{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:49:20Z","timestamp":1775857760303,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annallergy.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Allergy, Asthma & Immunology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.anai.2021.07.023","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T01:31:27Z","timestamp":1627867887000},"page":"682-688.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors associated with intubation and readmissions in patients with angioedema: A single-center experience al. \/ Ann Allergy Asthma Immunol 127 (2021) xxx\u2013xxx\"?>"],"prefix":"10.1016","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5688-9692","authenticated-orcid":false,"given":"Jose Manuel","family":"Martinez Manzano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin Bryan","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone A.","family":"Jarrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Quintero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zurab","family":"Azmaiparashvili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Eiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Patarroyo-Aponte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.anai.2021.07.023_bib0001","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.iac.2013.09.004","article-title":"Angioedema","volume":"34","author":"Bork","year":"2014","journal-title":"Immunol Allergy Clin North Am"},{"issue":"2","key":"10.1016\/j.anai.2021.07.023_bib0002","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2500\/aap.2013.34.3640","article-title":"National estimates of emergency department visits for angioedema and allergic reactions in the United States","volume":"34","author":"Kelly","year":"2013","journal-title":"Allergy Asthma Proc"},{"issue":"6","key":"10.1016\/j.anai.2021.07.023_bib0003","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.jaci.2015.07.041","article-title":"Deficiency of plasminogen activator inhibitor 2 in plasma of patients with hereditary angioedema with normal C1 inhibitor levels","volume":"137","author":"Joseph","year":"2016","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"10.1016\/j.anai.2021.07.023_bib0004","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMcp0803977","article-title":"Clinical practice. Hereditary angioedema","volume":"359","author":"Zuraw","year":"2008","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.anai.2021.07.023_bib0005","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jaip.2013.07.005","article-title":"ACE inhibitor-induced angioedema","volume":"1","author":"Baram","year":"2013","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"8","key":"10.1016\/j.anai.2021.07.023_bib0006","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1056\/NEJM200208223470820","article-title":"Bradykinin-mediated angioedema","volume":"347","author":"Nussberger","year":"2002","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.anai.2021.07.023_bib0007","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.iac.2017.03.001","article-title":"Histaminergic angioedema","volume":"37","author":"Busse","year":"2017","journal-title":"Immunol Allergy Clin North Am"},{"issue":"4","key":"10.1016\/j.anai.2021.07.023_bib0008","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/acem.12341","article-title":"A consensus parameter for the evaluation and management of angioedema in the emergency department","volume":"21","author":"Moellman","year":"2014","journal-title":"Acad Emerg Med"},{"issue":"6","key":"10.1016\/j.anai.2021.07.023_bib0009","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa0805538","article-title":"Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema","volume":"363","author":"Zuraw","year":"2010","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.anai.2021.07.023_bib0010","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJMoa0906393","article-title":"Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema","volume":"363","author":"Cicardi","year":"2010","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.anai.2021.07.023_bib0011","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa0905079","article-title":"Ecallantide for the treatment of acute attacks in hereditary angioedema","volume":"363","author":"Cicardi","year":"2010","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.anai.2021.07.023_bib0012","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jemermed.2017.05.037","article-title":"Novel therapies for angiotensin-converting enzyme inhibitor-induced angioedema: a systematic review of current evidence","volume":"53","author":"Riha","year":"2017","journal-title":"J Emerg Med"},{"issue":"14","key":"10.1016\/j.anai.2021.07.023_bib0013","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1001\/archinte.165.14.1637","article-title":"Incidence and