{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:28:47Z","timestamp":1774542527902,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.anai.2015.12.001","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T13:33:08Z","timestamp":1453555988000},"page":"151-155.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["How effective are the 6 European Society of Immunodeficiency warning signs for primary immunodeficiency disease?"],"prefix":"10.1016","volume":"116","author":[{"given":"Sevket","family":"Arslan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Ucar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Zafer","family":"Caliskaner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Reisli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukru Nail","family":"Guner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra Hazar","family":"Sayar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Baloglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2015.12.001_bib1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jaci.2004.06.044","article-title":"Primary immunodeficiency diseases: an update","volume":"114","author":"Notarangelo","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib2","first-page":"108","article-title":"Patient-centred screening for primary immunodeficiency, a multi-stage diagnostic protocol designed for non-immunologists: 2011 update","volume":"167","author":"de Vries","year":"2012","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib3","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.4049\/jimmunol.0901837","article-title":"Systematic classification of primary immunodeficiencies based on clinical, pathological, and laboratory parameters","volume":"183","author":"Samarghitean","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2249.2006.03126.x","article-title":"Early indicators of immunodeficiency in adults and children: protocols for screening for primary immunological defects","volume":"145","author":"Sewell","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies)","volume":"93","author":"Conley","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib6","unstructured":"http:\/\/esid.org\/Working-Parties\/Clinical\/Resources\/6-Warning-Signs-for-PID-in-Adults. Accessed September 6,\u00a02015."},{"key":"10.1016\/j.anai.2015.12.001_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/cei.12178","article-title":"New diagnostic criteria for common variable immune deficiency (CVID), which may assist with decisions to treat with intravenous or subcutaneous immunoglobulin","volume":"174","author":"Ameratunga","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4168\/aair.2013.5.2.88","article-title":"Clinical predictors of primary immunodeficiency diseases in children","volume":"5","author":"Reda","year":"2013","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.anai.2015.12.001_bib9","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jaci.2007.08.053","article-title":"Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee","volume":"120","author":"Geha","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib10","first-page":"162","article-title":"Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency","volume":"5","author":"Al-Herz","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib11","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jaci.2010.06.015","article-title":"Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: entering a new century, do we do better?","volume":"126","author":"Gennery","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib12","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1067\/mai.2002.122466","article-title":"Primary immunodeficiency disorders: antibody deficiency","volume":"109","author":"Ballow","year":"2002","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib13","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1183\/09031936.00020215","article-title":"Primary immunodeficiencies: not just paediatric diseases","volume":"45","author":"Gennery","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2015.12.001_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1081-1206(10)61142-8","article-title":"Practice parameter for the diagnosis and management of primary immunodeficiency","volume":"94","author":"Bonilla","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s40629-014-0030-4","article-title":"Immunodeficiency in adults a practical guide for the allergist","volume":"23","author":"Hausmann","year":"2014","journal-title":"Allergol J Int"},{"key":"10.1016\/j.anai.2015.12.001_bib16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2249.2011.04542.x","article-title":"The European internet-based patient and research database for primary immunodeficiencies: update 2011","volume":"167","author":"Gathmann","year":"2012","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jaci.2005.03.053","article-title":"From idiopathic infectious diseases to novel primary immunodeficiencies","volume":"116","author":"Casanova","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib18","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.cgh.2013.02.024","article-title":"Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency","volume":"11","author":"Agarwal","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.anai.2015.12.001_bib19","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1007\/s10620-015-3638-4","article-title":"Gastrointestinal pathologic abnormalities in pediatric- and adult-onset common variable immunodeficiency","volume":"60","author":"Lougaris","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.anai.2015.12.001_bib20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2500\/aap.2011.32.3492","article-title":"Hereditary angioedema: classification, pathogenesis, and diagnosis","volume":"32","author":"Banerji","year":"2011","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.anai.2015.12.001_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10875-015-0149-1","article-title":"The Duesseldorf warning signs for primary immunodeficiency: is it time to change the rules?","volume":"35","author":"Lankisch","year":"2015","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.anai.2015.12.001_bib22","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1542\/peds.2010-3680","article-title":"Clinical features that identify children with primary immunodeficiency diseases","volume":"127","author":"Subbarayan","year":"2011","journal-title":"Pediatrics"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120615008212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120615008212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:14:21Z","timestamp":1761052461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120615008212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1081120615008212"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2015.12.001","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"How effective are the 6 European Society of Immunodeficiency warning signs for primary immunodeficiency disease?","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2015.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}