{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:00:42Z","timestamp":1774418442567,"version":"3.50.1"},"reference-count":88,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.anai.2018.09.459","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T20:20:37Z","timestamp":1537561237000},"page":"537-544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Penicillin minor determinants"],"prefix":"10.1016","volume":"121","author":[{"suffix":"Jr","given":"N. Franklin","family":"Adkinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis M.","family":"Mendelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Ressler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Keogh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2018.09.459_bib0001","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1084\/jem.114.6.875","article-title":"Studies on the mechanism of the formation of the penicillin antigen. III. The N-(D-alpha-benzylpenicilloyl) group as an antigenic determinant responsible for hypersensitivity to penicillin G","volume":"114","author":"Levine","year":"1961","journal-title":"J Exp Med"},{"key":"10.1016\/j.anai.2018.09.459_bib0002","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.115.4.789","article-title":"Polyfunctional dinitrophenyl haptens as reagents for elicitation of immediate type allergic skin responses","volume":"115","author":"Parker","year":"1962","journal-title":"J Exp Med"},{"key":"10.1016\/j.anai.2018.09.459_bib0003","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1084\/jem.115.4.821","article-title":"The preparation and some properties of penicillenic acid derivatives relevant to penicillin hypersensitivity","volume":"115","author":"Parker","year":"1962","journal-title":"J Exp Med"},{"key":"10.1016\/j.anai.2018.09.459_bib0004","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1084\/jem.115.4.821","article-title":"Hypersensitivity to penicillenic acid derivatives in human beings with penicillin allergy","volume":"115","author":"Parker","year":"1962","journal-title":"J Exp Med"},{"issue":"12","key":"10.1016\/j.anai.2018.09.459_bib0005","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1172\/JCI105494","article-title":"Penicillin allergy and the heterogeneous immune responses of man to benzylpenicillin","volume":"45","author":"Levine","year":"1966","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.anai.2018.09.459_bib0006","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1159\/000230197","article-title":"Minor haptenic determinant-specific reagins of penicillin hypersensitivity in man","volume":"35","author":"Levine","year":"1969","journal-title":"Int Arch Allergy Appl Immunol"},{"issue":"8","key":"10.1016\/j.anai.2018.09.459_bib0007","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1001\/jama.1964.03070080005001","article-title":"Penicilloyl-polylysine as an intradermal test of penicillin sensitivity","volume":"189","author":"Brown","year":"1964","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.anai.2018.09.459_bib0008","first-page":"203","article-title":"Evaluation of intradermal skin tests in penicillin hypersensitivity","volume":"190","author":"Budd","year":"1964","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.anai.2018.09.459_bib0009","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0091-6749(77)90064-1","article-title":"Evaluation of penicillin hypersensitivity: value of clinical history and skin testing with penicilloyl-polylysine and penicillin G. A cooperative prospective study of the penicillin study group of the American Academy of Allergy","volume":"60","author":"Green","year":"1977","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0010","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3949\/ccjm.70.4.313","article-title":"Penicillin allergy: consider trying penicillin again","volume":"70","author":"Arroliga","year":"2003","journal-title":"Cleve Clin J Med"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0011","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1081-1206(10)60882-4","article-title":"Penicillin skin testing in patients with a history of \u03b2-lactam allergy","volume":"98","author":"del Real","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"6","key":"10.1016\/j.anai.2018.09.459_bib0012","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jhm.2036","article-title":"The impact of penicillin skin testing on clinical practice and antimicrobial stewardship","volume":"8","author":"Rimawi","year":"2013","journal-title":"J Hosp Med"},{"issue":"3","key":"10.1016\/j.anai.2018.09.459_bib0013","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jaip.2016.09.045","article-title":"A proactive approach to penicillin allergy testing in hospitalized patients","volume":"5","author":"Chen","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"3","key":"10.1016\/j.anai.2018.09.459_bib0014","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jaip.2017.02.012","article-title":"The effect of penicillin allergy testing on future health care utilization: a matched cohort study","volume":"5","author":"Macy","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"9S","key":"10.1016\/j.anai.2018.09.459_bib0015","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1016\/j.arth.2017.01.012","article-title":"Screening for beta-lactam allergy in joint arthroplasty patients to improve surgical prophylaxis practice","volume":"32","author":"McDanel","year":"2017","journal-title":"J Arthroplasty"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0016","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jaip.2017.11.012","article-title":"Use of a penicillin allergy screening algorithm and penicillin skin testing for transitioning hospitalized patients to first-line