characteristics of angioedema associated with enalapril","volume":"165","author":"Kostis","year":"2005","journal-title":"Arch Intern Med"},{"issue":"4","key":"10.1016\/j.anai.2021.07.023_bib0014","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1081-1206(10)60594-7","article-title":"Multicenter study of patients with angiotensin-converting enzyme inhibitor-induced angioedema who present to the emergency department","volume":"100","author":"Banerji","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.anai.2021.07.023_bib0015","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2500\/ajra.2014.28.3989","article-title":"Life-threatening angioedema induced by angiotensin-converting enzyme inhibitors: characteristics and risk factors","volume":"28","author":"Stauber","year":"2014","journal-title":"Am J Rhinol Allergy"},{"issue":"1","key":"10.1016\/j.anai.2021.07.023_bib0016","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0009-9236(96)90161-7","article-title":"Black Americans have an increased rate of angiotensin converting enzyme inhibitor-associated angioedema","volume":"60","author":"Brown","year":"1996","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.anai.2021.07.023_bib0017","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1081-1206(10)61206-9","article-title":"Pattern of hospitalizations for angioedema in New York between 1990 and 2003","volume":"95","author":"Lin","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"7","key":"10.1016\/j.anai.2021.07.023_bib0018","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/all.12313","article-title":"The EAACI\/GA(2) LEN\/EDF\/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update","volume":"69","author":"Zuberbier","year":"2014","journal-title":"Allergy"},{"issue":"8","key":"10.1016\/j.anai.2021.07.023_bib0019","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1111\/all.13384","article-title":"The international WAO\/EAACI guideline for the management of hereditary angioedema-the 2017 revision and update","volume":"73","author":"Maurer","year":"2018","journal-title":"Allergy"},{"issue":"11","key":"10.1016\/j.anai.2021.07.023_bib0020","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/j.ajem.2019.02.012","article-title":"Flexible nasotracheal intubation compared to blind nasotracheal intubation in the setting of simulated angioedema","volume":"37","author":"Parkey","year":"2019","journal-title":"Am J Emerg Med"},{"issue":"5","key":"10.1016\/j.anai.2021.07.023_bib0021","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1520\/JFS15129J","article-title":"Asphyxia due to angiotensin converting enzyme (ACE) inhibitor mediated angioedema of the tongue during the treatment of hypertensive heart disease","volume":"46","author":"Dean","year":"2001","journal-title":"J Forensic Sci"},{"issue":"12","key":"10.1016\/j.anai.2021.07.023_bib0022","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1161\/01.ATV.0000097770.66965.2A","article-title":"Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine","volume":"23","author":"Mason","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.anai.2021.07.023_bib0023","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/sj.bjp.0704753","article-title":"Amlodipine, but not verapamil or nifedipine, dilates rabbit femoral artery largely through a nitric oxide- and kinin-dependent mechanism","volume":"136","author":"Xu","year":"2002","journal-title":"Br J Pharmacol"},{"issue":"10","key":"10.1016\/j.anai.2021.07.023_bib0024","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.peptides.2010.07.008","article-title":"Mechanism of cigarette smoke-induced kinin B(1) receptor expression in rat airways","volume":"31","author":"Lin","year":"2010","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.anai.2021.07.023_bib0025","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1345\/aph.1L527","article-title":"Probable amlodipine-induced angioedema","volume":"43","author":"Southward","year":"2009","journal-title":"Ann Pharmacother"},{"issue":"4","key":"10.1016\/j.anai.2021.07.023_bib0026","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/1060028016682251","article-title":"Comparison of clinical factors between patients with angiotensin-converting enzyme inhibitor-induced angioedema and cough","volume":"51","author":"Hallberg","year":"2017","journal-title":"Ann Pharmacother"},{"issue":"9","key":"10.1016\/j.anai.2021.07.023_bib0027","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2019-232019","article-title":"Angioedema secondary to amlodipine and lisinopril: a documented progression","volume":"12","author":"Morgenthau","year":"2019","journal-title":"BMJ Case Rep"},{"issue":"6","key":"10.1016\/j.anai.2021.07.023_bib0028","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.jaip.2020.03.030","article-title":"Urticaria and angioedema across the