{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:54:44Z","timestamp":1768812884667,"version":"3.49.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.anai.2016.06.006","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T04:25:04Z","timestamp":1473395104000},"page":"234-240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Chronic rhinosinusitis phenotypes"],"prefix":"10.1016","volume":"117","author":[{"given":"John W.","family":"Steinke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Borish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2016.06.006_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012: a summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.anai.2016.06.006_bib2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1067\/mai.2003.67","article-title":"Cytseinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: Importance to eosinophilia and asthma","volume":"111","author":"Steinke","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib3","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1398-9995.2006.01225.x","article-title":"Differentiation of chronic sinus diseases by measurement of inflammatory mediators","volume":"61","author":"Van Zele","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2016.06.006_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2001.112374","article-title":"Total and specifc IgE in nasal polyps is related to local eosinophilic inflammation","volume":"107","author":"Bachert","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib5","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/00005537-200204000-00026","article-title":"Polypoid mucosa with eosinophilia and glandular hyperplasia in chronic sinusitis: a histopathological and immunohistchemical study","volume":"112","author":"Berger","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anai.2016.06.006_bib6","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/lary.21969","article-title":"Evidence for distinct histologic profile of nasal polyps with and without eosinophilia","volume":"121","author":"Payne","year":"2011","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anai.2016.06.006_bib7","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.otohns.2007.07.036","article-title":"Histological and immunological features of non-eosinophilic nasal polyps","volume":"137","author":"Kim","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anai.2016.06.006_bib8","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jaci.2010.07.007","article-title":"Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma","volume":"126","author":"Bachert","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib9","doi-asserted-by":"crossref","first-page":"151ra124","DOI":"10.1126\/scitranslmed.3003783","article-title":"Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis","volume":"4","author":"Abreu","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.anai.2016.06.006_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40413-014-0048-6","article-title":"The microbiome of the upper airways: focus on chronic rhinosinusitis","volume":"8","author":"Chalermwatanachai","year":"2015","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.anai.2016.06.006_bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000079994","article-title":"Evidence of bacterial biofilms in human chronic sinusitis","volume":"66","author":"Cryer","year":"2004","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.anai.2016.06.006_bib12","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/01.mlg.0000161346.30752.18","article-title":"Bacterial biofilms in surgical specimens of patients with chronic rhinosinusitis","volume":"115","author":"Sanclement","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anai.2016.06.006_bib13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4193\/Rhino12.194","article-title":"Feasibility of balloon sinuplasty in patients with chronic rhinosinusitis: the Graz experience","volume":"51","author":"Tomazic","year":"2013","journal-title":"Rhinology"},{"key":"10.1016\/j.anai.2016.06.006_bib14","first-page":"1","article-title":"Prognostic factors, outcomes and staging in ethmoid sinus surgery","volume":"102","author":"Kennedy","year":"1992","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anai.2016.06.006_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2500\/ajra.2010.24.3482","article-title":"Outcomes after endoscopic sinus surgery for unilateral versus bilateral chronic rhinosinusitis with nasal polyposis","volume":"24","author":"Lee","year":"2010","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.anai.2016.06.006_bib16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.anai.2013.06.033","article-title":"Sino-nasal outcome test (SNOT-22): a predictor of postsurgical improvement in patients with chronic sinusitis","volume":"111","author":"Kennedy","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib17","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jaci.2013.05.008","article-title":"Prominent role of interferon-\u03b3 in aspirin-exacerbated respiratory disease","volume":"132","author":"Steinke","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib18","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/rccm.201412-2278OC","article-title":"Cytokines in chronic rhinosinusitis: role in eosinophilia and aspirin-exacerbated respiratory disease","volume":"192","author":"Stevens","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2016.06.006_bib19","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jaci.2009.10.015","article-title":"Remodeling and inflammation in Chinese versus white patients with chronic rhinosinusitis","volume":"125","author":"Zhang","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/00016480902936919","article-title":"A\u00a0relationship between mast cells and alpha-smooth muscle actin-positive cells in the nasal polyps of chronic rhinosinusitis","volume":"562","author":"Nishijima","year":"2009","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1016\/j.anai.2016.06.006_bib21","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0091-6749(97)80019-X","article-title":"IL-5 synthesis is upregulated in human nasal polyp tissue","volume":"99","author":"Bachert","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib22","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.jaci.2008.02.010","article-title":"Nasal challenge with allergen leads to maxillary sinus inflammation","volume":"121","author":"Baroody","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib23","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.jaci.2005.02.029","article-title":"Prostaglandin, leukotiene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis","volume":"115","author":"Perez-Novo","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1067\/mai.2001.113046","article-title":"Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways","volume":"107","author":"Braunstahl","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib25","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jaci.2003.08.009","article-title":"Features of airway remodeling eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma","volume":"112","author":"Ponikau","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib26","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/all.12440","article-title":"Association between group 2 innate lymphoid cells enrichment, nasal polyps and allergy in chronic rhinosinusitis","volume":"69","author":"Miljkovic","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2016.06.006_bib27","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/cea.12462","article-title":"Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia","volume":"45","author":"Ho","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2016.06.006_bib28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jaci.2011.07.056","article-title":"Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis","volume":"128","author":"Gevaert","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1001\/jama.2015.19330","article-title":"Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial","volume":"315","author":"Bachert","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.anai.2016.06.006_bib30","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jaci.2014.04.028","article-title":"Airway surface mycosis in chronic TH2-associated airway disease","volume":"134","author":"Porter","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib31","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1148\/radiology.207.2.9577490","article-title":"Allergic fungal sinusitis: CT findings","volume":"207","author":"Mukherji","year":"1998","journal-title":"Radiology"},{"key":"10.1016\/j.anai.2016.06.006_bib32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/014556139407300610","article-title":"Allergic