{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:40:29Z","timestamp":1788172829875,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.anai.2019.07.014","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T19:40:54Z","timestamp":1563910854000},"page":"454-460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":89,"title":["Autoimmunity in common variable immunodeficiency"],"prefix":"10.1016","volume":"123","author":[{"given":"Shradha","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cunningham-Rundles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2019.07.014_bib1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaip.2015.07.025","article-title":"International Consensus Document (ICON): Common variable immunodeficiency disorders","volume":"4","author":"Bonilla","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.anai.2019.07.014_bib2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s10875-017-0464-9","article-title":"International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity","volume":"38","author":"Picard","year":"2018","journal-title":"J\u00a0Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2019.07.014_bib3","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.jaip.2019.02.004","article-title":"The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity","volume":"7","author":"Seidel","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.anai.2019.07.014_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","article-title":"The EUROclass trial: defining subgroups in common variable immunodeficiency","volume":"111","author":"Wehr","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.anai.2019.07.014_bib5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/jmedgenet-2015-103690","article-title":"Genes associated with common variable immunodeficiency: one diagnosis to rule them all?","volume":"53","author":"Bogaert","year":"2016","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.anai.2019.07.014_bib6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3389\/fimmu.2016.00220","article-title":"Genetic diagnosis using whole exome sequencing in common variable immunodeficiency","volume":"7","author":"Maffucci","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib7","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3389\/fimmu.2018.00636","article-title":"Evaluating the genetics of common variable immunodeficiency: monogenetic model and beyond","volume":"9","author":"de Valles-Ibanez","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1182\/blood-2007-11-124545","article-title":"Common variable immunodeficiency disorders: division into distinct clinical phenotypes","volume":"112","author":"Chapel","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.anai.2019.07.014_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib10","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1182\/blood-2011-09-377945","article-title":"Morbidity and mortality in common variable immune deficiency over 4 decades","volume":"119","author":"Resnick","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.anai.2019.07.014_bib11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s13023-018-0941-0","article-title":"The burden of common variable immunodeficiency disorders: a retrospective analysis of the European Society for Immunodeficiency (ESID) registry data","volume":"13","author":"Odnoletkova","year":"2018","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.anai.2019.07.014_bib12","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2016.09.023","article-title":"Update on the use of immunoglobulin in human disease: a review of evidence","volume":"139","author":"Perez","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fimmu.2012.00210","article-title":"Pathogenesis of autoimmunity in common variable immunodeficiency","volume":"3","author":"Warnatz","year":"2012","journal-title":"Front Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jaut.2005.04.006","article-title":"Treatment and outcome of autoimmune hematologic disease in common variable immunodeficiency (CVID)","volume":"25","author":"Wang","year":"2005","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.anai.2019.07.014_bib15","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10875-017-0434-2","article-title":"Neutropenia in patients with common variable immunodeficiency: a rare event associated with severe outcome","volume":"37","author":"Guffroy","year":"2017","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s10875-017-0456-9","article-title":"Autoimmune cytopenias and associated conditions in CVID: a report from the USIDNET Registry","volume":"38","author":"Feuille","year":"2018","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaut.2010.10.002","article-title":"Autoimmunity in common variable immunodeficiency: correlation with lymphocyte phenotype in the French DEFI study","volume":"36","author":"Boileau","year":"2011","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.anai.2019.07.014_bib18","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.clim.2008.02.013","article-title":"Memory B cells in common variable immunodeficiency: clinical associations and sex differences","volume":"128","author":"Sanchez-Ramon","year":"2008","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib19","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3389\/fimmu.2018.01656","article-title":"Is it safe to switch from intravenous immunoglobulin to subcutaneous immunoglobulin in patients with common variable immunodeficiency and autoimmune thrombocytopenia?","volume":"9","author":"Scheuerlein","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib20","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s10875-016-0282-5","article-title":"Use of thrombopoietin-receptor agonist in CVID-associated immune thrombocytopenia","volume":"36","author":"Carrabba","year":"2016","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib21","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-2141.2011.08880.x","article-title":"Efficacy and safety of rituximab in common variable immunodeficiency-associated immune cytopenias: a retrospective multicentre study on 33 patients","volume":"155","author":"Gobert","year":"2011","journal-title":"Br J Haematol"},{"key":"10.1016\/j.anai.2019.07.014_bib22","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1182\/blood-2011-12-309153","article-title":"How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment","volume":"120","author":"Ghanima","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.anai.2019.07.014_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jaci.2004.05.057","article-title":"Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency","volume":"114","author":"Bates","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib24","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jaip.2015.07.004","article-title":"Progression of common variable immunodeficiency interstitial lung disease accompanies distinct pulmonary and laboratory findings","volume":"3","author":"Maglione","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.anai.2019.07.014_bib25","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.anai.2017.01.004","article-title":"Predictors of granulomatous lymphocytic interstitial lung disease in common variable