{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:46:11Z","timestamp":1792086371465,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.anai.2014.12.003","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T22:07:02Z","timestamp":1421186822000},"page":"208-213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype"],"prefix":"10.1016","volume":"114","author":[{"given":"Seung-Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunna","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-Gyung","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Min","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Sim","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2014.12.003_bib1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1365-2222.2011.03929.x","article-title":"Severe asthma: from characteristics to phenotypes to endotypes","volume":"42","author":"Wenzel","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2014.12.003_bib2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.jaci.2005.08.035","article-title":"Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma","volume":"116","author":"Mascia","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.12.003_bib3","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1034\/j.1398-9995.2003.00276.x","article-title":"RANTES, eotaxin and eotaxin-2 expression and production in patients with aspirin triad","volume":"58","author":"Pods","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2014.12.003_bib4","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1164\/ajrccm.156.5.9702072","article-title":"Expression of interleukin-5 and granulocyte\u2013macrophage colony-stimulating factor in aspirin-sensitive and non\u2013aspirin-sensitive asthmatic airways","volume":"156","author":"Sousa","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2014.12.003_bib5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1164\/ajrccm.153.1.8542168","article-title":"Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects","volume":"153","author":"Nasser","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2014.12.003_bib6","first-page":"145","article-title":"Eosinophilic nasal polyps are a rich source of eotaxin, eotaxin-2 and eotaxin-3","volume":"44","author":"Olze","year":"2006","journal-title":"Rhinology"},{"key":"10.1016\/j.anai.2014.12.003_bib7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4168\/aair.2011.3.4.256","article-title":"Diagnostic value of clinical parameters in the prediction of aspirin-exacerbated respiratory disease in asthma","volume":"3","author":"Chang","year":"2011","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.anai.2014.12.003_bib8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4168\/aair.2014.6.4.288","article-title":"Cysteinyl leukotrienes and their receptors; emerging concepts","volume":"6","author":"Kanaoka","year":"2014","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.anai.2014.12.003_bib9","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1164\/ajrccm.157.4.9707089","article-title":"Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics","volume":"157","author":"Dahlen","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2014.12.003_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000351422","article-title":"The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma","volume":"162","author":"James","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.anai.2014.12.003_bib11","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1398-9995.2005.00836.x","article-title":"Aspirin-triggered 15-HETE generation in peripheral blood leukocytes is a specific and sensitive Aspirin-Sensitive Patients Identification Test (ASPITest)","volume":"60","author":"Kowalski","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2014.12.003_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.iac.2012.10.003","article-title":"Genetics of hypersensitivity to aspirin and nonsteroidal anti-inflammatory drugs","volume":"33","author":"Kim","year":"2013","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.anai.2014.12.003_bib13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4168\/aair.2013.5.5.258","article-title":"Unraveling the genetic basis of aspirin hypersensitivity in asthma beyond arachidonate pathways","volume":"5","author":"Park","year":"2013","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.anai.2014.12.003_bib14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/ng1256","article-title":"Positional cloning of a novel gene influencing asthma from chromosome 2q14","volume":"35","author":"Allen","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.anai.2014.12.003_bib15","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/gerona\/glt179","article-title":"Variants of asthma and chronic obstructive pulmonary disease genes and lung function decline in aging","volume":"69","author":"Poon","year":"2014","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.anai.2014.12.003_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1369\/jhc.7A7319.2007","article-title":"Regulation of expression and function of dipeptidyl peptidase 4 (DP4), DP8\/9, and DP10 in allergic responses of the lung in rats","volume":"56","author":"Schade","year":"2008","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.anai.2014.12.003_bib17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2222.1995.tb01000.x","article-title":"Early and late onset asthmatic responses following lysine\u2013aspirin inhalation in aspirin-sensitive asthmatic patients","volume":"25","author":"Park","year":"1995","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2014.12.003_bib18","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0091-6749(99)70297-6","article-title":"Specific IgG, but not specific IgE, antibodies to toluene diisocyanate-human serum albumin conjugate are associated with toluene diisocyanate bronchoprovocation test results","volume":"104","author":"Park","year":"1999","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.12.003_bib19","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.rmed.2009.11.024","article-title":"Association of the CCR3 gene polymorphism with aspirin exacerbated respiratory disease","volume":"104","author":"Kim","year":"2010","journal-title":"Respir Med"},{"key":"10.1016\/j.anai.2014.12.003_bib20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.otohns.2007.02.004","article-title":"The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?","volume":"137","author":"Hopkins","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anai.2014.12.003_bib21","doi-asserted-by":"crossref","first-page":"L196","DOI":"10.1152\/ajplung.00036.2008","article-title":"15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells","volume":"297","author":"Liu","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.anai.2014.12.003_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1078\/0171-9335-00302","article-title":"The multifunctional or moonlighting protein CD26\/DPPIV","volume":"82","author":"Boonacker","year":"2003","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.anai.2014.12.003_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/0-306-47920-6_10","article-title":"Dipeptidyl peptidase IV gene family. The DPIV family","volume":"524","author":"Chen","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.anai.2014.12.003_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/bj20021914","article-title":"Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases","volume":"373","author":"Qi","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.anai.2014.12.003_bib25","doi-asserted-by":"crossref","first-page":"C966","DOI":"10.1152\/ajpcell.00571.2005","article-title":"DPP10 is an inactivation modulatory protein of Kv4.3 and Kv1.4","volume":"291","author":"Li","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.anai.2014.12.003_bib26","doi-asserted-by":"crossref","first-page":"e13894","DOI":"10.1371\/journal.pone.0013894","article-title":"Unifying candidate gene and GWAS approaches in asthma","volume":"5","author":"Michel","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.anai.2014.12.003_bib27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jaci.2009.09.007","article-title":"Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans","volume":"125","author":"Wu","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.12.003_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1748-1716.1980.tb06656.x","article-title":"Identification of 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) as a major metabolite of arachidonic acid in human lung","volume":"110","author":"Hamberg","year":"1980","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.anai.2014.12.003_bib29","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1056\/NEJMoa073600","article-title":"A\u00a0chitinase-like protein in the lung and circulation of patients with severe asthma","volume":"357","author":"Chupp","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.anai.2014.12.003_bib30","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jaci.2013.03.003","article-title":"The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma","volume":"132","author":"Konradsen","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2014.12.003_bib31","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1084\/jem.20081271","article-title":"Role of breast regression protein 39 (BRP-39)\/chitinase 3-like-1 in Th2 and IL-13\u2013induced tissue responses and apoptosis","volume":"206","author":"Lee","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.anai.2014.12.003_bib32","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1056\/NEJMoa0708801","article-title":"Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function","volume":"358","author":"Ober","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.anai.2014.12.003_bib33","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1378\/chest.128.5.3127","article-title":"Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients","volume":"128","author":"Min","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.anai.2014.12.003_bib34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/thx.45.3.213","article-title":"Potassium channels and airway function: new therapeutic prospects","volume":"45","author":"Black","year":"1990","journal-title":"Thorax"},{"key":"10.1016\/j.anai.2014.12.003_bib35","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.mcn.2005.02.003","article-title":"Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels","volume":"29","author":"Ren","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.anai.2014.12.003_bib36","first-page":"123","article-title":"The potential therapeutic role of potassium channel modulators in asthma and chronic obstructive pulmonary disease","volume":"24","author":"Malerba","year":"2010","journal-title":"J\u00a0Biol Regul Homeost Agents"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120614008849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120614008849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:11:55Z","timestamp":1761052315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120614008849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S1081120614008849"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2014.12.003","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2014.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}