{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:57:53Z","timestamp":1794002273166,"version":"4.8.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.anai.2019.12.001","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T04:54:57Z","timestamp":1575867297000},"page":"326-332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Biologics in chronic rhinosinusitis with nasal polyposis"],"prefix":"10.1016","volume":"124","author":[{"given":"Tanya M.","family":"Laidlaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Buchheit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2 Suppl","key":"10.1016\/j.anai.2019.12.001_bib1","first-page":"S1","article-title":"Clinical practice guideline (update): adult sinusitis","volume":"152","author":"Rosenfeld","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"10.1016\/j.anai.2019.12.001_bib2","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2500\/aap.2013.34.3675","article-title":"Chronic rhinosinusitis: epidemiology and cost","volume":"34","author":"Halawi","year":"2013","journal-title":"Allergy Asthma Proc"},{"issue":"1","key":"10.1016\/j.anai.2019.12.001_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"issue":"1","key":"10.1016\/j.anai.2019.12.001_bib4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0194-59989570152-4","article-title":"The health impact of chronic sinusitis in patients seeking otolaryngologic care","volume":"113","author":"Gliklich","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"10.1016\/j.anai.2019.12.001_bib5","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jaci.2014.08.020","article-title":"Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: a meta-analysis of the literature","volume":"135","author":"Rajan","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.anai.2019.12.001_bib6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/alr.22249","article-title":"Patterns of olfactory dysfunction in chronic rhinosinusitis identified by hierarchical cluster analysis and machine learning algorithms","volume":"9","author":"Morse","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"issue":"4","key":"10.1016\/j.anai.2019.12.001_bib7","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/alr.22264","article-title":"Long-term revision rates for endoscopic sinus surgery","volume":"9","author":"Smith","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"issue":"3","key":"10.1016\/j.anai.2019.12.001_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/000348941112000304","article-title":"Revision rates after endoscopic sinus surgery: a recurrence analysis","volume":"120","author":"Mendelsohn","year":"2011","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jaip.2015.03.001","article-title":"Survey-defined patient experiences with aspirin-exacerbated respiratory disease","volume":"3","author":"Ta","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib10","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.jaip.2018.11.017","article-title":"Accidental ingestion of aspirin and nonsteroidal anti-inflammatory drugs is common in patients with aspirin-exacerbated respiratory disease","volume":"7","author":"Kiladejo","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"11","key":"10.1016\/j.anai.2019.12.001_bib11","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1056\/NEJMra1712125","article-title":"Aspirin-exacerbated respiratory disease","volume":"379","author":"White","year":"2018","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.anai.2019.12.001_bib12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1067\/mai.2000.109269","article-title":"Chronic sinusitis","volume":"106","author":"Hamilos","year":"2000","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2019.12.001_bib13","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jaci.2015.10.011","article-title":"Drivers of chronic rhinosinusitis: Inflammation versus infection","volume":"136","author":"Hamilos","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2019.12.001_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11908-019-0658-9","volume":"21","author":"Hamilos","year":"2019","journal-title":"Curr Infect Dis Rep"},{"issue":"2","key":"10.1016\/j.anai.2019.12.001_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11908-019-0657-x","article-title":"Biofilm formations in pediatric respiratory tract infection part 2: mucosal biofilm formation by respiratory pathogens and current and future therapeutic strategies to inhibit biofilm formation or eradicate established biofilm","volume":"21","author":"Hamilos","year":"2019","journal-title":"Curr Infect Dis Rep"},{"issue":"3","key":"10.1016\/j.anai.2019.12.001_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000079994","article-title":"Evidence of bacterial biofilms in human chronic sinusitis","volume":"66","author":"Cryer","year":"2004","journal-title":"ORL J Otorhinolaryngol Rel Spec"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib17","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1177\/194589240501900506","article-title":"Demonstration of biofilm in human bacterial chronic rhinosinusitis","volume":"19","author":"Ferguson","year":"2005","journal-title":"Am J Rhinol"},{"issue":"1","key":"10.1016\/j.anai.2019.12.001_bib18","first-page":"3","article-title":"Biofilms and chronic rhinosinusitis: systematic review of evidence, current concepts and directions for research","volume":"45","author":"Harvey","year":"2007","journal-title":"Rhinology"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.otohns.2010.07.017","article-title":"Biofilm and persistent inflammation in endoscopic sinus surgery","volume":"143","author":"Hochstim","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"6","key":"10.1016\/j.anai.2019.12.001_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/194589240401800607","article-title":"Evidence of bacterial biofilms on frontal recess stents in patients with chronic rhinosinusitis","volume":"18","author":"Perloff","year":"2004","journal-title":"Am J Rhinol"},{"issue":"4","key":"10.1016\/j.anai.2019.12.001_bib21","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/01.mlg.0000161346.30752.18","article-title":"Bacterial biofilms in surgical specimens of patients with chronic rhinosinusitis","volume":"115","author":"Sanclement","year":"2005","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.anai.2019.12.001_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2500\/ajra.2010.24.3462","article-title":"The impact of biofilms on outcomes after endoscopic sinus surgery","volume":"24","author":"Singhal","year":"2010","journal-title":"Am J Rhinol Allergy"},{"issue":"8","key":"10.1016\/j.anai.2019.12.001_bib23","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/lary.21024","article-title":"Different