{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:42:12Z","timestamp":1789879332172,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.anai.2015.08.006","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T22:13:41Z","timestamp":1442096021000},"page":"402-407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Respiratory diseases and allergic sensitization in swine breeders: a population-based cross-sectional study"],"prefix":"10.1016","volume":"115","author":[{"given":"Luigina","family":"Galli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Facchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8742-3986","authenticated-orcid":false,"given":"Elena","family":"Raffetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Donato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"D'Anna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2015.08.006_bib1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1378\/chest.08-2192","article-title":"Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents","volume":"136","author":"Eduard","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.anai.2015.08.006_bib2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ajim.20077","article-title":"Chronic obstructive pulmonary disease in never-smoking animal farmers working inside confinement buildings","volume":"46","author":"Mons\u00f3","year":"2004","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.anai.2015.08.006_bib3","first-page":"119","article-title":"Exposure and respiratory health in farming in temperate zones\u2014a review of the literature","volume":"9","author":"Omland","year":"2002","journal-title":"Ann Agric Environ Med"},{"key":"10.1016\/j.anai.2015.08.006_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/(SICI)1097-0274(199601)29:1<33::AID-AJIM5>3.0.CO;2-#","article-title":"Longitudinal evaluation of dose\u2013response relationships for environmental exposures and pulmonary function in swine production workers","volume":"29","author":"Reynolds","year":"1996","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.anai.2015.08.006_bib5","first-page":"705","article-title":"Agricultural lung diseases","volume":"108","author":"Kirkhorn","year":"2000","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.anai.2015.08.006_bib6","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1378\/chest.111.6.1733","article-title":"Accelerated lung function decline in swine confinement workers","volume":"111","author":"Senthilselvan","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.anai.2015.08.006_bib7","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1097\/00043764-199812000-00003","article-title":"Longitudinal changes in lung function associated with aspects of swine-confinement exposure","volume":"40","author":"Vogelzang","year":"1998","journal-title":"J\u00a0Occup Environ Med"},{"key":"10.1016\/j.anai.2015.08.006_bib8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/ajim.4700270309","article-title":"Respiratory dysfunction in swine production facility workers: dose\u2013response relationships of environmental exposures and pulmonary function","volume":"27","author":"Donham","year":"1995","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.anai.2015.08.006_bib9","first-page":"49","article-title":"Bronchodilator responsiveness in swine veterinarians","volume":"12","author":"Poole","year":"2007","journal-title":"J\u00a0Agromed"},{"key":"10.1016\/j.anai.2015.08.006_bib10","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1183\/09031936.04.00112102","article-title":"Occupational asthma in newly employed workers in intensive swine confinement facilities","volume":"24","author":"Dosman","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2015.08.006_bib11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1183\/09031936.01.17407470","article-title":"Respiratory symptoms in European animal farmers","volume":"17","author":"Radon","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2015.08.006_bib12","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.jaci.2004.11.046","article-title":"Endotoxin exposure and atopic sensitization in adult pig farmers","volume":"115","author":"Portengen","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.08.006_bib13","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.iac.2008.03.010","article-title":"Living on a farm: impact on asthma induction and clinical course","volume":"28","author":"von Mutius","year":"2008","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.anai.2015.08.006_bib14","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJMoa1007302","article-title":"Exposure to environmental microorganisms and childhood asthma","volume":"364","author":"Ege","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.anai.2015.08.006_bib15","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1136\/thx.43.9.697","article-title":"Respiratory symptoms in arable farmworkers: role of storage mites","volume":"43","author":"Blainey","year":"1988","journal-title":"Thorax"},{"key":"10.1016\/j.anai.2015.08.006_bib16","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1034\/j.1398-9995.1999.00115.x","article-title":"Risk factors associated with asthma and rhinoconjunctivitis among Swedish farmers","volume":"54","author":"Kronqvist","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2015.08.006_bib17","first-page":"223","article-title":"Respiratory