antibiotic therapy","volume":"6","author":"Ramsey","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"8","key":"10.1016\/j.anai.2018.09.459_bib0017","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1080\/00325481.2017.1370360","article-title":"Proactive penicillin allergy testing in primary care patients labeled as allergic: outcomes and barriers","volume":"129","author":"Sundquist","year":"2017","journal-title":"Postgrad Med"},{"issue":"2","key":"10.1016\/j.anai.2018.09.459_bib0018","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-0471","article-title":"Allergy testing in children with low-risk penicillin allergy symptoms","volume":"140","author":"Vyles","year":"2017","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0019","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jaip.2017.06.014","article-title":"Risk of allergic reactions to recurrent intravenous penicillin administration in penicillin skin test negative patients","volume":"6","author":"Dorman","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"7","key":"10.1016\/j.anai.2018.09.459_bib0020","first-page":"787","article-title":"Diagnosis of penicillin allergy by skin testing: the Manitoba experience","volume":"118","author":"Warrington","year":"1978","journal-title":"Can Med Assoc J"},{"issue":"2","key":"10.1016\/j.anai.2018.09.459_bib0021","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0091-6749(82)90105-1","article-title":"Penicillin allergy: clinical experience with a battery of skin-test reagents","volume":"69","author":"Solley","year":"1982","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2018.09.459_bib0022","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1081-1206(10)62546-X","article-title":"Frequency of systematic reactions to penicillin skin tests","volume":"85","author":"Valyasevi","year":"2000","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"6","key":"10.1016\/j.anai.2018.09.459_bib0023","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S1081-1206(10)61016-2","article-title":"Clinical outcomes of penicillin skin testing","volume":"95","author":"Nadarajah","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2018.09.459_bib0024","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S1081-1206(10)61100-3","article-title":"Safety and effectiveness of a preoperative allergy clinic in decreasing vancomycin use in patients with a history of penicillin allergy","volume":"97","author":"Park","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2018.09.459_bib0025","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0025-7125(16)32617-7","article-title":"Penicillin skin test as predictive and diagnostic aids in penicillin allergy","volume":"54","author":"Van Dellen","year":"1970","journal-title":"Med Clin North Am"},{"issue":"3","key":"10.1016\/j.anai.2018.09.459_bib0026","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0091-6749(81)90180-9","article-title":"Skin testing to detect penicillin allergy","volume":"68","author":"Sullivan","year":"1981","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2018.09.459_bib0027","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1398-9995.1995.tb05066.x","article-title":"Evaluation of adverse cutaneous reactions to aminopenicillins with emphasis on those manifested by maculopapular rashes","volume":"50","author":"Romano","year":"1995","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.anai.2018.09.459_bib0028","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/adc.76.6.513","article-title":"Aminopenicillin allergy","volume":"76","author":"Romano","year":"1997","journal-title":"Arch Dis Child"},{"issue":"2","key":"10.1016\/j.anai.2018.09.459_bib0029","first-page":"157","article-title":"Routine use of skin testing for immediate penicillin allergy to 6,764 patients in an outpatient clinic","volume":"55","author":"Sarti","year":"1985","journal-title":"Ann Allergy"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0030","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0021-8707(69)90066-5","article-title":"Prediction of penicillin allergy by immunological tests","volume":"43","author":"Levine","year":"1969","journal-title":"J Allergy"},{"key":"10.1016\/j.anai.2018.09.459_bib0031","first-page":"311","article-title":"The value of skin testing for penicillin allergy diagnosis","volume":"144","author":"VanArsdel","year":"1986","journal-title":"West J Med"},{"key":"10.1016\/j.anai.2018.09.459_bib0032","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1001\/archinte.1992.00400170105020","article-title":"Results of the National Institute of Allergy and Infectious Diseases Collaborative Clinical Trial to test the predictive value of skin testing with major and minor penicillin derivatives in hospitalized adults","volume":"152","author":"Sogn","year":"1992","journal-title":"Arch Intern Med"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0033","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJM197107012850104","article-title":"Routine use of penicillin skin testing on an inpatient service","volume":"285","author":"Adkinson","year":"1971","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.anai.2018.09.459_bib0034","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/adc.55.11.857","article-title":"Penicillin allergy, anti-penicillin IgE antibodies and immediate hypersensitivity skin reactions employing major and minor determinants of penicillin","volume":"55","author":"Chandra","year":"1980","journal-title":"Arch Dis Child"},{"issue":"1 Pt 1","key":"10.1016\/j.anai.2018.09.459_bib0035","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0091-6749(84)90487-1","article-title":"Routine elective penicillin allergy skin testing in children and adolescents: study of