{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:43:39Z","timestamp":1770911019781,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.anai.2015.04.025","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T05:15:52Z","timestamp":1435295752000},"page":"63-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Reduced airway microbiota diversity is associated with elevated allergic respiratory inflammation"],"prefix":"10.1016","volume":"115","author":[{"given":"Wenkai","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingche","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huajun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieli","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2015.04.025_bib1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0140-6736(12)62202-8","article-title":"Microbes and mucosal immune responses in asthma","volume":"381","author":"Hansel","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.anai.2015.04.025_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/mi.2010.19","article-title":"Tolerizing allergic responses in the lung","volume":"3","author":"Lloyd","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.anai.2015.04.025_bib3","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nm.3300","article-title":"Eosinophilic airway inflammation in nonallergic asthma","volume":"19","author":"Brusselle","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.anai.2015.04.025_bib4","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1164\/ajrccm.164.5.9910103","article-title":"Inhaled corticosteroids, combined with long-acting \u03b22-agonists, improve the perception of bronchoconstriction in asthma","volume":"164","author":"Bijl-Hofland","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2015.04.025_bib5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","article-title":"Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee Report","volume":"59","author":"Masoli","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2015.04.025_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.aller.2009.11.002","article-title":"Recent perspectives on global epidemiology of asthma in childhood","volume":"38","author":"Asher","year":"2010","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.anai.2015.04.025_bib7","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJMoa1007302","article-title":"Exposure to environmental microorganisms and childhood asthma","volume":"364","author":"Ege","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.anai.2015.04.025_bib8","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay fever, hygiene, and household size","volume":"299","author":"Strachan","year":"1989","journal-title":"BMJ"},{"key":"10.1016\/j.anai.2015.04.025_bib9","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(01)06252-3","article-title":"Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey","volume":"358","author":"Riedler","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.anai.2015.04.025_bib10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11882-013-0382-8","article-title":"The relationship between advances in understanding the microbiome and the maturing hygiene hypothesis","volume":"13","author":"Bendiks","year":"2013","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.anai.2015.04.025_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1164\/rccm.201010-1574OC","article-title":"Dysregulation of allergic airway inflammation in the absence of microbial colonization","volume":"184","author":"Herbst","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2015.04.025_bib12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/embor.2012.32","article-title":"Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma","volume":"13","author":"Russell","year":"2012","journal-title":"EMBO Rep"},{"key":"10.1016\/j.anai.2015.04.025_bib13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrmicro2801","article-title":"The microbiology of asthma","volume":"10","author":"Edwards","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.anai.2015.04.025_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/MOG.0b013e3283573017","article-title":"The impact of gut microbes in allergic diseases","volume":"28","author":"Russell","year":"2012","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.anai.2015.04.025_bib15","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1056\/NEJMoa052632","article-title":"Childhood asthma after bacterial colonization of the airway in neonates","volume":"357","author":"Bisgaard","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.anai.2015.04.025_bib16","doi-asserted-by":"crossref","first-page":"e8578","DOI":"10.1371\/journal.pone.0008578","article-title":"Disordered microbial communities in asthmatic airways","volume":"5","author":"Hilty","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.anai.2015.04.025_bib17","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s11882-013-0355-y","article-title":"Asthma microbiome studies and the potential for new therapeutic strategies","volume":"13","author":"Huang","year":"2012","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.anai.2015.04.025_bib18","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.330.6008.1168","article-title":"Bacteria and asthma: untangling the links","volume":"26","author":"Couzin Frankel","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.anai.2015.04.025_bib19","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/cr.2012.65","article-title":"Early exposure to germs and the hygiene hypothesis","volume":"22","author":"Umetsu","year":"2012","journal-title":"Cell Res"},{"key":"10.1016\/j.anai.2015.04.025_bib20","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/ACI.0b013e328349b166","article-title":"Early life exposures: impact on asthma and allergic disease","volume":"11","author":"Kozyrskyj","year":"2011","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.04.025_bib21","doi-asserted-by":"crossref","first-page":"e59174","DOI":"10.1371\/journal.pone.0059174","article-title":"Immunomodulatory effects of Escherichia coli ATCC 25922 on allergic airway inflammation in a mouse model","volume":"8","author":"Pang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.anai.2015.04.025_bib22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrmicro2536","article-title":"Shifting the balance: antibiotic effects on host-microbiota mutualism","volume":"9","author":"Willing","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.anai.2015.04.025_bib23","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4161\/gmic.23567","article-title":"Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma","volume":"4","author":"Russell","year":"2013","journal-title":"Gut Microbes"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120615003178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120615003178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:12:36Z","timestamp":1761052356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120615003178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1081120615003178"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2015.04.025","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced airway microbiota diversity is associated with elevated allergic respiratory inflammation","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2015.04.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}