_bib11","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.rmed.2007.06.005","article-title":"Evaluation of a simple, potentially individual device for exhaled breath temperature measurement","volume":"101","author":"Popov","year":"2007","journal-title":"Respir Med"},{"key":"10.1016\/j.anai.2014.03.019_bib12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1109\/JSEN.2009.2035732","article-title":"Development of an individual device for exhaled breath temperature measurement","volume":"10","author":"Popov","year":"2010","journal-title":"IEEE Sensors J"},{"issue":"suppl 94","key":"10.1016\/j.anai.2014.03.019_bib13","first-page":"S354","article-title":"Changes in exhaled breath temperature before, during and after the pollen season in subjects sensitised to grasses with rhinoconjunctivitis, with or without asthma","volume":"66","author":"Kralimarkova","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2014.03.019_bib14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2045-7022-2-2","article-title":"Mechanisms of allergen-specific immunotherapy","volume":"2","author":"Fujita","year":"2012","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.anai.2014.03.019_bib15","unstructured":"GINA guideline 2012. http:\/\/www.ginasthma.org\/local\/uploads\/files\/GINA_Report_March13.pdf. Accessed August 29,\u00a02013."},{"key":"10.1016\/j.anai.2014.03.019_bib16","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of spirometry, 1994 update","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2014.03.019_bib17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jaci.2012.06.025","article-title":"Periostin is a systemic biomarker of eosinophilic inflammation in asthmatic patients","volume":"130","author":"Jia","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.03.019_bib18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/01.moo.0000193186.15440.39","article-title":"Nasobronchial interaction mechanisms in allergic airways disease","volume":"14","author":"Braunstahl","year":"2006","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anai.2014.03.019_bib19","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/02770900902855936","article-title":"Airway hyperresponsiveness: a comparative study of methacholine and exercise challenges in seasonal allergic rhinitis with or without asthma","volume":"46","author":"Sin","year":"2009","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.anai.2014.03.019_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1034\/j.1399-3003.1999.13b14.x","article-title":"Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness","volume":"13","author":"Henriksen","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2014.03.019_bib21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1067\/mai.2002.121701","article-title":"Rhinitis as an independent risk factor for adult-onset asthma","volume":"109","author":"Guerra","year":"2002","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.03.019_bib22","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1398-9995.2004.00537.x","article-title":"Effect of immunotherapy on asthma progression, BHR and sputum eosinophils in allergic rhinitis","volume":"59","author":"Polosa","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2014.03.019_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1710-1492-6-27","article-title":"Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a randomized double blind study","volume":"6","author":"Prieto","year":"2010","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.anai.2014.03.019_bib24","first-page":"532","article-title":"Bronchial hyperresponsiveness and airway inflammation in patients with seasonal allergic rhinitis","volume":"21","author":"Skiepko","year":"2011","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.anai.2014.03.019_bib25","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jaci.2010.08.030","article-title":"Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study","volume":"126","author":"Marogna","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.03.019_bib26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jaci.2011.06.022","article-title":"Sustained 3-year efficacy of pre- and coseasonal 5\u2013grass-pollen sublingual immunotherapy tablets in patients with grass pollen-induced rhinoconjunctivitis","volume":"128","author":"Didier","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.03.019_bib27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2222.2008.03152.x","article-title":"Efficacy and safety of 5-grass pollen sublingual immunotherapy tablets in patients with different clinical profiles of allergic rhinoconjunctivitis","volume":"39","author":"Malling","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2014.03.019_bib28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1398-9995.2008.01767.x","article-title":"Agreement of efficacy assessments for five-grass pollen sublingual tablet immunotherapy","volume":"64","author":"Didier","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2014.03.019_bib29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1398-9995.2006.01276.x","article-title":"Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines","volume":"62","author":"Bousquet","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2014.03.019_bib30","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jaci.2009.02.033","article-title":"Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis","volume":"123","author":"Bousquet","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.03.019_bib31","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/cea.12121","article-title":"Visual analogue scale in patients treated for allergic rhinitis: an observational prospective study in primary care: asthma and rhinitis","volume":"43","author":"Demoly","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2014.03.019_bib32","doi-asserted-by":"crossref","first-page":"969","DOI":"10.5588\/ijtld.12.0657","article-title":"Increased exhaled breath temperature in subjects with uncontrolled asthma","volume":"17","author":"Garcia","year":"2013","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.anai.2014.03.019_bib33","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.pupt.2013.06.002","article-title":"Real life clinical study design supporting the effectiveness of extra-fine inhaled beclomethasone\/formoterol at the level of small airways of asthmatics","volume":"26","author":"Popov","year":"2013","journal-title":"Pulm Pharm Therapeut"},{"key":"10.1016\/j.anai.2014.03.019_bib34","doi-asserted-by":"crossref","first-page":"250","DOI":"10.5588\/ijtld.13.0525","article-title":"Exhaled breath temperature: broadening the horizons","volume":"18","author":"Kralimarkova","year":"2014","journal-title":"Int J Tuberc Lung Dis"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120614002038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120614002038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:10:04Z","timestamp":1761052204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120614002038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1081120614002038"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2014.03.019","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Objective approach for fending off the sublingual immunotherapy placebo effect in subjects with pollenosis: double-blinded, placebo-controlled trial","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2014.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}