{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:52:08Z","timestamp":1789869128600,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.anai.2016.07.032","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T15:13:21Z","timestamp":1472138001000},"page":"365-369.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of exhaled nitric oxide's ability to predict methacholine challenge in adults with nonobstructive spirometry"],"prefix":"10.1016","volume":"117","author":[{"given":"Andrew S.","family":"Nickels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiser G.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2016.07.032_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1183\/09031936.00202013","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2016.07.032_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.7326\/0003-4819-155-3-201108020-00008","article-title":"Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society","volume":"155","author":"Qaseem","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.anai.2016.07.032_bib3","first-page":"309","article-title":"Guidelines for methacholine and exercise challenge testing-1999","volume":"161","author":"Crapo","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"2 suppl","key":"10.1016\/j.anai.2016.07.032_bib4","doi-asserted-by":"crossref","first-page":"18S","DOI":"10.1378\/chest.10-0088","article-title":"Direct challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance","volume":"138","author":"Cockcroft","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.anai.2016.07.032_bib5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/rccm.9120-11ST","article-title":"An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications","volume":"184","author":"Dweik","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2016.07.032_bib6","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.4049\/jimmunol.164.11.5970","article-title":"Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis","volume":"164","author":"Guo","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.anai.2016.07.032_bib7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/thx.2003.014894","article-title":"Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath","volume":"59","author":"Lane","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.anai.2016.07.032_bib8","unstructured":"National Institute for Health and Care Excellence. Measuring fractional exhaled nitric oxide concentration in asthma: NIOX MINO, NIOX VERO and NObreath. April 2014. http:\/\/www.nice.org.uk\/guidance\/dg12. Accessed July 18,\u00a02016."},{"key":"10.1016\/j.anai.2016.07.032_bib9","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.rmed.2015.05.016","article-title":"Extended analysis of exhaled and nasal nitric oxide for the evaluation of chronic cough","volume":"109","author":"Maniscalco","year":"2015","journal-title":"Respir Med"},{"key":"10.1016\/j.anai.2016.07.032_bib10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1398-9995.2008.01855.x","article-title":"An economic evaluation of NIOX MINO airway inflammation monitor in the United Kingdom","volume":"64","author":"Price","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2016.07.032_bib11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.rmed.2013.02.018","article-title":"Exhaled nitric oxide to predict corticosteroid responsiveness and reduce asthma exacerbation rates","volume":"107","author":"Donohue","year":"2013","journal-title":"Respir Med"},{"key":"10.1016\/j.anai.2016.07.032_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/thx.53.2.91","article-title":"Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma","volume":"53","author":"Jatakanon","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.anai.2016.07.032_bib13","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1164\/ajrccm.164.5.2012125","article-title":"The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control","volume":"164","author":"Jones","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2016.07.032_bib14","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1034\/j.1399-3003.2000.15d11.x","article-title":"Effects of inhaled steroids on methacholine-induced bronchoconstriction and gas trapping in mild asthma","volume":"15","author":"Corsico","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2016.07.032_bib15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1046\/j.1440-1843.2003.00495.x","article-title":"Exhaled nitric oxide continues to reflect airway hyperresponsiveness and disease activity in inhaled corticosteroid-treated adult asthmatic patients","volume":"8","author":"Reid","year":"2003","journal-title":"Respirology"},{"issue":"2 suppl","key":"10.1016\/j.anai.2016.07.032_bib16","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1378\/chest.10-0231","article-title":"Bronchial hyperresponsiveness in the assessment of asthma control: Airway hyperresponsiveness in asthma: its measurement and clinical significance","volume":"138","author":"Brannan","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.anai.2016.07.032_bib17","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2016.07.032_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1378\/chest.82.1.15","article-title":"A\u00a0screening test for airways reactivity. An abbreviated methacholine inhalation challenge","volume":"82","author":"Chatham","year":"1982","journal-title":"Chest"},{"key":"10.1016\/j.anai.2016.07.032_bib19","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0140-6736(05)66422-7","article-title":"Refining