{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:04:55Z","timestamp":1774577095539,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.anai.2017.04.020","type":"journal-article","created":{"date-parts":[[2017,5,20]],"date-time":"2017-05-20T10:15:35Z","timestamp":1495275335000},"page":"83-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Frequency of untreated hypogammaglobulinemia in bronchiectasis"],"prefix":"10.1016","volume":"119","author":[{"given":"Melanie A.","family":"Ruffner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy R.","family":"Aksamit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron","family":"Thomashow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radmila","family":"Choate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"DiMango","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard M.","family":"Turino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth N.","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Fennelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles L.","family":"Daley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin L.","family":"Winthrop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Metersky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias A.","family":"Salathe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Leigh Anne","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peadar G.","family":"Noone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Tino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen E.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2017.04.020_bib1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1086\/587669","article-title":"Infections in 252 patients with common variable immunodeficiency","volume":"46","author":"Oksenhendler","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anai.2017.04.020_bib2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2017.04.020_bib3","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1182\/blood-2011-09-377945","article-title":"Morbidity and mortality in common variable immune deficiency over 4 decades","volume":"119","author":"Resnick","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.anai.2017.04.020_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1365-2249.2002.01974.x","article-title":"Humoral immunity and bronchiectasis","volume":"130","author":"Stead","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anai.2017.04.020_bib5","first-page":"69","article-title":"Evaluation of humoral immune function in patients with bronchiectasis","volume":"7","author":"Tabatabaie","year":"2008","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2017.04.020_bib6","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1183\/09031936.93.04080932","article-title":"Immunoglobulin G subclasses and spirometry in patients with chronic obstructive pulmonary disease","volume":"4","author":"O'Keeffe","year":"1991","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anai.2017.04.020_bib7","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1093\/ejcts\/ezt583","article-title":"Effect of hypogammaglobulinemia after lung transplantation: a single-institution study","volume":"45","author":"Ohsumi","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.anai.2017.04.020_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1056\/NEJM198001313020501","article-title":"Hypogammaglobulinemia in patients with cystic fibrosis","volume":"302","author":"Matthews","year":"1980","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.anai.2017.04.020_bib9","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.chest.2016.10.055","article-title":"Adult patients with bronchiectasis: a first look at the US Bronchiectasis Research Registry","volume":"151","author":"Aksamit","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.anai.2017.04.020_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12887-014-0299-y","article-title":"The etiologies of non-CF bronchiectasis in childhood: a systematic review of 989 subjects","volume":"14","author":"Brower","year":"2014","journal-title":"BMC Pediatr"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120617303368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120617303368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:18:23Z","timestamp":1761052703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120617303368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1081120617303368"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2017.04.020","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frequency of untreated hypogammaglobulinemia in bronchiectasis","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2017.04.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}