immunodeficiency","volume":"118","author":"Hartono","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib26","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jaci.2013.08.022","article-title":"Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency","volume":"133","author":"Maglione","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib27","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.humpath.2015.05.011","article-title":"Granulomatous and lymphocytic interstitial lung disease: a spectrum of pulmonary histopathologic lesions in common variable immunodeficiency\u2014histologic and immunohistochemical analyses of 16 cases","volume":"46","author":"Rao","year":"2015","journal-title":"Hum Pathol"},{"key":"10.1016\/j.anai.2019.07.014_bib28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s10875-012-9755-3","article-title":"Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID)","volume":"33","author":"Chase","year":"2013","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib29","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.anai.2013.06.013","article-title":"Optimizing immunoglobulin treatment for patients with primary immunodeficiency disease to prevent pneumonia and infection incidence: review of the current data","volume":"111","author":"Ballow","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.clim.2010.06.012","article-title":"Impact of trough IgG on pneumonia incidence in primary immunodeficiency: a meta-analysis of clinical studies","volume":"137","author":"Orange","year":"2010","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2019.01.051","article-title":"Double-blind, placebo-controlled, randomized trial on low-dose azithromycin prophylaxis in patients with primary antibody deficiencies","author":"Milito","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib32","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.jaci.2010.02.040","article-title":"Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22 years","volume":"125","author":"Lucas","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.clim.2009.11.014","article-title":"Common variable immunodeficiency and granulomatosis treated with infliximab","volume":"134","author":"Malbran","year":"2010","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib34","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s10875-012-9778-9","article-title":"Granulomatous disease in CVID: retrospective analysis of clinical characteristics and treatment efficacy in a cohort of 59 patients","volume":"33","author":"Boursiquot","year":"2013","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib35","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1007\/s10875-014-0079-3","article-title":"Infliximab for treatment of granulomatous disease in patients with common variable immunodeficiency","volume":"34","author":"Franxman","year":"2014","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib36","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.cgh.2013.02.024","article-title":"Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency","volume":"11","author":"Agarwal","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.anai.2019.07.014_bib37","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1097\/PAS.0b013e3180cab60c","article-title":"Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review","volume":"31","author":"Daniels","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anai.2019.07.014_bib38","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1086\/587669","article-title":"Infections in 252 patients with common variable immunodeficiency","volume":"46","author":"Oksenhendler","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anai.2019.07.014_bib39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ibd.21376","article-title":"Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease","volume":"17","author":"Agarwal","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.anai.2019.07.014_bib40","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1572-0241.2007.01141.x","article-title":"Successful treatment of common variable immunodeficiency disorder-associated diarrhea with budesonide: a case report","volume":"102","author":"Elnachef","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.anai.2019.07.014_bib41","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jaci.2009.06.018","article-title":"Pathogenesis and treatment of gastrointestinal disease in antibody deficiency syndromes","volume":"124","author":"Agarwal","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11894-016-0491-3","article-title":"Gastrointestinal disorders associated with common variable immune deficiency (CVID) and chronic granulomatous disease (CGD)","volume":"18","author":"Uzzan","year":"2016","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.anai.2019.07.014_bib43","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ajg.2017.246","article-title":"Vedolizumab in patients with common variable immune deficiency and gut inflammation","volume":"112","author":"Boland","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.anai.2019.07.014_bib44","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s10875-013-9873-6","article-title":"Nodular regenerative hyperplasia in common variable immunodeficiency","volume":"33","author":"Fuss","year":"2013","journal-title":"J\u00a0Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2019.07.014_bib45","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.humpath.2008.09.008","article-title":"Hepatitis in common variable immunodeficiency","volume":"40","author":"Daniels","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1016\/j.anai.2019.07.014_bib46","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s12016-017-8638-z","article-title":"Common variable immunodeficiency and liver involvement","volume":"55","author":"Song","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib47","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.autrev.2014.04.006","article-title":"Common variable immunodeficiency and autoimmunity: an inconvenient truth","volume":"13","author":"Xiao","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.anai.2019.07.014_bib48","doi-asserted-by":"crossref","first-page":"541","DOI":"10.12659\/AOT.890952","article-title":"Liver transplantation in patients with common variable immunodeficiency: a report of two cases","volume":"19","author":"Montalti","year":"2014","journal-title":"Ann Transplant"},{"key":"10.1016\/j.anai.2019.07.014_bib49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/lt.24979","article-title":"Liver transplantation in adults with liver disease due to common variable immunodeficiency leads to early recurrent disease and poor outcome","volume":"24","author":"Azzu","year":"2018","journal-title":"Liver Transpl"},{"key":"10.1016\/j.anai.2019.07.014_bib50","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.semarthrit.2018.02.013","article-title":"Phenotypic characterization of patients with rheumatologic manifestations of common variable immunodeficiency","volume":"48","author":"Gutierrez","year":"2018","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.anai.2019.07.014_bib51","first-page":"323","article-title":"Autoimmune phenotype in patients with common variable immunodeficiency","volume":"23","author":"Abolhassani","year":"2013","journal-title":"J\u00a0Invest Allergol Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib52","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.aller.2013.01.007","article-title":"Clinical and immunological features of common variable immunodeficiency in Mexican patients","volume":"42","author":"Ramirez-Vargas","year":"2014","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.anai.2019.07.014_bib53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11882-016-0597-6","article-title":"Autoimmune