sensitization","volume":"73","author":"Mendelson","year":"1984","journal-title":"J Allergy Clin Immunol"},{"issue":"20","key":"10.1016\/j.anai.2018.09.459_bib0036","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1001\/jama.1993.03510200062033","article-title":"Clinical experience with penicillin skin testing in a large inner-city STD clinic","volume":"270","author":"Gadde","year":"1993","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0037","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0022-3476(98)70499-8","article-title":"Diagnosis of penicillin, amoxicillin, and cephalosporin allergy: reliability of examination assessed by skin testing and oral challenge","volume":"132","author":"Pichichero","year":"1998","journal-title":"J Pediatr"},{"issue":"8","key":"10.1016\/j.anai.2018.09.459_bib0038","doi-asserted-by":"crossref","first-page":"701","DOI":"10.7205\/MILMED.170.8.701","article-title":"Penicillin skin testing: a 20-year study at the West Los Angeles Veterans Affairs Medical Center","volume":"170","author":"Klaustermeyer","year":"2005","journal-title":"Mil Med"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0039","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1610-0387.2007.06245.x","article-title":"PPL and MDM skin test: new test kit is helpful in detecting immediate-type allergy to beta-lactams","volume":"5","author":"Treudler","year":"2007","journal-title":"J Dtsch Dermatol Ges"},{"issue":"6","key":"10.1016\/j.anai.2018.09.459_bib0040","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0025-6196(11)60893-8","article-title":"Preoperative evaluation of patients with history of allergy to penicillin: comparison of 2 models of practice","volume":"83","author":"Frigas","year":"2008","journal-title":"Mayo Clin Proc"},{"issue":"5","key":"10.1016\/j.anai.2018.09.459_bib0041","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1445-5994.2008.01657.x","article-title":"Experience with a new commercial skin testing kit to identify IgE-mediated penicillin allergy","volume":"38","author":"Nolan","year":"2008","journal-title":"Intern Med J"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0042","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.annemergmed.2008.12.034","article-title":"The use of penicillin skin testing to assess the prevalence of penicillin allergy in an emergency department setting","volume":"54","author":"Raja","year":"2009","journal-title":"Ann Emerg Med"},{"issue":"5","key":"10.1016\/j.anai.2018.09.459_bib0043","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0091-6749(97)70159-3","article-title":"Skin testing with penicilloate and penilloate prepared by an improved method: amoxicillin oral challenge in patients with negative skin test responses to penicillin reagents","volume":"100","author":"Macy","year":"1997","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2018.09.459_bib0044","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.anai.2010.06.014","article-title":"Use of commercial anti-penicillin IgE fluorometric enzyme immunoassays to diagnose penicillin allergy","volume":"105","author":"Macy","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0045","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000288284","article-title":"Penicillin allergy: value of including amoxicillin as a determinant in penicillin skin testing","volume":"152","author":"Lin","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0046","first-page":"65","article-title":"Epidemiology of hypersensitivity reactions to penicillin in Slovenia","volume":"21","author":"Kopac","year":"2012","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"issue":"3","key":"10.1016\/j.anai.2018.09.459_bib0047","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.anai.2017.06.009","article-title":"Utility of minor determinants for skin testing in inpatient penicillin allergy evaluation","volume":"119","author":"Geng","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"5","key":"10.1016\/j.anai.2018.09.459_bib0048","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/1742-6723.12774","article-title":"De-labelling self-reported penicillin allergy within the emergency department through the use of skin tests and oral drug provocation testing","volume":"29","author":"Marwood","year":"2017","journal-title":"Emerg Med Australas"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0049","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jaip.2014.04.013","article-title":"Penicillin skin testing is a safe and effective tool for evaluating penicillin allergy in the pediatric population","volume":"2","author":"Fox","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"3","key":"10.1016\/j.anai.2018.09.459_bib0050","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/0091-6749(93)90188-L","article-title":"The frequency of skin test reactions to side-chain penicillin determinants","volume":"91","author":"Silviu-Dan","year":"1993","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"10.1016\/j.anai.2018.09.459_bib0051","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1034\/j.1398-9995.2001.00089.x","article-title":"Diagnostic evaluation of a large group of patients with immediate allergy to penicillins: the role of skin testing","volume":"56","author":"Torres","year":"2001","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0052","first-page":"257","article-title":"Assessment of a new brand of determinants for skin testing in a large group of patients with suspected beta-lactam allergy","volume":"17","author":"Matheu","year":"2007","journal-title":"J Invest Allergol Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0053","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1398-9995.2006.01272.x","article-title":"A comparison