{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:52:59Z","timestamp":1773978779168,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring LLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.anai.2021.07.015","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T05:55:10Z","timestamp":1626760510000},"page":"89-94.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Demographic and clinical characteristics of patients with hereditary angioedema in Canada"],"prefix":"10.1016","volume":"128","author":[{"given":"Erika Yue","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Caballero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"McCusker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Kanani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Lacuesta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rozita","family":"Borici-Mazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Waserman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Betschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anai.2021.07.015_bib0001","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13223-016-0176-3","article-title":"Hereditary angioedema: health-related quality of life in Canadian patients as measured by the SF-36","volume":"13","author":"Jindal","year":"2017","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"6","key":"10.1016\/j.anai.2021.07.015_bib0002","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2340\/00015555-2014","article-title":"Burden of illness in hereditary angioedema: a conceptual model","volume":"95","author":"Bygum","year":"2015","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"10.1016\/j.anai.2021.07.015_bib0003","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2500\/aap.2013.34.3685","article-title":"The humanistic burden of hereditary angioedema: results from the Burden of Illness Study in Europe","volume":"35","author":"Caballero","year":"2014","journal-title":"Allergy and Asthma Proceedings"},{"issue":"4","key":"10.1016\/j.anai.2021.07.015_bib0004","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.anai.2021.01.002","article-title":"Quality of life in patients with hereditary angioedema in Canada","volume":"126","author":"Lee","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"5","key":"10.1016\/j.anai.2021.07.015_bib0005","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2500\/aap.2010.31.3394","article-title":"The humanistic burden of hereditary angioedema: impact on health-related quality of life, productivity, and depression","volume":"31","author":"Lumry","year":"2010","journal-title":"Allergy Asthma Proc"},{"issue":"4","key":"10.1016\/j.anai.2021.07.015_bib0006","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.anai.2016.08.014","article-title":"Misdiagnosis trends in patients with hereditary angioedema from the real-world clinical setting","volume":"117","author":"Zanichelli","year":"2016","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"10.1016\/j.anai.2021.07.015_bib0007","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.amjmed.2005.09.064","article-title":"Hereditary angioedema: new findings concerning symptoms, affected organs, and course","volume":"119","author":"Bork","year":"2006","journal-title":"Am J Med"},{"issue":"5","key":"10.1016\/j.anai.2021.07.015_bib0008","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1365-2133.2009.09366.x","article-title":"Hereditary angio-oedema in Denmark: a nationwide survey","volume":"161","author":"Bygum","year":"2009","journal-title":"Br J Dermatol"},{"issue":"6","key":"10.1016\/j.anai.2021.07.015_bib0009","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.anai.2020.02.018","article-title":"Patient-reported burden of hereditary angioedema: findings from a patient survey in the United States","volume":"124","author":"Banerji","year":"2020","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"7","key":"10.1016\/j.anai.2021.07.015_bib0010","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1111\/jdv.14251","article-title":"The Icatibant Outcome Survey: experience of hereditary angioedema management from six European countries","volume":"31","author":"Caballero","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"10.1016\/j.anai.2021.07.015_bib0011","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s13023-019-1159-5","article-title":"Health-related quality of life and its risk factors in Chinese hereditary angioedema patients","volume":"14","author":"Liu","year":"2019","journal-title":"Orphanet J Rare Dis"},{"issue":"2","key":"10.1016\/j.anai.2021.07.015_bib0012","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.alit.2020.09.008","article-title":"The diagnosis and treatment of hereditary angioedema patients in Japan: a patient reported outcome survey","volume":"70","author":"Iwamoto","year":"2021","journal-title":"Allergol Int"},{"issue":"4","key":"10.1016\/j.anai.2021.07.015_bib0013","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/cea.12080","article-title":"Update on treatment of hereditary angioedema","volume":"43","author":"Xu","year":"2013","journal-title":"Clin Exp Allergy"},{"issue":"10","key":"10.1016\/j.anai.2021.07.015_bib0014","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMcp0803977","article-title":"Clinical practice. Hereditary angioedema","volume":"359","author":"Zuraw","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.anai.2021.07.015_bib0015","unstructured":"Canadian Blood Services. Fighting inflammation with inflammation. Available at:https:\/\/www.blood.ca\/en\/hospital-services\/transfusion-practice\/research-units\/fighting-inflammation-inflammation. Accessed March 12, 2021."},{"key":"10.1016\/j.anai.2021.07.015_bib0016","unstructured":"Johns Hopkins Medicine Pathology. Prevalence of autoimmune diseases. Available at: https:\/\/pathology.jhu.edu\/autoimmune\/prevalence. Accessed February 5, 2021."},{"issue":"5","key":"10.1016\/j.anai.2021.07.015_bib0017","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/0091-6749(86)90425-2","article-title":"Immunoregulatory disorders associated with hereditary angioedema. II. Serologic and cellular abnormalities","volume":"77","author":"Brickman","year":"1986","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anai.2021.07.015_bib0018","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13223-020-00437-x","article-title":"Co-occurrence between C1 esterase inhibitor deficiency and autoimmune disease: a systematic literature review","volume":"16","author":"Levy","year":"2020","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"4","key":"10.1016\/j.anai.2021.07.015_bib0019","first-page":"416","article-title":"Hereditary angioedema in Austria: prevalence and regional peculiarities","volume":"17","author":"Sch\u00f6ffl","year":"2019","journal-title":"J Dtsch Dermatol Ges"},{"issue":"3","key":"10.1016\/j.anai.2021.07.015_bib0020","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jaip.2014.11.012","article-title":"Clinical features of pediatric hereditary angioedema","volume":"3","author":"Nanda","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"8","key":"10.1016\/j.anai.2021.07.015_bib0021","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1111\/all.13384","article-title":"The international WAO\/EAACI guideline for the management of hereditary angioedema\u2014the 2017 revision and update","volume":"73","author":"Maurer","year":"2018","journal-title":"Allergy"},{"issue":"12","key":"10.1016\/j.anai.2021.07.015_bib0022","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1111\/all.12032","article-title":"Short-term prophylaxis in hereditary angioedema due to deficiency of the C1-inhibitor\u2014a long-term survey","volume":"67","author":"Farkas","year":"2012","journal-title":"Allergy"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120621005147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120621005147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:28:28Z","timestamp":1761053308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120621005147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1081120621005147"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2021.07.015","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Demographic and clinical characteristics of patients with hereditary angioedema in Canada","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2021.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}