and lymphoproliferative complications of common variable immunodeficiency","volume":"16","author":"Maglione","year":"2016","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.anai.2019.07.014_bib54","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1056\/NEJMoa1512234","article-title":"Loss of B cells in patients with heterozygous mutations in IKAROS","volume":"374","author":"Kuehn","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.anai.2019.07.014_bib55","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature20810","article-title":"Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis","volume":"542","author":"Rao","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.anai.2019.07.014_bib56","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.semarthrit.2006.09.005","article-title":"Common variable immunodeficiency in systemic lupus erythematosus","volume":"36","author":"Fernandez-Castro","year":"2007","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.anai.2019.07.014_bib57","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/bjd.17408","article-title":"Psoriasis in a cohort of patients with common variable immunodeficiency","volume":"180","author":"Megna","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.anai.2019.07.014_bib58","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/ced.12543","article-title":"Necrotizing and sarcoidal granulomas in the skin and synovial membrane, associated with common variable immunodeficiency","volume":"40","author":"Plana Pla","year":"2015","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.anai.2019.07.014_bib59","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/ACI.0000000000000218","article-title":"The autoimmune conundrum in common variable immunodeficiency disorders","volume":"15","author":"van de Ven","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib60","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1172\/JCI69854","article-title":"CVID-associated TACI mutations affect autoreactive B cell selection and activation","volume":"123","author":"Romberg","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.anai.2019.07.014_bib61","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaci.2018.06.012","article-title":"Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses","volume":"143","author":"Romberg","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib62","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122728","article-title":"BAFF-driven B cell hyperplasia underlies lung disease in common variable immunodeficiency","author":"Maglione","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.anai.2019.07.014_bib63","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2249.2006.03314.x","article-title":"Low numbers of regulatory T cells in common variable immunodeficiency: association with chronic inflammation in\u00a0vivo","volume":"147","author":"Fevang","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib64","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/ni902","article-title":"Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency","volume":"4","author":"Grimbacher","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib65","doi-asserted-by":"crossref","first-page":"13945","DOI":"10.1073\/pnas.0903543106","article-title":"B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans","volume":"106","author":"Warnatz","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.anai.2019.07.014_bib66","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jaci.2011.11.013","article-title":"CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia","volume":"129","author":"van Montfrans","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib67","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ng1601","article-title":"TACI is mutant in common variable immunodeficiency and IgA deficiency","volume":"37","author":"Castigli","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.anai.2019.07.014_bib68","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ng1600","article-title":"Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans","volume":"37","author":"Salzer","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.anai.2019.07.014_bib69","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1182\/blood-2008-02-141937","article-title":"Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes","volume":"113","author":"Salzer","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.anai.2019.07.014_bib70","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ajhg.2012.04.015","article-title":"Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity","volume":"90","author":"Lopez-Herrera","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.anai.2019.07.014_bib71","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/MIB.0000000000000266","article-title":"Atypical manifestation of LRBA deficiency with predominant IBD-like phenotype","volume":"21","author":"Serwas","year":"2015","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"10.1016\/j.anai.2019.07.014_bib72","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.jaci.2018.02.055","article-title":"Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects","volume":"142","author":"Schwab","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib73","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1126\/science.1243292","article-title":"Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage","volume":"342","author":"Angulo","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.anai.2019.07.014_bib74","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ni.2771","article-title":"Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110delta result in T cell senescence and human immunodeficiency","volume":"15","author":"Lucas","year":"2014","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.anai.2019.07.014_bib75","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.jaci.2018.01.039","article-title":"Loss-of-function nuclear factor kappaB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans","volume":"142","author":"Tuijnenburg","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2019.07.014_bib76","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.ajhg.2013.09.009","article-title":"Germline mutations in NFKB2 implicate the noncanonical NF-kappaB pathway in the pathogenesis of common variable immunodeficiency","volume":"93","author":"Chen","year":"2013","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.anai.2019.07.014_bib77","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s10875-007-9075-1","article-title":"Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency","volume":"27","author":"Quinti","year":"2007","journal-title":"J\u00a0Clin Immunol"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120619305320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120619305320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:23:13Z","timestamp":1761052993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120619305320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":77,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S1081120619305320"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2019.07.014","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoimmunity in common variable immunodeficiency","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2019.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}