biofilms, different disease? A clinical outcomes study","volume":"120","author":"Foreman","year":"2010","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.anai.2019.12.001_bib24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.anai.2016.06.006","article-title":"Chronic rhinosinusitis phenotypes","volume":"117","author":"Steinke","year":"2016","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.anai.2019.12.001_bib25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0030-6665(00)80018-3","article-title":"Geographic variation in allergic fungal rhinosinusitis","volume":"33","author":"Ferguson","year":"2000","journal-title":"Otolaryngol Clin North Am"},{"issue":"11","key":"10.1016\/j.anai.2019.12.001_bib26","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1398-9995.2006.01225.x","article-title":"Differentiation of chronic sinus diseases by measurement of inflammatory mediators","volume":"61","author":"Van Zele","year":"2006","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.anai.2019.12.001_bib27","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.anai.2017.05.019","article-title":"Distribution, subtype population, and IgE positivity of mast cells in chronic rhinosinusitis with nasal polyps","volume":"119","author":"Baba","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"6","key":"10.1016\/j.anai.2019.12.001_bib28","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/rccm.201412-2278OC","article-title":"Cytokines in chronic rhinosinusitis: role in eosinophilia and aspirin-exacerbated respiratory disease","volume":"192","author":"Stevens","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.anai.2019.12.001_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/iid3.161","article-title":"Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps","volume":"5","author":"Poposki","year":"2017","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.anai.2019.12.001_bib30","article-title":"IL-5R\u03b1 marks nasal polyp IgG4 and IgE-secreting cells in aspirin-exacerbated respiratory disease","author":"Buchheit","year":"2019","journal-title":"BioRxiv Preprint"},{"issue":"2","key":"10.1016\/j.anai.2019.12.001_bib31","doi-asserted-by":"crossref","first-page":"E61","DOI":"10.1002\/lary.27564","article-title":"Dexpramipexole depletes blood and tissue eosinophils in nasal polyps with no change in polyp size","volume":"129","author":"Laidlaw","year":"2019","journal-title":"Laryngoscope"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib32","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jaci.2011.07.056","article-title":"Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis","volume":"128","author":"Gevaert","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2019.12.001_bib33","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jaci.2011.08.037","article-title":"Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps","volume":"128","author":"Tan","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2019.12.001_bib34","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jaci.2013.01.043","article-title":"Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression","volume":"131","author":"Hulse","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2019.12.001_bib35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.4168\/aair.2015.7.4.321","article-title":"Local immunoglobulin e in the nasal mucosa: clinical implications","volume":"7","author":"De Schryver","year":"2015","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.anai.2019.12.001_bib36","article-title":"IgE plasma level in asthmatics with nasal polyps is independent of atopy","volume":"48","author":"Vizuete","year":"2016","journal-title":"Eur Respir J"},{"issue":"7720","key":"10.1016\/j.anai.2019.12.001_bib37","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41586-018-0449-8","article-title":"Allergic inflammatory memory in human respiratory epithelial progenitor cells","volume":"560","author":"Ordovas-Montanes","year":"2018","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.anai.2019.12.001_bib38","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1111\/all.13424","article-title":"Role of IL-13Ralpha2 in modulating IL-13-induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa","volume":"73","author":"Liu","year":"2018","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.anai.2019.12.001_bib39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/all.13489","article-title":"Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps","volume":"74","author":"Zhang","year":"2019","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib40","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/alr.21298","article-title":"Interleukin-4 and interleukin-13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression","volume":"4","author":"Wise","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"issue":"8","key":"10.1016\/j.anai.2019.12.001_bib41","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.4049\/jimmunol.1500905","article-title":"Aspirin-exacerbated respiratory disease involves a cysteinyl leukotriene-driven IL-33-mediated mast cell activation pathway","volume":"195","author":"Liu","year":"2015","journal-title":"J\u00a0Immunol"},{"issue":"7","key":"10.1016\/j.anai.2019.12.001_bib42","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/thoraxjnl-2016-208772","article-title":"The role of interleukin-33 in chronic rhinosinusitis","volume":"72","author":"Kim","year":"2017","journal-title":"Thorax"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib43","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.jaci.2015.10.020","article-title":"Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease","volume":"137","author":"Buchheit","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.anai.2019.12.001_bib44","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jaci.2013.04.005","article-title":"Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis","volume":"132","author":"Nagarkar","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2019.12.001_bib45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.alit.2014.12.006","article-title":"Immunopathology of chronic rhinosinusitis","volume":"64","author":"Kato","year":"2015","journal-title":"Allergol