{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:25:18Z","timestamp":1793139918770,"version":"4.5.0"},"reference-count":97,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.anai.2020.07.007","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T12:38:09Z","timestamp":1594989489000},"page":"388-392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["The impact of psychological stress on mast cells"],"prefix":"10.1016","volume":"125","author":[{"given":"Theoharis C.","family":"Theoharides","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1-2","key":"10.1016\/j.anai.2020.07.007_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2003.10.041","article-title":"Critical role of mast cells in inflammatory diseases and the effect of acute stress","volume":"146","author":"Theoharides","year":"2004","journal-title":"J\u00a0Neuroimmunol"},{"issue":"5","key":"10.1016\/j.anai.2020.07.007_bib2","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.clinthera.2020.04.002","article-title":"Stress, inflammation, and autoimmunity: the 3 modern erinyes","volume":"42","author":"Theoharides","year":"2020","journal-title":"Clin Ther"},{"issue":"12","key":"10.1016\/j.anai.2020.07.007_bib3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/1744666X.2018.1536547","article-title":"Stress, mindfulness, and the allergic patient","volume":"14","author":"Marshall","year":"2018","journal-title":"Expert Rev Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/PSY.0b013e31815c1b71","article-title":"A\u00a0bidirectional relationship between psychosocial factors and atopic disorders: a systematic review and meta-analysis","volume":"70","author":"Chida","year":"2008","journal-title":"Psychosom Med"},{"issue":"4","key":"10.1016\/j.anai.2020.07.007_bib5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.anai.2013.07.018","article-title":"A\u00a0probable case report of stress-induced anaphylaxis","volume":"112","author":"Alevizos","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"4","key":"10.1016\/j.anai.2020.07.007_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2500\/108854100778248917","article-title":"Stress, immune regulation, and immunity: applications for asthma","volume":"21","author":"Marshall","year":"2000","journal-title":"Allergy Asthma Proc"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.anai.2012.03.003","article-title":"Contribution of stress to asthma worsening through mast cell activation","volume":"109","author":"Theoharides","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000363447","article-title":"Psychological stress and asthma: a new enemy within","volume":"164","author":"Vliagoftis","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"issue":"3","key":"10.1016\/j.anai.2020.07.007_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11154-016-9367-y","article-title":"Stress-related skin disorders","volume":"17","author":"Alexopoulos","year":"2016","journal-title":"Rev Endocr Metab Disord"},{"issue":"4","key":"10.1016\/j.anai.2020.07.007_bib10","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000084752","article-title":"Psychophysiological reactivity under mental stress in atopic dermatitis","volume":"210","author":"Seiffert","year":"2005","journal-title":"Dermatology"},{"issue":"3","key":"10.1016\/j.anai.2020.07.007_bib11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.autrev.2007.11.007","article-title":"Stress as a trigger of autoimmune disease","volume":"7","author":"Stojanovich","year":"2008","journal-title":"Autoimmun Rev"},{"issue":"10","key":"10.1016\/j.anai.2020.07.007_bib12","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.autrev.2013.02.006","article-title":"Effect of stress on brain inflammation and multiple sclerosis","volume":"12","author":"Karagkouni","year":"2013","journal-title":"Autoimmun Rev"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jaip.2013.09.004","article-title":"The Mastocytosis Society survey on mast cell disorders: patient experiences and perceptions","volume":"2","author":"Jennings","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"3","key":"10.1016\/j.anai.2020.07.007_bib14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.iac.2018.04.006","article-title":"Patient perceptions in mast cell disorders","volume":"38","author":"Jennings","year":"2018","journal-title":"Immunol Allergy Clin North Am"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1056\/NEJMra1409760","article-title":"Mast cells. mastocytosis, and related disorders","volume":"373","author":"Theoharides","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.anai.2020.07.007_bib16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/1744666X.2019.1596800","article-title":"Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?","volume":"15","author":"Theoharides","year":"2019","journal-title":"Expert Rev Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.mcna.2019.09.002","article-title":"Mast cell activation: when the whole is greater than the sum of its parts","volume":"104","author":"Khokhar","year":"2020","journal-title":"Med Clin North Am"},{"issue":"20","key":"10.1016\/j.anai.2020.07.007_bib18","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.anai.2020.07.007_bib19","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1111\/j.1365-2230.2008.03043.x","article-title":"Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1","volume":"34","author":"Theoharides","year":"2008","journal-title":"Clin Exp