ages","volume":"8","author":"Saini","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.anai.2021.07.023_bib0029","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000368404","article-title":"Boccon-Gibod I. Diagnosis and treatment of bradykinin-mediated angioedema: outcomes from an angioedema expert consensus meeting","volume":"165","author":"Craig","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"issue":"5","key":"10.1016\/j.anai.2021.07.023_bib0030","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1056\/NEJMoa1312524","article-title":"A randomized trial of icatibant in ACE-inhibitor-induced angioedema","volume":"372","author":"Ba\u015f","year":"2015","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.anai.2021.07.023_bib0031","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.jaip.2017.03.003","article-title":"Randomized trial of icatibant for angiotensin-converting enzyme inhibitor-induced upper airway angioedema","volume":"5","author":"Sinert","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.anai.2021.07.023_bib0032","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.annemergmed.2014.07.014","article-title":"Ecallantide for the acute treatment of angiotensin-converting enzyme inhibitor-induced angioedema: a multicenter, randomized, controlled trial","volume":"65","author":"Lewis","year":"2015","journal-title":"Ann Emerg Med"},{"issue":"1","key":"10.1016\/j.anai.2021.07.023_bib0033","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/1060028015607037","article-title":"Off-label use of agents for management of serious or life-threatening angiotensin converting enzyme inhibitor-induced angioedema","volume":"50","author":"Culley","year":"2016","journal-title":"Ann Pharmacother"},{"issue":"9","key":"10.1016\/j.anai.2021.07.023_bib0034","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1056\/NEJM197208312870907","article-title":"Tranexamic acid therapy in hereditary angioneurotic edema","volume":"287","author":"Sheffer","year":"1972","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.anai.2021.07.023_bib0035","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.revmed.2018.04.014","article-title":"[Tranexamic acid as first-line emergency treatment for episodes of bradykinin-mediated angioedema induced by ACE inhibitors]","volume":"39","author":"Beauch\u00eane","year":"2018","journal-title":"Rev Med Interne"},{"issue":"6","key":"10.1016\/j.anai.2021.07.023_bib0036","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.anai.2021.02.011","article-title":"The use of intravenous tranexamic acid for patients with angiotensin-converting enzyme inhibitor-induced angioedema: a case series","volume":"126","author":"Martinez Manzano","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"10.1016\/j.anai.2021.07.023_bib0037","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1081-1206(10)60493-0","article-title":"Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma","volume":"101","author":"Joseph","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"11","key":"10.1016\/j.anai.2021.07.023_bib0038","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1097\/HJH.0b013e32834b4b9b","article-title":"Long-term follow-up of 111 patients with angiotensin-converting enzyme inhibitor-related angioedema","volume":"29","author":"Beltrami","year":"2011","journal-title":"J Hypertens"},{"issue":"3","key":"10.1016\/j.anai.2021.07.023_bib0039","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.rmed.2011.11.003","article-title":"The effects of cigarette smoke on airway inflammation in asthma and COPD: therapeutic implications","volume":"106","author":"Tamimi","year":"2012","journal-title":"Respir Med"},{"issue":"10","key":"10.1016\/j.anai.2021.07.023_bib0040","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa021322","article-title":"The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease","volume":"350","author":"Celli","year":"2004","journal-title":"N Engl J Med"}],"container-title":["Annals of Allergy, Asthma & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120621005226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1081120621005226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:27:38Z","timestamp":1761053258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1081120621005226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1081120621005226"],"URL":"https:\/\/doi.org\/10.1016\/j.anai.2021.07.023","relation":{},"ISSN":["1081-1206"],"issn-type":[{"value":"1081-1206","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors associated with intubation and readmissions in patients with angioedema: A single-center experience al. \/ Ann Allergy Asthma Immunol 127 (2021) xxx\u2013xxx\"?>","name":"articletitle","label":"Article Title"},{"value":"Annals of Allergy, Asthma & Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anai.2021.07.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}