of the performance of two penicillin reagent kits in the diagnosis of beta-lactam hypersensitivity","volume":"62","author":"Romano","year":"2007","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.anai.2018.09.459_bib0054","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1398-9995.2008.01874.x","article-title":"Benzylpenicillin skin testing is still important in diagnosing immediate hypersensitivity reactions to penicillins","volume":"64","author":"Romano","year":"2009","journal-title":"Allergy"},{"issue":"9","key":"10.1016\/j.anai.2018.09.459_bib0055","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1398-9995.2009.02318.x","article-title":"The very limited usefulness of skin testing with penicilloyl-polylysine and the minor determinant mixture in evaluating nonimmediate reactions to penicillins","volume":"65","author":"Romano","year":"2010","journal-title":"Allergy"},{"issue":"11","key":"10.1016\/j.anai.2018.09.459_bib0056","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1136\/jcp.2010.088203","article-title":"Retrospective case series analysis of penicillin allergy testing in a UK specialist regional allergy clinic","volume":"64","author":"Richter","year":"2011","journal-title":"J Clin Pathol"},{"issue":"2","key":"10.1016\/j.anai.2018.09.459_bib0057","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5415\/apallergy.2014.4.2.106","article-title":"Penicillin allergy evaluation: experience from a drug allergy clinic in an Arabian Gulf Country, Kuwait","volume":"4","author":"Al-Ahmad","year":"2014","journal-title":"Asia Pac Allergy"},{"issue":"3","key":"10.1016\/j.anai.2018.09.459_bib0058","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jaip.2014.11.002","article-title":"Improving the effectiveness of penicillin allergy de-labeling","volume":"3","author":"Bourke","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.anai.2018.09.459_bib0059","series-title":"The Chemistry of Penicillin","author":"Clarke","year":"1949"},{"key":"10.1016\/j.anai.2018.09.459_bib0060","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0091-6749(99)70439-2","article-title":"Natural evolution of skin test sensitivity in patients allergic to beta-lactam antibiotics","volume":"103","author":"Blanca","year":"1999","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2018.09.459_bib0061","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1398-9995.1994.tb02275.x","article-title":"Immediate allergic reactions to amoxicillin","volume":"49","author":"Vega","year":"1994","journal-title":"Allergy"},{"key":"10.1016\/j.anai.2018.09.459_bib0062","series-title":"Allergology","first-page":"125","article-title":"Reaginic penicillin sensitivity","author":"Siegel","year":"1962"},{"key":"10.1016\/j.anai.2018.09.459_bib0063","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0021-8707(64)90080-2","article-title":"Antigenic specificities of skin-sensitizing antibodies in sera from patients with immediate systemic allergic reactions to penicillin","volume":"35","author":"Siegel","year":"1964","journal-title":"J Allergy"},{"issue":"5","key":"10.1016\/j.anai.2018.09.459_bib0064","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1365-2222.1990.tb03139.x","article-title":"Allergy to penicillin with good tolerance to other penicillins: study of the incidence in patients allergic to beta-lactams","volume":"20","author":"Blanca","year":"1990","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.anai.2018.09.459_bib0065","first-page":"542","article-title":"Studies on the immunological mechanisms of penicillin allergy, II: Antigenic specificities of allergic wheal-and-flare skin responses in patients with histories of penicillin allergy","volume":"7","author":"Levine","year":"1964","journal-title":"Immunology"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0066","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.anai.2010.08.002","article-title":"Drug allergy: an updated practice parameter","volume":"105","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"7","key":"10.1016\/j.anai.2018.09.459_bib0067","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1398-9995.1988.tb01628.x","article-title":"Anaphylaxis to amoxicillin but good tolerance for benzyl penicillin: in vivo and in vitro studies of specific IgE antibodies","volume":"43","author":"Blanca","year":"1988","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.anai.2018.09.459_bib0068","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1398-9995.1996.tb00146.x","article-title":"Clinical cross-reactivity between amoxicillin and cephadroxil in patients allergic to amoxicillin and with good tolerance of penicillin","volume":"51","author":"Sastre","year":"1996","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.anai.2018.09.459_bib0069","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1365-2125.1993.tb04157.x","article-title":"A population based case-cohort study of drug-induced anaphylaxis","volume":"35","author":"van der Klauw","year":"1993","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.anai.2018.09.459_bib0070","first-page":"264","article-title":"The time for penicillin skin testing is here","volume":"1","author":"Solensky","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2018.09.459_bib0071","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jaci.2014.08.045","article-title":"Patients with positive skin test results to penicillin should not undergo penicillin or amoxicillin challenge","volume":"135","author":"Park","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2018.09.459_bib0072","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1046\/j.1365-2222.2002.01296.x","article-title":"Controlled administration of penicillin to patients with a positive history but