fungal sinusitis with intracranial extension and frontal lobe symptoms: a case report","volume":"73","author":"Lydiatt","year":"1994","journal-title":"Ear Nose Throat J"},{"key":"10.1016\/j.anai.2016.06.006_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2500\/ajra.2015.29.4123","article-title":"Factors driving the aspirin exacerbated respiratory disease phenotype","volume":"29","author":"Steinke","year":"2015","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.anai.2016.06.006_bib34","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jaci.2014.08.020","article-title":"Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: a meta-analysis of the literature","volume":"135","author":"Rajan","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib35","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S1081-1206(10)61323-3","article-title":"Chronic hyperplastic eosiniphilic sinusistis as a predictor of aspirin-exacerbated respiratory disease","volume":"94","author":"Mascia","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib36","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1067\/mai.2002.122458","article-title":"Chronic sinusitis in severe asthma is related to sputum eosinophilia","volume":"109","author":"ten Brinke","year":"2002","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib37","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.jaci.2005.08.035","article-title":"Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma","volume":"116","author":"Mascia","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib38","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1164\/ajrccm.157.4.9707089","article-title":"Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics","volume":"157","author":"Dahlen","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2016.06.006_bib39","first-page":"194","article-title":"Is nasal polyposis in cystic fibrosis a direct manifestation of genetic mutation or a complication of chronic infection?","volume":"34","author":"De Gaudemar","year":"1996","journal-title":"Rhinology"},{"key":"10.1016\/j.anai.2016.06.006_bib40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1177\/000348941212100904","article-title":"Etiology of nasal polyps in cystic fibrosis: not a unimodal disease","volume":"121","author":"Payne","year":"2012","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"suppl 2","key":"10.1016\/j.anai.2016.06.006_bib41","first-page":"S15","article-title":"Subclassification of chronic rhinosinusitis","volume":"123","author":"Han","year":"2013","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anai.2016.06.006_bib42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S1081-1206(10)62612-9","article-title":"National guidelines needed to manage rhinitis and prevent complications","volume":"82","author":"Rachelefsky","year":"1999","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib43","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jaci.2005.05.017","article-title":"Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey","volume":"116","author":"Arbes","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jpeds.2007.03.001","article-title":"Aeroallergen sensitization in healthy children: racial and socioeconomic correlates","volume":"151","author":"Stevenson","year":"2007","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.anai.2016.06.006_bib45","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2500\/ajra.2014.28.4054","article-title":"Elevated total serum IgE in nonatopic patients with aspirin-exacerbated respiratory disease","volume":"284","author":"Johns","year":"2014","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.anai.2016.06.006_bib46","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jaci.2008.03.002","article-title":"Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps","volume":"121","author":"Kato","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib47","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1081-1206(10)62807-4","article-title":"Does inhaled pollen enter the sinus cavities?","volume":"81","author":"Adkins","year":"1998","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib48","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1086\/313661","article-title":"Nose blowing propels nasal fluid into the paranasal sinuses","volume":"30","author":"Gwaltney","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anai.2016.06.006_bib49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1081-1206(10)62529-X","article-title":"\u201cAllergic sinusitis\u201d revisited","volume":"85","author":"Slavin","year":"2000","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib50","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jaci.2010.03.041","article-title":"Acute exacerbations of chronic rhinosinusitis occur in a distinct seasonal pattern","volume":"126","author":"Rank","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib51","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S1081-1206(10)61435-4","article-title":"Effectiveness of immunotherapy for recurring sinusitis associated with allergic rhinitis as assessed by the Sinusitis Outcomes Questionnaire","volume":"92","author":"Nathan","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib52","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1001\/jama.2015.7544","article-title":"Medical therapies for adult chronic sinusitis: a systematic review","volume":"314","author":"Rudmik","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.anai.2016.06.006_bib53","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jaci.2012.07.047","article-title":"Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma","volume":"131","author":"Gevaert","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib54","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3109\/02770903.2012.757780","article-title":"Effects of omalizumab in non-atopic asthma: results from a Spanish multicenter registry","volume":"50","author":"de Llano","year":"2013","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.anai.2016.06.006_bib55","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jaip.2015.01.012","article-title":"Omalizumab in the treatment of aspirin-exacerbated respiratory disease","volume":"3","author":"Bergmann","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.anai.2016.06.006_bib56","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jaci.2004.08.012","article-title":"Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi","volume":"114","author":"Shin","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib57","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.jaci.2004.03.038","article-title":"Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial","volume":"113","author":"Weschta","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib58","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2500\/ajra.2015.29.4246","article-title":"Amphotericin B nasal irrigation as an adjuvant therapy after functional endoscopic sinus surgery","volume":"29","author":"Jiang","year":"2015","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.anai.2016.06.006_bib59","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jaci.2008.04.022","article-title":"Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3","volume":"122","author":"Kisich","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib60","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jaci.2004.07.013","article-title":"Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis","volume":"114","author":"Van Zele","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.06.006_bib61","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2500\/ajra.2011.25.3564","article-title":"Association of T cells and eosinophils with Staphylococcus aureus exotoxin A and toxic shock syndrome toxin 1 in nasal polyps","volume":"25","author":"Kim","year":"2011","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.anai.2016.06.006_bib62","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jaci.2011.08.037","article-title":"Evidence for intranasal anti-nuclear autoantibodies in chronic rhinosinusitis with nasal polyps","volume":"128","author":"Tan","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120616303180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120616303180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:15:47Z","timestamp":1761052547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120616303180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S1081120616303180"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2016.06.006","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic rhinosinusitis phenotypes","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2016.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}