{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:54:37Z","timestamp":1779191677767,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"am","delay-in-days":414,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Research on Allergic Disease and Immunology of Health Labor Sciences Research"},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.anai.2015.01.013","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T14:15:38Z","timestamp":1424355338000},"page":"289-298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis"],"prefix":"10.1016","volume":"114","author":[{"given":"Tomohisa","family":"Iinuma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heizaburo","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Inamine-Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Ohki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshioki","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urara","family":"Funakoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syuji","family":"Yonekura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiju","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Hirahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2015.01.013_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.anai.2015.01.013_bib2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jaci.2011.08.004","article-title":"Chronic rhinosinusitis: epidemiology and medical management","volume":"128","author":"Hamilos","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib3","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jaci.2008.07.008","article-title":"Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease","volume":"122","author":"Zhang","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jaci.2009.05.017","article-title":"Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese","volume":"124","author":"Cao","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib5","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.otohns.2007.07.036","article-title":"Histological and immunological features of non-eosinophilic nasal polyps","volume":"137","author":"Kim","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anai.2015.01.013_bib6","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4193\/Rhino10.261","article-title":"Mucosal eosinophilia and recurrence of nasal polyps\u2014new classification of chronic rhinosinusitis","volume":"49","author":"Nakayama","year":"2011","journal-title":"Rhinology"},{"key":"10.1016\/j.anai.2015.01.013_bib7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.anl.2011.01.007","article-title":"New clinical diagnostic criteria for eosinophilic chronic rhinosinusitis","volume":"38","author":"Sakuma","year":"2011","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anai.2015.01.013_bib8","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1398-9995.2006.01132.x","article-title":"Distinct features of chronic rhinosinusitis with and without nasal polyps","volume":"61","author":"Polzehl","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2015.01.013_bib9","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of effector CD4 T cell populations (*)","volume":"28","author":"Zhu","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib10","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/ni.1677","article-title":"IL-4 inhibits TGF-beta\u2013induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(\u2212) effector T cells","volume":"9","author":"Dardalhon","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib11","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/ni.1867","article-title":"The transcription factor PU.1 is required for the development of IL-9\u2013producing T cells and allergic inflammation","volume":"11","author":"Chang","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib12","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/j.1398-9995.2007.01464.x","article-title":"Detection of natural killer T cells in the sinus mucosa from asthmatics with chronic sinusitis","volume":"62","author":"Yamamoto","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2015.01.013_bib13","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2731","article-title":"Innate and adaptive immune responses in asthma","volume":"18","author":"Holgate","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.anai.2015.01.013_bib14","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S1074-7613(01)00243-6","article-title":"IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in\u00a0vivo","volume":"15","author":"Fort","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.anai.2015.01.013_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4049\/jimmunol.169.1.443","article-title":"New IL-17 family members promote Th1 or Th2 responses in the lung: in\u00a0vivo function of the novel cytokine IL-25","volume":"169","author":"Hurst","year":"2002","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ni.1846","article-title":"Regulation of IL-9 expression by IL-25 signaling","volume":"11","author":"Angkasekwinai","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib17","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nm.2735","article-title":"Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB(+) myeloid population that exacerbates asthmatic pathology","volume":"18","author":"Petersen","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.anai.2015.01.013_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/all.12054","article-title":"Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps","volume":"68","author":"Gevaert","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2015.01.013_bib19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2001.112374","article-title":"Total and specific IgE in nasal polyps is related to local eosinophilic inflammation","volume":"107","author":"Bachert","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib20","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1182\/blood-2010-02-267542","article-title":"Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome","volume":"116","author":"Terrier","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.anai.2015.01.013_bib21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2011.03.043","article-title":"Allergen-induced expression of IL-25 and\u00a0IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses","volume":"128","author":"Corrigan","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib22","first-page":"183","article-title":"Staging in rhinosinusitis","volume":"31","author":"Lund","year":"1993","journal-title":"Rhinology"},{"key":"10.1016\/j.anai.2015.01.013_bib23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.clim.2012.01.008","article-title":"Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells","volume":"143","author":"Inamine","year":"2012","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib24","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ni.1659","article-title":"Transforming growth factor-beta \u2018reprograms\u2019 the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset","volume":"9","author":"Veldhoen","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib25","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.1073\/pnas.85.18.6934","article-title":"Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity","volume":"85","author":"Uyttenhove","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.anai.2015.01.013_bib26","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1164\/rccm.200909-1462OC","article-title":"IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways","volume":"183","author":"Kearley","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2015.01.013_bib27","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jaci.2003.08.042","article-title":"FcepsilonRI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokines","volume":"112","author":"Lora","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib28","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1165\/rcmb.4887","article-title":"Interleukin-9 induces goblet cell hyperplasia during repair of human airway epithelia","volume":"28","author":"Vermeer","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.anai.2015.01.013_bib29","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1165\/ajrcmb.22.6.3927","article-title":"Interleukin-9 upregulates mucus expression in the airways","volume":"22","author":"Louahed","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.anai.2015.01.013_bib30","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.jaci.2008.02.018","article-title":"T-cell regulation in chronic paranasal sinus disease","volume":"121","author":"Van Bruaene","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib31","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.2500\/ajra.2011.25.3645","article-title":"The characterization of IL-17A expression in patients with chronic rhinosinusitis with nasal polyps","volume":"25","author":"Jiang","year":"2011","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.anai.2015.01.013_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/35065111","article-title":"Visualizing the generation of memory CD4 T cells in the whole body","volume":"410","author":"Reinhardt","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.anai.2015.01.013_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nri2496","article-title":"Migration, maintenance and recall of memory T cells in peripheral tissues","volume":"9","author":"Woodland","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.coi.2009.02.005","article-title":"Generation and maintenance of memory CD4(+) T cells","volume":"21","author":"van Leeuwen","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib35","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells","volume":"29","author":"Surh","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.anai.2015.01.013_bib36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.it.2013.11.003","article-title":"Pathogenic memory type Th2 cells in allergic inflammation","volume":"35","author":"Endo","year":"2014","journal-title":"Trends Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ni.1984","article-title":"Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells","volume":"12","author":"Islam","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib38","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.immuni.2011.08.017","article-title":"Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3","volume":"35","author":"Endo","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.anai.2015.01.013_bib39","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1165\/rcmb.2012-0304OC","article-title":"Transcription of interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells","volume":"49","author":"Kouzaki","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.anai.2015.01.013_bib40","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0091-6749(95)70298-9","article-title":"Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis","volume":"96","author":"Hamilos","year":"1995","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib41","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1067\/mhn.2000.110961","article-title":"Chronic rhinosinusitis: allergy and sinus computed tomography relationships","volume":"123","author":"Emanuel","year":"2000","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anai.2015.01.013_bib42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1398-9995.2011.02709.x","article-title":"Asthma in adults and its association with chronic rhinosinusitis: the GA2LEN survey in Europe","volume":"67","author":"Jarvis","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2015.01.013_bib43","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jaci.2011.06.048","article-title":"Asthma in the elderly: Current understanding and future research needs\u2014a report of a National Institute on Aging (NIA) workshop","volume":"128","author":"Hanania","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.01.013_bib44","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1378\/chest.08-1595","article-title":"Association of IL-17RB gene polymorphism with asthma","volume":"135","author":"Jung","year":"2009","journal-title":"Chest"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120615000447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120615000447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:12:50Z","timestamp":1761052370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120615000447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1081120615000447"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2015.01.013","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2015.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}