negative skin and specific serum IgE tests","volume":"32","author":"Torres","year":"2002","journal-title":"Clin Exp Allergy"},{"issue":"6","key":"10.1016\/j.anai.2018.09.459_bib0073","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1081-1206(10)60973-8","article-title":"Elective penicillin skin testing in a pediatric outpatient setting","volume":"97","author":"Jost","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"5","key":"10.1016\/j.anai.2018.09.459_bib0074","first-page":"157","article-title":"\u201cIn vivo\u201d and \u201cin vitro\u201d tests in the diagnosis of beta-lactams allergy","volume":"39","author":"Palma-Carlos","year":"2007","journal-title":"Eur Ann Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0075","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S1081-1206(10)60621-7","article-title":"Female sex as a risk factor for penicillin allergy","volume":"99","author":"Park","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0076","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1365-2222.2007.02867.x","article-title":"Oral challenges are needed in the diagnosis of beta-lactam hypersensitivity","volume":"38","author":"Bousquet","year":"2008","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0077","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1081-1206(10)60402-4","article-title":"Skin testing and oral penicillin challenge in patients with a history of remote penicillin allergy","volume":"100","author":"Goldberg","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.anai.2018.09.459_bib0078","first-page":"91","article-title":"Diagnosis of immediate-type beta-lactam allergy in vitro by flow-cytometric basophil activation test and sulfidoleukotriene production: A multicenter study","volume":"19","author":"De Weck","year":"2009","journal-title":"J Invest Allergol Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0079","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000319209","article-title":"Collaboration between allergists and pharmacists increases \u03b2-lactam antibiotic prescriptions in patients with a history of penicillin allergy","volume":"154","author":"Park","year":"2011","journal-title":"Int Arch Allergy Immunol"},{"issue":"3","key":"10.1016\/j.anai.2018.09.459_bib0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000328212","article-title":"Diagnosis of immediate hypersensitivity to \u03b2-lactam antibiotics can be made safely with current approaches","volume":"157","author":"Celik","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0081","first-page":"41","article-title":"Diagnosis of patients with immediate hypersensitivity to beta-lactams using retest","volume":"22","author":"Garc\u00eda N\u00fa\u00f1ez","year":"2012","journal-title":"J Invest Allergol Clin Immunol"},{"issue":"8","key":"10.1016\/j.anai.2018.09.459_bib0082","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/all.12195","article-title":"Diagnosis of penicillin allergy revisited: the value of case history, skin testing, specific IgE and prolonged challenge","volume":"68","author":"Hjortlund","year":"2013","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.anai.2018.09.459_bib0083","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5415\/apallergy.2013.3.2.115","article-title":"Utility of penicillin allergy testing in patients presenting with a history of penicillin allergy","volume":"3","author":"Sagar","year":"2013","journal-title":"Asia Pac Allergy"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0084","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000446961","article-title":"The importance of amoxicillin and amoxicillin-clavulanate determinants in the diagnosis of immediate allergic reactions to \u03b2-lactams","volume":"170","author":"Confino-Cohen","year":"2016","journal-title":"Int Arch Allergy Immunol"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1710-1492-11-1","article-title":"Amoxicillin rash in patients with infectious mononucleosis: evidence of true drug sensitization","volume":"11","author":"\u00d3nodi-Nagy","year":"2015","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0086","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.anai.2016.04.021","article-title":"Penicillin skin testing in hospitalized patients with \u03b2-lactam allergies: effect on antibiotic selection and cost","volume":"117","author":"King","year":"2016","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.anai.2018.09.459_bib0087","first-page":"27","article-title":"Drug allergy evaluation for betalactam hypersensitivity: cross-reactivity with cephalosporines, carbapenems and negative predictive value","volume":"36","author":"Al-Ahmad","year":"2018","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1016\/j.anai.2018.09.459_bib0088","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13223-016-0165-6","article-title":"Prevalence of beta-lactam allergy: a retrospective chart review of drug allergy assessment in a predominantly pediatric population","volume":"12","author":"Abrams","year":"2016","journal-title":"Allergy Asthma Clin Immunol"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120618312067?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120618312067?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:20:59Z","timestamp":1761052859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120618312067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":88,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S1081120618312067"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2018.09.459","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Penicillin minor determinants","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2018.09.459","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}