{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:01:17Z","timestamp":1791478877900,"version":"4.3.4"},"reference-count":19,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma &amp; Immunology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.anai.2021.01.016","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T01:55:27Z","timestamp":1610934927000},"page":"655-660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"title":["Hereditary alpha-tryptasemia in 101 patients with mast cell activation\u2013related symptomatology including anaphylaxis"],"prefix":"10.1016","volume":"126","author":[{"given":"Matthew P.","family":"Giannetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Bormans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Castells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.anai.2021.01.016_bib1","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/ng.3696","article-title":"Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number","volume":"48","author":"Lyons","year":"2016","journal-title":"Nat Genet"},{"issue":"10","key":"10.1016\/j.anai.2021.01.016_bib2","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.jaip.2020.05.057","article-title":"Hereditary alpha-tryptasemia: UK prevalence and variability in disease expression","volume":"8","author":"Robey","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"6","key":"10.1016\/j.anai.2021.01.016_bib3","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.aller.2014.05.002","article-title":"Clinical characteristics and risk profile of patients with elevated baseline serum tryptase","volume":"42","author":"Fellinger","year":"2014","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.anai.2021.01.016_bib4","doi-asserted-by":"crossref","unstructured":"Greiner G, Sprinzl B, G\u00f3rska A, et\u00a0al. Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis [e-pub ahead of print]. Blood. https:\/\/doi.org\/10.1182\/blood.2020006157, accessed October 1, 2020.","DOI":"10.1182\/blood.2020006157"},{"key":"10.1016\/j.anai.2021.01.016_bib5","doi-asserted-by":"crossref","unstructured":"Lyons JJ, Chovanec J, O\u2019Connell MP, et\u00a0al. Heritable risk for severe anaphylaxis associated with increased \u03b1-tryptase-encoding germline copy number at TPSAB1 [e-pub ahead of print]. J Allergy Clin Immunol https:\/\/doi.org\/10.1016\/j.jaci.2020.06.035, accessed October 1, 2020.","DOI":"10.1016\/j.jaci.2020.06.035"},{"issue":"7","key":"10.1016\/j.anai.2021.01.016_bib6","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.4049\/jimmunol.138.7.2184","article-title":"Evaluation of human peripheral blood leukocytes for mast cell tryptase","volume":"138","author":"Castells","year":"1987","journal-title":"J\u00a0Immunol"},{"issue":"6","key":"10.1016\/j.anai.2021.01.016_bib7","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.jaci.2006.02.026","article-title":"Tryptase genetics and anaphylaxis","volume":"117","author":"Caughey","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2021.01.016_bib8","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1074\/jbc.274.6.3355","article-title":"Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3","volume":"274","author":"Pallaoro","year":"1999","journal-title":"J\u00a0Biol Chem"},{"issue":"5","key":"10.1016\/j.anai.2021.01.016_bib9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jaci.2009.07.026","article-title":"Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations","volume":"124","author":"Trivedi","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.anai.2021.01.016_bib10","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.jaci.2013.11.039","article-title":"Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities","volume":"133","author":"Lyons","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.anai.2021.01.016_bib11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jaci.2011.04.037","article-title":"Mast cell activation syndrome: a newly recognized disorder with systemic clinical manifestations","volume":"128","author":"Hamilton","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.anai.2021.01.016_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1056\/NEJMra1409760","article-title":"Mast cells, mastocytosis, and related disorders","volume":"373","author":"Theoharides","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.anai.2021.01.016_bib13","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jaip.2019.01.006","article-title":"Proposed diagnostic algorithm for patients with suspected mast cell activation syndrome","volume":"7","author":"Valent","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"11","key":"10.1016\/j.anai.2021.01.016_bib14","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1182\/blood-2016-09-731893","article-title":"Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts","volume":"129","author":"Valent","year":"2017","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.anai.2021.01.016_bib15","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.4049\/jimmunol.138.8.2611","article-title":"Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells","volume":"138","author":"Schwartz","year":"1987","journal-title":"J\u00a0Immunol"},{"issue":"5","key":"10.1016\/j.anai.2021.01.016_bib16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.anai.2015.07.019","article-title":"Anaphylaxis\u2013a practice parameter update 2015","volume":"115","author":"Lieberman","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"4","key":"10.1016\/j.anai.2021.01.016_bib17","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jaip.2019.10.048","article-title":"Idiopathic anaphylaxis: a form of mast cell activation syndrome","volume":"8","author":"Giannetti","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.anai.2021.01.016_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.anai.2019.09.026","article-title":"Clinical response to omalizumab in patients with hereditary \u03b1-tryptasemia","volume":"124","author":"Mendoza Alvarez","year":"2020","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.anai.2021.01.016_bib19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jaci.2009.03.050","article-title":"Anaphylaxis in the community: learning from the survivors","volume":"124","author":"Simons","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["Annals of Allergy, Asthma &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120621000247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120621000247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:26:36Z","timestamp":1761053196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120621000247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S1081120621000247"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2021.01.016","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hereditary alpha-tryptasemia in 101 patients with mast cell activation\u2013related symptomatology including anaphylaxis","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2021.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}