Dermatol"},{"issue":"5","key":"10.1016\/j.anai.2020.07.007_bib20","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.jaci.2014.05.023","article-title":"High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient","volume":"134","author":"Theoharides","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2020.07.007_bib21","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.jaci.2012.01.041","article-title":"Increased serum CRH levels with decreased skin CRHR-1 gene expression in psoriasis and atopic dermatitis","volume":"129","author":"Vasiadi","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"32","key":"10.1016\/j.anai.2020.07.007_bib22","doi-asserted-by":"crossref","first-page":"11408","DOI":"10.1073\/pnas.0504197102","article-title":"Identification of mast cell progenitors in adult mice","volume":"102","author":"Chen","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.immuni.2012.07.003","article-title":"Developmental origin and functional specialization of mast cell subsets","volume":"37","author":"Gurish","year":"2012","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.anai.2020.07.007_bib24","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ni.2109","article-title":"Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils","volume":"12","author":"Galli","year":"2011","journal-title":"Nat Immunol"},{"issue":"6","key":"10.1016\/j.anai.2020.07.007_bib25","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/exd.13008","article-title":"Skin mast cells: are we missing the forest for the trees?","volume":"25","author":"Theoharides","year":"2016","journal-title":"Exp Dermatol"},{"issue":"5","key":"10.1016\/j.anai.2020.07.007_bib26","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.clinthera.2016.03.036","article-title":"Danger signals and inflammation","volume":"38","author":"Theoharides","year":"2016","journal-title":"Clin Ther"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/imr.12629","article-title":"Non-IgE mediated mast cell activation","volume":"282","author":"Redegeld","year":"2018","journal-title":"Immunol Rev"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jaci.2018.01.034","article-title":"Mast cells signal their importance in health and disease","volume":"142","author":"Olivera","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2020.07.007_bib29","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nri2782","article-title":"Mast cell-orchestrated immunity to pathogens","volume":"10","author":"Abraham","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.anai.2020.07.007_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fimmu.2012.00146","article-title":"Role and relevance of mast cells in fungal infections","volume":"3","author":"Saluja","year":"2012","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.anai.2020.07.007_bib31","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.clinthera.2018.05.004","article-title":"Effects of mycotoxins on neuropsychiatric symptoms and immune processes","volume":"40","author":"Ratnaseelan","year":"2018","journal-title":"Clin Ther"},{"key":"10.1016\/j.anai.2020.07.007_bib32","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fimmu.2012.00238","article-title":"Novel identified receptors on mast cells","volume":"3","author":"Migalovich-Sheikhet","year":"2012","journal-title":"Front Immunol"},{"issue":"9","key":"10.1016\/j.anai.2020.07.007_bib33","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/exd.13288","article-title":"Neuroendocrinology of mast cells: challenges and controversies","volume":"26","author":"Theoharides","year":"2017","journal-title":"Exp Dermatol"},{"issue":"11","key":"10.1016\/j.anai.2020.07.007_bib34","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tips.2004.09.007","article-title":"Mast cells as targets of corticotropin-releasing factor and related peptides","volume":"25","author":"Theoharides","year":"2004","journal-title":"Trends Pharmacol Sci"},{"issue":"20","key":"10.1016\/j.anai.2020.07.007_bib35","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1073\/pnas.0602210103","article-title":"Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process","volume":"103","author":"Donelan","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10.1016\/j.anai.2020.07.007_bib36","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1073\/pnas.1000803107","article-title":"IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin","volume":"107","author":"Theoharides","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7542","key":"10.1016\/j.anai.2020.07.007_bib37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"Mcneil","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.anai.2020.07.007_bib38","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jaci.2014.07.036","article-title":"Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses","volume":"135","author":"Sumpter","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"7","key":"10.1016\/j.anai.2020.07.007_bib39","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri3690","article-title":"Mast cell secretory granules: armed for battle","volume":"14","author":"Wernersson","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.anai.2020.07.007_bib40","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-065X.2007.00512.x","article-title":"Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation","volume":"217","author":"Boyce","year":"2007","journal-title":"Immunol Rev"},{"issue":"3","key":"10.1016\/j.anai.2020.07.007_bib41","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.iac.2006.05.005","article-title":"Mast cell mediators in allergic inflammation and mastocytosis","volume":"26","author":"Castells","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"issue":"6","key":"10.1016\/j.anai.2020.07.007_bib42","first-page":"1355","article-title":"Stimulated