{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:01:41Z","timestamp":1790532101671,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.anai.2017.07.023","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:15:56Z","timestamp":1510704956000},"page":"429-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Decreased expression of indolamine 2,3-dioxygenase in childhood allergic asthma and its inverse correlation with fractional concentration of exhaled nitric oxide"],"prefix":"10.1016","volume":"119","author":[{"given":"Ying","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2017.07.023_bib1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000445500","article-title":"Tryptophan metabolism in allergic disorders","volume":"169","author":"Gostner","year":"2016","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.anai.2017.07.023_bib2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.humimm.2010.05.017","article-title":"Tryptophan metabolism in allergic rhinitis: the effect of pollen allergen exposure","volume":"71","author":"Ciprandi","year":"2010","journal-title":"Hum Immunol"},{"key":"10.1016\/j.anai.2017.07.023_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000128584","article-title":"High serum tryptophan concentration in pollinosis patients is associated with unresponsiveness to pollen extract therapy","volume":"147","author":"Kositz","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.anai.2017.07.023_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2500\/ajra.2015.29.4210","article-title":"Serum indolamine 2,3 dioxygenase as a marker in the evaluation of allergic rhinitis","volume":"29","author":"Refaat","year":"2015","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.anai.2017.07.023_bib5","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.molimm.2005.06.022","article-title":"Indoleamine 2,3-dioxygenase (IDO) activity is lower in atopic than in non-atopic individuals and is enhanced by environmental factors protecting from atopy","volume":"43","author":"Raitala","year":"2006","journal-title":"Mol Immunol"},{"key":"10.1016\/j.anai.2017.07.023_bib6","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1365-2222.2004.01984.x","article-title":"Asymptomatic atopy is associated with increased indoleamine 2,3-dioxygenase activity and interleukin-10 production during seasonal allergen exposure","volume":"34","author":"von Bubnoff","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2017.07.023_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jaci.2007.10.011","article-title":"Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids","volume":"121","author":"Maneechotesuwan","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2017.07.023_bib8","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1398-9995.2012.02830.x","article-title":"The indoleamine 2,3-dioxygenase (IDO) pathway controls allergy","volume":"67","author":"von Bubnoff","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2017.07.023_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.iac.2012.06.005","article-title":"Exhaled nitric oxide","volume":"32","author":"Stewart","year":"2012","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.anai.2017.07.023_bib10","doi-asserted-by":"crossref","first-page":"23778","DOI":"10.1074\/jbc.M700669200","article-title":"Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide","volume":"282","author":"Thomas","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.anai.2017.07.023_bib11","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1021\/bi060143j","article-title":"Interactions between nitric oxide and indoleamine 2,3-dioxygenase","volume":"45","author":"Samelson-Jones","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.anai.2017.07.023_bib12","first-page":"167","article-title":"Guidelines for the diagnosis and prevention of bronchial asthma in children (2016 edition)","volume":"54","year":"2016","journal-title":"Chin J Pediatr"},{"key":"10.1016\/j.anai.2017.07.023_bib13","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri1457","article-title":"IDO expression by dendritic cells: tolerance and tryptophan catabolism","volume":"4","author":"Mellor","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.anai.2017.07.023_bib14","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0091-6749(03)02014-1","article-title":"Indoleamine 2,3-dioxygenase\u2013expressing antigen-presenting cells and peripheral T-cell tolerance: another piece to the atopic puzzle?","volume":"112","author":"von Bubnoff","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2017.07.023_bib15","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jaci.2007.11.021","article-title":"Indoleamine 2,3-dioxygenase\u2013dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model","volume":"121","author":"Taher","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2017.07.023_bib16","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1073\/pnas.0708809105","article-title":"Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation","volume":"105","author":"Xu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.anai.2017.07.023_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2008.08.008","article-title":"IDO: A double-edged sword for T(H)1\/T(H)2 regulation","volume":"121","author":"Xu","year":"2008","journal-title":"Immunol Lett"},{"key":"10.1016\/j.anai.2017.07.023_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1165\/rcmb.2009-0167OC","article-title":"Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure","volume":"44","author":"Paveglio","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.anai.2017.07.023_bib19","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nri2163","article-title":"IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation","volume":"7","author":"Puccetti","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.anai.2017.07.023_bib20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jaci.2003.11.025","article-title":"Immunologic influences on allergy and the TH1\/TH2 balance","volume":"113","author":"Romagnani","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2017.07.023_bib21","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1136\/thoraxjnl-2013-203728","article-title":"Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design","volume":"68","author":"van der Sluijs","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.anai.2017.07.023_bib22","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1398-9995.2012.02862.x","article-title":"Tryptophan, neopterin, and nitrite in allergy","volume":"67","author":"Ciprandi","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2017.07.023_bib23","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.aller.2011.01.001","article-title":"Nitric oxide metabolites in allergic rhinitis: the effect of pollen allergen exposure","volume":"39","author":"Ciprandi","year":"2011","journal-title":"Allergol Immunopathol"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120617305902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120617305902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:17:56Z","timestamp":1761052676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120617305902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1081120617305902"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2017.07.023","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreased expression of indolamine 2,3-dioxygenase in childhood allergic asthma and its inverse correlation with fractional concentration of exhaled nitric oxide","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2017.07.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}