clinical diagnosis with likelihood ratios","volume":"365","author":"Grimes","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.anai.2016.07.032_bib20","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3389\/fphys.2012.00460","article-title":"Airway hyperresponsiveness in asthma: mechanisms, clinical significance, and treatment","volume":"3","author":"Brannan","year":"2012","journal-title":"Front Physiol"},{"key":"10.1016\/j.anai.2016.07.032_bib21","doi-asserted-by":"crossref","first-page":"e90018","DOI":"10.1371\/journal.pone.0090018","article-title":"Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial iNOS","volume":"9","author":"Roos","year":"2014","journal-title":"PloS one"},{"key":"10.1016\/j.anai.2016.07.032_bib22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jaci.2012.02.025","article-title":"Methacholine challenge test: diagnostic characteristics in asthmatic patients receiving controller medications","volume":"130","author":"Sumino","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.07.032_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1378\/chest.104.1.149","article-title":"Diagnostic value of the bronchial provocation test with methacholine in asthma: a Bayesian analysis approach","volume":"104","author":"Perpina","year":"1993","journal-title":"Chest"},{"key":"10.1016\/j.anai.2016.07.032_bib24","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.4065\/82.11.1350","article-title":"Use of exhaled nitric oxide in predicting response to inhaled corticosteroids for chronic cough","volume":"82","author":"Hahn","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.anai.2016.07.032_bib25","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1164\/rccm.200411-1498OC","article-title":"Exhaled nitric oxide: a predictor of steroid response","volume":"172","author":"Smith","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anai.2016.07.032_bib26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1378\/chest.12-0416","article-title":"Normal values and thresholds for the clinical interpretation of exhaled nitric oxide levels in the US general population: results from the National Health and Nutrition Examination Survey 2007-2010","volume":"143","author":"See","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.anai.2016.07.032_bib27","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1378\/chest.06-1385","article-title":"Methacholine challenge testing: identifying its diagnostic role, testing, coding, and reimbursement","volume":"131","author":"Birnbaum","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.anai.2016.07.032_bib28","unstructured":"Center for Medicare and Medicaid Services. Physician Fee Schedule Search. http:\/\/www.cms.gov\/apps\/physician-fee-schedule\/search\/search-criteria.aspx. Accessed March 20,\u00a02016."},{"key":"10.1016\/j.anai.2016.07.032_bib29","series-title":"Uniform Reporting Manual for Respiratory Care","author":"American Association for Respiratory Care","year":"2012"},{"key":"10.1016\/j.anai.2016.07.032_bib30","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2500\/aap.2006.27.2903","article-title":"Assessment of mid flow rate measurements in patients undergoing methacholine challenge","volume":"27","author":"Simon","year":"2006","journal-title":"Allergy Proc"},{"key":"10.1016\/j.anai.2016.07.032_bib31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jaci.2010.05.016","article-title":"Forced expiratory flow between 25% and 75% of vital capacity and FEV1\/forced vital capacity ratio in relation to clinical and physiological parameters in asthmatic children with normal FEV1 values","volume":"126","author":"Simon","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2016.07.032_bib32","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0895-4356(96)00006-6","article-title":"Generalizability of clinical studies conducted at tertiary care medical centers: a population-based analysis","volume":"49","author":"Layde","year":"1996","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.anai.2016.07.032_bib33","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4065\/71.3.266","article-title":"History of the Rochester Epidemiology Project","volume":"71","author":"Melton","year":"1996","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.anai.2016.07.032_bib34","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/archinte.1965.03860160078013","article-title":"Methacholine aerosol as test for bronchial asthma","volume":"115","author":"Parker","year":"1965","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.anai.2016.07.032_bib35","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1378\/chest.111.4.866","article-title":"A\u00a0short protocol for methacholine provocation testing adapted to the Rosenthal-Chai dosimeter technique","volume":"111","author":"Jorres","year":"1997","journal-title":"Chest"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120616304756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120616304756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:15:24Z","timestamp":1761052524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120616304756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1081120616304756"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2016.07.032","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of exhaled nitric oxide's ability to predict methacholine challenge in adults with nonobstructive spirometry","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2016.07.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}