mast cells release inflammatory cytokines: potential suppression and therapeutical aspects","volume":"32","author":"Varvara","year":"2018","journal-title":"J\u00a0Biol Regul Homeost Agents"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/imr.12634","article-title":"Mast cells as sources of cytokines, chemokines, and growth factors","volume":"282","author":"Mukai","year":"2018","journal-title":"Immunol Rev"},{"issue":"5863","key":"10.1016\/j.anai.2020.07.007_bib44","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/297229a0","article-title":"Differential release of serotonin and histamine from mast cells","volume":"297","author":"Theoharides","year":"1982","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.anai.2020.07.007_bib45","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.4049\/jimmunol.171.9.4830","article-title":"IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells","volume":"171","author":"Kandere-Grzybowska","year":"2003","journal-title":"J\u00a0Immunol"},{"issue":"12","key":"10.1016\/j.anai.2020.07.007_bib46","doi-asserted-by":"crossref","first-page":"7665","DOI":"10.4049\/jimmunol.174.12.7665","article-title":"Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor","volume":"174","author":"Cao","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.anai.2020.07.007_bib47","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-065X.2007.00519.x","article-title":"Differential release of mast cell mediators and the pathogenesis of inflammation","volume":"217","author":"Theoharides","year":"2007","journal-title":"Immunol Rev"},{"issue":"4","key":"10.1016\/j.anai.2020.07.007_bib48","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.4049\/jimmunol.1003383","article-title":"Mast cells as sensors of cell injury through IL-33 recognition","volume":"186","author":"Enoksson","year":"2011","journal-title":"J\u00a0Immunol"},{"issue":"20","key":"10.1016\/j.anai.2020.07.007_bib49","doi-asserted-by":"crossref","first-page":"E4002","DOI":"10.1073\/pnas.1524845114","article-title":"SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors","volume":"114","author":"Taracanova","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"40","key":"10.1016\/j.anai.2020.07.007_bib50","doi-asserted-by":"crossref","first-page":"E9381","DOI":"10.1073\/pnas.1810133115","article-title":"Substance P and IL-33 administered together stimulate a marked secretion of IL-1\u03b2 from human mast cells, inhibited by methoxyluteolin","volume":"115","author":"Taracanova","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib51","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2500\/aap.2018.38.4105","article-title":"Interleukin 33 and interleukin 4 regulate interleukin 31 gene expression and secretion from human laboratory of allergic diseases 2 mast cells stimulated by substance P and\/or immunoglobulin E","volume":"39","author":"Petra","year":"2018","journal-title":"Allergy Asthma Proc"},{"issue":"9","key":"10.1016\/j.anai.2020.07.007_bib52","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1002\/eji.201444546","article-title":"Mast cell activation: a complex interplay of positive and negative signaling pathways","volume":"44","author":"Sibilano","year":"2014","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib53","first-page":"1","article-title":"Interleukin-1 family cytokines and mast cells: activation and inhibition","volume":"33","author":"Gallenga","year":"2019","journal-title":"J\u00a0Biol Regul Homeost Agents"},{"issue":"9","key":"10.1016\/j.anai.2020.07.007_bib54","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1471-4906(02)02274-3","article-title":"Probing the roles of mast cells and basophils in natural and acquired immunity, physiology and disease","volume":"23","author":"Marone","year":"2002","journal-title":"Trends Immunol"},{"issue":"6","key":"10.1016\/j.anai.2020.07.007_bib55","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri2327","article-title":"Immunomodulatory mast cells: negative, as well as positive, regulators of immunity","volume":"8","author":"Galli","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.anai.2020.07.007_bib56","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/ACI.0b013e32832e9af1","article-title":"Mast cells: makers and breakers of allergic inflammation","volume":"9","author":"Hakim-Rad","year":"2009","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbadis.2010.12.014","article-title":"Mast cells and inflammation","volume":"1822","author":"Theoharides","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.it.2017.10.005","article-title":"Mast cells as drivers of disease and therapeutic targets","volume":"39","author":"Siebenhaar","year":"2018","journal-title":"Trends Immunol"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib59","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jaci.2016.01.020","article-title":"Prenatal maternal distress affects atopic dermatitis in offspring mediated by oxidative stress","volume":"138","author":"Chang","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/pai.12680","article-title":"Maternal prenatal stress and child atopic dermatitis up to age 2 years: the Ulm SPATZ Health Study","volume":"28","author":"Braig","year":"2017","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.anai.2020.07.007_bib61","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.psyneuen.2017.12.014","article-title":"Prenatal and early postnatal stress and later life inflammation","volume":"88","author":"Pedersen","year":"2018","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib62","first-page":"112","article-title":"Soluble