health and allergy among young farmers and non-farming rural males in Denmark: the SUS study","volume":"9","author":"Sigsgaard","year":"2004","journal-title":"J\u00a0Agromed"},{"key":"10.1016\/j.anai.2015.08.006_bib18","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1183\/09031936.05.00035205","article-title":"Interpretative strategies for lung function tests","volume":"26","author":"Pellegrino","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2015.08.006_bib19","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1164\/rccm.2601014","article-title":"ATS Workshop Proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate: executive summary","volume":"173","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2015.08.006_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2500\/105065888781693212","article-title":"Nasal cytology in clinical practice","volume":"2","author":"Meltzer","year":"1988","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.anai.2015.08.006_bib21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1398-9995.2011.02728.x","article-title":"Allergic rhinitis and its impact on asthma. Practical guide to skin prick tests in allergy to aeroallergens","volume":"67","author":"Bousquet","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2015.08.006_bib22","unstructured":"Global Initiative on Asthma Web site. http:\/\/www.ginasthma.org\/. Accessed May\u00a02015."},{"key":"10.1016\/j.anai.2015.08.006_bib23","series-title":"World Allergy Organization. Evidence Based Approaches to Diagnosis and Management. World Allergy Organization (WAO) White Book on Allergy: Update 2013","first-page":"16","year":"2013"},{"key":"10.1016\/j.anai.2015.08.006_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.7326\/0003-4819-155-3-201108020-00008","article-title":"Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society","volume":"155","author":"Qaseem","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.anai.2015.08.006_bib25","unstructured":"Minetti S, Raffetti E, Lodi-Rizzini F, et\u00a0al. Respiratory allergy in immigrants to a highly industrialised area in Italy according to area of origin and time period [published online ahead of print November 8, 2014]. Allergol Immunopathol (Madr). pii:S0301-0546(14)00145-1."},{"key":"10.1016\/j.anai.2015.08.006_bib26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/pai.12250","article-title":"Cross-sectional comparison of the characteristics of respiratory allergy in immigrants and Italian children","volume":"25","author":"Lombardi","year":"2014","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.anai.2015.08.006_bib27","series-title":"Global Alliance Against Chronic Respiratory Diseases\u2014I Documento di strategia","first-page":"23","article-title":"L'epidemiologia in Italia della malattie respiratorie croniche","year":"2008"},{"key":"10.1016\/j.anai.2015.08.006_bib28","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1183\/09031936.00061611","article-title":"Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010","volume":"39","author":"de Marco","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2015.08.006_bib29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.rmed.2007.08.002","article-title":"Respiratory symptoms\/diseases, impaired lung function, and drug use in two Italian general population samples","volume":"102","author":"Simoni","year":"2008","journal-title":"Respir Med"},{"key":"10.1016\/j.anai.2015.08.006_bib30","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1046\/j.1365-2222.2001.01246.x","article-title":"Farming, rural lifestyle and atopy in adults from southern Germany\u2014results from the MONICA\/KORA study Augsburg","volume":"31","author":"Filipiak","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2015.08.006_bib31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1365-2222.2002.01310.x","article-title":"Low prevalence of atopy in young Danish farmers and farming students born and raised on a farm","volume":"32","author":"Portengen","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2015.08.006_bib32","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1378\/chest.127.1.372","article-title":"Allergic rhinitis, asthma, and atopy among grape farmers in a rural population in Crete, Greece","volume":"127","author":"Chatzi","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.anai.2015.08.006_bib33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/ACI.0b013e32835ad0d2","article-title":"The hygiene hypothesis in allergy and asthma: an update","volume":"13","author":"Brooks","year":"2013","journal-title":"Curr Opin Allergy Clin Immunol"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120615005359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120615005359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:15:34Z","timestamp":1761052534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120615005359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S1081120615005359"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2015.08.006","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Respiratory diseases and allergic sensitization in swine breeders: a population-based cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2015.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}