Int"},{"issue":"6","key":"10.1016\/j.anai.2019.12.001_bib46","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.jaci.2012.01.079","article-title":"Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy","volume":"129","author":"Wen","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib47","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1001\/jama.2015.19330","article-title":"Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial","volume":"315","author":"Bachert","year":"2016","journal-title":"JAMA"},{"issue":"10209","key":"10.1016\/j.anai.2019.12.001_bib48","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(19)31881-1","article-title":"Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials","volume":"394","author":"Bachert","year":"2019","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.anai.2019.12.001_bib49","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1016\/j.jaip.2019.03.044","article-title":"Dupilumab improves nasal polyp burden and asthma control in patients with CRSwNP and AERD","volume":"7","author":"Laidlaw","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"9","key":"10.1016\/j.anai.2019.12.001_bib50","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1136\/thx.2010.152835","article-title":"Efficacy of omalizumab in the treatment of nasal polyps","volume":"66","author":"Vennera Mdel","year":"2011","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.anai.2019.12.001_bib51","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jaci.2012.07.047","article-title":"Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma","volume":"131","author":"Gevaert","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib52","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.jaci.2015.09.034","article-title":"Omalizumab reduces cysteinyl leukotriene and 9alpha,11beta-prostaglandin F2 overproduction in aspirin-exacerbated respiratory disease","volume":"137","author":"Hayashi","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2019.12.001_bib53","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.anai.2018.05.007","article-title":"Omalizumab can inhibit respiratory reaction during aspirin desensitization","volume":"121","author":"Lang","year":"2018","journal-title":"Ann Allergy Asthma Immunology"},{"issue":"4","key":"10.1016\/j.anai.2019.12.001_bib54","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.jaci.2017.05.044","article-title":"Reduced need for surgery in severe nasal polyposis with mepolizumab: randomized trial","volume":"140","author":"Bachert","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.anai.2019.12.001_bib55","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jaip.2018.01.038","article-title":"A\u00a0retrospective analysis of mepolizumab in subjects with aspirin-exacerbated respiratory disease","volume":"6","author":"Tuttle","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib56","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jaci.2006.05.031","article-title":"Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps","volume":"118","author":"Gevaert","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"10056","key":"10.1016\/j.anai.2019.12.001_bib57","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(16)31324-1","article-title":"Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting beta2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial","volume":"388","author":"Bleecker","year":"2016","journal-title":"Lancet"},{"issue":"10056","key":"10.1016\/j.anai.2019.12.001_bib58","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/S0140-6736(16)31322-8","article-title":"Benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial","volume":"388","author":"FitzGerald","year":"2016","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.anai.2019.12.001_bib59","first-page":"AB12","article-title":"Clinical efficacy of benralizumab in patients with severe, uncontrolled eosinophilic asthma and nasal polyposis: pooled analysis of the SIROCCO and CALIMA trials","volume":"141","author":"Harrison","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2019.12.001_bib60","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.4049\/jimmunol.1000730","article-title":"IL-33 exacerbates eosinophil-mediated airway inflammation","volume":"185","author":"Stolarski","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.anai.2019.12.001_bib61","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cyto.2016.10.010","article-title":"Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells","volume":"90","author":"Ishinaga","year":"2017","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.anai.2019.12.001_bib62","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.jaci.2017.07.051","article-title":"Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity","volume":"141","author":"Werder","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2019.12.001_bib63","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.jaci.2018.08.051","article-title":"IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity","volume":"143","author":"Ravanetti","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2019.12.001_bib64","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1164\/rccm.201212-2227OC","article-title":"IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps","volume":"188","author":"Shaw","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.anai.2019.12.001_bib67","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.4049\/jimmunol.174.12.8183","article-title":"Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity","volume":"174","author":"Ying","year":"2005","journal-title":"J\u00a0Immunol"},{"issue":"22","key":"10.1016\/j.anai.2019.12.001_bib68","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1056\/NEJMoa1402895","article-title":"Effects of an anti-TSLP antibody on allergen-induced asthmatic responses","volume":"370","author":"Gauvreau","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"10","key":"10.1016\/j.anai.2019.12.001_bib69","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1056\/NEJMoa1704064","article-title":"Tezepelumab in adults with uncontrolled asthma","volume":"377","author":"Corren","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.anai.2019.12.001_bib70","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4168\/aair.2011.3.3.186","article-title":"Increased expression and role of thymic stromal lymphopoietin in nasal polyposis","volume":"3","author":"Kimura","year":"2011","journal-title":"Allergy Asthma Immunol Res"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120619314620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120619314620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:23:48Z","timestamp":1761053028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120619314620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1081120619314620"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2019.12.001","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biologics in chronic rhinosinusitis with nasal polyposis","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2019.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}