cytokine receptors and receptor antagonists are sequentially released after trauma","volume":"39","author":"Cinat","year":"1995","journal-title":"J\u00a0Trauma"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib63","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0008-6363(03)00340-7","article-title":"Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in apolipoprotein E knockout mice","volume":"59","author":"Huang","year":"2003","journal-title":"Cardiovasc Res"},{"issue":"45","key":"10.1016\/j.anai.2020.07.007_bib64","doi-asserted-by":"crossref","first-page":"16136","DOI":"10.1073\/pnas.1415191111","article-title":"Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress","volume":"111","author":"Hodes","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10.1016\/j.anai.2020.07.007_bib65","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0024-3205(90)90129-F","article-title":"Mast cells: the immune gate to the brain","volume":"46","author":"Theoharides","year":"1990","journal-title":"Life Sci"},{"key":"10.1016\/j.anai.2020.07.007_bib66","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12974-015-0388-3","article-title":"Mast cells in meningiomas and brain inflammation","volume":"12","author":"Polyzoidis","year":"2015","journal-title":"J\u00a0Neuroinflammation"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib67","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0006-8993(03)02975-5","article-title":"Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice","volume":"980","author":"Kandere-Grzybowska","year":"2003","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib68","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1007074420772","article-title":"Inflammatory mediators and modulation of blood-brain barrier permeability","volume":"20","author":"Abbott","year":"2000","journal-title":"Cell Mol Neurobiol"},{"issue":"33","key":"10.1016\/j.anai.2020.07.007_bib69","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.2174\/138161211798220918","article-title":"Cytokine signaling modulates blood-brain barrier function","volume":"17","author":"Pan","year":"2011","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.anai.2020.07.007_bib70","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2741\/2174","article-title":"Corticotropin-releasing hormone and the blood-brain-barrier","volume":"12","author":"Theoharides","year":"2007","journal-title":"Front Biosci"},{"issue":"3","key":"10.1016\/j.anai.2020.07.007_bib71","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1124\/jpet.102.038497","article-title":"Corticotropin-releasing hormone and brain mast cells regulate blood-brain-barrier permeability induced by acute stress","volume":"303","author":"Esposito","year":"2002","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.anai.2020.07.007_bib72","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.brainres.2010.09.085","article-title":"Brain metastases of mouse mammary adenocarcinoma is increased by acute stress","volume":"1366","author":"Rozniecki","year":"2010","journal-title":"Brain Res"},{"issue":"1-2","key":"10.1016\/j.anai.2020.07.007_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(99)01855-7","article-title":"Morphological and functional demonstration of rat dura mast cell-neuron interactions in\u00a0vitro and in\u00a0vivo","volume":"849","author":"Rozniecki","year":"1999","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib74","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1084\/jem.194.1.71","article-title":"Brain mast cells act as an immune gate to the hypothalamic-pituitary-adrenal axis in dogs","volume":"194","author":"Matsumoto","year":"2001","journal-title":"J\u00a0Exp Med"},{"issue":"3","key":"10.1016\/j.anai.2020.07.007_bib75","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1081-1206(10)60717-X","article-title":"Nasal provocation of patients with allergic rhinitis and the hypothalamic-pituitary-adrenal axis","volume":"98","author":"Kalogeromitros","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"26","key":"10.1016\/j.anai.2020.07.007_bib76","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/S0024-3205(00)00899-7","article-title":"Studies on the involvement of histamine in the hypothalamic-pituitary-adrenal axis activation induced by nerve growth factor","volume":"67","author":"Scaccianoce","year":"2000","journal-title":"Life Sci"},{"issue":"6","key":"10.1016\/j.anai.2020.07.007_bib77","first-page":"1690","article-title":"Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans","volume":"77","author":"Mastorakos","year":"1993","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib78","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1210\/en.2003-0805","article-title":"Corticotropin-releasing hormone and its structurally related urocortin are synthesized and secreted by human mast cells","volume":"145","author":"Kempuraj","year":"2004","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.anai.2020.07.007_bib79","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/er.2012-1092","article-title":"Key role of CRF in the skin stress response system","volume":"34","author":"Slominski","year":"2013","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib80","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2133.2008.08958.x","article-title":"On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders","volume":"160","author":"Slominski","year":"2009","journal-title":"Br J Dermatol"},{"issue":"3","key":"10.1016\/j.anai.2020.07.007_bib81","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1600-0625.2006.00382.x","article-title":"The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease","volume":"15","author":"O\u2019Kane","year":"2006","journal-title":"Exp Dermatol"},{"issue":"10","key":"10.1016\/j.anai.2020.07.007_bib82","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1096\/fj.00-0850rev","article-title":"Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors","volume":"15","author":"Slominski","year":"2001","journal-title":"FASEB J"},{"issue":"11","key":"10.1016\/j.anai.2020.07.007_bib83","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1210\/jc.2003-030377","article-title":"Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways","volume":"88","author":"Crompton","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.anai.2020.07.007_bib84","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1210\/endo.139.1.5660","article-title":"Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its pro-inflammatory effects","volume":"139","author":"Theoharides","year":"1998","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.anai.2020.07.007_bib85","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1136\/gutjnl-2013-305690","article-title":"Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism","volume":"63","author":"Vanuytsel","year":"2014","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.anai.2020.07.007_bib86","doi-asserted-by":"crossref","first-page":"e48934","DOI":"10.1371\/journal.pone.0048934","article-title":"Neurotensin and CRH interactions augment human mast cell activation","volume":"7","author":"Alysandratos","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib87","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/jid.2011.334","article-title":"Substance P (SP) induces expression of functional corticotropin-releasing hormone receptor-1 (CRHR-1) in human mast cells","volume":"132","author":"Asadi","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"issue":"6","key":"10.1016\/j.anai.2020.07.007_bib88","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0940-2993(96)80075-3","article-title":"Imidazole fungicides provoke histamine release from mast cells and induce airway contraction","volume":"48","author":"Gietzen","year":"1996","journal-title":"Exp Toxicol Pathol"},{"issue":"3","key":"10.1016\/j.anai.2020.07.007_bib89","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.bbi.2010.11.008","article-title":"Effects of stressors and immune activating agents on peripheral and central cytokines in mouse strains that differ in stressor responsivity","volume":"25","author":"Gibb","year":"2011","journal-title":"Brain Behav Immun"},{"issue":"2","key":"10.1016\/j.anai.2020.07.007_bib90","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jaci.2013.07.040","article-title":"Circadian regulation of allergic reactions by the mast cell clock in mice","volume":"133","author":"Nakamura","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.anai.2020.07.007_bib91","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S0022-3565(24)38092-9","article-title":"Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors","volume":"288","author":"Singh","year":"1999","journal-title":"J\u00a0Pharmacol Exp Ther"},{"issue":"5","key":"10.1016\/j.anai.2020.07.007_bib92","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.jaci.2018.08.053","article-title":"Mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stress-induced intestinal permeability","volume":"143","author":"D\u2019Costa","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4426","key":"10.1016\/j.anai.2020.07.007_bib93","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.6153130","article-title":"Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein","volume":"207","author":"Theoharides","year":"1980","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.anai.2020.07.007_bib94","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/labinvest.2012.116","article-title":"Evidence questioning cromolyn\u2019s effectiveness and selectivity as a \u2018mast cell stabilizer\u2019 in mice","volume":"92","author":"Oka","year":"2012","journal-title":"Lab Invest"},{"issue":"3","key":"10.1016\/j.anai.2020.07.007_bib95","doi-asserted-by":"crossref","first-page":"e33805","DOI":"10.1371\/journal.pone.0033805","article-title":"Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans","volume":"7","author":"Weng","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.anai.2020.07.007_bib96","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.jaci.2014.10.032","article-title":"The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells","volume":"135","author":"Weng","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2020.07.007_bib97","first-page":"1345","article-title":"Stress, inflammation and natural treatments","volume":"32","author":"Theoharides","year":"2018","journal-title":"J\u00a0Biol Regul Homeost Agents"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120620304841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120620304841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:24:19Z","timestamp":1761053059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120620304841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":97,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1081120620304841"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2020.07.007","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of psychological stress on mast cells","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2020.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}